公开(公告)号：US08224444B2

公开(公告)日：2012-07-17

申请号：US11975654

申请日：2007-10-19

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen ,  Shai Ayal

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen ,  Shai Ayal

IPC分类号： A61N1/00

CPC分类号： A61N1/36114

摘要： Apparatus is provided including an electrode device, adapted to be coupled to a site of a subject; and a control unit, adapted to drive the electrode device to apply a current to the site intermittently during alternating “on” and “off” periods, each of the “on” periods having an “on” duration equal to between 1 and 10 seconds, and each of the “off” periods having an “off” duration equal to at least 50% of the “on” duration. Other embodiments are also described.

摘要翻译： 提供了包括电极装置的装置，其适于联接到受试者的部位; 以及控制单元，其适于在交替的“接通”和“关闭”周期期间驱动电极装置间歇地施加电流到场地，每个“接通”周期具有等于1至10秒的“接通”持续时间 ，并且每个“关闭”周期具有等于“开启”持续时间的至少50％的“关闭”持续时间。 还描述了其它实施例。

公开(公告)号：US20110098796A1

公开(公告)日：2011-04-28

申请号：US12947608

申请日：2010-11-16

申请人： Tamir Ben-David ,  Shai Ayal ,  Ehud Cohen

发明人： Tamir Ben-David ,  Shai Ayal ,  Ehud Cohen

IPC分类号： A61N1/05

CPC分类号： A61N1/0556 ,  A61N1/36114

摘要： Apparatus is provided for application to a nerve of a subject, including an electrode cuff, which includes a housing, which is configured to be placed at least partially around the nerve so as to define an inner surface of the housing that faces the nerve. A plurality of insulating elements are coupled to the inner surface of the housing at respective insulating element longitudinal positions along the housing, such that the inner surface of the housing and pairs of the insulating elements define one or more respective cavities at respective cavity longitudinal positions along the housing. One or more electrodes are fixed to the housing in fewer than all of the cavities, such that at least one of the cavities is an empty cavity that does not have an electrode positioned therein. Other embodiments are also described.

摘要翻译： 提供了用于施用于受试者神经的装置，包括电极箍，其包括壳体，其被构造成至少部分地围绕神经放置，以限定外壳面向神经的内表面。 多个绝缘元件在沿着壳体的相应绝缘元件纵向位置处联接到壳体的内表面，使得壳体的内表面和成对的绝缘元件在相应的腔纵向位置处限定一个或多个相应的腔 住房。 一个或多个电极在少于所有的空腔中固定到壳体，使得至少一个空腔是不具有位于其中的电极的空腔。 还描述了其它实施例。

公开(公告)号：US20100042194A1

公开(公告)日：2010-02-18

申请号：US12589132

申请日：2009-10-19

申请人： Shai Ayal ,  Ehud Cohen

发明人： Shai Ayal ,  Ehud Cohen

IPC分类号： A61N1/05

CPC分类号： A61N1/0556 ,  A61N1/36017 ,  A61N1/3605

摘要： Apparatus is provided for applying current to a nerve, including a housing, adapted to be placed in a vicinity of the nerve, and at least one cathode and at least one anode, fixed to the housing. The apparatus further includes two or more passive electrodes, fixed to the housing, and a conducting element, which electrically couples the passive electrodes to one another. Other embodiments are also described.

摘要翻译： 提供了用于向包括适于放置在神经附近的包括壳体的神经施加电流的装置，以及固定到壳体的至少一个阴极和至少一个阳极。 该装置还包括固定到壳体的两个或多个无源电极和将无源电极彼此电耦合的导电元件。 还描述了其它实施例。

公开(公告)号：US20100042186A1

公开(公告)日：2010-02-18

申请号：US12228630

申请日：2008-08-13

申请人： Tamir Ben-David ,  Shai Ayal ,  Ehud Cohen ,  Yossi Gross ,  Nir Schain

发明人： Tamir Ben-David ,  Shai Ayal ,  Ehud Cohen ,  Yossi Gross ,  Nir Schain

IPC分类号： A61N1/36 ,  A61N1/05

CPC分类号： A61N1/0556 ,  A61B5/04001 ,  A61B5/4041 ,  A61B5/6846 ,  A61N1/36114

摘要： Apparatus is provided for application to a nerve of a subject, the apparatus comprising an electrode device, which comprises a housing, which is configured to be placed at least partially around the nerve, so as to define an outer surface of the electrode device and an inner surface that faces the nerve. The electrode device further comprises one or more first electrode contact surfaces, fixed to the inner surface of the housing, and one or more second electrode contact surfaces, fixed to the outer surface of the housing. Other embodiments are also described.

摘要翻译： 提供了用于对受试者的神经施用的装置，该装置包括电极装置，该电极装置包括壳体，该壳体构造成至少部分地围绕神经放置，以限定电极装置的外表面，以及 面向神经的内表面。 电极装置还包括固定到壳体的内表面的一个或多个第一电极接触表面和固定到外壳的外表面的一个或多个第二电极接触表面。 还描述了其它实施例。

公开(公告)号：US07634317B2

公开(公告)日：2009-12-15

申请号：US11062324

申请日：2005-02-18

申请人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/00

CPC分类号： A61B5/412 ,  A61B5/024 ,  A61B5/4029 ,  A61B5/4041 ,  A61B5/7217 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3627

摘要： Apparatus is provided including an electrode device, adapted to be coupled to a site of a subject; and a control unit, adapted to drive the electrode device to apply a current to the site intermittently during alternating “on” and “off” periods, each of the “on” periods having an “on” duration equal to between 1 and 10 seconds, and each of the “off” periods having an “off” duration equal to at least 50% of the “on” duration. Other embodiments are also described.

摘要翻译： 提供了包括电极装置的装置，其适于联接到受试者的部位; 以及控制单元，其适于在交替的“接通”和“关闭”周期期间驱动电极装置间歇地施加电流到场地，每个“接通”周期具有等于1至10秒的“接通”持续时间 ，并且每个“关闭”周期具有等于“开启”持续时间的至少50％的“关闭”持续时间。 还描述了其它实施例。

公开(公告)号：US07627384B2

公开(公告)日：2009-12-01

申请号：US11280884

申请日：2005-11-15

申请人： Shai Ayal ,  Ehud Cohen

发明人： Shai Ayal ,  Ehud Cohen

IPC分类号： A61N1/08

CPC分类号： A61N1/0556 ,  A61N1/36017 ,  A61N1/3605

摘要： Apparatus is provided for applying current to a nerve, including a housing, adapted to be placed in a vicinity of the nerve, and at least one cathode and at least one anode, fixed to the housing. The apparatus further includes two or more passive electrodes, fixed to the housing, and a conducting element, which electrically couples the passive electrodes to one another. Other embodiments are also described.

摘要翻译： 提供了用于向包括适于放置在神经附近的包括壳体的神经施加电流的装置，以及固定到壳体的至少一个阴极和至少一个阳极。 该装置还包括固定到壳体的两个或多个无源电极和将无源电极彼此电耦合的导电元件。 还描述了其它实施例。

公开(公告)号：US20050149154A1

公开(公告)日：2005-07-07

申请号：US10745514

申请日：2003-12-29

申请人： Ehud Cohen ,  Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra

发明人： Ehud Cohen ,  Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra

IPC分类号： A61N1/05

CPC分类号： A61N1/0551 ,  A61N1/0556

摘要： A dual electrode arrangement, is provided, wherein two, preferably unidirectional, electrode configurations flank a nerve junction from which a preselected nerve branch issues, proximally and distally to the junction, with respect to the brain. The arrangement is conducive to the following: generating efferent action-potential propagations, substantially restricted to the preselected nerve branch, inhibiting afferent action-potential propagations, from the preselected nerve branch, selectively generating action-potential propagations, in a subset of nerve fibers of a predetermined diameter range, substantially restricted to the preselected nerve branch, and selectively inhibiting action-potential propagations, in a subset of nerve fibers of a predetermined diameter range, substantially restricted to the preselected nerve branch. The dual electrode arrangement is further conducive to monitoring naturally-occurring, efferent action-potential propagations, heading towards the preselected nerve branch, and monitoring naturally-occurring, afferent action-potential propagations, from the preselected nerve branch. The unidirectional electrode configurations may be monopolar, bipolar, tripolar, or multipolar. Communication with extracorporeal stations, and closed loop operations are also provided.

摘要翻译： 提供了双电极布置，其中两个，优选单向的电极构型位于神经交界处，神经交叉点相对于脑，预选的神经分支向近端向近端和远端发出接合。 该装置有利于：产生传播动作电位传播，基本上限于预选的神经分支，抑制来自预选神经分支的传入动作潜在传播，选择性地产生动作电位传播，在神经纤维的子集中 基本上限于预选神经分支的预定直径范围，以及基本上限于预选神经分支的预定直径范围的神经纤维的子集中选择性抑制动作电位传播。 双电极布置还有助于监测自然发生的，传出的动作电位传播，朝向预选的神经分支，并且从预选的神经分支监测天然存在的，传入的动作电位传播。 单向电极配置可以是单极性，双极性，三极性或多极性。 还提供与体外站的沟通和闭环操作。

公开(公告)号：US20050102007A1

公开(公告)日：2005-05-12

申请号：US10981939

申请日：2004-11-05

申请人： Shai Ayal ,  Ehud Cohen ,  Ron Dabby

发明人： Shai Ayal ,  Ehud Cohen ,  Ron Dabby

IPC分类号： A61N1/18 ,  A61N1/34 ,  A61N1/36 ,  A61N1/372

CPC分类号： A61N1/36021 ,  A61N1/36003 ,  A61N1/36007 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/37205

摘要： A method for treating spasticity of a subject is provided, including driving a current into a nerve of the subject that includes one or more sensory fibers, and configuring the current so as to inhibit propagation of action potentials in one or more of the sensory fibers, so as to treat the spasticity. In a preferred embodiment, the sensory fibers include one or more Ia sensory fibers, and configuring the current includes configuring the current so as to inhibit propagation of the action potentials in at least one of the Ia sensory fibers.

公开(公告)号：US20050038490A1

公开(公告)日：2005-02-17

申请号：US10948516

申请日：2004-09-23

申请人： Yossi Gross ,  Shai Ayal ,  Ehud Cohen

发明人： Yossi Gross ,  Shai Ayal ,  Ehud Cohen

IPC分类号： A61N20060101 ,  A61N1/05 ,  A61N1/34 ,  A61N1/36 ,  A61N1/362

CPC分类号： A61N1/0556 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/36071 ,  A61N1/36114

摘要： Apparatus is provided for applying current to a nerve. A cathode is adapted to be placed in a vicinity of a cathodic longitudinal site of the nerve and to apply a cathodic current to the nerve. A primary inhibiting anode is adapted to be placed in a vicinity of a primary anodal longitudinal site of the nerve and to apply a primary anodal current to the nerve. A secondary inhibiting anode is adapted to be placed in a vicinity of a secondary anodal longitudinal site of the nerve and to apply a secondary anodal current to the nerve, the secondary anodal longitudinal site being closer to the primary anodal longitudinal site than to the cathodic longitudinal site.

摘要翻译： 提供用于向神经施加电流的装置。 阴极适于放置在神经的阴极纵向位置附近，并将阴极电流施加于神经。 初级抑制阳极适于放置在神经的主要阳极纵向位置附近，并向神经施加初级阳极电流。 辅助抑制阳极适于放置在神经的次级阳极纵向位置附近，并将次要阳极电流施加到神经，次级阳极纵向位置比阴极纵向更靠近初级阳极纵向位置 现场。

公开(公告)号：US06600954B2

公开(公告)日：2003-07-29

申请号：US09824682

申请日：2001-04-04

申请人： Ehud Cohen ,  Shai Ayal

发明人： Ehud Cohen ,  Shai Ayal

IPC分类号： A61N134

CPC分类号： A61N1/36071

摘要： A method and apparatus particularly useful for pain control by selectively blocking the propagation of body-generated action potentials travelling through a nerve bundle by using a tripolar electrode device to generate unidirectional action potentials to serve as collision blocks with the body-generated action potentials representing pain sensations in the small-diameter sensory fibers. In the described preferred embodiments there are a plurality of electrode devices spaced along the length of the nerve bundle which are sequentially actuated with delays corresponding to the velocity of propagation of the body-generated action potentials through the large-diameter fibers to produce a “green wave” effect which minimizes undesired anodal blocking of the large-diameter fibers while maximizing the collision blocking of the small-diameter fibers.