公开(公告)号：US20180286048A1

公开(公告)日：2018-10-04

申请号：US15997915

申请日：2018-06-05

Applicant: Mauna Kea Technologies

Inventor： Nicolas Linard ,  Barbara Andre ,  Julien Dauguet ,  Tom Vercauteren

IPC: G06T7/00 ,  G06T7/174

Abstract: According to a first aspect, the invention relates to a method to support clinical decision by characterizing images acquired in sequence through a video medical device. The method comprises defining at least one image quantitative criterion, storing sequential images in a buffer, for each image (10) in the buffer, automatically determining, using a first algorithm, at least one output based on said image quantitative criterion and attaching said output to a timeline (11).

公开(公告)号：US20160253801A1

公开(公告)日：2016-09-01

申请号：US15028188

申请日：2014-10-13

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： Nicolas Linard ,  Barbara Andre ,  Julien Dauguet ,  Tom Vercauteren

IPC: G06T7/00

CPC classification number: G06T7/0016 ,  G06T7/174 ,  G06T2207/10068

Abstract: According to a first aspect, the invention relates to a method to support clinical decision by characterizing images acquired in sequence through a video medical device. The method comprises defining at least one image quantitative criterion, storing sequential images in a buffer, for each image (10) in the buffer, automatically determining, using a first algorithm, at least one output based on said image quantitative criterion and attaching said output to a timeline (11).

Abstract translation: 根据第一方面，本发明涉及一种通过表征通过视频医疗装置顺序获取的图像来支持临床决定的方法。 该方法包括定义至少一个图像定量标准，对缓冲器中的每个图像（10）存储顺序图像，使用第一算法，基于所述图像定量标准自动确定至少一个输出，并附加所述输出 到时间线（11）。

公开(公告)号：US20150265153A1

公开(公告)日：2015-09-24

申请号：US14731949

申请日：2015-06-05

Applicant: Nicolas Boularot ,  Arnaud Cressant

Inventor： Nicolas Boularot ,  Arnaud Cressant

IPC: A61B5/00

CPC classification number: A61B5/0084 ,  A61B1/00154 ,  A61B1/313 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/6814 ,  A61B5/6864 ,  A61B5/6868 ,  A61B5/6882 ,  A61B90/11 ,  A61B2503/40 ,  A61B2560/063 ,  A61B2562/0238 ,  G02B23/26

Abstract: An intracranial implant to position a fiber bundle to a specified region of a brain of an animal. The implant may include a base support to be fixed to a skull of the animal over an orifice drilled in the skull, a hollow conduit arranged through the base support to guide the fiber bundle to the brain of the animal through the drilled orifice and a first locking member arranged on the base support, to cooperate with a ferrule of the fiber bundle, the first locking member configured to lock the fiber bundle to the specified region of the brain of the animal.

Abstract translation: 将颅内植入物定位于动物脑的特定区域的纤维束。 植入物可以包括在头部钻孔的孔上固定到动物颅骨的基部支撑件，布置成穿过基部支撑件的中空导管，以通过钻孔将纤维束引导到动物的大脑，第一 锁定构件，其布置在所述基部支撑件上，以与所述纤维束的套圈配合，所述第一锁定构件配置成将所述纤维束锁定到所述动物的脑的特定区域。

公开(公告)号：US08969777B2

公开(公告)日：2015-03-03

申请号：US14117997

申请日：2012-05-16

Applicant: Nicolas Savoire ,  Tom Vercauteren

Inventor： Nicolas Savoire ,  Tom Vercauteren

IPC: H01L27/00 ,  G06T5/20 ,  G02B21/36 ,  G06T5/00

CPC classification number: G06T5/20 ,  G02B21/365 ,  G06T5/006 ,  G06T5/008 ,  G06T2207/10056

Abstract: A method for processing images acquired by image detectors with non-uniform transfer functions and irregular spatial locations includes the steps of accumulating data from multiple images, defining an affinity graph which edges define pairs of detectors that measure related signal, performing statistical analysis on the accumulated data with respect to each pair of detectors, and solving a system of equations constructed from the results of the statistical analysis to estimate each detector transfer function, a set of solutions to the system of equations comprising a calibration of an imaging system.

Abstract translation: 用于处理由具有不均匀传递函数和不规则空间位置的图像检测器获取的图像的方法包括以下步骤：从多个图像中累积数据，定义关联图，边缘定义测量相关信号的检测器对，对累积的 关于每对检测器的数据，以及求解由统计分析的结果构建的等式的系统以估计每个检测器传递函数，包括成像系统校准的方程组的一组解。

公开(公告)号：US08718398B2

公开(公告)日：2014-05-06

申请号：US13141991

申请日：2009-12-28

Applicant: Aymeric Perchant ,  Nicolas Savoire

Inventor： Aymeric Perchant ,  Nicolas Savoire

IPC: G06K9/40

CPC classification number: G02B6/06 ,  G06T7/80 ,  G06T2207/10068

Abstract: A method to process an image acquired through an optical-fiber guide includes acquiring a first reference image through the optical-fiber guide, acquiring a second calibration image through the optical-fiber guide, spatially identifying each fiber of the optical-fiber guide of the second calibration image in a first detection map, acquiring a recalibration image through the optical-fiber guide, determining a geometrical transformation to make the recalibration image coincide with the first reference image, deriving a new detection map spatially identifying each fiber of the optical-fiber guide of the recalibration image, wherein the new detection map is derived using the geometrical transformation and the first detection map, and individually processing zones of an acquired image corresponding to each fiber of the optical-fiber guide using the new detection map.

Abstract translation: 一种处理通过光纤引导获得的图像的方法，包括：通过光纤引导获取第一参考图像，通过光纤引导获取第二校准图像，在空间上识别光纤引导件的每个光纤 在第一检测图中获取第二校准图像，通过光纤引导件获取重新校准图像，确定几何变换以使重新校准图像与第一参考图像一致，导出空间上识别光纤的每个光纤的新的检测图 引导重新校正图像，其中使用几何变换和第一检测图导出新的检测图，并且使用新的检测图单独处理与光纤引导件的每个光纤相对应的获取的图像的区域。

公开(公告)号：US20140117207A1

公开(公告)日：2014-05-01

申请号：US14117997

申请日：2012-05-16

Applicant: Nicolas Savoire ,  Tom Vercauteren

Inventor： Nicolas Savoire ,  Tom Vercauteren

IPC: G06T5/20

CPC classification number: G06T5/20 ,  G02B21/365 ,  G06T5/006 ,  G06T5/008 ,  G06T2207/10056

Abstract: According to a first aspect, the invention relates to a method for processing images acquired by means image detectors with non-uniform transfer functions and irregular spatial locations, comprising: accumulating data from multiple images; defining an affinity graph linking individual detectors that measure related signal; performing statistical analysis on the accumulated data from the linked detectors; and solving a system constructed from the results of the statistical analysis to estimate each detector transfer function, the set of which compose a calibration of an imaging system.

Abstract translation: 根据第一方面，本发明涉及一种用于处理由具有非均匀传递函数和不规则空间位置的装置图像检测器获取的图像的方法，包括：从多个图像累积数据; 定义连接测量相关信号的各个检测器的亲和度图; 对所连接的检测器的累积数据进行统计分析; 并根据统计分析结果求解一个系统，以估计每个检测器传递函数，其中的一组组成成像系统的校准。

公开(公告)号：US08600134B2

公开(公告)日：2013-12-03

申请号：US13144518

申请日：2010-01-29

Applicant: Tom Vercauteren ,  Aymeric Perchant ,  Francois Lacombe ,  Nicolas Savoire

Inventor： Tom Vercauteren ,  Aymeric Perchant ,  Francois Lacombe ,  Nicolas Savoire

IPC: G06K9/00

CPC classification number: G06T5/50 ,  G06T3/4038 ,  G06T3/4053 ,  G06T2207/10068 ,  G06T2207/30028 ,  G06T2207/30104

Abstract: A method for processing images acquired in real time through a medical device, said images being loaded into a buffer, comprising the steps of: stopping the loading of the images into the buffer, processing loaded images using an incremental algorithm, displaying successively intermediate results of the processing, resuming the loading and stopping the processing based on an evaluation of said intermediate results.

Abstract translation: 一种用于处理通过医疗设备实时获取的图像的方法，所述图像被加载到缓冲器中，包括以下步骤：停止将图像加载到缓冲器中，使用增量算法处理加载的图像，显​​示连续的中间结果 处理，基于所述中间结果的评估恢复加载和停止处理。

公开(公告)号：US20120123236A1

公开(公告)日：2012-05-17

申请号：US13386468

申请日：2010-07-19

Applicant: Nicolas Boularot ,  Arnaud Cressant

Inventor： Nicolas Boularot ,  Arnaud Cressant

IPC: A61B5/04 ,  A61B19/00

CPC classification number: A61B5/0084 ,  A61B1/00154 ,  A61B1/313 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/6814 ,  A61B5/6864 ,  A61B5/6868 ,  A61B5/6882 ,  A61B90/11 ,  A61B2503/40 ,  A61B2560/063 ,  A61B2562/0238 ,  G02B23/26

Abstract: An intracranial implant to position a fiber bundle to a specified region of a brain of an animal. The implant may include a base support to be fixed to a skull of the animal over an orifice drilled in the skull, a hollow conduit arranged through the base support to guide the fiber bundle to the brain of the animal through the drilled orifice and a first locking member arranged on the base support, to cooperate with a ferrule of the fiber bundle, the first locking member configured to lock the fiber bundle to the specified region of the brain of the animal.

Abstract translation: 将颅内植入物定位于动物脑的特定区域的纤维束。 植入物可以包括在头部钻孔的孔上固定到动物颅骨的基部支撑件，布置成穿过基部支撑件的中空导管，以通过钻孔将纤维束引导到动物的大脑，第一 锁定构件，其布置在所述基部支撑件上，以与所述纤维束的套圈配合，所述第一锁定构件配置成将所述纤维束锁定到所述动物的脑的特定区域。

公开(公告)号：US08081310B2

公开(公告)日：2011-12-20

申请号：US11629213

申请日：2005-06-09

Applicant: Bertrand Viellerobe ,  Florence Jean ,  Genevieve Bourg-Heckly ,  Alexandre Loiseau

Inventor： Bertrand Viellerobe ,  Florence Jean ,  Genevieve Bourg-Heckly ,  Alexandre Loiseau

IPC: G01N21/64

CPC classification number: G01N21/6458 ,  G01N21/6428 ,  G01N2021/6417 ,  G01N2021/6423

Abstract: The invention relates to a method for producing a fluorescent fiber image of a sample, wherein a sample is scanned with the aid of an excitation signal; the fluorescent signal emanating from the sample is detected, wherein the excitation signal and fluorescent signal use the same optical path; the optical path is used to excite at least two fluorophores contained in the sample; a final image is produced, including areas that are colored according to the at least two fluorophores. The multimarking according to the invention makes it possible to simultaneously acquire two images in two different wavelength bands. The system according to the invention can comprise a spectrometer for spectral quantification of the fluorescent signal.

Abstract translation: 本发明涉及一种用于制备样品的荧光纤维图像的方法，其中借助于激发信号扫描样品; 检测从样品发出的荧光信号，其中激发信号和荧光信号使用相同的光路; 光路用于激发样品中包含的至少两个荧光团; 产生最终图像，包括根据至少两个荧光团着色的区域。 根据本发明的多标记使得可以同时获取两个不同波长带中的两个图像。 根据本发明的系统可以包括用于荧光信号的光谱定量的光谱仪。

公开(公告)号：US20110261262A1

公开(公告)日：2011-10-27

申请号：US13178688

申请日：2011-07-08

Applicant: Tom Vercauteren ,  Aymeric Perchant ,  Nicholas Ayache ,  Xavier Pennec ,  Gregoire Malandain

Inventor： Tom Vercauteren ,  Aymeric Perchant ,  Nicholas Ayache ,  Xavier Pennec ,  Gregoire Malandain

IPC: H04N5/00

CPC classification number: G06K9/00134 ,  G02B21/367 ,  G06T3/4038 ,  G06T7/35 ,  G06T2207/10056

Abstract: The present invention concerns a mosaicing method taking into account motion distortions, irregularly sampled frames and non-rigid deformations of the imaged tissue. The invention relates to a method for mosaicing frames from a video sequence acquired from a scanning device such as a scanning microscope, the method comprising the steps of: a) compensating for motion and motion distortion due to the scanning microscope, b) applying a global optimisation of inter-frame registration to align consistently the frames c) applying a construction algorithm on the registered frames to construct a mosaic, and d) applying a fine frame-to-mosaic non rigid registration. The method is based on a hierarchical framework that is able to recover a globally consistent alignment of the input frames, to compensate for the motion distortions and to capture the non-rigid deformations.

Abstract translation: 本发明涉及考虑到成像组织的运动失真，不规则采样帧和非刚性变形的镶嵌方法。 本发明涉及一种用于从诸如扫描显微镜的扫描装置获取的视频序列拼接帧的方法，所述方法包括以下步骤：a）补偿由扫描显微镜引起的运动和运动失真，b）应用全局 框架间注册的优化以一致地对准帧c）在注册的帧上应用构造算法以构建马赛克，以及d）应用精细的帧到马赛克非刚性注册。 该方法基于能够恢复输入帧的全局一致对齐的分层框架，以补偿运动失真并捕获非刚性变形。