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    Isolated protein processed to peptides which form complexes with HLA molecules
    44.
    发明授权
    Isolated protein processed to peptides which form complexes with HLA molecules 失效
    分离的蛋白质加工成与HLA分子形成复合物的肽

    公开(公告)号：US06245333B1

    公开(公告)日：2001-06-12

    申请号：US09179281

    申请日：1998-10-26

    申请人： Pierre Coulie ,  Thierry Boon-Falleur

    发明人： Pierre Coulie ,  Thierry Boon-Falleur

    IPC分类号： A61K3900

    CPC分类号： C12Q1/6881 ,  A61K39/00 ,  C07K14/4748 ,  C07K14/70539 ,  C12Q1/6886 ,  C12Q2600/172 ,  G01N33/56977

    摘要： A nucleic acid molecule which codes for a tumor rejection antigen precursor which is in turn processed to antigens presented by an HLA molecule is described. The HLA molecule may be HLA-A2, HLA-A28, HLA-B13, HLA-B44, or HLA-Cw6. The antigens are also described. These materials are useful in diagnostic and therapeutic methodologies. The tumor rejection antigen precursor is not tyrosinase, which has previously been identified as a tumor rejection antigen precursor processed to an antigen presented by HLA-B44.

    摘要翻译： 描述了编码肿瘤排斥抗原前体的核酸分子，其又被加工成由HLA分子呈递的抗原。 HLA分子可以是HLA-A2，HLA-A28，HLA-B13，HLA-B44或HLA-Cw6。 还描述了抗原。 这些材料可用于诊断和治疗方法。 肿瘤排斥抗原前体不是酪氨酸酶，其先前已经被鉴定为被HLA-B44呈递的抗原加工的肿瘤排斥抗原前体。

    Isolated nucleic acid molecules which encode tumor rejection antigens found in dage
    49.
    发明授权
    Isolated nucleic acid molecules which encode tumor rejection antigens found in dage 有权
    编码肿瘤排斥抗原的分离的核酸分子

    公开(公告)号：US06339149B1

    公开(公告)日：2002-01-15

    申请号：US09131831

    申请日：1998-08-11

    申请人： Pierre Coulie ,  Hideyuki Ikeda ,  Thierry Boon-Falleur

    发明人： Pierre Coulie ,  Hideyuki Ikeda ,  Thierry Boon-Falleur

    IPC分类号： C07H504

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10S530/828

    摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as DAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described.

    摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为DAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为GAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。

    Methods for treating subject with DAGE derived peptides
    50.
    发明授权
    Methods for treating subject with DAGE derived peptides 失效
    用DAGE衍生肽治疗受试者的方法

    公开(公告)号：US06297050B1

    公开(公告)日：2001-10-02

    申请号：US09322360

    申请日：1999-05-28

    申请人： Pierre Coulie ,  Hideyuki Ikeda ,  Thierry Boon-Falleur

    发明人： Pierre Coulie ,  Hideyuki Ikeda ,  Thierry Boon-Falleur

    IPC分类号： C12N508

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10S530/828

    摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as DAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described.

    摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为DAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为GAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。