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    SYNTHESIS AND BIOLOGICAL ACTIVITIES OF NEW TRICYCLIC-BIS-ENONES (TBES)
    45.
    发明申请
    SYNTHESIS AND BIOLOGICAL ACTIVITIES OF NEW TRICYCLIC-BIS-ENONES (TBES) 有权
    新TRICYCLIC-BIS-ENONES（TBES）的合成和生物活性

    公开(公告)号：US20110009363A1

    公开(公告)日：2011-01-13

    申请号：US12777120

    申请日：2010-05-10

    申请人： Tadashi Honda ,  Chitra Sundararajan ,  Gordon W. Gribble ,  Michael B. Sporn ,  Karen T. Liby

    发明人： Tadashi Honda ,  Chitra Sundararajan ,  Gordon W. Gribble ,  Michael B. Sporn ,  Karen T. Liby

    IPC分类号： A61K31/695 ,  A61K31/277 ,  A61K31/4164 ,  A61K31/40 ,  A61P35/00 ,  A61P35/02

    CPC分类号： C07F7/0812 ,  C07C49/743 ,  C07C255/47 ,  C07C2603/26 ,  C07D207/337 ,  C07D209/08 ,  C07D233/64 ,  C07D295/145 ,  C07F7/081

    摘要： This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these compounds are also disclosed. The inventors demonstrate the ability of these new TBEs to inhibit proliferation of human myeloma cells, inhibit the induction of iNOS in cells stimulated with interferon-γ, induce heme oxygenase-1 (HO-1), induce CD11b expression—a leukemia differentiation marker, inhibit proliferation of leukemia cells, induce apoptosis in human lung cancer, and induce apoptosis in other cancerous cells. The TBEs of this invention are expected to be useful agents for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.

    摘要翻译： 本发明描述了新型三环双烯衍生物（TBE），如TBE-31，TBE-34，TBE-45和水溶性TBE。 还公开了制备这些化合物的方法。 发明人证明了这些新型TBE抑制人骨髓瘤细胞增殖的能力，抑制了用干扰素-γ刺激的细胞中诱导iNOS，诱导血红素加氧酶-1（HO-1），诱导CD11b表达 - 白血病分化标记， 抑制白血病细胞增殖，诱导人肺癌细胞凋亡，诱导其他癌细胞凋亡。 预期本发明的TBE可用于治疗和预防许多疾病，包括癌症，神经障碍，炎症和涉及氧化应激的病理学的有用试剂。

    Tricyclic-Bis-Enone Derivatives and Methods of Use Thereof
    47.
    发明申请
    Tricyclic-Bis-Enone Derivatives and Methods of Use Thereof 有权
    三环双 - 二烯酮衍生物及其使用方法

    公开(公告)号：US20100261930A1

    公开(公告)日：2010-10-14

    申请号：US12722053

    申请日：2010-03-11

    申请人： Tadashi Honda ,  Frank G. Favaloro ,  Gordon W. Gribble ,  Michael B. Sporn ,  Nanjoo Suh

    发明人： Tadashi Honda ,  Frank G. Favaloro ,  Gordon W. Gribble ,  Michael B. Sporn ,  Nanjoo Suh

    IPC分类号： C07C255/47 ,  C07C49/737

    CPC分类号： C07C62/38 ,  C07C225/12 ,  C07C255/47 ,  C07C271/18 ,  C07C2603/00 ,  C07C2603/26 ,  C07F7/1804

    摘要： Novel tricyclic-bis-enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and/or treatment of cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotropic lateral sclerosis, rheumatoid arthritis, inflammatory bowel disease, and all other diseases whose pathogenesis is believed to involve excessive production of either nitric oxide (NO) or prostaglandins or the overexpression of iNOS or COX-2 genes or gene products. Further, methods for the synthesis of the TBE compounds of the invention utilize cheap commercially available reagents and are highly cost effective and amenable to scale-up. Additional high efficiency synthetic methods that utilize novel intermediates as well as the synthesis of these intermediates are also provided. Furthermore, the invention also provides methods for designing novel and water-soluble TBEs.

    摘要翻译： 提供了新的三环双烯衍生物（TBE）以及制备这种TBE的方法。 还提供了用于预防和/或治疗癌症，阿尔茨海默氏病，帕金森病，多发性硬化，肌萎缩性侧索硬化，类风湿性关节炎，炎症性肠病以及其发病机制被认为涉及过量产生一氧化氮的所有其它疾病的方法 NO）或前列腺素或iNOS或COX-2基因或基因产物的过表达。 此外，用于合成本发明的TBE化合物的方法使用便宜的市售试剂，并且是高成本有效的并且适于放大。 还提供了利用新型中间体以及这些中间体的合成的其它高效合成方法。 此外，本发明还提供了设计新型和水溶性TBE的方法。

    Tricyclic-bis-enone derivatives and methods of use thereof
    49.
    发明授权
    Tricyclic-bis-enone derivatives and methods of use thereof 有权
    三环 - 双烯酮衍生物及其使用方法

    公开(公告)号：US07678830B2

    公开(公告)日：2010-03-16

    申请号：US11672449

    申请日：2007-02-07

    申请人： Tadashi Honda ,  Frank G. Favaloro ,  Gordon W. Gribble ,  Michael B. Sporn ,  Nanjoo Suh

    发明人： Tadashi Honda ,  Frank G. Favaloro ,  Gordon W. Gribble ,  Michael B. Sporn ,  Nanjoo Suh

    IPC分类号： A61K31/275 ,  C07C255/47

    CPC分类号： C07C62/38 ,  C07C225/12 ,  C07C255/47 ,  C07C271/18 ,  C07C2603/00 ,  C07C2603/26 ,  C07F7/1804

    摘要： Novel tricyclic-bis-enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and/or treatment of cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotropic lateral sclerosis, rheumatoid arthritis, inflammatory bowel disease, and all other diseases whose pathogenesis is believed to involve excessive production of either nitric oxide (NO) or prostaglandins or the overexpression of iNOS or COX-2 genes or gene products. Further, methods for the synthesis of the TBE compounds of the invention utilize cheap commercially available reagents and are highly cost effective and amenable to scale-up. Additional high efficiency synthetic methods that utilize novel intermediates as well as the synthesis of these intermediates are also provided. Furthermore, the invention also provides methods for designing novel and water-soluble TBEs.

    摘要翻译： 提供了新的三环双烯衍生物（TBE）以及制备这种TBE的方法。 还提供了用于预防和/或治疗癌症，阿尔茨海默氏病，帕金森病，多发性硬化，肌萎缩性侧索硬化，类风湿性关节炎，炎症性肠病以及其发病机制被认为涉及过量产生一氧化氮的所有其它疾病的方法 NO）或前列腺素或iNOS或COX-2基因或基因产物的过表达。 此外，用于合成本发明的TBE化合物的方法使用便宜的市售试剂，并且是高成本有效的并且适于放大。 还提供了利用新型中间体以及这些中间体的合成的其它高效合成方法。 此外，本发明还提供了设计新型和水溶性TBE的方法。

    IMAGE PROCESSING APPARATUS, IMAGE PROCESSING METHOD, AND COMPUTER PROGRAM PRODUCT
    50.
    发明申请
    IMAGE PROCESSING APPARATUS, IMAGE PROCESSING METHOD, AND COMPUTER PROGRAM PRODUCT 审中-公开
    图像处理设备，图像处理方法和计算机程序产品

    公开(公告)号：US20080198394A1

    公开(公告)日：2008-08-21

    申请号：US12032319

    申请日：2008-02-15

    申请人： Yuuta HAMADA ,  Naoki Kozuka ,  Tadashi Honda ,  Hirofumi Horikawa

    发明人： Yuuta HAMADA ,  Naoki Kozuka ,  Tadashi Honda ,  Hirofumi Horikawa

    IPC分类号： G06K15/00

    CPC分类号： H04N1/32144 ,  G06K1/121 ,  H04N1/32299 ,  H04N1/32304 ,  H04N1/32325 ,  H04N2201/3269 ,  H04N2201/3271 ,  H04N2201/3274

    摘要： A print-information acquiring unit acquires print object information as an image and predetermined information to be encoded. A code-image creating unit encodes the predetermined information according to a predetermined encode rule to create a plurality of types of code images. A layer-image creating unit creates a plurality of types of layer images including the code images for each of the types. A combined-image creating unit superimposes the types of layer images according to a predetermined superimposition rule to create a combined image. A printing unit prints the combined image created by the combined-image creating unit on a recording medium.

    摘要翻译： 打印信息获取单元获取作为图像的打印对象信息和要编码的预定信息。 代码图像创建单元根据预定的编码规则对预定信息进行编码，以创建多种类型的代码图像。 层图像创建单元创建包括用于每种类型的代码图像的多种类型的层图像。 组合图像创建单元根据预定的叠加规则叠加层图像的类型以创建组合图像。 打印单元将由组合图像创建单元创建的组合图像打印在记录介质上。