公开(公告)号：US08559003B2

公开(公告)日：2013-10-15

申请号：US13384456

申请日：2009-09-17

申请人： Huei Pei Kuo ,  Shih-Yuan Wang ,  Min Hu ,  Zhiyong Li ,  Alexandre M. Bratkovski

发明人： Huei Pei Kuo ,  Shih-Yuan Wang ,  Min Hu ,  Zhiyong Li ,  Alexandre M. Bratkovski

IPC分类号： G01J3/44

CPC分类号： G01N21/658 ,  B82Y15/00 ,  B82Y30/00

摘要： An electrically driven device for surface enhanced Raman spectroscopy includes a first electrode, a substrate positioned proximate to the first electrode, a plurality of cone shaped protrusions formed integrally with or on a substrate surface, a Raman signal-enhancing material coated on each protrusion, and a second electrode positioned relative to the first electrode at a predetermined distance. Each of the protrusions has a tip with a radius of curvature ranging from about 0.1 nm to about 100 nm. The second electrode is positioned relative to the first electrode such that the electrodes together produce an electric field when a voltage bias is applied therebetween. The electric field has a field distribution that creates a stronger field gradient at a region proximate to the tips than at other portions of the substrate.

摘要翻译： 用于表面增强拉曼光谱的电驱动装置包括第一电极，靠近第一电极定位的基板，与基底表面一体地形成的多个锥形突起，涂覆在每个突起上的拉曼信号增强材料，以及 相对于第一电极以预定距离定位的第二电极。 每个突起具有具有约0.1nm至约100nm范围的曲率半径的尖端。 第二电极相对于第一电极定位，使得当在其之间施加电压偏置时，电极一起产生电场。 电场具有场分布，其在靠近尖端的区域处产生比在衬底的其它部分更强的场梯度。

公开(公告)号：US20110317160A1

公开(公告)日：2011-12-29

申请号：US13254897

申请日：2009-03-13

申请人： Zhiyong Li ,  Min Hu

发明人： Zhiyong Li ,  Min Hu

IPC分类号： G01J3/44 ,  B29C35/02 ,  C23F1/02 ,  B29C70/00

CPC分类号： G01N21/554 ,  B82Y30/00 ,  G01N21/553 ,  G01N21/658

摘要： Broad band structures for surface enhanced Raman spectroscopy are disclosed herein. Each embodiment of the structure is made up of a metal layer, and a dielectric layer established on at least a portion of the metal layer. The dielectric layer has a controlled thickness that varies from at least one portion of the dielectric layer to at least another portion of the dielectric layer. Nanostructures are established on the dielectric layer at least at the portion and the other portion, the nanostructures thus being configured to exhibit variable plasmon resonances.

摘要翻译： 本文公开了用于表面增强拉曼光谱的宽带结构。 结构的每个实施例由金属层和建立在金属层的至少一部分上的电介质层组成。 电介质层具有从电介质层的至少一部分到电介质层的至少另一部分变化的受控厚度。 至少在部分和另一部分，在电介质层上建立纳米结构，因此纳米结构被构造成表现出可变的等离子体共振。

公开(公告)号：US08810788B2

公开(公告)日：2014-08-19

申请号：US13254897

申请日：2009-03-13

申请人： Zhiyong Li ,  Min Hu

发明人： Zhiyong Li ,  Min Hu

IPC分类号： G01J3/44 ,  G01N21/65 ,  G01N21/55

CPC分类号： G01N21/554 ,  B82Y30/00 ,  G01N21/553 ,  G01N21/658

摘要： Broad band structures for surface enhanced Raman spectroscopy are disclosed herein. Each embodiment of the structure is made up of a metal layer, and a dielectric layer established on at least a portion of the metal layer. The dielectric layer has a controlled thickness that varies from at least one portion of the dielectric layer to at least another portion of the dielectric layer. Nanostructures are established on the dielectric layer at least at the portion and the other portion, the nanostructures thus being configured to exhibit variable plasmon resonances.

摘要翻译： 本文公开了用于表面增强拉曼光谱的宽带结构。 结构的每个实施例由金属层和建立在金属层的至少一部分上的电介质层组成。 电介质层具有从电介质层的至少一部分到电介质层的至少另一部分变化的受控厚度。 至少在部分和另一部分，在电介质层上建立纳米结构，因此纳米结构被构造成表现出可变的等离子体共振。

公开(公告)号：US20120281729A1

公开(公告)日：2012-11-08

申请号：US13387075

申请日：2010-01-29

申请人： Fung Suong Ou ,  Zhiyong Li ,  Huei Pei Kuo ,  Min Hu

发明人： Fung Suong Ou ,  Zhiyong Li ,  Huei Pei Kuo ,  Min Hu

IPC分类号： G01K5/48 ,  B44C1/22

CPC分类号： B82Y15/00 ,  G01N21/658 ,  H01L29/0665

摘要： An environment sensitive device is disclosed. The device includes a substrate, a three-dimensional structure established on the substrate, a first coating established on a first portion of the three-dimensional structure, and a second coating established on a second portion of the three-dimensional structure. The first and second coatings contain different materials that are configured to respond differently when exposed to a predetermined external stimulus.

摘要翻译： 公开了一种环境敏感设备。 该装置包括衬底，在衬底上建立的三维结构，在三维结构的第一部分上建立的第一涂层和建立在三维结构的第二部分上的第二涂层。 第一和第二涂层包含不同的材料，其被配置成当暴露于预定的外部刺激时不同地响应。

公开(公告)号：US20120188539A1

公开(公告)日：2012-07-26

申请号：US13014683

申请日：2011-01-26

申请人： Michael J. Stuke ,  Shih-Yuan (SY) Wang ,  Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Huei Pei Kuo

发明人： Michael J. Stuke ,  Shih-Yuan (SY) Wang ,  Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Huei Pei Kuo

IPC分类号： G01J3/44 ,  B82Y20/00

CPC分类号： B82Y20/00 ,  G01N21/658

摘要： A nanorod surface enhanced Raman spectroscopy (SERS) apparatus, system and method of SERS using nanorods that are activated with a key. The nanorod SERS apparatus includes a plurality of nanorods, an activator to move the nanorods from an inactive to an active configuration and the key to trigger the activator. The nanorod SERS system further includes a Raman signal detector and an illumination source. The method of SERS using nanorods includes activating a plurality of nanorods with the key, illuminating the activated plurality of nanorods, and detecting a Raman scattering signal when the nanorods are in the active configuration.

摘要翻译： 纳米棒表面增强拉曼光谱（SERS）装置，使用由键激活的纳米棒的SERS的系统和方法。 纳米棒SERS装置包括多个纳米棒，激活剂将纳米棒从非活性构型移动到活性构型，以及触发激活剂的键。 纳米棒SERS系统还包括拉曼信号检测器和照明源。 使用纳米棒的SERS的方法包括用键激活多个纳米棒，照亮激活的多个纳米棒，以及当纳米棒处于活动配置时检测拉曼散射信号。

公开(公告)号：US20120119315A1

公开(公告)日：2012-05-17

申请号：US13384950

申请日：2010-01-29

申请人： Fung Suong Ou ,  Huei Pei Kuo ,  Zhiyong Li ,  Min Hu

发明人： Fung Suong Ou ,  Huei Pei Kuo ,  Zhiyong Li ,  Min Hu

IPC分类号： H01L23/48 ,  H01L21/28 ,  H01L31/0224

CPC分类号： G01N21/658 ,  B82Y15/00 ,  G01J3/44 ,  G01N27/12

摘要： A sensing device (10, 10′) includes a substrate (14), and first and second electrodes (EIC, EICS, EO) established on the substrate (14). The first electrode (EIC, EICS) has a three-dimensional shape, and the second electrode (EO) is electrically isolated from and surrounds a perimeter of the first electrode (EIC, EICS).

摘要翻译： 感测装置（10,10'）包括衬底（14）以及在衬底（14）上建立的第一和第二电极（EIC，EICS，EO）。 第一电极（EIC，EICS）具有三维形状，并且第二电极（EO）与第一电极（EIC，EICS）的周边电隔离并围绕第一电极的周边。

公开(公告)号：US20120113420A1

公开(公告)日：2012-05-10

申请号：US13384456

申请日：2009-09-17

申请人： Huei Pei Kuo ,  Shih-Yuan Wang ,  Min Hu ,  Zhiyong Li ,  Alexander M. Bratkovski

发明人： Huei Pei Kuo ,  Shih-Yuan Wang ,  Min Hu ,  Zhiyong Li ,  Alexander M. Bratkovski

IPC分类号： G01J3/44

CPC分类号： G01N21/658 ,  B82Y15/00 ,  B82Y30/00

摘要： An electrically driven device (10) for surface enhanced Raman spectroscopy includes a first electrode (16), a substrate (12) positioned proximate to the first electrode (16), a plurality of cone shaped protrusions (12′) formed integrally with or on a substrate surface (S), a Raman signal-enhancing material (14) coated on each protrusion (12′), and a second electrode (18) positioned relative to the first electrode (16) at a predetermined distance, D. Each of the protrusions (12′) has a tip (22) with a radius of curvature, r, ranging from about 0.1 nm to about 100 nm. The second electrode (18) is positioned relative to the first electrode (16) such that the electrodes (16, 18) together produce an electric field (EF) when a voltage bias is applied therebetween. The electric field (EF) has a field distribution that creates a stronger field gradient at a region proximate to the tips (22) than at other portions of the substrate (12).

摘要翻译： 用于表面增强拉曼光谱的电驱动装置（10）包括第一电极（16），靠近第一电极（16）定位的基板（12），与该第一电极（16）一体形成的多个锥形突起 涂覆在每个突起（12'）上的衬底表面（S），拉曼信号增强材料（14）和相对于第一电极（16）以预定距离D定位的第二电极（D）。 突起（12'）具有从约0.1nm至约100nm范围内的具有曲率半径r的尖端（22）。 第二电极（18）相对于第一电极（16）定位，使得当施加电压时，电极（16,18）一起产生电场（EF）。 电场（EF）具有在靠近尖端（22）的区域处比在衬底（12）的其它部分处产生更强的场梯度的场分布。

公开(公告)号：US07947485B2

公开(公告)日：2011-05-24

申请号：US11144586

申请日：2005-06-03

申请人： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Philip J. Kuekes

发明人： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Philip J. Kuekes

IPC分类号： C12M1/00 ,  G01N15/06 ,  C07H21/04

CPC分类号： G01N33/48721 ,  B82Y5/00 ,  B82Y10/00 ,  G01N27/414

摘要： Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a single electron transistor including a first terminal, a second terminal, and a nanogap or at least one quantum dot positioned between the first terminal and the second terminal. A nitrogenous material disposed on the at least one quantum dot is configured for an interaction with an identifiable configuration of a molecule. The molecule sensor develops an electronic effect responsive to the interaction. The molecule guide is configured for guiding at least a portion of the molecule substantially near the molecule sensor to enable the interaction.

摘要翻译： 公开了用于检测生物聚合物的组成部分的装置和方法。 分子分析装置包括分子传感器和分子引导件。 分子传感器包括单电子晶体管，其包括位于第一端子和第二端子之间的第一端子，第二端子和纳米隙隙或至少一个量子点。 设置在至少一个量子点上的含氮材料被配置用于与分子的可识别构型的相互作用。 分子传感器产生响应于相互作用的电子效应。 分子引导件被配置用于基本上在分子传感器附近引导分子的至少一部分，以实现相互作用。

公开(公告)号：US07805028B2

公开(公告)日：2010-09-28

申请号：US12253123

申请日：2008-10-16

申请人： Zhiyong Li ,  Michael Tan ,  Shih-Yuan Wang ,  Wei Wu ,  Jing Tang

发明人： Zhiyong Li ,  Michael Tan ,  Shih-Yuan Wang ,  Wei Wu ,  Jing Tang

IPC分类号： G02B6/00 ,  G02B6/32 ,  G02B6/10

CPC分类号： G02B6/02328 ,  B82Y20/00 ,  G01N21/05 ,  G01N21/31 ,  G01N21/645 ,  G01N21/658 ,  G01N2021/0346 ,  G01N2021/052 ,  G01N2021/6467 ,  G01N2021/7763 ,  G01N2021/7783 ,  G02B6/1226

摘要： An optical sensor, sensing system and method of sensing employ a half-core hollow optical waveguide adjacent to a surface of an optical waveguide layer of a substrate. The half-core hollow optical waveguide and the adjacent optical waveguide layer cooperatively provide both an optical path that confines and guides an optical signal and an internal hollow channel. The optical path and channel extend longitudinally along a hollow core of the half-core hollow optical waveguide. The system further includes an optical source at an input of the optical path and an optical detector at an output of the optical path. A spectroscopic interaction between an analyte material that is introduced into the channel and an optical signal propagating along the optical path determines a characteristic of the analyte material.

摘要翻译： 光学传感器，感测系统和感测方法使用与衬底的光波导层的表面相邻的半芯空心光波导。 半芯空心光波导和相邻的光波导层协同地提供限制和引导光信号和内部中空通道的光路。 光路和通道沿半芯空心光波导的中空芯纵向延伸。 该系统还包括在光路的输入处的光源和在光路的输出处的光学检测器。 引入到通道中的分析物质与沿光路传播的光信号之间的光谱相互作用决定了分析物质的特性。

公开(公告)号：US20060164635A1

公开(公告)日：2006-07-27

申请号：US11044421

申请日：2005-01-27

申请人： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

发明人： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01N21/658 ,  G01N2201/0873

摘要： Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed in a waveguide. The molecular analysis device also includes a wavelength demultiplexer and radiation sensors disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.