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147 条记录 (耗时 0.067 秒)

    Glycopegylated Factor Ix
    41.
    发明申请
    Glycopegylated Factor Ix 审中-公开
    糖基化因子Ix

    公开(公告)号：US20080255026A1

    公开(公告)日：2008-10-16

    申请号：US11915239

    申请日：2006-05-25

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe ,  Panneerselvam Krishnasamy

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe ,  Panneerselvam Krishnasamy

    IPC分类号： A61K38/02 ,  C07K2/00 ,  C12P21/06

    CPC分类号： A61K38/4846 ,  A61K47/549 ,  A61K47/60 ,  C12N9/644 ,  C12Y304/21022

    摘要： The present invention provides conjugates between Factor Ix and PEG moieties. The conjugates are linked via a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. Conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供因子Ix和PEG部分之间的缀合物。 缀合物通过插入在肽和修饰基团之间并共价连接到肽上的糖基连接基团连接。 通过糖基转移酶的作用由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。

    Glycopegylated Follicle Stimulating Hormone
    42.
    发明申请
    Glycopegylated Follicle Stimulating Hormone 审中-公开
    糖基化卵泡刺激激素

    公开(公告)号：US20080015142A1

    公开(公告)日：2008-01-17

    申请号：US10581538

    申请日：2004-12-03

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe

    IPC分类号： A61K38/24 ,  C07K14/59

    CPC分类号： C07K14/59 ,  A61K38/17 ,  Y02A50/471

    摘要： The present invention provides conjugates between follicle stimulating hormone and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

    摘要翻译： 本发明提供了促卵泡激素和PEG部分之间的缀合物。 缀合物经由完整的糖基连接基团连接，该基团介于并共价连接到肽和修饰基团之间。 通过糖基转移酶的作用，缀合物由糖基化和未糖基化的肽形成。 糖基转移酶将修饰的糖部分连接到肽上的氨基酸或糖基残基上。 还提供了包括缀合物的药物制剂。 缀合物的制备方法也在本发明的范围内。

    Glycopegylated factor IX
    45.
    发明授权
    Glycopegylated factor IX 有权
    糖基化因子IX

    公开(公告)号：US08632770B2

    公开(公告)日：2014-01-21

    申请号：US12851651

    申请日：2010-08-06

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe ,  Krishnasamy Panneer-Selvam

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe ,  Krishnasamy Panneer-Selvam

    IPC分类号： A61K38/48

    CPC分类号： A61K38/4846 ,  A61K47/549 ,  A61K47/60 ,  Y02A50/471

    摘要： The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供因子IX和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。

    GLYCOPEGYLATED FACTOR IX
    48.
    发明申请
    GLYCOPEGYLATED FACTOR IX 有权
    糖蛋白因子九

    公开(公告)号：US20100081791A1

    公开(公告)日：2010-04-01

    申请号：US12605028

    申请日：2009-10-23

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe ,  Krishnasamy Panneerselvam

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe ,  Krishnasamy Panneerselvam

    IPC分类号： C07K14/435

    CPC分类号： A61K38/4846 ,  A61K47/549 ,  A61K47/60 ,  C12N9/644 ,  C12Y304/21022

    摘要： The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. Conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供因子IX和PEG部分之间的缀合物。 缀合物通过插入在肽和修饰基团之间并共价连接到肽上的糖基连接基团连接。 通过糖基转移酶的作用由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。

    GLYCOPEGYLATED FACTOR IX
    49.
    发明申请
    GLYCOPEGYLATED FACTOR IX 审中-公开
    糖蛋白因子九

    公开(公告)号：US20090081188A1

    公开(公告)日：2009-03-26

    申请号：US12184956

    申请日：2008-08-01

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe ,  Krishnasamy Panneerselvam

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn Bowe ,  Krishnasamy Panneerselvam

    IPC分类号： A61K38/48 ,  C12N9/96 ,  C12P21/04 ,  A61P7/00

    CPC分类号： A61K38/4846 ,  A61K47/549 ,  A61K47/60 ,  Y02A50/471

    摘要： The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供因子IX和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。

    Glycopegylated factor IX
    50.
    发明授权
    Glycopegylated factor IX 有权
    糖基化因子IX

    公开(公告)号：US08404809B2

    公开(公告)日：2013-03-26

    申请号：US12605028

    申请日：2009-10-23

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn L. Bowe ,  Krishnasamy Panneerselvam

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  Caryn L. Bowe ,  Krishnasamy Panneerselvam

    IPC分类号： C07K14/435

    CPC分类号： A61K38/4846 ,  A61K47/549 ,  A61K47/60 ,  C12N9/644 ,  C12Y304/21022

    摘要： Conjugates between Factor IX and PEG moieties are disclosed in the present application. The conjugates are linked via a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. Conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 在本申请中公开了因子IX和PEG部分之间的缀合物。 缀合物通过插入在肽和修饰基团之间并共价连接到肽上的糖基连接基团连接。 通过糖基转移酶的作用由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。