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公开(公告)号：US08568446B2
公开(公告)日：2013-10-29
申请号：US12779400
申请日：2010-05-13
申请人： Takashi Kurokawa , Christopher W. Widenhouse , Agnieszka Seyda , Jeffrey S. Swayze , Foster B. Stulen , Mark H. Ransick , Richard W. Timm , Shailendra K. Parihar , Shelby L. Cook Kornbluth
发明人： Takashi Kurokawa , Christopher W. Widenhouse , Agnieszka Seyda , Jeffrey S. Swayze , Foster B. Stulen , Mark H. Ransick , Richard W. Timm , Shailendra K. Parihar , Shelby L. Cook Kornbluth
IPC分类号： A61M37/00
CPC分类号： A61B17/0057 , A61B10/0275 , A61B10/0283 , A61B17/00491 , A61B17/07207 , A61B17/12099 , A61B17/12186 , A61B2017/00495 , A61B2017/00641 , A61B2017/22067 , A61F5/0083 , A61M5/19 , A61M5/204 , A61M5/2448 , A61M5/31586 , A61M25/10 , A61M2005/2414
摘要： A surgical device comprises a housing, a plurality of media reservoirs, an end effector, and a pumping device. Each media reservoir is configured to receive at least one component of a tissue repair composition. The end effector is configured for insertion into a lumen to deliver a tissue repair composition into that lumen. The end effector has at least one fluid conduit and at least one orifice in communication with the fluid conduit. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the plurality of media reservoirs through the fluid conduit of the end effector such that the tissue repair composition is expelled from the at least one orifice. The media reservoirs may contain medical fluid components such as viable cells and scaffold material to repair a fistula or address some other condition in a patient.
摘要翻译： 手术装置包括壳体，多个介质容器，末端执行器和泵送装置。 每个介质储存器构造成接收组织修复组合物的至少一个组分。 末端执行器构造成用于插入内腔以将组织修复组合物递送到该内腔中。 末端执行器具有至少一个流体导管和与流体导管连通的至少一个孔口。 抽吸装置可操作以通过端部执行器的流体管道促使包含多个介质容器的内容物的至少一部分的组织修复组合物，使得组织修复组合物从至少一个孔排出。 介质储存器可以包含医疗流体组分，例如活细胞和支架材料，以修复瘘管或解决患者中的一些其他状况。
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42.发明申请公开(公告)号：US20130157368A1
公开(公告)日：2013-06-20
申请号：US13331283
申请日：2011-12-20
申请人： Charito Buensuceso , Agnieszka Seyda , David C. Colter , Sridevi Dhanaraj , Brian C. Kramer , Jason Elliot Ekert , Amanda Lynn Kauffman
发明人： Charito Buensuceso , Agnieszka Seyda , David C. Colter , Sridevi Dhanaraj , Brian C. Kramer , Jason Elliot Ekert , Amanda Lynn Kauffman
IPC分类号： C12N5/071 , C12N15/867
CPC分类号： C12N15/86 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/25 , C12N2510/00
摘要： We have disclosed an induced pluripotent stem cell and the method of preparing the induced pluripotent stem cell from a human kidney-derived cell. More particularly, we have disclosed a human kidney-derived iPS cell which may be differentiated into cells of ectoderm, mesoderm, and endoderm lineages.
摘要翻译： 我们已经公开了诱导多能干细胞和从人肾源细胞制备诱导的多能干细胞的方法。 更具体地，我们已经公开了可以分化成外胚层，中胚层和内胚层谱系的细胞的人肾来源的iPS细胞。
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43.发明申请公开(公告)号：US20130157365A1
公开(公告)日：2013-06-20
申请号：US13330931
申请日：2011-12-20
IPC分类号： C12N5/071
CPC分类号： C12N5/0605 , C12N5/0696 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/025
摘要： We have disclosed an induced pluripotent stem cell and the method of preparing the induced pluripotent stem cell from a human umbilical cord tissue-derived cell. More particularly, we have disclosed a human umbilical cord tissue-derived iPS cell which may be differentiated into cells of ectoderm, mesoderm, and endoderm lineages.
摘要翻译： 我们已经公开了诱导多能干细胞和从人脐带组织来源的细胞制备诱导的多能干细胞的方法。 更具体地，我们已经公开了可以分化成外胚层，中胚层和内胚层谱系细胞的人脐带组织来源的iPS细胞。
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公开(公告)号：US20090162411A1
公开(公告)日：2009-06-25
申请号：US12337413
申请日：2008-12-17
CPC分类号： A61K35/22 , A61K9/0024 , A61K9/1652 , A61K9/48 , A61K35/12 , A61L27/34 , A61L27/3604 , A61L27/365 , A61L27/3683
摘要： Provided are therapeutic implants comprising renal tissue encapsulated within a polymer bead. Also disclosed are methods for treating a disease state in a subject comprising implanting within said subject a therapeutic implant comprising renal tissue encapsulated within a polymer bead. Also provided are methods for making a therapeutic implant comprising: providing renal tissue; mixing the renal tissue with a solution comprising a polymer, thereby forming a tissue-polymer suspension; extruding the tissue-polymer suspension into an bead-forming solution, thereby forming a therapeutic implant comprising beads of said polymer within which the renal tissue is encapsulated.
摘要翻译： 提供包含包封在聚合物珠内的肾组织的治疗性植入物。 还公开了用于治疗受试者的疾病状态的方法，包括在所述受试者内植入包含封装在聚合物珠内的肾组织的治疗性植入物。 还提供了用于制备治疗性植入物的方法，包括：提供肾组织; 将肾组织与包含聚合物的溶液混合，由此形成组织 - 聚合物悬浮液; 将组织 - 聚合物悬浮液挤出成珠形成溶液，从而形成治疗性植入物，其包含所述聚合物的珠粒，肾组织在其中被包封。
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公开(公告)号：US20060182752A1
公开(公告)日：2006-08-17
申请号：US10514215
申请日：2003-05-15
CPC分类号： A61K48/0041 , A61K9/5146 , A61K47/32 , A61K47/34 , C08G63/19 , C08G63/52 , C08G63/64 , C08G63/672 , C08G63/6856 , C08G2261/126 , C12N15/87
摘要： Biocompatible non-toxic polyarylate triblock copolymers having an A-B-A structure wherein each A is a water-soluble, hydrophilic polymer end block and the B middle block is an polyarylate oligomer. The polymers spontaneously self-assemble to form low CAC nanospheres having utility as transfection agents for gene delivery.
摘要翻译： 具有A-B-A结构的生物相容性无毒多芳基化合物三嵌段共聚物，其中每个A是水溶性亲水性聚合物端嵌段，B中间嵌段是聚芳基化合物低聚物。 聚合物自发地自组装形成低CAC纳米球，其具有用作基因递送的转染剂。
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公开(公告)号：US20110282324A1
公开(公告)日：2011-11-17
申请号：US12779400
申请日：2010-05-13
申请人： Takashi Kurokawa , Christopher W. Widenhouse , Agnieszka Seyda , Jeffrey S. Swayze , Foster B. Stulen , Mark H. Ransick , Richard W. Timm , Shailendra K. Parihar , Shelby L. Cook Kornbluth
发明人： Takashi Kurokawa , Christopher W. Widenhouse , Agnieszka Seyda , Jeffrey S. Swayze , Foster B. Stulen , Mark H. Ransick , Richard W. Timm , Shailendra K. Parihar , Shelby L. Cook Kornbluth
CPC分类号： A61B17/0057 , A61B10/0275 , A61B10/0283 , A61B17/00491 , A61B17/07207 , A61B17/12099 , A61B17/12186 , A61B2017/00495 , A61B2017/00641 , A61B2017/22067 , A61F5/0083 , A61M5/19 , A61M5/204 , A61M5/2448 , A61M5/31586 , A61M25/10 , A61M2005/2414
摘要： A surgical device comprises a housing, a plurality of media reservoirs, an end effector, and a pumping device. Each media reservoir is configured to receive at least one component of a tissue repair composition. The end effector is configured for insertion into a lumen to deliver a tissue repair composition into that lumen. The end effector has at least one fluid conduit and at least one orifice in communication with the fluid conduit. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the plurality of media reservoirs through the fluid conduit of the end effector such that the tissue repair composition is expelled from the at least one orifice. The media reservoirs may contain medical fluid components such as viable cells and scaffold material to repair a fistula or address some other condition in a patient.
摘要翻译： 手术装置包括壳体，多个介质容器，末端执行器和泵送装置。 每个介质储存器构造成接收组织修复组合物的至少一个组分。 末端执行器构造成用于插入内腔以将组织修复组合物递送到该内腔中。 末端执行器具有至少一个流体导管和与流体导管连通的至少一个孔口。 抽吸装置可操作以通过端部执行器的流体管道促使包含多个介质容器的内容物的至少一部分的组织修复组合物，使得组织修复组合物从至少一个孔排出。 介质储存器可以包含医疗流体组分，例如活细胞和支架材料，以修复瘘管或解决患者中的一些其他状况。
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47.发明申请Treatment of osteochondral diseases using postpartum-derived cells and products thereof 审中-公开使用产后来源的细胞及其产品治疗骨软骨病公开(公告)号：US20060154366A1
公开(公告)日：2006-07-13
申请号：US11315969
申请日：2005-12-22
申请人： Laura Brown , Sridevi Dhanaraj , Agnieszka Seyda
发明人： Laura Brown , Sridevi Dhanaraj , Agnieszka Seyda
IPC分类号： C12N5/08
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products such as lysates related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions such as osteoarthritis.
摘要翻译： 源自产后组织的细胞及其分离和诱导分化成软骨形成或成骨表型细胞的方法由本发明提供。 本发明进一步提供产后来源的细胞和产物如与其相关的裂解物的培养物和组合物。 本发明的产后衍生细胞及其相关产品具有多种用途，包括但不限于研究，诊断和治疗应用，例如治疗骨和软骨病症如骨关节炎。
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