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193 条记录 (耗时 0.052 秒)

    Method for measuring carbon nanotubes taken-up by a plurality of living cells
    42.
    发明授权
    Method for measuring carbon nanotubes taken-up by a plurality of living cells 有权
    用于测量由多个活细胞摄取的碳纳米管的方法

    公开(公告)号：US08632671B2

    公开(公告)日：2014-01-21

    申请号：US13121395

    申请日：2009-10-02

    申请人： Rockford K. Draper ,  Paul Pantano ,  Ru-Hung Wang ,  Carole Mikoryak

    发明人： Rockford K. Draper ,  Paul Pantano ,  Ru-Hung Wang ,  Carole Mikoryak

    IPC分类号： G01N27/447

    CPC分类号： G01N27/44717 ,  G01N33/54346 ,  G01N2015/0038 ,  G01N2015/0693

    摘要： The present invention provides methods, apparatuses and kits for determining the presence and the concentration of nanoparticles in a given area, solution or region via cellular uptake and/or adsorption monitored through laboratory equipment. For example, the present invention provides a method of quantifying one or more nanoparticles by incubating a nanoparticle solution comprising one or more nanoparticles with one or more cells; isolating the one or more cells; lysing the one or more cells to release a cell lysate; separating the cell lysate electrophoretically on a gel; digitizing the gel to form a gel image; quantifying the nanoparticle intensity in the gel image; and correlating the nanoparticle intensity to a cell-associated nanoparticle concentration.

    摘要翻译： 本发明提供用于通过实验室设备监测的细胞摄取和/或吸附来确定给定区域，溶液或区域中纳米颗粒的存在和浓度的方法，装置和试剂盒。 例如，本发明提供了通过将包含一种或多种纳米颗粒的纳米颗粒溶液与一种或多种细胞孵育来定量一种或多种纳米颗粒的方法; 隔离一个或多个细胞; 裂解一个或多个细胞以释放细胞裂解物; 在凝胶上电泳分离细胞裂解物; 将凝胶数字化以形成凝胶图像; 量化凝胶图像中的纳米颗粒强度; 并将纳米颗粒强度与细胞相关纳米颗粒浓度相关联。

    Predictive and therapeutic markers in ovarian cancer
    43.
    发明授权
    Predictive and therapeutic markers in ovarian cancer 有权
    预测和治疗标志物在卵巢癌

    公开(公告)号：US08404829B2

    公开(公告)日：2013-03-26

    申请号：US11814798

    申请日：2006-01-19

    申请人： Joe W. Gray ,  Yinghui Guan ,  Wen-Lin Kuo ,  Jane Fridlyand ,  Gordon B. Mills

    发明人： Joe W. Gray ,  Yinghui Guan ,  Wen-Lin Kuo ,  Jane Fridlyand ,  Gordon B. Mills

    IPC分类号： C07H20/04 ,  C07H21/02 ,  A61K48/00

    CPC分类号： G01N33/57449 ,  G01N2800/44 ,  G01N2800/52

    摘要： Cancer markers may be developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genes in the human chromosomal regions, 8q24, 11q13, 20q11-q13, were found to be amplified indicating in vivo drug resistance in diseases such as ovarian cancer. Diagnosis and assessment of amplification levels certain genes shown to be amplified, including PVT1, can be useful in prediction of poor outcome of patient's response and drug resistance in ovarian cancer patients with low survival rates. Certain genes were found to be high priority therapeutic targets by the identification of recurrent aberrations involving genome sequence, copy number and/or gene expression are associated with reduced survival duration in certain diseases and cancers, specifically ovarian cancer. Therapeutics to inhibit amplification and inhibitors of one of these genes, PVT1, target drug resistance in ovarian cancer patients with low survival rates is described.

    摘要翻译： 可以开发癌症标志物以检测特征在于凋亡抑制基因如侵袭性癌症的表达增加的特征。 发现人染色体区域中的基因8q24,11q13,20q11-q13被扩增，表明在诸如卵巢癌等疾病中的体内耐药性。 扩增级别的诊断和评估显示要扩增的某些基因（包括PVT1）可用于预测低存活率的卵巢癌患者患者反应和耐药性差的结果。 通过鉴定涉及基因组序列的复发性畸变，拷贝数和/或基因表达与某些疾病和癌症（特别是卵巢癌）的生存期降低有关，某些基因被认为是高度优先的治疗靶点。 描述了抑制这些基因之一的抑制剂的治疗剂，PVT1，具有低存活率的卵巢癌患者中的靶药物抗性。

    COUPLED ELECTROCHEMICAL SYSTEM FOR REDUCTION OF POLYOLS TO HYDROCARBONS
    44.
    发明申请
    COUPLED ELECTROCHEMICAL SYSTEM FOR REDUCTION OF POLYOLS TO HYDROCARBONS 审中-公开
    用于将多元醇还原成烃类的联合电化学体系

    公开(公告)号：US20110233054A1

    公开(公告)日：2011-09-29

    申请号：US13074117

    申请日：2011-03-29

    申请人： J. Michael Robinson

    发明人： J. Michael Robinson

    IPC分类号： C25B9/00

    CPC分类号： C25B3/04 ,  C25B15/08

    摘要： A coupled electrochemical system for its use is disclosed, where a polyol feed, especially a biomass polyol containing feed is reduced in a reducing solution including HI and a metal ion capable of converting I2 to HI during polyol reduction to hydrocarbon or iodohydrocarbon products and where the metal ions are capable of electrochemical reduction so that the system can be run on a batch, semi-continuous or continuous basis. The system is capable of producing hydrocarbon solvent, fuels and lubricating oils.

    摘要翻译： 公开了一种用于其使用的耦合电化学系统，其中多元醇进料，特别是含有生物多元醇的进料在还原溶液中被还原，所述还原溶液包括HI和能够在多元醇还原期间将I2转化为HI的金属离子形成烃或碘代烃产物， 金属离子能够进行电化学还原，使得系统可以分批，半连续或连续运行。 该系统能够生产烃类溶剂，燃料和润滑油。

    Particulate matter sensor with a heater
    45.
    发明授权
    Particulate matter sensor with a heater 有权
    带加热器的颗粒物传感器

    公开(公告)号：US07998417B2

    公开(公告)日：2011-08-16

    申请号：US12196478

    申请日：2008-08-22

    申请人： Matthew Hall

    发明人： Matthew Hall

    IPC分类号： G01N27/00 ,  G01N31/12 ,  G01N7/00 ,  G01N21/00 ,  G01N31/00 ,  G01N33/00 ,  G01N37/00

    CPC分类号： G01N15/0656 ,  Y10T29/49826

    摘要： An apparatus to detect particulate matter. The apparatus includes a sensor electrode, a shroud, and a heater. The electrode measures a chemical composition within an exhaust stream. The shroud surrounds at least a portion of the sensor electrode, exclusive of a distal end of the sensor electrode exposed to the exhaust stream. The shroud defines an air gap between the sensor electrode and the shroud and an opening toward the distal end of the sensor electrode. The heater is mounted relative to the sensor electrode. The heater burns off particulate matter in the air gap between the sensor electrode and the shroud.

    摘要翻译： 检测颗粒物的装置。 该装置包括传感器电极，护罩和加热器。 电极测量排气流中的化学成分。 护罩围绕传感器电极的至少一部分，不包括暴露于排气流的传感器电极的远端。 护罩限定传感器电极和护罩之间的气隙以及朝向传感器电极的远端的开口。 加热器相对于传感器电极安装。 加热器消除传感器电极和护罩之间的气隙中的颗粒物质。

    Method for providing fault tolerance to multiple servers
    47.
    发明授权
    Method for providing fault tolerance to multiple servers 有权
    为多个服务器提供容错的方法

    公开(公告)号：US07831859B2

    公开(公告)日：2010-11-09

    申请号：US12140594

    申请日：2008-06-17

    申请人： Vijay K. Garg ,  Vinit A. Ogale

    发明人： Vijay K. Garg ,  Vinit A. Ogale

    IPC分类号： G06F11/00

    CPC分类号： G06F11/2041 ,  G06F11/1658 ,  G06F11/2097 ,  Y10S707/99955

    摘要： A method for providing fault tolerance to multiple computer servers is disclosed. Basically, t backup computer servers are utilized to back up data from multiple active computer servers such that up to t faults can be tolerated. Data from the active computer servers are categorized under their respective data structure accordingly. In response to any access to data within one or more of the active computer servers, backup operations are performed on the accessed data in the t backup computer servers according to their data structures such that data with similar data structures are grouped under their respective fusible data structure within the t backup computer servers.

    摘要翻译： 公开了一种用于向多个计算机服务器提供容错的方法。 基本上，t备份计算机服务器用于备份来自多个活动计算机服务器的数据，从而可以容忍多达t个故障。 活动计算机服务器的数据相应地分类在它们各自的数据结构之下。 响应于对一个或多个活动计算机服务器中的数据的任何访问，根据其数据结构对备份计算机服务器中的访问数据执行备份操作，使得具有相似数据结构的数据被分组在它们各自的可熔数据下 t备份计算机服务器内的结构。

    System and method of firewall design utilizing decision diagrams
    49.
    发明授权
    System and method of firewall design utilizing decision diagrams 失效
    使用决策图的防火墙设计的系统和方法

    公开(公告)号：US07818793B2

    公开(公告)日：2010-10-19

    申请号：US11386365

    申请日：2006-03-22

    申请人： Mohamed G. Gouda ,  Xiang-Yang Alex Liu

    发明人： Mohamed G. Gouda ,  Xiang-Yang Alex Liu

    IPC分类号： G06F9/00

    CPC分类号： H04L63/0263

    摘要： A system, method and computer-usable medium for designing a firewall to protect a data processing system. A user first specifies a firewall decision diagram. The firewall decision diagram is then reduced and marked. Finally, a firewall is generated from the marked firewall decision diagram.

    摘要翻译： 一种用于设计防火墙以保护数据处理系统的系统，方法和计算机可用介质。 用户首先指定防火墙决策图。 然后减少并标记防火墙决策图。 最后，从标记的防火墙决策图生成防火墙。