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公开(公告)号：US20120020938A1
公开(公告)日：2012-01-26
申请号：US12804647
申请日：2010-07-26
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
CPC分类号： A61K35/15 , A61K35/17 , A61K35/28 , A61K35/407 , A61K2035/122
摘要： The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject.
摘要翻译： 本公开涉及涉及用于将至少一种治疗剂递送至生物组织或受试者的生物细胞的组合物，方法，系统，计算机实施的方法及其计算机程序产品。
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公开(公告)号：US20120020885A1
公开(公告)日：2012-01-26
申请号：US12806338
申请日：2010-08-09
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
IPC分类号： A61K49/00 , A61P35/00 , A61P35/02 , A61P37/06 , C12N5/00 , A61K35/12 , A61P31/00 , A61P9/10 , A61P3/10 , A61P1/12 , A61P17/02 , A61P3/04 , C12Q1/02 , A61P1/02
CPC分类号： A61K38/18 , A61K35/28 , A61K35/30 , A61K35/407 , A61K35/545 , A61K38/19 , A61K38/20 , A61K38/2066 , A61K38/21 , C12N2510/00
摘要： The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject.
摘要翻译： 本公开涉及涉及用于将至少一种治疗剂递送至生物组织或受试者的生物细胞的组合物，方法，系统，计算机实施的方法及其计算机程序产品。
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公开(公告)号：US20120022337A1
公开(公告)日：2012-01-26
申请号：US12804649
申请日：2010-07-26
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
CPC分类号： A61K35/15 , A61K35/17 , A61K35/28 , A61K35/407 , A61K2035/122
摘要： The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject.
摘要翻译： 本公开涉及涉及用于将至少一种治疗剂递送至生物组织或受试者的生物细胞的组合物，方法，系统，计算机实施的方法及其计算机程序产品。
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公开(公告)号：US20120020987A1
公开(公告)日：2012-01-26
申请号：US12804648
申请日：2010-07-26
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
CPC分类号： A61K35/15 , A61K35/17 , A61K35/28 , A61K35/407 , A61K2035/122
摘要： The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject.
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公开(公告)号：US20120020949A1
公开(公告)日：2012-01-26
申请号：US12804640
申请日：2010-07-26
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
CPC分类号： A61K35/15 , A61K35/17 , A61K35/28 , A61K35/407 , A61K2035/122
摘要： The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject.
摘要翻译： 本公开涉及涉及用于将至少一种治疗剂递送至生物组织或受试者的生物细胞的组合物，方法，系统，计算机实施的方法及其计算机程序产品。
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公开(公告)号：US20120020939A1
公开(公告)日：2012-01-26
申请号：US12804650
申请日：2010-07-26
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
IPC分类号： A61K48/00
CPC分类号： C12N15/1138 , C12N2310/14 , C12N2310/141 , C12N2330/51
摘要： The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject.
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7.发明申请Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject 有权用于调节脊椎动物受试者中棕色脂肪组织活性的方法，装置和系统公开(公告)号：US20120290023A1
公开(公告)日：2012-11-15
申请号：US13068421
申请日：2011-05-09
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Stephen L. Malaska , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Stephen L. Malaska , Elizabeth A. Sweeney , Lowell L. Wood, JR.
CPC分类号： A61F7/02 , A61F7/007 , A61F7/106 , A61F7/12 , A61F2007/0002 , A61F2007/0011 , A61F2007/0056 , A61F2007/0075 , A61F2007/009 , A61F2007/0093 , A61F2007/0226 , A61F2007/0233 , A61F2007/029 , A61F2007/101 , A61F2007/126 , A61N1/0534 , A61N1/36 , A61N1/36014 , A61N1/3605 , A61N1/36053 , A61N1/3606 , A61N1/36135 , A61N2/002 , A61N2/004 , A61N5/025 , A61N5/04 , A61N7/00 , A61N2007/0008
摘要： Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject.
摘要翻译： 本文公开了用于治疗脊椎动物受试者中的疾病，病症或病症的装置，系统和方法。 提供了一种装置，其包括配置成施加到脊椎动物的一个或多个组织的一个或多个冷却元件，所述脊椎动物受到调节脊椎动物受试者的棕色脂肪组织的至少一种活动，以及可编程控制器，其被配置为向该脊椎动物 或更多个冷却元件，以响应关于脊椎动物对象的一个或多个生理状况的信息。
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8.发明申请公开(公告)号：US20120289758A1
公开(公告)日：2012-11-15
申请号：US13199577
申请日：2011-09-01
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Stephen L. Malaska , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Stephen L. Malaska , Elizabeth A. Sweeney , Lowell L. Wood, JR.
CPC分类号： A61F7/02 , A61F7/007 , A61F7/106 , A61F7/12 , A61F2007/0002 , A61F2007/0011 , A61F2007/0056 , A61F2007/0075 , A61F2007/009 , A61F2007/0093 , A61F2007/0226 , A61F2007/0233 , A61F2007/029 , A61F2007/101 , A61F2007/126 , A61N1/0534 , A61N1/36 , A61N1/36014 , A61N1/3605 , A61N1/36053 , A61N1/3606 , A61N1/36135 , A61N2/002 , A61N2/004 , A61N5/025 , A61N5/04 , A61N7/00 , A61N2007/0008
摘要： Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject.
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9.发明申请Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject 有权用于调节脊椎动物受试者中棕色脂肪组织活性的方法，装置和系统公开(公告)号：US20120290051A1
公开(公告)日：2012-11-15
申请号：US13199566
申请日：2011-09-01
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Stephen L. Malaska , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Stephen L. Malaska , Elizabeth A. Sweeney , Lowell L. Wood, JR.
IPC分类号： A61F7/12
CPC分类号： A61N1/0534 , A61F7/106 , A61F7/12 , A61F2007/0002 , A61F2007/0056 , A61F2007/0075 , A61F2007/009 , A61F2007/0093 , A61F2007/029 , A61F2007/101 , A61F2007/126 , A61N1/36 , A61N1/3605 , A61N5/025 , A61N5/04
摘要： Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more passive cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more passive cooling elements is configured to be implantable, and wherein the one or more passive cooling elements includes a first portion configured to be in association with the one or more tissues to be cooled, and a second portion configured to be placed in association with one or more tissues adjacent to an external epidermal tissue of the vertebrate subject.
摘要翻译： 本文公开了用于治疗脊椎动物受试者中的疾病，病症或病症的装置，系统和方法。 提供了一种装置，其包括被配置为施加到脊椎动物的一个或多个组织的一个或多个被动冷却元件，所述脊椎动物经受至少一种脊椎动物受试者的棕色脂肪组织的活性，其中至少一部分一个或多个 被动冷却元件被构造成可植入，并且其中所述一个或多个被动冷却元件包括构造成与所述一个或多个要冷却的组织相关联的第一部分，以及第二部分，其被配置为与一个或多个被冷却元件 与脊椎动物受试者的外表皮组织相邻的更多组织。
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10.发明申请公开(公告)号：US20120289763A1
公开(公告)日：2012-11-15
申请号：US13068420
申请日：2011-05-09
申请人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Stephen L. Malaska , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Stephen L. Malaska , Elizabeth A. Sweeney , Lowell L. Wood, JR.
CPC分类号： A61F7/02 , A61F7/007 , A61F7/106 , A61F7/12 , A61F2007/0002 , A61F2007/0011 , A61F2007/0056 , A61F2007/0075 , A61F2007/009 , A61F2007/0093 , A61F2007/0226 , A61F2007/0233 , A61F2007/029 , A61F2007/101 , A61F2007/126 , A61N1/0534 , A61N1/36 , A61N1/36014 , A61N1/3605 , A61N1/36053 , A61N1/3606 , A61N1/36135 , A61N2/002 , A61N2/004 , A61N5/025 , A61N5/04 , A61N7/00 , A61N2007/0008
摘要： Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more passive cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more passive cooling elements is configured to be implantable, and wherein the one or more passive cooling elements includes a first portion configured to be in association with the one or more tissues to be cooled, and a second portion configured to be placed in association with one or more tissues adjacent to an external epidermal tissue of the vertebrate subject.
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