公开(公告)号：US20110053920A1

公开(公告)日：2011-03-03

申请号：US12939527

申请日：2010-11-04

Applicant: Edward R. Bacon ,  Thomas Bailey ,  Nadine C. Becknell ,  Diane E. Gingrich ,  Greg Hostetler ,  Robert L. Hudkins ,  Keith S. Learn ,  Jason C. Wagner

Inventor： Edward R. Bacon ,  Thomas Bailey ,  Nadine C. Becknell ,  Diane E. Gingrich ,  Greg Hostetler ,  Robert L. Hudkins ,  Keith S. Learn ,  Jason C. Wagner

IPC: A61K31/541 ,  C07D487/04 ,  A61K31/519 ,  C07D471/04 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/517 ,  C07D417/14 ,  C07D473/00 ,  A61K31/52 ,  A61P25/00 ,  A61P29/00 ,  A61P9/00 ,  A61P3/10 ,  A61P3/04

CPC classification number: C07D401/14 ,  C07D403/04 ,  C07D487/04

Abstract: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).

Abstract translation: 本发明涉及化学组成，其制备方法和组合物的用途。 特别地，本发明涉及包含式（I）的取代杂双环嘧啶的组合物：其中R 1，R 2，R 3，R 4，R 5，X，W和环A如本文所定义; 式（I）的取代杂双环嘧啶的药物组合物; 及其用于治疗慢性神经变性疾病，神经创伤性疾病，抑郁症和/或糖尿病的用途。 更具体地，本发明涉及式（I）的取代的吡唑并嘧啶。

公开(公告)号：US07851468B2

公开(公告)日：2010-12-14

申请号：US11803320

申请日：2007-05-14

Applicant: Edward R. Bacon ,  Thomas Bailey ,  Nadine C. Becknell ,  Diane E. Gingrich ,  Greg Hostetler ,  Robert L. Hudkins ,  Keith S. Learn ,  Jason C. Wagner

Inventor： Edward R. Bacon ,  Thomas Bailey ,  Nadine C. Becknell ,  Diane E. Gingrich ,  Greg Hostetler ,  Robert L. Hudkins ,  Keith S. Learn ,  Jason C. Wagner

IPC: A61K31/541 ,  A61K31/5355 ,  A61K31/497 ,  A61K31/519 ,  C07D279/12 ,  C07D417/14 ,  C07D413/14 ,  C07D519/00 ,  C07D487/04 ,  A61K31/517

CPC classification number: C07D401/14 ,  C07D403/04 ,  C07D487/04

Abstract: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).

Abstract translation: 本发明涉及化学组成，其制备方法和组合物的用途。 特别地，本发明涉及包含式（I）的取代杂双环嘧啶的组合物：其中R 1，R 2，R 3，R 4，R 5，X，W和环A如本文所定义; 式（I）的取代杂双环嘧啶的药物组合物; 及其用于治疗慢性神经变性疾病，神经创伤性疾病，抑郁症和/或糖尿病的用途。 更具体地，本发明涉及式（I）的取代的吡唑并嘧啶。

公开(公告)号：US20080215573A1

公开(公告)日：2008-09-04

申请号：US12029849

申请日：2008-02-12

Applicant: Da-shan Shiu ,  Thomas B. Wilborn ,  Roland Rick ,  Srinivasa Rao Nagaram ,  Chalapathi Rao Emani ,  Ramachandran Gurumoorthy ,  Jesus Chao ,  Steve Doerfler ,  Peter Ang ,  Srividya Kunisetti ,  Gwang-Hyun Gho ,  Thomas Bailey

Inventor： Da-shan Shiu ,  Thomas B. Wilborn ,  Roland Rick ,  Srinivasa Rao Nagaram ,  Chalapathi Rao Emani ,  Ramachandran Gurumoorthy ,  Jesus Chao ,  Steve Doerfler ,  Peter Ang ,  Srividya Kunisetti ,  Gwang-Hyun Gho ,  Thomas Bailey

IPC: G06F17/30

CPC classification number: H04W36/0083 ,  H04B1/70754 ,  H04W36/14 ,  H04W88/06

Abstract: Techniques for inter-frequency neighbor list searching are disclosed. Embodiments disclosed herein address the need for inter-frequency neighbor list searching. In one embodiment, a searcher is deployed to search a PN space with a first set of search parameters and to return search results. A subset of those results is selected, along with a previously saved search result, to form a set of PN locations for a second search. The second search is performed on a window around each of the PN locations, using a second set of search parameters. The maximum peak from the second search is saved for use in future iterations. In one embodiment, the subset is selected as the highest energy level peaks from the first search. In one embodiment, if a maximum peak is deemed to correspond to a valid base station when the position of that maximum peak is within a pre-determined time offset from a previous maximum peak.

Abstract translation: 公开了频间邻居列表搜索技术。 本文公开的实施例解决了对频间邻居列表搜索的需要。 在一个实施例中，部署搜索器以利用第一组搜索参数搜索PN空间并返回搜索结果。 选择这些结果的子集以及先前保存的搜索结果以形成用于第二搜索的一组PN位置。 使用第二组搜索参数，在围绕每个PN位置的窗口上执行第二搜索。 第二次搜索的最大峰值被保存以供将来的迭代使用。 在一个实施例中，子集被选择为来自第一搜索的最高能级峰值。 在一个实施例中，如果当该最大峰值的位置在与先前最大峰值的预定时间偏移之内时，认为最大峰值对应于有效基站。

公开(公告)号：US07330452B2

公开(公告)日：2008-02-12

申请号：US10461270

申请日：2003-06-13

Applicant: Da-shan Shiu ,  Thomas B. Wilborn ,  Roland Rick ,  Srinivasa Rao Nagaram ,  Chalapathi Rao Emani ,  Ramachandran Gurumoorthy ,  Jesus Chao ,  Steve Doerfler ,  Peter Ang ,  Srividya Kunisetti ,  Gwang-Hyun Gho ,  Thomas Bailey

Inventor： Da-shan Shiu ,  Thomas B. Wilborn ,  Roland Rick ,  Srinivasa Rao Nagaram ,  Chalapathi Rao Emani ,  Ramachandran Gurumoorthy ,  Jesus Chao ,  Steve Doerfler ,  Peter Ang ,  Srividya Kunisetti ,  Gwang-Hyun Gho ,  Thomas Bailey

IPC: H04B7/216

CPC classification number: H04W36/0083 ,  H04B1/70754 ,  H04W36/14 ,  H04W88/06

Abstract: Techniques for inter-frequency neighbor list searching are disclosed. Embodiments disclosed herein address the need for inter-frequency neighbor list searching. In one embodiment, a searcher is deployed to search a PN space with a first set of search parameters and to return search results. A subset of those results are selected, along with a previously saved search result, to form a set of PN locations for a second search. The second search is performed on a window around each of the PN locations, using a second set of search parameters. The maximum peak from the second search is saved for use in future iterations. In one embodiment, the subset is selected as the highest energy level peaks from the first search. In one embodiment, if a maximum peak is deemed to correspond to a valid base station when the position of that maximum peak is within a pre-determined time offset from a previous maximum peak.

Abstract translation: 公开了频间邻居列表搜索技术。 本文公开的实施例解决了对频间邻居列表搜索的需要。 在一个实施例中，部署搜索器以利用第一组搜索参数搜索PN空间并返回搜索结果。 选择这些结果的子集以及先前保存的搜索结果，以形成用于第二次搜索的一组PN位置。 使用第二组搜索参数，在围绕每个PN位置的窗口上执行第二搜索。 第二次搜索的最大峰值被保存以供将来的迭代使用。 在一个实施例中，子集被选择为来自第一搜索的最高能级峰值。 在一个实施例中，如果当该最大峰值的位置在与先前最大峰值的预定时间偏移之内时，认为最大峰值对应于有效基站。

公开(公告)号：US20080004452A1

公开(公告)日：2008-01-03

申请号：US11785997

申请日：2007-04-23

Applicant: Robert Jordan ,  Thomas Bailey ,  Susan Rippin ,  Dongcheng Dai

Inventor： Robert Jordan ,  Thomas Bailey ,  Susan Rippin ,  Dongcheng Dai

IPC: C07D209/72

CPC classification number: C07D209/50 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12

Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.

Abstract translation: 使用二，三和四环酰肼衍生物及其类似物的方法，以及含有它们的药物组合物，用于治疗或预防病毒感染和与之相关的疾病，特别是由正痘病毒引起的那些病毒感染和相关疾病。

公开(公告)号：US20060235051A1

公开(公告)日：2006-10-19

申请号：US10561153

申请日：2004-06-18

Applicant: Robert Jordan ,  Thomas Bailey ,  Susan Rippin

Inventor： Robert Jordan ,  Thomas Bailey ,  Susan Rippin

IPC: A61K31/4439 ,  A61K31/407 ,  A61K31/403 ,  C07D403/02

CPC classification number: A61K31/403 ,  A61K31/407 ,  A61K31/4439

Abstract: Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.

Abstract translation: 使用二，三和四环酰肼衍生物及其类似物的方法，以及含有它们的药物组合物，用于治疗或预防病毒感染和与之相关的疾病，特别是由正痘病毒引起的那些病毒感染和相关疾病。

公开(公告)号：US20060108119A1

公开(公告)日：2006-05-25

申请号：US10995980

申请日：2004-11-23

Applicant: Thomas Bailey ,  James Chambers

Inventor： Thomas Bailey ,  James Chambers

IPC: E21B33/035

CPC classification number: E21B33/085 ,  Y10S285/92

Abstract: A latch assembly is connectable to a riser. A rotating control device can be positioned with the riser, sealing the rotating control device with the latch assembly and removably latching the rotating control device to the latch assembly and to the riser. The latch assembly can be remotely actuated. The latch assembly can provide an auxiliary safety mechanism to provide a backup actuation mechanism to unlatch the rotating control device from the latch assembly. The latch assembly can be bolted to the riser. Alternately, the latch assembly can be latched with the riser using a similar latching mechanism as used to latch the latch assembly to the rotating control device. A pressure transducer protector assembly can protect a transducer for monitoring wellbore pressure in the riser. A remote indicator panel can indicate the status of the latch assembly.

公开(公告)号：US20060102387A1

公开(公告)日：2006-05-18

申请号：US11284308

申请日：2005-11-21

Applicant: Darryl Bourgoyne ,  Don Hannegan ,  Thomas Bailey ,  James Chambers ,  Timothy Wilson

Inventor： Darryl Bourgoyne ,  Don Hannegan ,  Thomas Bailey ,  James Chambers ,  Timothy Wilson

IPC: E21B15/02

CPC classification number: E21B23/006 ,  E21B21/001 ,  E21B21/08 ,  E21B33/085 ,  E21B2021/006

Abstract: A holding member provides for releasably positioning a rotating control head assembly in a subsea housing. The holding member engages an internal formation in the subsea housing to resist movement of the rotating control head assembly relative to the subsea housing. The rotating control head assembly is sealed with the subsea housing when the holding member engages the internal formation. An extendible portion of the holding member assembly extrudes an elastomer between an upper portion and a lower portion of the internal housing to seal the rotating control head assembly with the subsea housing. Pressure relief mechanisms release excess pressure in the subsea housing and a pressure compensation mechanism pressurize bearings in the bearing assembly at a predetermined pressure.

Abstract translation: 保持构件用于将旋转的控制头组件可释放地定位在海底外壳中。 保持构件接合海底外壳内的内部结构，以抵抗旋转控制头组件相对于海底外壳的移动。 当保持构件接合内部结构时，旋转控制头组件被海底壳体密封。 保持构件组件的可延伸部分在弹性体的内部壳体的上部和下部之间挤压弹性体，以与海底壳体密封旋转的控制头组件。 压力释放机构释放海底外壳中的过压，并且压力补偿机构以预定的压力对轴承组件中的轴承加压。

公开(公告)号：US20060031361A1

公开(公告)日：2006-02-09

申请号：US11168650

申请日：2005-06-28

Applicant: Thomas Bailey ,  Christopher Jenkins ,  Jonathan Roberts ,  Kieran Scott

Inventor： Thomas Bailey ,  Christopher Jenkins ,  Jonathan Roberts ,  Kieran Scott

IPC: G06F15/16 ,  G06F17/30

CPC classification number: G06F3/0481 ,  H04L51/04

Abstract: This invention relates to a method, apparatus, or computer program for conversation annotation for instant messaging systems. The instant messaging method comprises: providing a graphical user interface; determining a selection of two or more existing messages; creating, on an instruction from the GUI, a relationship between the selected messages; and indicating, using links or edges on between the messages, the relationship between the messages. All related messages may be selected with a single selection and printed, stored, or deleted as a batch.

Abstract translation: 本发明涉及用于即时通讯系统的对话注释的方法，装置或计算机程序。 即时消息收发方法包括：提供图形用户界面; 确定两个或多个现有消息的选择; 根据GUI的指令创建所选择的消息之间的关系; 并指示使用消息之间的链接或边缘消息之间的关系。 所有相关消息可以通过单个选择进行选择，并作为批次进行打印，存储或删除。

公开(公告)号：US20050288258A1

公开(公告)日：2005-12-29

申请号：US10511430

申请日：2003-04-23

Applicant: Guy Diana ,  Thomas Bailey ,  Dorothy Young ,  Srinivas Chunduru

Inventor： Guy Diana ,  Thomas Bailey ,  Dorothy Young ,  Srinivas Chunduru

IPC: A61K31/675 ,  C07D213/66 ,  C07F9/58 ,  C07F9/6558

CPC classification number: C07D213/66 ,  C07F9/58 ,  C07F9/65583 ,  C07F9/65586

Abstract: Pyridine derivatives that exhibit antiviral activity are disclosed.

Abstract translation: 公开了具有抗病毒活性的吡啶衍生物。