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公开(公告)号：US4935750A
公开(公告)日：1990-06-19
申请号：US401599
申请日：1989-08-31
申请人： William G. Hawkins
发明人： William G. Hawkins
CPC分类号： B41J2/1604 , B41J2/1623 , B41J2/1628 , B41J2/1629 , B41J2/1631 , B41J2/1635
摘要： A thermal ink jet printhead having an ink inlet and a plurality of droplet emitting nozzles is disclosed in which a patterned gasket is provided around each inlet during mass printhead fabrication. A plurality of printheads are obtained by dicing two mated substrates mounted in a holding film frame. A confronting surface of one of the substrates contains a plurality of sets of heating elements and addressing electrodes. The confronting surface of the other substrate contains a plurality of sets of recesses which serve as ink flow directing channels in communication with the nozzles and a reservoir having inlets in the opposite surface of the other substrate. In one embodiment, a polymeric thick film layer is deposited and photo-patterned to provide each inlet with a gasket, the surface of which is coated with a reflowable and curable adhesive for adherence to an ink supply such as an ink cartridge. In another embodiment, a compliant material such as silicone is screen printed directly around the printhead inlets.
摘要翻译： 公开了一种具有墨水入口和多个液滴喷射喷嘴的热喷墨打印头，其中在大量打印头制造期间围绕每个入口设置图案化垫圈。 通过切割安装在保持膜框架中的两个配合的基板来获得多个打印头。 一个基板的相对表面包含多组加热元件和寻址电极。 另一个基板的相对表面包含多组凹槽，其用作与喷嘴连通的油墨流动导向通道，以及具有在另一个基板的相对表面中的入口的储存器。 在一个实施例中，沉积聚合物厚膜层并进行光刻图案以为每个入口提供垫圈，垫圈的表面涂覆有可回流和可固化的粘合剂，用于粘附到诸如墨盒的墨水供应。 在另一个实施例中，柔性材料如硅树脂直接围绕打印头入口进行丝网印刷。
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公开(公告)号：US4532530A
公开(公告)日：1985-07-30
申请号：US588166
申请日：1984-03-09
申请人： William G. Hawkins
发明人： William G. Hawkins
CPC分类号： B41J2/14129 , B41J2/1603 , B41J2/1628 , B41J2/1629 , B41J2/1631 , B41J2/1642 , B41J2/1646
摘要： A carriage type, bubble jet ink printing system having improved bubble generating resistors that operate more efficiently and consume lower power, without sacrificing operating lifetimes. The resistor material is heavily doped polycrystalline silicon which can be formed on the same process lines with those for integrated circuits to reduce equipment costs and achieve higher yields. Glass mesas thermally isolate the active portion of the resistor from the silicon supporting substrate and from the electrode connecting points, so that the electrode connection points are maintained relatively cool during operation. A thermally grown dielectric layer permits a thinner electrical isolation layer between the resistor and its protective, ink interfacing tantalum layer, thus increasing the thermal energy transfer to the ink.
摘要翻译： 一种具有改进的气泡发生电阻器的支架式气泡喷墨印刷系统，其操作更有效并且消耗更低的功率，而不牺牲使用寿命。 电阻材料是重掺杂的多晶硅，其可以在与集成电路相同的工艺线上形成，以降低设备成本并实现更高的产量。 玻璃台面将电阻器的有源部分与硅支撑衬底和电极连接点热隔离，使得电极连接点在操作期间保持相对较冷。 热生长的介电层允许电阻器与其保护性油墨接合钽层之间的较薄的电隔离层，从而增加对油墨的热能转移。
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公开(公告)号：US08461311B2
公开(公告)日：2013-06-11
申请号：US13155577
申请日：2011-06-08
CPC分类号： C07K14/4747 , C07K14/52
摘要： Disclosed are TNF-related apoptosis-inducing ligand (TRAIL) trimers (TR3) and nucleic acids encoding covalently linked TRAIL trimers. A TRAIL trimer can have greater stability compared to native TRAIL, and can retain the native killing ability of TRAIL. Target specificity of a TR3 can be shown by blocking its activity with soluble death receptor 5 (DR5-Fc). Also disclosed are modified TRAIL trimers and nucleic. acids encoding them. These modifications include additional functional domains, such as antibody fragments (scFvs). A TR3 comprising an additional functional domain can allow for cell-specific delivery of the TR3. The inventors disclose TR3-decorated RBCs that target cell killing in a model of pancreatic cancer.
摘要翻译： 公开了TNF相关凋亡诱导配体（TRAIL）三聚体（TR3）和编码共价连接的TRAIL三聚体的核酸。 与天然TRAIL相比，TRAIL三聚体可以具有更高的稳定性，并且可以保留TRAIL的天然杀伤能力。 可通过用可溶性死亡受体5（DR5-Fc）阻断其活性来显示TR3的靶特异性。 还公开了修饰的TRAIL三聚体和核酸。 编码它们的酸。 这些修饰包括额外的功能域，例如抗体片段（scFv）。 包含附加功能域的TR3可以允许TR3的细胞特异性递送。 本发明人公开了在胰腺癌模型中靶向细胞杀伤的TR3装饰的RBC。
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公开(公告)号：US08143222B2
公开(公告)日：2012-03-27
申请号：US12255947
申请日：2008-10-22
CPC分类号： C07D221/22 , A61K47/54
摘要： Pharmaceutical compounds, pharmaceutical compositions and methods of treatment are disclosed, wherein a compound comprises a targeting moiety which, in free form, binds a cell receptor with a dissociation constant Kd of less than about 10−7 M, and a pharmaceutically active moiety, wherein the targeting moiety is other than an oligopeptide, a polypeptide, a peptidomimetic, a protein or a protein domain, and wherein the targeting moiety and the pharmaceutically active moiety are covalently attached. In some aspects, the targeting moiety binds a sigma-2 receptor with high affinity and high specificity, and the pharmaceutically active moiety is a pro-apoptotic peptide moiety. Methods of cancer treatment are disclosed comprising administering a disclosed pharmaceutical compound to a subject in need of thereof. The treatments selectively induce apoptosis in cancer cells. These methods can further comprise co-administration of radiation therapy and/or an additional chemotherapeutic agent.
摘要翻译： 公开了药物化合物，药物组合物和治疗方法，其中化合物包含以游离形式结合小于约10-7M的解离常数Kd的细胞受体的靶向部分和药学活性部分，其中 靶向部分不同于寡肽，多肽，肽模拟物，蛋白质或蛋白质结构域，并且其中靶向部分和药学活性部分共价连接。 在一些方面，靶向部分以高亲和力和高特异性结合σ-2受体，并且药物活性部分是促凋亡肽部分。 公开了癌症治疗方法，其包括将所公开的药物化合物施用于需要其的受试者。 治疗选择性诱导癌细胞凋亡。 这些方法还可以包括放射治疗和/或另外的化学治疗剂的共同给药。
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45.发明授权公开(公告)号：US06310968B1
公开(公告)日：2001-10-30
申请号：US09198787
申请日：1998-11-24
申请人： William G. Hawkins , Daniel Gagnon
发明人： William G. Hawkins , Daniel Gagnon
IPC分类号： G06K900
CPC分类号： G01T1/1615 , A61B6/037 , G01T1/2985
摘要： A method of ML-EM image reconstruction is provided for use in connection with a diagnostic imaging apparatus (10) that generates projection data. The method includes collecting projection data, including measured emission projection data. An initial emission map and attenuation map are assumed. The emission map and the attenuation map are iteratively updated. With each iteration, the emission map is recalculated by taking a previous emission map and adjusting it based upon: (i) the measured emission projection data; (ii) a reprojection of the previous emission map which is carried out with a multi-dimensional projection model; and, (iii) a reprojection of the attenuation map. As well, with each iteration, the attenuation map is recalculated by taking a previous attenuation map and adjusting it based upon: (i) the measured emission projection data; and, (ii) a reprojection of the previous emission map which is carried out with the multi-dimensional projection model. In a preferred embodiment, with source-assisted reconstruction, the recalculation of the attenuation map is additionally based upon: (iii) measured transmission projection data; and, (iv) a reference or blank data set of measured transmission projection data taken without the subject present in the imaging apparatus (10).
摘要翻译： 提供了一种ML-EM图像重建方法，用于与产生投影数据的诊断成像设备（10）相结合。 该方法包括收集投影数据，包括测量的发射投影数据。 假设初始发射图和衰减图。 发射图和衰减图迭代更新。 通过每次迭代，通过采取先前的发射图并根据以下进行调整来重新计算发射图：（i）测量的发射投影数据; （ii）用多维投影模型进行的先前发射图的重新投影; 和（iii）衰减图的重新投射。 同样地，通过每次迭代，通过采取先前的衰减图并且基于以下来调整衰减图来重新计算衰减图：（i）测量的发射投影数据; 和（ii）用多维投影模型进行的先前发射图的重新投射。 在优选实施例中，通过源辅助重建，衰减映射的重新计算另外基于：（iii）测量的传输投影数据; 以及（iv）在成像装置（10）中没有被摄体存在的测量的透射投影数据的参考或空白数据集。
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公开(公告)号：US5767517A
公开(公告)日：1998-06-16
申请号：US733947
申请日：1996-10-21
申请人： William G. Hawkins
发明人： William G. Hawkins
CPC分类号： G01T1/1648
摘要： A method of resampling of a sinogram from a fan beam SPECT includes the steps of angular resampling of the sinogram using frequency modulation, and thence transfers resampling of the sinogram using linear interpolation. This permits the use of parallel geometry algorithms in quantitative work without the expected degradation of resolution or the introduction of artifacts.
摘要翻译： 从风扇光束SPECT重新采样正弦图的方法包括使用频率调制对正弦图进行角度重采样的步骤，并且然后使用线性插值来转移正弦图的重采样。 这允许在定量工作中使用并行几何算法，而不会导致预期的分辨率降低或引入伪影。
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公开(公告)号：US5428498A
公开(公告)日：1995-06-27
申请号：US952015
申请日：1992-09-28
申请人： William G. Hawkins , Cathie J. Burke , Thomas E. Watrobski , Thomas A. Tellier , Sophie Vandebroek
发明人： William G. Hawkins , Cathie J. Burke , Thomas E. Watrobski , Thomas A. Tellier , Sophie Vandebroek
IPC分类号： H01L27/04 , H01L21/822 , H01L27/02 , H02H3/22
CPC分类号： H01L27/0251 , H01L27/0259
摘要： An electrostatic discharge protection device for a connector associated with an integrated circuit chip, particularly one associated with a thermal ink-jet printhead. A MOS field effect device extends along at least one edge of the connector on the chip. A bipolar transistor, parasitic to the field effect device, conducts current from the connector to ground in response to a voltage between the connector and ground in excess of a predetermined threshold. A zone of a predetermined electrical resistance is operatively disposed between the bipolar transistor and ground. The zone may substantially encircle the bonding pad of the connector to evenly distribute local incidences of high voltage. The invention enables integrated circuits to pass ESD requirements of office products, which is 15 kV by Human Body Model testing.
摘要翻译： 一种用于与集成电路芯片相关联的连接器的静电放电保护装置，特别是与热喷墨打印头相关联的静电放电保护装置。 MOS场效应器件沿芯片上连接器的至少一个边缘延伸。 寄生到场效应器件的双极晶体管响应于连接器和地之间的电压超过预定阈值而将电流从连接器传导到地。 预定电阻的区域可操作地设置在双极晶体管和地之间。 该区域可以基本上环绕连接器的焊盘，以均匀分布高电压的局部发生。 本发明使得集成电路能够通过人体模型测试传递15kV的办公产品的ESD要求。
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公开(公告)号：US5300968A
公开(公告)日：1994-04-05
申请号：US943822
申请日：1992-09-10
申请人： William G. Hawkins
发明人： William G. Hawkins
CPC分类号： B41J2/04541 , B41J2/04543 , B41J2/04563 , B41J2/0457 , B41J2/0458 , B41J2/04588 , B41J2/0459 , B41J2/04591 , B41J2/04598 , B41J2/195
摘要： A controller controls an ink jet printing apparatus that propels ink jet droplets on demand from a printhead having a plurality of drop ejectors. The printhead includes a plurality of heater elements which are responsive to electrical input signals, each input signal having an amplitude and time duration which produce a temporary vapor bubble and cause a quantity of ink to be ejected for creation of a mark on a copy sheet. The controller has power supply means and delay means that vary the amplitude and duration of the input signals in relation to the printhead temperature.
摘要翻译： 控制器控制从具有多个液滴喷射器的打印头按要求推动喷墨滴的喷墨打印设备。 打印头包括响应于电输入信号的多个加热器元件，每个输入信号具有产生暂时蒸汽气泡的振幅和持续时间，并且导致一定量的墨被喷射以在复印纸上产生标记。 控制器具有相对于打印头温度改变输入信号的幅度和持续时间的电源装置和延迟装置。
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49.发明授权
公开(公告)号：US5208606A
公开(公告)日：1993-05-04
申请号：US795596
申请日：1991-11-21
CPC分类号： B41J2/1606
摘要： A thermal ink jet printhead has an outer, metallic hydrophobic coating on its front face to repel ink. Eliminating the accumulation of ink at the nozzles of the printhead allows an ink droplet to be accurately ejected and ensures the directionality of the ejected ink droplet onto the printing medium. The outer coating is formed of a metal selected from the group of noble metals, including gold, platinum, palladium, silver, rhodium and ruthenium. An adhesion layer is preferably deposited between the front face of the printhead and the outer ink-repellent coating. The metallic coating is preferably applied by electroplating, wet electroless plating, evaporation, sputtering, ion plating, CVD or plasma CVD.
摘要翻译： 热喷墨打印头在其前面具有外部金属疏水涂层以排斥油墨。 在打印头的喷嘴处消除墨水的积聚允许墨滴被精确地喷射并确保喷射的墨滴在打印介质上的方向性。 外涂层由选自贵金属，包括金，铂，钯，银，铑和钌的金属形成。 粘合层优选沉积在打印头的前表面和外部防墨涂层之间。 金属涂层优选通过电镀，湿化学镀，蒸发，溅射，离子镀，CVD或等离子体CVD来进行。
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50.发明授权Temperature control transducer and MOS driver for thermal ink jet printing chips 失效用于热喷墨打印芯片的温度控制传感器和MOS驱动器
公开(公告)号：US5081473A
公开(公告)日：1992-01-14
申请号：US558092
申请日：1990-07-26
CPC分类号： B41J2/1626 , B41J2/1601 , B41J2/1642 , B41J2/1646 , H01L27/0688 , B41J2202/13
摘要： A transducer for a thermal ink jet printhead has a primary heating region having a tantalum layer, a silicon nitride layer and a polysilicon resistor layer. An n.sup.- drift layer resistor serves as a secondary heating region and a field layer of silicon dioxide acts as an insulator. The field layer is sandwiched between the primary heating region and the secondary heating region. The secondary heating region by heating the field layer causes the heat generated in the primary heating region to be directed toward ink which lies above the primary heating region. An electrical contact connects the polysilicon resistor layer of the primary heating region to a driving transistor located on the same silicon wafer as the transducer. The driving transistor has a field oxide layer sandwiched between an n.sup.- drift layer and a field plate layer, the field plate layer causing secondary pinch off of the n.sup.- drift layer thus enabling higher operating voltages.
摘要翻译： 用于热喷墨打印头的换能器具有具有钽层，氮化硅层和多晶硅电阻层的初级加热区域。 n漂移层电阻器用作二次加热区域，二氧化硅的场层用作绝缘体。 场层被夹在主加热区和次加热区之间。 通过加热场层的二次加热区域，使得在一次加热区域中产生的热量朝向位于主加热区域上方的墨水。 电接触将主加热区域的多晶硅电阻层连接到位于与换能器相同的硅晶片上的驱动晶体管。 驱动晶体管具有夹在n漂移层和场板层之间的场氧化物层，所述场板层引起n漂移层的次级夹断，从而实现更高的工作电压。
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