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1.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease 有权新型核苷酸和氨基酸序列，以及其用于诊断心脏病的测定和方法公开(公告)号：US20060172311A1
公开(公告)日：2006-08-03
申请号：US11043824
申请日：2005-01-27
申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
CPC分类号： G01N33/6893 , C07K14/705 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2800/324 , G01N2800/325 , G01N2800/327
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。
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2.发明申请公开(公告)号：US20060040278A1
公开(公告)日：2006-02-23
申请号：US11050857
申请日：2005-01-27
申请人： Gad Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
发明人： Gad Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
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公开(公告)号：US20050277156A1
公开(公告)日：2005-12-15
申请号：US11043590
申请日：2005-01-27
申请人： Gad Cojocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
发明人： Gad Cojocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
IPC分类号： A61K38/17 , C07K14/705 , G01N33/53 , G01N33/74
CPC分类号： G01N33/74 , G01N2800/321 , G01N2800/325
摘要： Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein.
摘要翻译： 新型BNP变体。 根据本发明的新型BNP变体可任选地用于本文所述的BNP变体可检测疾病的诊断。
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4.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer 有权核苷酸和氨基酸序列，以及其用于诊断卵巢癌的测定和方法公开(公告)号：US07553948B2
公开(公告)日：2009-06-30
申请号：US11714282
申请日：2007-03-06
申请人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
发明人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
摘要翻译： 卵巢癌的新型标志物既敏感又准确。 与卵巢正常组织相反，这些标志物特异性地在卵巢癌中过表达和/或差异表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与卵巢癌中可能诊断相关的信息。 本发明的标记物单独或组合显示卵巢癌与非癌状态之间的高度差异检测。
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5.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer 有权新型核苷酸和氨基酸序列，以及其用于诊断卵巢癌的测定和方法公开(公告)号：US20090004648A1
公开(公告)日：2009-01-01
申请号：US11714282
申请日：2007-03-06
申请人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
发明人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
摘要翻译： 卵巢癌的新型标志物既敏感又准确。 与卵巢正常组织相反，这些标志物特异性地在卵巢癌中过表达和/或差异表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与卵巢癌中可能诊断相关的信息。 本发明的标记物单独或组合显示卵巢癌与非癌状态之间的高度差异检测。
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6.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer 有权核苷酸和氨基酸序列，以及其用于诊断卵巢癌的测定和方法公开(公告)号：US07906635B2
公开(公告)日：2011-03-15
申请号：US12354641
申请日：2009-01-15
申请人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
发明人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/156 , Y10T436/143333
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
摘要翻译： 卵巢癌的新型标志物既敏感又准确。 与卵巢正常组织相反，这些标志物特异性地在卵巢癌中过表达和/或差异表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与卵巢癌中可能诊断相关的信息。 本发明的标记物单独或组合显示卵巢癌与非癌状态之间的高度差异检测。
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7.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis 有权核苷酸和氨基酸序列，以及用于诊断的测定及其使用方法公开(公告)号：US07842459B2
公开(公告)日：2010-11-30
申请号：US11051646
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
发明人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
摘要翻译： 新型剪接变体核酸序列。 根据本发明的新型剪接变体及其核酸序列可任选地用于诊断如本文所述的变体可检测的疾病。
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8.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis 有权新型核苷酸和氨基酸序列，以及用于诊断的测定和方法公开(公告)号：US20100120022A1
公开(公告)日：2010-05-13
申请号：US11051646
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
发明人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
摘要翻译： 新型剪接变体核酸序列。 根据本发明的新型剪接变体及其核酸序列可任选地用于诊断如本文所述的变体可检测的疾病。
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9.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease 失效核苷酸和氨基酸序列，以及其用于诊断心脏病的测定和方法公开(公告)号：US07714100B2
公开(公告)日：2010-05-11
申请号：US11978203
申请日：2007-10-29
申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
IPC分类号： A61K38/00
CPC分类号： C07K14/705 , C07H21/04 , C07K16/18 , C07K2317/34 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/324 , G01N2800/325 , G01N2800/327
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。
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10.发明申请Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of Use Thereof for Diagnosis of Cardiac Disease 审中-公开新型核苷酸和氨基酸序列及其用于诊断心脏病的测定及方法公开(公告)号：US20100248270A1
公开(公告)日：2010-09-30
申请号：US12623957
申请日：2009-11-23
申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
CPC分类号： C07K14/705 , C07H21/04 , C07K16/18 , C07K2317/34 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/324 , G01N2800/325 , G01N2800/327
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。
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