公开(公告)号：US20240350404A1

公开(公告)日：2024-10-24

申请号：US18612007

申请日：2024-03-21

Applicant: Fertin Pharma A/S

Inventor： Sanne Skov Jensen ,  Gitte Nykjær Nikolajsen ,  Simon Laursen ,  Dorthe Schackinger Boesen

IPC: A61K9/00 ,  A61K31/00

CPC classification number: A61K9/0056 ,  A61K31/658

Abstract: An orally dissolvable or chewable tableted powder formulation, includes one or more mesoporous silica carriers loaded with a liquid cannabinoid suspension or solution; one or more water-soluble agents in an amount of 20-80% by weight of the tableted powder formulation; and one or more flavors, wherein the liquid cannabinoid suspension or solution includes one or more cannabinoids and one or more non-volatile solvents in a weight ratio of cannabinoid to solvent of 10:1 to 1:10.

公开(公告)号：US20220152013A1

公开(公告)日：2022-05-19

申请号：US17098550

申请日：2020-11-16

Applicant: Fertin Pharma A/S

Inventor： Kent Albin Nielsen ,  Jessie Poulsen

IPC: A61K31/465 ,  A61K9/68 ,  A61K9/20 ,  A61K47/26 ,  A61K47/02 ,  A61K47/14 ,  A61K47/32 ,  A61K47/44

Abstract: A solid oral nicotine formulation is disclosed, the formulation comprises a nicotine-ion exchange resin combination, and a salt comprising inorganic divalent cations, wherein the salt has a water-solubility of at least 5 grams per 100 mL of water measured at 25 degrees Celsius, atmospheric pressure and pH 7.0.

公开(公告)号：US20210346295A1

公开(公告)日：2021-11-11

申请号：US17245279

申请日：2021-04-30

Applicant: FERTIN PHARMA A/S

Inventor： Helle WITTORFF ,  Christine Nøhr Pedersen

IPC: A61K9/16 ,  A61K45/06 ,  A61K33/30 ,  A61K31/191 ,  A61K31/194 ,  A61K9/00

Abstract: A flowpack for oral delivery of active ingredients comprises a population of particles and one or more active ingredients, the population of particles including at least two types of sugar alcohol particles, wherein at least one of said two types of sugar alcohol particles comprises granulated sugar alcohol particles.

公开(公告)号：US20210345656A1

公开(公告)日：2021-11-11

申请号：US16770375

申请日：2018-12-07

Applicant: Fertin Pharma A/S

Inventor： Bruno Provstgaard Nielsen ,  Kent Albin Nielsen

IPC: A24B15/16 ,  A24B15/40 ,  A24B15/38 ,  A24B15/28 ,  A24B13/00 ,  A61K9/20 ,  A61K31/465

Abstract: The invention relates to an oral nicotine formulation for use in the alleviation of nicotine craving, the formulation comprising a content of nicotine and a content of a pH regulating agent, wherein the formulation is designed for the content of nicotine to dissolve in the oral saliva within a period of less than 90 seconds upon oral administration, and wherein at least 40% by weight of the nicotine is absorbed through the oral mucosa.

公开(公告)号：US11096894B2

公开(公告)日：2021-08-24

申请号：US15982758

申请日：2018-05-17

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/18 ,  A61K9/20 ,  A61P1/02 ,  A61K9/00 ,  A61K45/06

Abstract: The invention relates to an oral tablet suitable for active pharmaceutical ingredients comprising a population of particles, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and the non-DC areas resulting in induced saliva generation upon mastication of the tablet.

公开(公告)号：US10980831B2

公开(公告)日：2021-04-20

申请号：US15933942

申请日：2018-03-23

Applicant: FERTIN PHARMA A/S

Inventor： Jesper Neergaard

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/20 ,  A61K31/192 ,  A61K9/68 ,  A61K31/167

Abstract: The invention relates to a solid pharmaceutical tablet for oral delivery, the tablet comprising calcium carbonate in an amount of more than 30% by weight of the tablet and organic water-insoluble components in an amount of more than 20% by weight of the tablet, wherein the tablet is designed to be masticated into a coherent residual containing the organic water-insoluble components, and wherein the tablet is adapted to release more than 80% of the calcium carbonate within 5 minutes of mastication.

公开(公告)号：US20210106534A1

公开(公告)日：2021-04-15

申请号：US17046504

申请日：2019-05-15

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/20 ,  A61K9/00

Abstract: The invention relates to a disintegrating oral tablet suitable for active pharmaceutical ingredients comprising a population of particles and at least one flavor ingredient, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and
the non-DC areas resulting in a burst of the at least one flavor ingredient upon mastication of the tablet.

公开(公告)号：US10695292B2

公开(公告)日：2020-06-30

申请号：US15735723

申请日：2016-06-23

Applicant: Fertin Pharma A/S

Inventor： Heidi Ziegler Bruun

IPC: A61K9/68 ,  A61K47/30 ,  A61K47/26 ,  A61K47/24 ,  A61K33/16 ,  A61K47/02 ,  A61P1/00

Abstract: The invention relates to a chewing gum composition for use in the alleviation of xerostomia induced by radiotherapy treatment, where the chewing gum composition comprises gum base and substantially no flavour ingredients. Moreover, the invention also relates to a dosage regimen for administering the chewing gum composition for use in alleviation of xerostomia induced by radiotherapy treatment. So in one embodiment of the invention the chewing gum composition is administered to a human subject before and/or during and/or after radiotherapy treatment.

公开(公告)号：US20200085806A1

公开(公告)日：2020-03-19

申请号：US16471847

申请日：2016-12-20

Applicant: Fertin Pharma A/S

Inventor： Kent Albin Nielsen

IPC: A61K31/4439 ,  A61K9/00 ,  A61K47/36

Abstract: The invention relates to a mucoadhesive oromucosal formulation comprising a nicotine complex, said nicotine complex comprising nicotine in ionic complex with at least one mucoadhesive water-soluble anionic polymer.

公开(公告)号：US10543205B2

公开(公告)日：2020-01-28

申请号：US15356175

申请日：2016-11-18

Applicant: Helle Wittorff ,  Heidi Ziegler Bruun ,  Dorthe Schackinger Boesen

Inventor： Helle Wittorff ,  Heidi Ziegler Bruun ,  Dorthe Schackinger Boesen

IPC: A61K31/465 ,  A61K9/20 ,  A61K9/00

Abstract: The invention relates an oral delivery vehicle tablet containing nicotine, the delivery vehicle tablet being formed by compression of a plurality of particles, the oral delivery vehicle tablet comprising nicotine, the oral delivery vehicle tablet comprising sugar alcohol(s) in an amount of 40 to 100% by weight of the delivery vehicle tablet, wherein at least 10% by weight of the delivery vehicle tablet comprises a plurality of particles consisting of erythritol and wherein the delivery vehicle tablet comprises a plurality of further sugar alcohol particles in an amount of at least 10% by weight of the delivery vehicle tablet, wherein said further sugar alcohol particles comprise at least one sugar alcohol and wherein said further sugar alcohols particles have a composition which is different from said particles consisting of erythritol.