公开(公告)号：US20220064201A1

公开(公告)日：2022-03-03

申请号：US17459350

申请日：2021-08-27

Applicant: Academia Sinica

Inventor： Po-Wen CHUNG ,  Chia-Hui WU ,  Yi-Shiuan TSAI ,  Chun-An HSIEH

IPC: C07H1/00 ,  C07H3/02 ,  B01J41/02 ,  B01J41/10

Abstract: Disclosed is a stabilized acyclic saccharide composite, which includes a LDH-based (layered double hydroxide-based) material and acyclic saccharides intercalated in interlayer regions of the LDH-based material. The acyclic saccharides stabilized and trapped in the LDH-based material give an opportunity for direct functionalization to other valuable molecules in the pharmaceutical, chemical or carbohydrate industries. Further, a novel pathway for saccharide transformation and aldol condensation without the drawbacks associated with enzymatic catalysts is achieved through the acyclic saccharides trapped by the LDH-based material.

公开(公告)号：US11254719B2

公开(公告)日：2022-02-22

申请号：US16519461

申请日：2019-07-23

Applicant: ACADEMIA SINICA

Inventor： Che-Kun James Shen ,  Yu-Chiau Shyu

IPC: A61K39/00 ,  C07K14/47 ,  A01K67/027 ,  A61K38/17 ,  A61K45/06

Abstract: A genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis.

公开(公告)号：US20220011228A1

公开(公告)日：2022-01-13

申请号：US17282163

申请日：2019-10-03

Applicant: ACADEMIA SINICA

Inventor： Pei-Kuen WEI ,  Ming-Yang PAN ,  Kuang-Li LEE

IPC: G01N21/552

Abstract: A method and apparatus for surface plasmon resonance imaging are provided for imaging the surface plasmon resonance signals caused by the interaction of biomolecules. In particular, the method and apparatus can image the slightly spectral change in a surface plasmon resonance mode by comparing the light intensities of two bands in the frequency domain of the surface plasmon.

公开(公告)号：US20210390971A1

公开(公告)日：2021-12-16

申请号：US17335487

申请日：2021-06-01

Applicant: ACADEMIA SINICA

Inventor： TSAO YU ,  SYU-SIANG WANG ,  SZU-WEI FU ,  ALEXANDER CHAO-FU KANG ,  HSIN-MIN WANG

IPC: G10L21/0272 ,  G10L25/48 ,  G10L15/20

Abstract: An acoustic scene conversion method, comprising: receiving sound signals including user's speech and scenic sounds; processing the sound signals according to an artificial intelligence model to generate enhanced speech signals without scenic sounds; and mixing the enhanced speech signals with new scenic sounds to produce converted sound signals.

公开(公告)号：US20210363196A1

公开(公告)日：2021-11-25

申请号：US17327514

申请日：2021-05-21

Applicant: ACADEMIA SINICA

Inventor： Wen-Hsiung LI ,  Anandharaj MARIMUTHU ,  Jui-Jen CHANG ,  Yu-Ju LIN ,  Rizwana Parveen Rani MOHAMED GOBIL ,  Chieh-Chen HUANG

IPC: C07K14/195 ,  C12P7/06 ,  C12P19/02 ,  C12P19/14 ,  C12N9/42 ,  C12N9/02

Abstract: The present disclosure relates to a recombinant protein comprising a plurality of type II cohesin repeats. The present disclosure provides a recombinant cellulosome complex comprising: the recombinant protein comprising a plurality of type II cohesin repeats; a recombinant cellulosome complex integrating protein A comprising a plurality of type I cohesin repeats, a plurality of cellulose-binding modules and a type II dockerin; and a plurality of recombinant enzymes each comprising a type I dockerin. A cell, a method for digesting a cellulose and a method for producing ethanol are also provided.

公开(公告)号：US20210332146A1

公开(公告)日：2021-10-28

申请号：US17211619

申请日：2021-03-24

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey WONG ,  Chung-Yi WU ,  Ming-Hung Tsai

IPC: C07K16/28 ,  C12P21/00

Abstract: The present disclosure relates to a novel class of anti-CD20 monoclonal antibodies comprising a homogeneous population of anti-CD20 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-CD20 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.

公开(公告)号：US20210292401A1

公开(公告)日：2021-09-23

申请号：US17342514

申请日：2021-06-08

Applicant: Academia Sinica

Inventor： Ruey-Bing YANG ,  Yuh-Charn Lin

IPC: C07K16/22 ,  A61K39/395 ,  C07K16/18 ,  A61P35/00

Abstract: An isolated anti-SCUBE2 antibody or a binding fragment thereof is disclosed. The anti-SCUBE2 antibody comprises an antigen binding region that specifically binds to a target domain located within SCUBE2 (SEQ ID NO: 66) and exhibits a property of inhibiting VEGF-induced angiogenesis. The target domain is selected from the group consisting of the EGF-like motifs 4 to 6 ranging from a.a. position 175 to 323, or the spacer region ranging from a.a. position 441 to 659, or the first cys-rich motif ranging from a.a. position 668 to 725 of SCUBE2 (SEQ ID NO: 66). The anti-SCUBE2 antibody or binding fragment thereof is for use in treating a disease associated with VEGF-induced angiogenesis, or for use in treating a tumor or inhibiting tumor angiogenesis and cancer cell growth in a subject in need thereof.

公开(公告)号：US11123424B2

公开(公告)日：2021-09-21

申请号：US16450810

申请日：2019-06-24

Applicant: Academia Sinica

Inventor： Yu-Chan Chao ,  Wei-Ting Hsu ,  Hui-Wen Chang ,  Chia-Yu Chang

IPC: C12N7/00 ,  A61K39/215 ,  A61K39/12 ,  A61K39/225 ,  C07K14/01 ,  G01N33/569 ,  C12N15/86 ,  A61K39/00

Abstract: A baculovirus displaying a porcine epidemic diarrhea virus S protein or S1 domain thereof is provided for preventing porcine epidemic diarrhea virus infection.

公开(公告)号：US11107963B2

公开(公告)日：2021-08-31

申请号：US15865644

申请日：2018-01-09

Applicant: Academia Sinica

Inventor： Maw-Kuen Wu ,  Phillip M Wu ,  Yang-Yuan Chen ,  Chung-Chieh Chang ,  Pai-Chun Wei ,  Tian-Wey Lan ,  Yu-Ruei Wu

IPC: H01L35/16 ,  H01L35/26 ,  H01L35/34 ,  C01B19/00

Abstract: At least one of the present embodiments generally relates to an apparatus and a method for enhancing the figure of merit (zT) in composite thermoelectric materials using aerogel such as e.g., silicate/silica aerogel, carbon aerogel, chalcogenide aerogel and metal oxide aerogel. For example, the present embodiments provide apparatuses and methods for the addition of aerogels to two commonly used p and n type thermoelectric materials and thereby enhancing their thermoelectric figure of merits to record levels.

公开(公告)号：US20210198332A1

公开(公告)日：2021-07-01

申请号：US17105858

申请日：2020-11-27

Applicant: ACADEMIA SINICA

Inventor： Benjamin Pang-Hsien TU ,  Rita PY CHEN ,  Joseph Jen-Tse HUANG ,  Yijuang CHERN ,  Yu-Song JANG ,  Xiang-Me LAI ,  Tai-Yan LIAO ,  Te-Hsien KUNG

IPC: C07K14/47

Abstract: Bipartite molecules comprising a peptide affinity moiety and at least one charged moiety and uses thereof in reducing formation of abnormal protein aggregate and treating diseases associated with such abnormal protein aggregate, including neurodegenerative disease characterized by formation of protein aggregates.