公开(公告)号：US09005336B2

公开(公告)日：2015-04-14

申请号：US13203591

申请日：2010-02-26

申请人： Toshihiko Kaneko ,  Yuichi Tanaka ,  Tatsuro Ohira ,  Naoyuki Matsui

发明人： Toshihiko Kaneko ,  Yuichi Tanaka ,  Tatsuro Ohira ,  Naoyuki Matsui

IPC分类号： B01D3/34 ,  C11B9/02 ,  B01D53/14 ,  B01D53/46 ,  B01D3/38 ,  A61L9/013 ,  B01D53/77

CPC分类号： C11B9/027 ,  A61L9/013 ,  B01D3/38 ,  B01D53/1493 ,  B01D53/46 ,  B01D53/77 ,  B01D2251/21 ,  B01D2257/302 ,  B01D2257/404 ,  B01D2257/70

摘要： To develop a means for effectively utilize terpene compounds contained in tree leaves, whereby branches and leaves cut in tree thinning and pruning can be effectively utilized as a resource. For this purpose, provided are a monoterpene component-rich essential oil containing 90% or more of monoterpene components; a method for producing the monoterpene component-rich essential oil which includes subjecting coniferous leaves to microwave steam distillation and collecting a distillate thus obtained; and a method for removing environmental pollutants which includes bringing the monoterpene component-rich essential oil into contact with atmosphere containing the environmental pollutants.

摘要翻译： 开发有效利用树叶中含有萜烯化合物的手段，可以有效利用树叶和树枝剪切的树枝和树叶作为资源。 为此，提供含有90％以上的单萜组分的富含单萜组分的精油; 一种富含单萜成分的精油的制造方法，其包括对针叶进行微波蒸馏蒸馏并收集由此得到的馏出物; 以及一种除去环境污染物的方法，其中包括使单萜组分丰富的精油与含有环境污染物的气氛接触。

公开(公告)号：US08501733B2

公开(公告)日：2013-08-06

申请号：US13055830

申请日：2009-07-24

申请人： Takafumi Motoki ,  Toshihiko Kaneko ,  Noboru Yamamoto ,  Afzal Khan

发明人： Takafumi Motoki ,  Toshihiko Kaneko ,  Noboru Yamamoto ,  Afzal Khan

IPC分类号： C07D513/10 ,  A61K31/547

CPC分类号： C07D513/10

摘要： A compound represented by the general formula (I): or a pharmaceutically acceptable salt thereof, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.

摘要翻译： 由通式（I）表示的化合物或其药学上可接受的盐具有Abeta产生抑制作用或BACE1抑制作用，可用作由Abeta引起的神经变性疾病的预防或治疗剂，并以阿尔茨海默病 型痴呆症。

公开(公告)号：US06699870B2

公开(公告)日：2004-03-02

申请号：US10281194

申请日：2002-10-28

申请人： Nobuhisa Watanabe ,  Norio Karibe ,  Kazuki Miyazaki ,  Fumihiro Ozaki ,  Atsushi Kamada ,  Shuhei Miyazawa ,  Yoshimitsu Naoe ,  Toshihiko Kaneko ,  Itaru Tsukada ,  Tadashi Nagakura ,  Hiroki Ishihara ,  Kohtarou Kodama ,  Hideyuki Adachi

发明人： Nobuhisa Watanabe ,  Norio Karibe ,  Kazuki Miyazaki ,  Fumihiro Ozaki ,  Atsushi Kamada ,  Shuhei Miyazawa ,  Yoshimitsu Naoe ,  Toshihiko Kaneko ,  Itaru Tsukada ,  Tadashi Nagakura ,  Hiroki Ishihara ,  Kohtarou Kodama ,  Hideyuki Adachi

IPC分类号： A61K31502

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D237/28 ,  C07D237/34 ,  C07D249/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D409/14 ,  C07D411/14 ,  C07D417/04 ,  C07D417/14 ,  C07D451/06 ,  C07D471/08 ,  C07D491/04 ,  C07D491/08 ,  C07D491/10

摘要： The present invention provides a phthalazine compound as a therapeutic agent for erectile dysfunction represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: wherein R1 and R2 are the same as or different from each other and represent a halogen atom, a C1 to C4 alkyl group which may be substituted with a halogen atom, a C1 to C4 alkoxy group which may be substituted with a halogen atom or a cyano group; X represents a cyano group, a nitro group, a halogen atom, a hydroxyimino group which may be substituted or a heteroaryl group which may be substituted; Y represents a heteroaryl group, an aryl group which may be substituted, an alkynyl group which may substituted, an alkenyl group, an alkyl group, an optionally substituted saturated or unsaturated 4- to 8-membered amine ring, and the cyclic amine compound is a monocyclic compound, bicyclic compound or a spiro compound; l is an integer of 1 to 3; provided that the case where l is 1 or 2, X is a cyano group, a nitro group or a chlorine atom, R1 is a chlorine atom, R2 is a methoxy group and Y is a 5- or 6-memberred amine ring substituted with a hydroxyl group is excluded.

摘要翻译： 本发明提供作为下式表示的勃起功能障碍治疗剂的酞嗪化合物，其药理学上可接受的盐或其水合物：其中R 1和R 2彼此相同或不同， 可以被卤素原子取代的C1〜C4烷基，可被卤素原子或氰基取代的C1〜C4烷氧基; X表示氰基，硝基，卤素原子，可被取代的羟基亚氨基或可被取代的杂芳基; Y表示可以被取代的杂芳基，可以被取代的芳基，可以被取代的炔基，烯基，烷基，任选取代的饱和或不饱和的4-至8-元胺环，环胺化合物是 单环化合物，双环化合物或螺环化合物; l为1〜3的整数， 条件是其中l为1或2，X为氰基，硝基或氯原子，R 1为氯原子，R 2为甲氧基，Y为5-或6 被羟基取代的胺基环被排除。

公开(公告)号：US5134111A

公开(公告)日：1992-07-28

申请号：US451468

申请日：1989-12-15

申请人： Makoto Okita ,  Hiroshi Shirota ,  Masayuki Tanaka ,  Toshihiko Kaneko ,  Katsuya Tagami ,  Shigeki Hibi ,  Yasushi Okamoto ,  Seiichiro Nomoto ,  Takeshi Suzuki ,  Kenichi Chiba ,  Masaki Goto ,  Ryoichi Hashida ,  Hideki Ono ,  Hideto Ohhara ,  Hideki Sakurai ,  Shigeru Souda ,  Yoshimasa Machida ,  Kouichi Katayama ,  Isao Yamatsu

发明人： Makoto Okita ,  Hiroshi Shirota ,  Masayuki Tanaka ,  Toshihiko Kaneko ,  Katsuya Tagami ,  Shigeki Hibi ,  Yasushi Okamoto ,  Seiichiro Nomoto ,  Takeshi Suzuki ,  Kenichi Chiba ,  Masaki Goto ,  Ryoichi Hashida ,  Hideki Ono ,  Hideto Ohhara ,  Hideki Sakurai ,  Shigeru Souda ,  Yoshimasa Machida ,  Kouichi Katayama ,  Isao Yamatsu

IPC分类号： C07C39/225 ,  C07C43/215 ,  C07C43/23 ,  C07C43/30 ,  C07C43/313 ,  C07C43/315 ,  C07C45/00 ,  C07C45/29 ,  C07C45/30 ,  C07C45/51 ,  C07C45/54 ,  C07C45/59 ,  C07C45/63 ,  C07C45/71 ,  C07C47/57 ,  C07C47/575 ,  C07C49/83 ,  C07C49/84 ,  C07C59/68 ,  C07C69/157 ,  C07F7/18

CPC分类号： C07F7/1852 ,  C07C39/225 ,  C07C43/215 ,  C07C43/23 ,  C07C43/30 ,  C07C43/313 ,  C07C43/315 ,  C07C45/00 ,  C07C45/298 ,  C07C45/30 ,  C07C45/305 ,  C07C45/513 ,  C07C45/54 ,  C07C45/59 ,  C07C45/63 ,  C07C45/71 ,  C07C47/57 ,  C07C47/575 ,  C07C49/83 ,  C07C49/84 ,  C07C59/68

摘要： A naphthalene derivative having the formula is new and useful for medicine. ##STR1## [wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroarylalkyl group;R.sup.3 and R.sup.4 are the same or different and represent a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxy group, a carboxyalkyl group, an aminoalkyl group, or a cyano group;R.sup.5 represents a group of the formula, --OR.sup.7, (wherein R.sup.7 represents a hydrogen atom or a lower alkyl group), or a group of the formula ##STR2## (wherein R.sup.8 and R.sup.9 are the same or different and represent a hydrogen atom or a lower alkyl group, or R.sup.8 and R.sup.9 can form, along with the nitrogen atom bonded with R.sup.8 and R.sup.9, a ring which may contain an oxygen atom);R.sup.6 independently represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, an amino group, an arylalkyl group, or an aryl group; andm is 0 or an integer of from 1 to 2, and n is 0 or an integer of from 1 to 4.]

公开(公告)号：US4932458A

公开(公告)日：1990-06-12

申请号：US301153

申请日：1989-01-25

申请人： Norihiro Iwamoto ,  Hiroyuki Tsuboi ,  Toshihiko Kaneko

发明人： Norihiro Iwamoto ,  Hiroyuki Tsuboi ,  Toshihiko Kaneko

IPC分类号： B22D17/32 ,  B22D18/02 ,  B22D27/11

CPC分类号： B22D27/11 ,  B22D17/32

摘要： A method of and a system for operating a squeeze plunger in a die cast machine. When the fill-up of molten metal in a cavity is completed by an injection plunger, the moving speed of the injection plunger is rapidly decreased. When the speed at this time becomes lower than a preset value, a preset delay time is measured. After a lapse of this delay time, the squeeze plunger is operated to press a molding material in the cavity, so that plastic flows are caused in the molding material.

摘要翻译： 一种用于在压铸机中操作挤压柱塞的方法和系统。 当通过注射柱塞完成空腔中的熔融金属填充时，注射柱塞的移动速度快速降低。 当此时的速度低于预设值时，测量预设的延迟时间。 在经过该延迟时间之后，挤压柱塞被操作以将空腔中的模制材料挤压，从而在模制材料中引起塑性流动。

公开(公告)号：US20110105427A1

公开(公告)日：2011-05-05

申请号：US12917669

申请日：2010-11-02

申请人： Jane Daun ,  Heather A. Davis ,  Bruce DeCosta ,  Fabian Gusovsky ,  Ieharu Hishinuma ,  Yimin Jiang ,  Toshihiko Kaneko ,  Kouichi Kikuchi ,  Seiichi Kobayashi ,  André Lescarbeau ,  Xiang-Yi Li ,  Kenzo Muramoto ,  Norihito Ohi ,  Marc Pesant ,  Boris M. Seletsky ,  Motohiro Soejima ,  Mark Spyvee ,  Lynda Tremblay ,  Ye Yao ,  Hiromitsu Yokohama ,  Yan (Janet) Zhao ,  Wanjun Zheng

发明人： Jane Daun ,  Heather A. Davis ,  Bruce DeCosta ,  Fabian Gusovsky ,  Ieharu Hishinuma ,  Yimin Jiang ,  Toshihiko Kaneko ,  Kouichi Kikuchi ,  Seiichi Kobayashi ,  André Lescarbeau ,  Xiang-Yi Li ,  Kenzo Muramoto ,  Norihito Ohi ,  Marc Pesant ,  Boris M. Seletsky ,  Motohiro Soejima ,  Mark Spyvee ,  Lynda Tremblay ,  Ye Yao ,  Hiromitsu Yokohama ,  Yan (Janet) Zhao ,  Wanjun Zheng

IPC分类号： A61K31/437 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/541 ,  A61K31/4545 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/55 ,  A61K31/439 ,  A61K31/4725 ,  A61K31/695 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61P17/06 ,  A61P11/06 ,  A61P9/00

CPC分类号： A61K31/437 ,  C07D471/04

摘要： The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.

摘要翻译： 本发明提供了具有式（I）的化合物：其中R 1，R 2，R 3和n如本文中一般和本领域和亚类所述，并且另外提供其药物组合物，及其用于治疗炎症或自身免疫的方法 和增殖性疾病以及作为细胞粘附分子表达和炎性细胞因子信号转导的抑制剂。

公开(公告)号：US07868002B2

公开(公告)日：2011-01-11

申请号：US11906056

申请日：2007-09-28

申请人： Jane Daun ,  Heather A. Davis ,  Bruce DeCosta ,  Fabian Gusovsky ,  Ieharu Hishinuma ,  Yimin Jiang ,  Toshihiko Kaneko ,  Kouichi Kikuchi ,  Seiichi Kobayashi ,  André Lescarbeau ,  Xiang-Yi Li ,  Kenzo Muramoto ,  Norihito Ohi ,  Marc Pesant ,  Boris M. Seletsky ,  Motohiro Soejima ,  Mark Spyvee ,  Lynda Tremblay ,  Ye Yao ,  Hiromitsu Yokohama ,  Yan (Janet) Zhao ,  Wanjun Zheng

发明人： Jane Daun ,  Heather A. Davis ,  Bruce DeCosta ,  Fabian Gusovsky ,  Ieharu Hishinuma ,  Yimin Jiang ,  Toshihiko Kaneko ,  Kouichi Kikuchi ,  Seiichi Kobayashi ,  André Lescarbeau ,  Xiang-Yi Li ,  Kenzo Muramoto ,  Norihito Ohi ,  Marc Pesant ,  Boris M. Seletsky ,  Motohiro Soejima ,  Mark Spyvee ,  Lynda Tremblay ,  Ye Yao ,  Hiromitsu Yokohama ,  Yan (Janet) Zhao ,  Wanjun Zheng

IPC分类号： C07D413/14 ,  C07D471/02 ,  A61K31/4745 ,  A61K31/5377 ,  A61P11/06 ,  A61P19/02 ,  A61P25/00 ,  A61P3/10 ,  A61P9/00

CPC分类号： A61K31/437 ,  C07D471/04

摘要： As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds.

摘要翻译： 如上所述，仍然需要开发可用于治疗炎性或自身免疫性和增殖性疾病的新型治疗剂。 本发明提供了通式（I）的新型化合物及其药物组合物，如本文中一般和本课程和亚类所述，以及制备和使用这些化合物的方法。

公开(公告)号：US06498159B1

公开(公告)日：2002-12-24

申请号：US09508197

申请日：2000-03-08

申请人： Nobuhisa Watanabe ,  Norio Karibe ,  Kazuki Miyazaki ,  Fumihiro Ozaki ,  Atsushi Kamada ,  Shuhei Miyazawa ,  Yoshimitsu Naoe ,  Toshihiko Kaneko ,  Itaru Tsukada ,  Tadashi Nagakura ,  Hiroki Ishihara ,  Kohtarou Kodama ,  Hideyuki Adachi

发明人： Nobuhisa Watanabe ,  Norio Karibe ,  Kazuki Miyazaki ,  Fumihiro Ozaki ,  Atsushi Kamada ,  Shuhei Miyazawa ,  Yoshimitsu Naoe ,  Toshihiko Kaneko ,  Itaru Tsukada ,  Tadashi Nagakura ,  Hiroki Ishihara ,  Kohtarou Kodama ,  Hideyuki Adachi

IPC分类号： A61K31502

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D237/28 ,  C07D237/34 ,  C07D249/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D409/14 ,  C07D411/14 ,  C07D417/04 ,  C07D417/14 ,  C07D451/06 ,  C07D471/08 ,  C07D491/04 ,  C07D491/08 ,  C07D491/10

摘要： The present invention provides a phthalazine compound as a therapeutic agent for erectile dysfunction represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: wherein R1 and R2 are the same as or different from each other and represent a halogen atom, a C1 to C4 alkyl group which may be substituted with a halogen atom, a C1 to C4 alkoxy group which may be substituted with a halogen atom or a cyano group; X represents a cyano group, a nitro group, a halogen atom, a hydroxyimino group which may be substituted or a heteroaryl group which may be substituted; Y represents a heteroaryl group, an aryl group which may be substituted, an alkynyl group which may substituted, an alkenyl group, an alkyl group, an optionally substituted saturated or unsaturated 4- to 8-membered amine ring, and the cyclic amine compound is a monocyclic compound, bicyclic compound or a spiro compound; l is an integer of 1 to 3; provided that the case where l is 1 or 2, X is a cyano group, a nitro group or a chlorine atom, R1 is a chlorine atom, R2 is a methoxy group and Y is a 5- or 6-membered amine ring substituted with a hydroxyl group is excluded.

摘要翻译： 本发明提供作为下述式表示的勃起功能障碍治疗剂的酞嗪化合物，其药理学上可接受的盐或其水合物：其中R1和R2彼此相同或不同，表示卤素原子， 可以被卤素原子取代的C1〜C4烷基，可被卤素原子或氰基取代的C1〜C4烷氧基; X表示氰基，硝基，卤素原子，可被取代的羟基亚氨基或可被取代的杂芳基; Y表示可以被取代的杂芳基，可以被取代的芳基，可以被取代的炔基，烯基，烷基，任选取代的饱和或不饱和的4-至8-元胺环，环胺化合物是 单环化合物，双环化合物或螺环化合物; l为1〜3的整数， 条件是其中l为1或2的情况，X为氰基，硝基或氯原子，R 1为氯原子，R 2为甲氧基，Y为被5或6元环取代的5-或6-元胺环 不包括羟基。

公开(公告)号：US5475024A

公开(公告)日：1995-12-12

申请号：US166019

申请日：1993-10-14

申请人： Yoshitake Ogata ,  Makoto Ikeda ,  Seiichiro Nomoto ,  Makoto Okita ,  Naoyuki Shimomura ,  Toshihiko Kaneko ,  Takashi Yamanaka ,  Ieharu Hishinuma ,  Junichi Nagakawa ,  Kazuo Hirota ,  Kaname Miyamoto ,  Toru Horie ,  Tsuneo Wakabayashi

发明人： Yoshitake Ogata ,  Makoto Ikeda ,  Seiichiro Nomoto ,  Makoto Okita ,  Naoyuki Shimomura ,  Toshihiko Kaneko ,  Takashi Yamanaka ,  Ieharu Hishinuma ,  Junichi Nagakawa ,  Kazuo Hirota ,  Kaname Miyamoto ,  Toru Horie ,  Tsuneo Wakabayashi

IPC分类号： C07D317/50 ,  C07D317/54 ,  C07D317/56 ,  C07D317/60 ,  C07D317/70 ,  C07D405/12 ,  C07D413/12 ,  C07D493/04 ,  A61K31/36

CPC分类号： C07D317/50 ,  C07D317/54 ,  C07D317/56 ,  C07D317/60 ,  C07D317/70 ,  C07D405/12 ,  C07D413/10 ,  C07D493/04

摘要： A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.

摘要翻译： 新的苯并间二氧杂环戊烯衍生物在苯环中具有取代基，其是羧烷基硫代烷基等，并且有效治疗肝脏疾病。

公开(公告)号：US5298649A

公开(公告)日：1994-03-29

申请号：US774237

申请日：1991-10-10

申请人： Makoto Okita ,  Hiroshi Shirota ,  Masayuki Tanaka ,  Toshihiko Kaneko ,  Katsuya Tagami ,  Shigeki Hibi ,  Yasushi Okamoto ,  Seiichiro Nomoto ,  Takeshi Suzuki ,  Kenichi Chiba ,  Masaki Goto ,  Ryoichi Hashida ,  Hideki Ono ,  Hideto Ohhara ,  Hideki Sakurai ,  Shigeru Souda ,  Yoshimasa Machida ,  Kouichi Katayama ,  Isao Yamatsu

发明人： Makoto Okita ,  Hiroshi Shirota ,  Masayuki Tanaka ,  Toshihiko Kaneko ,  Katsuya Tagami ,  Shigeki Hibi ,  Yasushi Okamoto ,  Seiichiro Nomoto ,  Takeshi Suzuki ,  Kenichi Chiba ,  Masaki Goto ,  Ryoichi Hashida ,  Hideki Ono ,  Hideto Ohhara ,  Hideki Sakurai ,  Shigeru Souda ,  Yoshimasa Machida ,  Kouichi Katayama ,  Isao Yamatsu

IPC分类号： C07C39/225 ,  C07C43/215 ,  C07C43/23 ,  C07C43/30 ,  C07C43/313 ,  C07C43/315 ,  C07C45/00 ,  C07C45/29 ,  C07C45/30 ,  C07C45/51 ,  C07C45/54 ,  C07C45/59 ,  C07C45/63 ,  C07C45/71 ,  C07C47/57 ,  C07C47/575 ,  C07C49/83 ,  C07C49/84 ,  C07C59/68 ,  C07C69/157 ,  C07F7/18 ,  C07C69/76

CPC分类号： C07F7/1852 ,  C07C39/225 ,  C07C43/215 ,  C07C43/23 ,  C07C43/30 ,  C07C43/313 ,  C07C43/315 ,  C07C45/00 ,  C07C45/298 ,  C07C45/30 ,  C07C45/305 ,  C07C45/513 ,  C07C45/54 ,  C07C45/59 ,  C07C45/63 ,  C07C45/71 ,  C07C47/57 ,  C07C47/575 ,  C07C49/83 ,  C07C49/84 ,  C07C59/68

摘要： A naphthalene derivative having the formula is new and useful for medicine. ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroarylalkyl group;R.sup.3 and R.sup.4 are the same or different and represent a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group;R.sup.5 represents a group of the formula, --OR.sup.7, (wherein R.sup.7 represents a hydrogen atom or a lower alkyl group), or a group of the formula, ##STR2## (wherein R.sup.8 and R.sup.9 are the same or different and represent a hydrogen atom or a lower alkyl group.

摘要翻译： 具有该式的萘衍生物是新的并且可用于药物。 其中R 1表示氢原子，低级烷基或酰基; R2独立地表示氢原子，低级烷基，低级烷氧基，卤素原子，环烷基，环烷基烷基，羟基，可被取代的芳基，芳基可以被取代的芳基烷基 杂芳基或杂芳基烷基; R3和R4相同或不同，表示氢原子，低级烷基，低级烯基，可以具有取代基的芳基，芳基可以被取代的芳基烷基，芳基可以被取代的芳基烯基 烷氧基烷基，杂芳基，杂芳基烷基，羧基，羧基烷基，氨基烷基或氰基; R5表示式-OR7的基团（其中R7表示氢原子或低级烷基）或下式的基团，其中R8和R9相同或不同，表示氢原子 或低级烷基。