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41.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of endometriosis 审中-公开新型核苷酸和氨基酸序列，以及其用于诊断子宫内膜异位症的测定及其使用方法公开(公告)号：US20060014166A1
公开(公告)日：2006-01-19
申请号：US11043788
申请日：2005-01-27
申请人： Yossi Cohen , Sarah Pollock , Amit Novik , Alexander Diber
发明人： Yossi Cohen , Sarah Pollock , Amit Novik , Alexander Diber
CPC分类号： C07K14/47 , C07K2319/00 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2800/364
摘要： Novel markers for endometriosis that are both sensitive and accurate. These markers are differentially expressed in endometriosis specifically, as opposed to normal tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of endometriosis. The markers of the present invention, alone or in combination, show a high degree of differential detection between endometriosis and non-endometriosis states.
摘要翻译： 子宫内膜异位症的新型标记物既敏感又准确。 与正常组织相反，这些标志物特异性地在子宫内膜异位症中差异表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与子宫内膜异位症的可能诊断相关的信息。 本发明的标记单独或组合显示子宫内膜异位症和非子宫内膜异位症状态之间的高度差异检测。
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42.发明申请Methods and systems for identifying naturally occurring antisense transcripts and methods, kits and arrays utilizing same 审中-公开用于鉴定天然存在的反义转录物的方法和系统以及使用其的方法，试剂盒和阵列公开(公告)号：US20050009771A1
公开(公告)日：2005-01-13
申请号：US10764503
申请日：2004-01-27
申请人： Erez Levanon , Jeanne Bernstein , Sarah Pollock , Alex Diber , Zurit Levine , Sergey Nemzer , Vladimir Grebinsky , Hanqing Xie , Brian Meloon , Andrew Olson , Dvir Dahary , Yossi Cohen , Avi Shoshan , Shira Walach , Alon Wasserman , Rami Khosravi , Galit Rotman
发明人： Erez Levanon , Jeanne Bernstein , Sarah Pollock , Alex Diber , Zurit Levine , Sergey Nemzer , Vladimir Grebinsky , Hanqing Xie , Brian Meloon , Andrew Olson , Dvir Dahary , Yossi Cohen , Avi Shoshan , Shira Walach , Alon Wasserman , Rami Khosravi , Galit Rotman
CPC分类号： C12Q1/6876 , C12N15/111 , C12N2310/11 , C12N2320/11 , C12N2330/10 , C12Q2600/136 , C12Q2600/158 , G16B30/00 , Y02A50/58 , Y02A90/26
摘要： A method of identifying putative naturally occurring antisense transcripts is provided. The method is effected by (a) computationally aligning a first database including sense-oriented polynucleotide sequences with a second database including expressed polynucleotide sequences; and (b) identifying expressed polynucleotide sequences from the second database being capable of forming a duplex with at least one sense-oriented polynucleotide sequence of the first database, thereby identifying putative naturally occurring antisense transcripts. Also provided are polynucleotides and polypeptide sequences identified by the above-described methodology.
摘要翻译： 提供了鉴定推定的天然存在的反义转录物的方法。 该方法通过以下步骤来实现：（a）计算对齐包含有意向多核苷酸序列的第一数据库与包括表达的多核苷酸序列的第二数据库; 和（b）从第二数据库鉴定表达的多核苷酸序列能够与第一数据库的至少一个有义向多核苷酸序列形成双链体，从而鉴定推定的天然存在的反义转录物。 还提供了通过上述方法鉴定的多核苷酸和多肽序列。
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公开(公告)号：US07601692B2
公开(公告)日：2009-10-13
申请号：US11471652
申请日：2006-06-21
申请人： Zurit Levine , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman , Sarah Pollock
发明人： Zurit Levine , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman , Sarah Pollock
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/523 , C12Q2600/156 , C12Q2600/158
摘要： Novel MCP-1 splice variant polypeptides and polynucleotides encoding same are provided. Also provided are pharmaceutical compositions comprising the splice variant polypeptides and polynucleotides, vectors and host cells comprising same. The compositions of the present invention are useful to treat various MCP-1 related disorders as well as for diagnosing, determining predisposition and/or prognosis of various disorders.
摘要翻译： 提供了新的MCP-1剪接变体多肽和编码它们的多核苷酸。 还提供了包含剪接变体多肽和多核苷酸，载体和包含其的宿主细胞的药物组合物。 本发明的组合物可用于治疗各种MCP-1相关疾病以及用于诊断，确定各种疾病的倾向和/或预后。
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公开(公告)号：US20080182299A1
公开(公告)日：2008-07-31
申请号：US11978204
申请日：2007-10-29
申请人： Gad S. Colocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
发明人： Gad S. Colocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
CPC分类号： G01N33/74 , C07K14/58 , G01N2800/324 , G01N2800/325 , Y10T436/143333
摘要： Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein.
摘要翻译： 新型BNP变体。 根据本发明的新型BNP变体可任选地用于本文所述的BNP变体可检测疾病的诊断。
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45.发明申请Novel thrombospondin-1 polynucleotides encoding variant thrombospondin-1 polypeptides and methods using same 审中-公开编码变体血小板反应蛋白-1多肽的新型血小板反应蛋白-1多核苷酸及其使用方法公开(公告)号：US20070219125A1
公开(公告)日：2007-09-20
申请号：US11709841
申请日：2007-02-23
申请人： Gad Cojocaru , Zurit Levine , Michal Ayalon-Soffer , Amir Toporik , Sarah Pollock , Galit Rotman , Merav Beiman
发明人： Gad Cojocaru , Zurit Levine , Michal Ayalon-Soffer , Amir Toporik , Sarah Pollock , Galit Rotman , Merav Beiman
IPC分类号： A61K38/36 , C07H21/04 , C07K14/745 , C07K16/36 , C12N5/10
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and phamaceutical compositions which can be used to treat various disorders such as cancer and retinopathies, using the polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于治疗各种疾病如癌症和视网膜病变的方法和药物组合物，使用本发明的多肽和多核苷酸。
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公开(公告)号：US20050277156A1
公开(公告)日：2005-12-15
申请号：US11043590
申请日：2005-01-27
申请人： Gad Cojocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
发明人： Gad Cojocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
IPC分类号： A61K38/17 , C07K14/705 , G01N33/53 , G01N33/74
CPC分类号： G01N33/74 , G01N2800/321 , G01N2800/325
摘要： Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein.
摘要翻译： 新型BNP变体。 根据本发明的新型BNP变体可任选地用于本文所述的BNP变体可检测疾病的诊断。
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公开(公告)号：US20100184839A1
公开(公告)日：2010-07-22
申请号：US12598286
申请日：2008-04-30
申请人： Avishay Vaknin , Pini Akiva , Sarah Pollock , Lily Bazak , Erez Levanon , Tomer Zekharya , Alex Golubev , Gady Cojocaru , Liat Dassa , Sarit Edelheit-Flohr , Ronen Shemesh , Anat Amir , Yossi Cohen
发明人： Avishay Vaknin , Pini Akiva , Sarah Pollock , Lily Bazak , Erez Levanon , Tomer Zekharya , Alex Golubev , Gady Cojocaru , Liat Dassa , Sarit Edelheit-Flohr , Ronen Shemesh , Anat Amir , Yossi Cohen
IPC分类号： A61K31/7088 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： The invention relates to the identification of allelic polymorphism in a diabetes associated gene, particularly in a gene encoding phosphofructokinase (PFK) and use thereof for diagnosing diabetes predisposition and state and for predicting the response to a therapeutic agent.
摘要翻译： 本发明涉及鉴定糖尿病相关基因中的等位基因多态性，特别是在编码磷酸果糖激酶（PFK）的基因中的等位基因多态性及其用于诊断糖尿病倾向和状态以及预测对治疗剂的应答的用途。
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公开(公告)号：US07332569B2
公开(公告)日：2008-02-19
申请号：US11043590
申请日：2005-01-27
申请人： Gad S. Cojocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
发明人： Gad S. Cojocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
IPC分类号： C07K14/435
CPC分类号： G01N33/74 , G01N2800/321 , G01N2800/325
摘要： Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein.
摘要翻译： 新型BNP变体。 根据本发明的新型BNP变体可任选地用于本文所述的BNP变体可检测疾病的诊断。
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公开(公告)号：US20070092484A1
公开(公告)日：2007-04-26
申请号：US11471652
申请日：2006-06-21
申请人： Zurit Levine , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman , Sarah Pollock
发明人： Zurit Levine , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman , Sarah Pollock
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/523 , C12Q2600/156 , C12Q2600/158
摘要： Novel MCP-1 splice variant polypeptides and polynucleotides encoding same are provided. Also provided are pharmaceutical compositions comprising the splice variant polypeptides and polynucleotides, vectors and host cells comprising same. The compositions of the present invention are useful to treat various MCP-1 related disorders as well as for diagnosing, determining predisposition and/or prognosis of various disorders.
摘要翻译： 提供了新的MCP-1剪接变体多肽和编码它们的多核苷酸。 还提供了包含剪接变体多肽和多核苷酸的药物组合物，载体和包含其的宿主细胞。 本发明的组合物可用于治疗各种MCP-1相关疾病以及用于诊断，确定各种疾病的倾向和/或预后。
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50.发明申请Methods of identifying putative gene products by interspecies sequence comparison and biomolecular sequences uncovered thereby 审中-公开通过种间序列比较和生物分子序列鉴定推定基因产物的方法公开(公告)号：US20070082337A1
公开(公告)日：2007-04-12
申请号：US11043591
申请日：2005-01-27
申请人： Rotem Sorek , Sarah Pollock , Alex Diber , Zurit Levine , Sergey Nemzer , Guy Kol , Assaf Wool , Ami Haviv , Yuval Cohen , Yossi Cohen , Ronen Shemesh , Kinneret Savitsky
发明人： Rotem Sorek , Sarah Pollock , Alex Diber , Zurit Levine , Sergey Nemzer , Guy Kol , Assaf Wool , Ami Haviv , Yuval Cohen , Yossi Cohen , Ronen Shemesh , Kinneret Savitsky
CPC分类号： G16B30/00
摘要： A method of identifying alternatively spliced exons is provided. The method comprising, scoring each of a plurality of exon sequences derived from genes of a species according to at least one sequence parameter, wherein exon sequences of the plurality of exon sequences scoring above a predetermined threshold represent alternatively spliced exons, thereby identifying the alternatively spliced exons.
摘要翻译： 提供了一种识别可变剪接外显子的方法。 所述方法包括：根据至少一个序列参数对来自物种基因的多个外显子序列中的每一个进行评分，其中得分高于预定阈值的多个外显子序列的外显子序列代表可变剪接的外显子，由此鉴定可变剪接 外显子
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