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    Process for producing optical active 4-hydroxy-2-cyclopentenone
    41.
    发明授权
    Process for producing optical active 4-hydroxy-2-cyclopentenone 失效
    光学活性4-羟基-2-环戊烯酮的制备方法

    公开(公告)号：US5395977A

    公开(公告)日：1995-03-07

    申请号：US31182

    申请日：1993-03-12

    申请人： Fumio Toda ,  Yorihiko Inoue ,  Masayoshi Minai

    发明人： Fumio Toda ,  Yorihiko Inoue ,  Masayoshi Minai

    IPC分类号： C07B53/00 ,  C07B57/00 ,  C07C45/78 ,  C07C45/85 ,  C07C49/707

    CPC分类号： C07C45/78 ,  C07C45/85

    摘要： A process for producing optically active 4-hydroxy-2-cyclopentenone [1] which comprises reacting 4-hydroxy-2-cyclopentenone represented by the formula: ##STR1## with an optically active propargyl alcohol derivative represented by the general formula: ##STR2## wherein R and R.sup.1 each independently represent a halogenated phenyl group, an alkylphenyl group, or an alkyl group which may be substituted with one or more halogen atom(s), and * indicates an asymmetric carbon atom, to form an optically active complex [3] consisting essentially of optically active 4-hydroxy-2-cyclopentenone represented by the formula [1] ##STR3## wherein * indicates an asymmetric carbon atom, and the optically active propargyl alcohol derivative [2], and then decomposing the optically active complex [3].

    摘要翻译： 一种制备光学活性的4-羟基-2-环戊烯酮的方法[1]，其包括使由下式表示的4-羟基-2-环戊烯酮与由下列通式表示的光学活性炔丙醇衍生物反应： 其中R和R 1各自独立地表示卤代苯基，烷基苯基或可以被一个或多个卤素原子取代的烷基，和*表示不对称碳原子以形成光学活性 基本上由式[1]表示的光学活性4-羟基-2-环戊烯酮[3]组成的复合物[3]，其中*表示不对称碳原子和光学活性炔丙醇衍生物[2]，然后 分解光学活性复合物[3]。

    Optically active aromatic carboxylic acid derivatives and process for producing the same
    46.
    发明授权
    Optically active aromatic carboxylic acid derivatives and process for producing the same 失效
    光学活性芳族羧酸衍生物及其制备方法

    公开(公告)号：US5019298A

    公开(公告)日：1991-05-28

    申请号：US186020

    申请日：1988-04-25

    申请人： Masayoshi Minai ,  Takayuki Higashii

    发明人： Masayoshi Minai ,  Takayuki Higashii

    IPC分类号： C07C65/24 ,  C07C69/76 ,  C12P7/42 ,  C12P41/00

    CPC分类号： C12P7/42 ,  C07C65/24 ,  C07C69/76 ,  C12P41/00

    摘要： Disclosed are optically active aromatic carboxylic acid derivatives represented by the formula (I): ##STR1## (wherein R.sub.2 represents an alkoxyalkyl group having 1 to 20 carbon atoms or an alkyl group having 1 to 20 carbon atoms, which alkyl group may be substituted with a halogen atom; represents a number of 1 or 2; m represents a number of 0 or 1; and * indicates asymmetric carbon atom) and a process for producing such derivatives through the following reaction steps: ##STR2## The optically active aromatic carboxylic acid derivatives represented by the above-described formula (I) are useful as a liquid crystal material and can be also utilized as an intermeidate for the preparation of pharmaceuticals, agricultural chemicals and the like.

    摘要翻译： 公开了由式（I）表示的光学活性芳族羧酸衍生物：其中R 2表示碳原子数1〜20的烷氧基烷基或碳原子数1〜20的烷基，该烷基可以 被卤素原子取代;数为1或2; m表示0或1的数; *表示不对称碳原子），以及通过以下反应步骤制备该衍生物的方法：＆lt; IMAGE＆gt; +图像光学活性芳族羧酸衍生物（I）。 由上述式（I）表示的光学活性芳族羧酸衍生物可用作液晶材料，也可用作制备药物，农药等的中间体。

    Process for preparing oxocyclopentene derivatives
    47.
    发明授权
    Process for preparing oxocyclopentene derivatives 失效
    制备氧代环戊烯衍生物的方法

    公开(公告)号：US4970345A

    公开(公告)日：1990-11-13

    申请号：US831067

    申请日：1986-02-20

    申请人： Masayoshi Minai

    发明人： Masayoshi Minai

    IPC分类号： C07C45/59 ,  C07C45/62 ,  C07C45/66 ,  C07C49/493 ,  C07C49/507 ,  C07C49/743 ,  C07C49/747

    CPC分类号： C07C49/507 ,  C07C45/59 ,  C07C45/62 ,  C07C45/66 ,  C07C49/493 ,  C07C49/743 ,  C07C49/747

    摘要： A process for preparing oxocyclopentenes of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or lower alkenyl and R.sup.2 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, substituted or unsubstituted aryl, ar(lower)alkyl, thienyl or cycloalkyl, which comprises subjecting a furan-carbinol of the formula: ##STR2## wherein R.sup.1 is as defined above and R.sup.3 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, substituted or unsubstituted aryl, ar(lower)alkyl, thienyl or cycloalkyl to rearrangement, subjecting the resultant hydroxycyclopentenone of the formula: ##STR3## wherein R.sup.1 and R.sup.3 are each as defined above to hydrogenation and subjecting the resulting hydroxycyclopentanone of the formula; ##STR4## wherein R.sup.1 and R.sup.2 are each as defined above to dehydration.

    摘要翻译： 制备下式的氧代环戊烯的方法：其中R1是氢，低级烷基或低级烯基，R2是氢，低级烷基，低级烯基，低级炔基，取代或未取代的芳基，芳（低级）烷基，噻吩基或环烷基 其包括使下式的呋喃甲醇：其中R 1如上定义，R 3是氢，低级烷基，低级烯基，低级炔基，取代或未取代的芳基，芳（低级）烷基，噻吩基或环烷基， 重新排列，得到下式的所得羟基环戊烯酮：其中R 1和R 3各自如上所定义氢化并使所得到的式的羟基环戊酮进行氢化; 其中R1和R2各自如上所定义脱水。

    Method for inversion of optically active 4-hydroxy-2-cyclopentenones
    48.
    发明授权
    Method for inversion of optically active 4-hydroxy-2-cyclopentenones 失效
    光学活性4-羟基-2-环戊烯酮的反转方法

    公开(公告)号：US4683323A

    公开(公告)日：1987-07-28

    申请号：US758801

    申请日：1985-07-25

    申请人： Masayoshi Minai ,  Yuji Ueda

    发明人： Masayoshi Minai ,  Yuji Ueda

    IPC分类号： C07C45/64 ,  C07C45/67 ,  C07C49/707 ,  C07C203/08 ,  C07C309/63 ,  C07C143/68

    CPC分类号： C07C201/02 ,  C07C303/28 ,  C07C45/64 ,  C07C45/673 ,  C07B2200/07 ,  C07C2101/08

    摘要： By hydrolyzing a sulfonic acid ester or a nitric acid ester of an optically active 4-hydroxy-2-cyclopentenone, the steric inversion of the hydroxyl group at the 4-position of the cyclopentenone mentioned above is effected.4-hydroxy-2-cyclopentenone is useful as a raw material of prostaglandins (natural substance is an (R)-substance) having stimulative action to uterine muscle and vasodilator action. For instance, 4(S)-hydroxy-2-cyclopentenone can be configurationally inverted to R-isomer. Accordingly, this method is extremely meaningful in the synthesis of prostaglandins.

    摘要翻译： 通过水解光学活性的4-羟基-2-环戊烯酮的磺酸酯或硝酸酯，可以实现上述环戊烯酮在4-位的羟基的立体倒置。 4-羟基-2-环戊烯酮可用作具有对子宫肌肉和血管扩张剂作用的刺激作用的前列腺素（天然物质是（R））的原料。 例如，可以将4（S） - 羟基-2-环戊烯酮构型反转成R-异构体。 因此，这种方法在前列腺素的合成中是非常有意义的。

    Process for preparing 2-cyclopentenone derivatives
    49.
    发明授权
    Process for preparing 2-cyclopentenone derivatives 失效
    2-环戊烯酮衍生物的制备方法

    公开(公告)号：US4496767A

    公开(公告)日：1985-01-29

    申请号：US543152

    申请日：1983-10-18

    申请人： Masayoshi Minai ,  Tadashi Katsura

    发明人： Masayoshi Minai ,  Tadashi Katsura

    IPC分类号： C07C45/00 ,  C07C45/59 ,  C07C45/61 ,  C07C45/62 ,  C07C45/65 ,  C07C45/66 ,  C07C45/67 ,  C07C49/587 ,  C07C49/597 ,  C07C49/647 ,  C07C49/683 ,  C07C49/703 ,  C07C49/707 ,  C07C49/743 ,  C07C49/747 ,  C07C67/00

    CPC分类号： C07C45/676 ,  C07C45/59 ,  C07C45/62 ,  C07C45/65 ,  C07C45/66

    摘要： A novel process for preparing 2-cyclopentenones of the formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl or alkenyl and R.sub.2 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl or aralkyl, which comprises esterifying a mixture of a 3-hydroxy-4-cyclopentenone of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are each as defined above and a 4-hydroxy-2-cyclopentenone of the formulas: ##STR3## wherein R.sub.1 and R.sub.2 are each as defined above with an aliphatic carboxylic acid to give a mixture of the 4-hydroxy-2-cyclopentenone (III) and the cyclopentenone ester of the formula: ##STR4## wherein R.sub.1 and R.sub.2 are each as defined above and R is hydrogen or C.sub.1 -C.sub.4 alkyl and subjecting the resulting mixture to reduction.

    摘要翻译： 一种制备下式的2-环戊烯酮的新方法：其中R1是氢，烷基或烯基，R2是烷基，烯基，炔基，环烷基，芳基或芳烷基，其包括将3- （II）的羟基-4-环戊烯酮，其中R 1和R 2各自如上所定义，和下式的4-羟基-2-环戊烯酮：其中R 1和R 2各自为 （III）和下式的环戊烯酮的混合物：其中R 1和R 2各自如上所定义，R是氢原子 或C 1 -C 4烷基，并将所得混合物还原。