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公开(公告)号：US20050245747A1
公开(公告)日：2005-11-03
申请号：US11104091
申请日：2005-04-12
申请人： Edward Bacon , Sankar Chatterjee , Derek Dunn , Marie-Edith Gourdel , Greg Hostetler , Mohamed Iqbal , Brigitte Lesur , Philippe Louvet , Eric Riguet , Dominique Schweizer , Christophe Yue
发明人： Edward Bacon , Sankar Chatterjee , Derek Dunn , Marie-Edith Gourdel , Greg Hostetler , Mohamed Iqbal , Brigitte Lesur , Philippe Louvet , Eric Riguet , Dominique Schweizer , Christophe Yue
IPC分类号： C07C317/10 , C07C317/44 , C07C323/65 , C07D205/04 , C07D207/16 , C07D207/325 , C07D207/333 , C07D209/10 , C07D209/48 , C07D211/74 , C07D213/34 , C07D213/40 , C07D215/12 , C07D261/08 , C07D295/185 , C07D307/38 , C07D307/79 , C07D317/56 , C07D319/18 , C07D319/20 , C07D321/10 , C07D327/08 , C07D333/18 , C07D333/28 , C07D333/54 , C07D345/00 , C07D405/12 , C07D409/12 , C07D249/16 , C07D209/18 , C07D235/04 , C07D249/08 , C07D403/02
CPC分类号： C07C317/10 , C07C317/44 , C07C323/65 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/16 , C07C2601/18 , C07D207/325 , C07D207/333 , C07D209/48 , C07D213/40 , C07D295/185 , C07D307/38 , C07D307/79 , C07D333/54
摘要： The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.
摘要翻译： 本发明涉及化学组成，其制备方法和组合物的用途。 特别地，本发明涉及包含式（I）的取代的联芳基 - 甲亚磺酰基乙酰胺的组合物：其中Ar，Y，R 1，R 2，R 2， 4，R 5，q和x如本文所定义; 及其用于治疗疾病的用途，包括治疗与发作性睡眠相关的嗜睡，阻塞性睡眠呼吸暂停或转移工作障碍; 帕金森病 阿尔茨海默氏病; 注意力缺陷障碍 注意缺陷多动障碍; 萧条; 或与神经系统疾病相关的疲劳; 以及促进觉醒。
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公开(公告)号：US07981907B2
公开(公告)日：2011-07-19
申请号：US12199167
申请日：2008-08-27
申请人： Edward R. Bacon , Sankar Chatterjee , Derek Dunn , Marie-Edith Gourdel , Greg Hostetler , Mohamed Iqbal , Brigitte Lesur , Philippe Louvet , Eric Riguet , Dominique Schweizer , Christophe Yue
发明人： Edward R. Bacon , Sankar Chatterjee , Derek Dunn , Marie-Edith Gourdel , Greg Hostetler , Mohamed Iqbal , Brigitte Lesur , Philippe Louvet , Eric Riguet , Dominique Schweizer , Christophe Yue
IPC分类号： A61K31/445
CPC分类号： C07C317/10 , C07C317/44 , C07C323/65 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/16 , C07C2601/18 , C07D207/325 , C07D207/333 , C07D209/48 , C07D213/40 , C07D295/185 , C07D307/38 , C07D307/79 , C07D333/54
摘要： The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.
摘要翻译： 本发明涉及化学组成，其制备方法和组合物的用途。 特别地，本发明涉及包含式（I）的取代的联芳基 - 甲亚磺酰基乙酰胺的组合物：其中Ar，Y，R 1，R 2，R 4，R 5，q和x如本文所定义; 及其用于治疗疾病的用途，包括治疗与发作性睡眠相关的嗜睡，阻塞性睡眠呼吸暂停或转移工作障碍; 帕金森病 阿尔茨海默氏病; 注意力缺陷障碍 注意缺陷多动障碍; 萧条; 或与神经系统疾病相关的疲劳; 以及促进觉醒。
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公开(公告)号：US07449481B2
公开(公告)日：2008-11-11
申请号：US11104091
申请日：2005-04-12
申请人： Edward R. Bacon , Sankar Chatterjee , Derek Dunn , Marie-Edith Gourdel , Greg Hostetler , Mohamed Iqbal , Brigitte Lesur , Philippe Louvet , Eric Riguet , Dominique Schweizer , Christophe Yue
发明人： Edward R. Bacon , Sankar Chatterjee , Derek Dunn , Marie-Edith Gourdel , Greg Hostetler , Mohamed Iqbal , Brigitte Lesur , Philippe Louvet , Eric Riguet , Dominique Schweizer , Christophe Yue
IPC分类号： A61K31/445 , C07D333/02
CPC分类号： C07C317/10 , C07C317/44 , C07C323/65 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/16 , C07C2601/18 , C07D207/325 , C07D207/333 , C07D209/48 , C07D213/40 , C07D295/185 , C07D307/38 , C07D307/79 , C07D333/54
摘要： The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.
摘要翻译： 本发明涉及化学组成，其制备方法和组合物的用途。 特别地，本发明涉及包含式（I）的取代的联芳基 - 甲亚磺酰基乙酰胺的组合物：其中Ar，Y，R 1，R 2，R 2， 4，R 5，q和x如本文所定义; 及其用于治疗疾病的用途，包括治疗与发作性睡眠相关的嗜睡，阻塞性睡眠呼吸暂停或转移工作障碍; 帕金森病 阿尔茨海默氏病; 注意力缺陷障碍 注意缺陷多动障碍; 萧条; 或与神经系统疾病相关的疲劳; 以及促进觉醒。
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公开(公告)号：US20070281949A1
公开(公告)日：2007-12-06
申请号：US11803320
申请日：2007-05-14
申请人： Edward Bacon , Thomas Bailey , Nadine Becknell , Diane Gingrich , Greg Hostetler , Robert Hudkins , Keith Learn , Jason Wagner
发明人： Edward Bacon , Thomas Bailey , Nadine Becknell , Diane Gingrich , Greg Hostetler , Robert Hudkins , Keith Learn , Jason Wagner
IPC分类号： A61K31/519 , A61K31/517 , C07D487/02 , C07D403/02
CPC分类号： C07D401/14 , C07D403/04 , C07D487/04
摘要： The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).
摘要翻译： 本发明涉及化学组成，其制备方法和组合物的用途。 特别地，本发明涉及包含式（I）的取代的杂双环嘧啶的组合物：其中R 1，R 2，R 3， R 4，R 5，X，W和环A如本文所定义; 式（I）的取代杂双环嘧啶的药物组合物; 以及它们在治疗慢性神经变性疾病，神经创伤性疾病，抑郁症和/或糖尿病中的用途。 更具体地，本发明涉及式（I）的取代的吡唑并嘧啶。
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公开(公告)号：US06906193B2
公开(公告)日：2005-06-14
申请号：US10415774
申请日：2001-10-31
IPC分类号： A61K31/47 , A61K31/4706 , A61K31/4709 , A61K31/473 , A61P29/00 , A61P43/00 , C07D215/42 , C07D215/52 , C07D219/08 , C07D221/18 , C07D409/04 , C07D215/38 , A61K31/60 , C07D215/44
CPC分类号： C07D215/42 , C07D221/18
摘要： Compounds useful for the treatment of pain in accord with the following structural diagram, wherein R1, R2, R3, R4 and R5 are any of a number of groups as defined in the specification, A and D are as defined in the specification, and pharmaceutical compositions and methods of treatment utilising such compounds.
摘要翻译： 可用于治疗疼痛的化合物，符合以下结构图，其中R 1，R 2，R 3，R 3， 4和R 5是说明书中定义的若干基团中的任何一个，A和D如说明书中所定义，以及使用这些化合物的药物组合物和治疗方法。
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公开(公告)号：US20110053920A1
公开(公告)日：2011-03-03
申请号：US12939527
申请日：2010-11-04
申请人： Edward R. Bacon , Thomas Bailey , Nadine C. Becknell , Diane E. Gingrich , Greg Hostetler , Robert L. Hudkins , Keith S. Learn , Jason C. Wagner
发明人： Edward R. Bacon , Thomas Bailey , Nadine C. Becknell , Diane E. Gingrich , Greg Hostetler , Robert L. Hudkins , Keith S. Learn , Jason C. Wagner
IPC分类号： A61K31/541 , C07D487/04 , A61K31/519 , C07D471/04 , C07D413/14 , A61K31/5377 , A61K31/517 , C07D417/14 , C07D473/00 , A61K31/52 , A61P25/00 , A61P29/00 , A61P9/00 , A61P3/10 , A61P3/04
CPC分类号： C07D401/14 , C07D403/04 , C07D487/04
摘要： The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).
摘要翻译： 本发明涉及化学组成，其制备方法和组合物的用途。 特别地，本发明涉及包含式（I）的取代杂双环嘧啶的组合物：其中R 1，R 2，R 3，R 4，R 5，X，W和环A如本文所定义; 式（I）的取代杂双环嘧啶的药物组合物; 及其用于治疗慢性神经变性疾病，神经创伤性疾病，抑郁症和/或糖尿病的用途。 更具体地，本发明涉及式（I）的取代的吡唑并嘧啶。
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![Substituted pyrazolo[3,4-d]pyrimidines](/abs-image/US/2010/12/14/US07851468B2/abs.jpg.150x150.jpg)
公开(公告)号：US07851468B2
公开(公告)日：2010-12-14
申请号：US11803320
申请日：2007-05-14
申请人： Edward R. Bacon , Thomas Bailey , Nadine C. Becknell , Diane E. Gingrich , Greg Hostetler , Robert L. Hudkins , Keith S. Learn , Jason C. Wagner
发明人： Edward R. Bacon , Thomas Bailey , Nadine C. Becknell , Diane E. Gingrich , Greg Hostetler , Robert L. Hudkins , Keith S. Learn , Jason C. Wagner
IPC分类号： A61K31/541 , A61K31/5355 , A61K31/497 , A61K31/519 , C07D279/12 , C07D417/14 , C07D413/14 , C07D519/00 , C07D487/04 , A61K31/517
CPC分类号： C07D401/14 , C07D403/04 , C07D487/04
摘要： The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): wherein R1, R2, R3, R4, R5, X, W, and ring A are as defined herein; pharmaceutical compositions of substituted heterobicyclic pyrimidines of Formula (I); and their use in the treatment of chronic neurodegenerative diseases, neurotraumatic diseases, depression and/or diabetes. More particularly, the present invention relates to substituted pyrazolopyrimidines of Formula (I).
摘要翻译： 本发明涉及化学组成，其制备方法和组合物的用途。 特别地，本发明涉及包含式（I）的取代杂双环嘧啶的组合物：其中R 1，R 2，R 3，R 4，R 5，X，W和环A如本文所定义; 式（I）的取代杂双环嘧啶的药物组合物; 及其用于治疗慢性神经变性疾病，神经创伤性疾病，抑郁症和/或糖尿病的用途。 更具体地，本发明涉及式（I）的取代的吡唑并嘧啶。
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公开(公告)号：US06815447B2
公开(公告)日：2004-11-09
申请号：US10415785
申请日：2003-10-02
IPC分类号： C07D40112
CPC分类号： C07D401/12
摘要： Compounds useful for the treatment of pain in accord with the following structural diagram, wherein R1, R2 and R3 are any of a number of groups as defined in the specification and pharmaceutical compositions and methods of treatment utilising such compounds.
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