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    Equipment for subsurface autofluorescence spectroscopy
    1.
    发明授权
    Equipment for subsurface autofluorescence spectroscopy 有权
    地下自发荧光光谱仪

    公开(公告)号：US07336990B2

    公开(公告)日：2008-02-26

    申请号：US10500162

    申请日：2002-12-20

    Applicant: Magalie Genet ,  Geneviève Bourg-Heckly ,  Sandrine Vilette ,  François Lacombe ,  Alexandre Loiseau ,  Benjamin Abrat

    Inventor： Magalie Genet ,  Geneviève Bourg-Heckly ,  Sandrine Vilette ,  François Lacombe ,  Alexandre Loiseau ,  Benjamin Abrat

    IPC: A61B6/00

    CPC classification number: G01N21/6486 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  G01N21/6456

    Abstract: An equipment includes an excitation source (1), elements for injecting (2) an excitation signal produced by the source in an ordered bundle (3) of flexible optical fibers, elements for analyzing (21, 22) an emitted autofluorescence signal. The equipment also includes at the output of the optical fiber bundle (3) an optical head (4) designed to be placed in contact with the biological tissue (6), the optical head being equipped with optical elements adapted to cause the excitation signal output from the bundle (3) to converge into a subsurface analyzing zone (5), the same optical fiber(s) used for excitation of the bundle (3) being used for detecting the signal emitted by the subsurface analyzing zone, elements (D) placed upstream of the injection elements (2) being further provided to separate the wavelength of the excitation signal and the wavelength of the autofluorescence signal.

    Abstract translation: 一种设备包括激励源（1），用于注入（2）由柔性光纤的有序束（3）中的源产生的激励信号的元件，用于分析（21,22）发射的自发荧光信号的元件。 所述设备还包括在所述光纤束（3）的输出端处设计成与所述生物组织（6）接触的光学头（4），所述光学头装备有适于使所述激发信号输出 从束（3）收敛到地下分析区（5）中，用于激发束（3）的相同光纤用于检测由地下分析区发出的信号，元件（D） 放置在注入元件（2）的上游的进一步提供以分离激发信号的波长和自发荧光信号的波长。

    Miniaturized focusing optical head in particular for endoscope
    2.
    发明授权
    Miniaturized focusing optical head in particular for endoscope 有权
    微型聚焦光学头，特别是内窥镜

    公开(公告)号：US07221824B2

    公开(公告)日：2007-05-22

    申请号：US10499987

    申请日：2002-12-20

    Applicant: Frederic Berier ,  Stephane Bourriaux ,  Magalie Genet ,  Bertrand Viellerobe ,  Alexandre Loiseau ,  Benjamin Abrat

    Inventor： Frederic Berier ,  Stephane Bourriaux ,  Magalie Genet ,  Bertrand Viellerobe ,  Alexandre Loiseau ,  Benjamin Abrat

    IPC: G02B6/32 ,  G02B6/06 ,  G02B27/02

    CPC classification number: A61B1/00188 ,  A61B2562/0242 ,  A61B2562/146

    Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

    Abstract translation: 一种用于装备柔性光纤束的远端的光学头，设计成被推动与分析表面接触并且包括用于将激发信号聚焦到位于分析器下方特定深度处的所谓的激发焦点的光学元件 表面，并对由纤维束承载的激发焦点反向散射的信号采样。 头部包括光纤保持器管，其中插入在纤维束的远端部分的一侧和另一个光学元件上，其中光学元件包括与纤维束的端部接触的板，其中指数接近 光纤芯和聚焦光学块的输出窗口进一步提供适于提供指标适应以消除在分析表面上发生的寄生反射。

    Multimarking fibre-type fluorescence microscopic imaging method and system
    5.
    发明授权
    Multimarking fibre-type fluorescence microscopic imaging method and system 有权
    多标记纤维型荧光显微镜成像方法及系统

    公开(公告)号：US08081310B2

    公开(公告)日：2011-12-20

    申请号：US11629213

    申请日：2005-06-09

    Applicant: Bertrand Viellerobe ,  Florence Jean ,  Genevieve Bourg-Heckly ,  Alexandre Loiseau

    Inventor： Bertrand Viellerobe ,  Florence Jean ,  Genevieve Bourg-Heckly ,  Alexandre Loiseau

    IPC: G01N21/64

    CPC classification number: G01N21/6458 ,  G01N21/6428 ,  G01N2021/6417 ,  G01N2021/6423

    Abstract: The invention relates to a method for producing a fluorescent fiber image of a sample, wherein a sample is scanned with the aid of an excitation signal; the fluorescent signal emanating from the sample is detected, wherein the excitation signal and fluorescent signal use the same optical path; the optical path is used to excite at least two fluorophores contained in the sample; a final image is produced, including areas that are colored according to the at least two fluorophores. The multimarking according to the invention makes it possible to simultaneously acquire two images in two different wavelength bands. The system according to the invention can comprise a spectrometer for spectral quantification of the fluorescent signal.

    Abstract translation: 本发明涉及一种用于制备样品的荧光纤维图像的方法，其中借助于激发信号扫描样品; 检测从样品发出的荧光信号，其中激发信号和荧光信号使用相同的光路; 光路用于激发样品中包含的至少两个荧光团; 产生最终图像，包括根据至少两个荧光团着色的区域。 根据本发明的多标记使得可以同时获取两个不同波长带中的两个图像。 根据本发明的系统可以包括用于荧光信号的光谱定量的光谱仪。

    Multimarking Fibre-Type Fluorescence Microscopic Imaging Method And System
    7.
    发明申请
    Multimarking Fibre-Type Fluorescence Microscopic Imaging Method And System 有权
    多标记纤维型荧光显微镜成像方法与系统

    公开(公告)号：US20080029711A1

    公开(公告)日：2008-02-07

    申请号：US11629213

    申请日：2005-06-09

    Applicant: Bertrand Viellerobe ,  Florence Jean ,  Genevieve Bourg-Heckly ,  Alexandre Loiseau

    Inventor： Bertrand Viellerobe ,  Florence Jean ,  Genevieve Bourg-Heckly ,  Alexandre Loiseau

    IPC: G01N21/64

    CPC classification number: G01N21/6458 ,  G01N21/6428 ,  G01N2021/6417 ,  G01N2021/6423

    Abstract: The invention relates to a method for producing a fluorescent fiber image of a sample, wherein a sample is scanned with the aid of an excitation signal; the fluorescent signal emanating from the sample is detected, wherein the excitation signal and fluorescent signal use the same optical path; the optical path is used to excite at least two fluorophors contained in the sample; a final image is produced, including areas that are colored according to the at least two fluorophors. The multimarking according to the invention makes it possible to simultaneously acquire two images in two different wavelength bands. The system according to the invention can comprise a spectrometer for spectral quantification of the fluorescent signal.

    Abstract translation: 本发明涉及一种用于制备样品的荧光纤维图像的方法，其中借助于激发信号扫描样品; 检测从样品发出的荧光信号，其中激发信号和荧光信号使用相同的光路; 光路用于激发样品中包含的至少两种荧光体; 产生最终图像，包括根据至少两个荧光体着色的区域。 根据本发明的多标记使得可以同时获取两个不同波长带中的两个图像。 根据本发明的系统可以包括用于荧光信号的光谱定量的光谱仪。

    Miniaturized focusing optical head in particular for endoscope
    8.
    发明申请
    Miniaturized focusing optical head in particular for endoscope 有权
    微型聚焦光学头，特别是内窥镜

    公开(公告)号：US20050157981A1

    公开(公告)日：2005-07-21

    申请号：US10499987

    申请日：2002-12-20

    Applicant: Frederic Berier ,  Stephane Bourriaux ,  Magalie Genet ,  Bertrand Viellerobe ,  Alexandre Loiseau ,  Benjamin Abrat

    Inventor： Frederic Berier ,  Stephane Bourriaux ,  Magalie Genet ,  Bertrand Viellerobe ,  Alexandre Loiseau ,  Benjamin Abrat

    IPC: G02B23/26 ,  A61B1/00 ,  G02B21/02 ,  G02B6/32

    CPC classification number: A61B1/00188 ,  A61B2562/0242 ,  A61B2562/146

    Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

    Abstract translation: 一种用于装备柔性光纤束的远端的光学头，设计成被推动与分析表面接触并且包括用于将激发信号聚焦到位于分析器下方特定深度处的所谓的激发焦点的光学元件 表面，并对由纤维束承载的激发焦点反向散射的信号采样。 头部包括光纤保持器管，其中插入在纤维束的远端部分的一侧和另一个光学元件上，其中光学元件包括与纤维束的端部接触的板，其中指数接近 光纤芯和聚焦光学块的输出窗口进一步提供适于提供指标适应以消除在分析表面上发生的寄生反射。

    Equipment for spectroscopy of subsurface autofluorescence
    9.
    发明申请
    Equipment for spectroscopy of subsurface autofluorescence 有权
    地下自发荧光光谱仪

    公开(公告)号：US20050018185A1

    公开(公告)日：2005-01-27

    申请号：US10500162

    申请日：2002-12-20

    Applicant: Magalie Genet ,  Genevieve Bourg-Heckly ,  Sandrine Vilette ,  Francois Lacombe ,  Alexandre Loiseau ,  Benjamin Abrat

    Inventor： Magalie Genet ,  Genevieve Bourg-Heckly ,  Sandrine Vilette ,  Francois Lacombe ,  Alexandre Loiseau ,  Benjamin Abrat

    IPC: A61B1/00 ,  A61B5/00 ,  G01N21/64 ,  G01J3/30 ,  G01N21/25 ,  G01T1/10

    CPC classification number: G01N21/6486 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  G01N21/6456

    Abstract: The invention concerns an equipment comprising an excitation source (1), means for injecting (2) an excitation signal produced by said source in an ordered bundle (3) of flexible optical fibers, means for analyzing (21, 22) an emitted autofluorescence signal. The invention is characterized in that it comprises in output of the optical fiber bundle (3) an optical head (4) designed to be placed in contact with the biological tissue (6), said optical head being equipped with optical means adapted to cause the excitation signal output from said bundle (3) to converge into a subsurface analyzing zone (5), the same optical fiber(s) used for excitation of said bundle (3) being used for detecting the signal emitted by said subsurface analyzing zone, means (D) placed upstream of the injection means (2) being further provided to separate the wavelength of the excitation signal and the wavelength of the autofluorescence signal.

    Abstract translation: 本发明涉及一种包括激励源（1）的设备，用于在柔性光纤的有序束（3）中注入（2）由所述源产生的激励信号的装置，用于分析（21,22）发射的自发荧光信号 。 本发明的特征在于，其包括在光纤束（3）的输出中，设计成与生物组织（6）接触的光学头（4），所述光学头装备有适于引起 从所述束（3）输出的会聚到地下分析区（5）的激励信号，用于激发所述束（3）的相同光纤用于检测由所述地下分析区发射的信号， 放置在注入装置（2）上游的（D）还被提供以分离激发信号的波长和自发荧光信号的波长。

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