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    SOLUBLE ZCYTOR 11 CYTOKINE RECEPTORS
    41.
    发明申请
    SOLUBLE ZCYTOR 11 CYTOKINE RECEPTORS 有权
    可溶性ZCYTOR 11细胞因子受体

    公开(公告)号：US20110081344A1

    公开(公告)日：2011-04-07

    申请号：US12943181

    申请日：2010-11-10

    申请人： Wayne R. Kindsvogel ,  Stavros Topouzis

    发明人： Wayne R. Kindsvogel ,  Stavros Topouzis

    IPC分类号： A61K39/395 ,  C07K14/00 ,  C07K16/18 ,  A61K38/16 ,  A61P11/06 ,  A61P37/00 ,  A61P17/06

    CPC分类号： C07K14/7155 ,  C07K14/715 ,  C07K16/2866 ,  C07K2319/00 ,  C07K2319/30

    摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zcytor11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides and antibodies can also be used to block TIF activity in vitro and in vivo, and may be used in conjunction with TIF and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了新颖的多肽组合，编码多肽的多核苷酸以及可用作新的细胞因子拮抗剂的可溶性zcytor11受体的相关组合物和方法，以及用于检测刺激造血，淋巴和骨髓细胞的增殖和/或发育的配体的方法 体外和体内。 配体结合受体多肽和抗体也可用于在体外和体内阻断TIF活性，并可与TIF和其它细胞因子结合使用以选择性刺激免疫系统。 本发明还包括生产蛋白质的方法，用途及其抗体。

    Dimerized polypeptide fusions
    42.
    发明授权
    Dimerized polypeptide fusions 失效
    二聚体多肽融合

    公开(公告)号：US06291646B1

    公开(公告)日：2001-09-18

    申请号：US09583210

    申请日：2000-05-30

    申请人： Andrzej Z. Sledziewski ,  Lillian Anne Bell ,  Wayne R. Kindsvogel

    发明人： Andrzej Z. Sledziewski ,  Lillian Anne Bell ,  Wayne R. Kindsvogel

    IPC分类号： C07K1900

    CPC分类号： C07K14/71 ,  C07K14/72 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2319/30

    摘要： Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof.

    摘要翻译： 公开了生产分泌的受体类似物和生物活性肽二聚体的方法。 用于产生分泌的受体类似物和生物活性肽二聚体的方法利用编码受体类似物的DNA序列或需要二聚化的肽连接到二聚化蛋白的生物活性。 受体类似物包括配体结合结构域。 还公开了包含与二聚化蛋白融合的人PDGF受体的基本上胞外结构域的多肽，该部分能够结合人PDGF或其同种型。 多肽可以用于确定人PDGF或其同种型的存在和用于纯化人PDGF或其同种型的方法。

    Soluble Zcytor 11 Cytokine Receptors
    49.
    发明申请
    Soluble Zcytor 11 Cytokine Receptors 审中-公开
    可溶性Zcytor 11细胞因子受体

    公开(公告)号：US20100047168A1

    公开(公告)日：2010-02-25

    申请号：US12489236

    申请日：2009-06-22

    申请人： Wayne R. Kindsvogel ,  Stavros Topouzis

    发明人： Wayne R. Kindsvogel ,  Stavros Topouzis

    IPC分类号： A61K51/08 ,  A61K38/16 ,  A61K49/00 ,  C07K14/00 ,  A61K39/00 ,  A61K38/43 ,  C12N9/00 ,  C07K16/00 ,  A61P37/02

    CPC分类号： C07K14/7155 ,  C07K14/715 ,  C07K16/2866 ,  C07K2319/00 ,  C07K2319/30

    摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zcytor11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides and antibodies can also be used to block TIF activity in vitro and in vivo, and may be used in conjunction with TIF and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了新颖的多肽组合，编码多肽的多核苷酸以及可用作新的细胞因子拮抗剂的可溶性zcytor11受体的相关组合物和方法，以及用于检测刺激造血，淋巴和骨髓细胞的增殖和/或发育的配体的方法 体外和体内。 配体结合受体多肽和抗体也可用于在体外和体内阻断TIF活性，并可与TIF和其它细胞因子结合使用以选择性刺激免疫系统。 本发明还包括生产蛋白质的方法，用途及其抗体。

    Soluble Zcytor11 cytokine receptors
    50.
    发明授权
    Soluble Zcytor11 cytokine receptors 有权

    公开(公告)号：US07045498B2

    公开(公告)日：2006-05-16

    申请号：US09925055

    申请日：2001-08-08

    申请人： Wayne R. Kindsvogel ,  Stavros Topouzis

    发明人： Wayne R. Kindsvogel ,  Stavros Topouzis

    IPC分类号： A61K38/19 ,  A61K45/00 ,  C07K14/47

    CPC分类号： C07K14/7155 ,  C07K14/715 ,  C07K16/2866 ,  C07K2319/00 ,  C07K2319/30

    摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zcytor11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides and antibodies can also be used to block TIF activity in vitro and in vivo, and may be used in conjunction with TIF and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.