公开(公告)号：US20210077144A1

公开(公告)日：2021-03-18

申请号：US17056040

申请日：2019-05-20

申请人： National University of Ireland, Galway

发明人： Sean CUMMINS ,  Nigel PHELAN ,  Stephen COX ,  Martin O'HALLORAN

IPC分类号： A61B17/3207

摘要： A device (1, 30, 40, 50, 60) for denuding a vein comprises a vein denuding head (3) operatively attached to an elongated catheter member (2) and configured for transluminal delivery and deployment in the vein. The vein denuding head comprises a helical coil (4) that is self-adjustable from an uncoiled delivery configuration suitable for transluminal delivery within the catheter member and a coiled deployed configuration having a diameter greater than the vein to be denuded that circumferentially engages an internal lumen of the vein when deployed. The helical coil has an abrasive surface configured to circumferentially denude the internal lumen of the vein when the coil is moved axially along the body lumen in the coiled configuration. The helical coil may be a single helical coil element.

公开(公告)号：US20200297503A1

公开(公告)日：2020-09-24

申请号：US16897332

申请日：2020-06-10

申请人： National University of Ireland, Galway

发明人： Gerry CLARKE ,  Brendan Boland ,  Mark Bruzzi ,  Amy L. Ladd ,  Arnold-Peter C. Weiss ,  Filip Stockmans

IPC分类号： A61F2/42 ,  A61F2/30

摘要： An implant (30) for a mammalian bone joint (3) for spacing a first bone (2) of the joint from a second bone (1) of the joint while allowing translational movement of the second bone in relation to the first bone is described. The implant comprises (a) a distal part (31) configured for intramedullary engagement with an end of the second bone, (b) a proximal part (34) having a platform (15) configured for non-engaging abutment of an end of the first bone and translational movement thereon, and (c) an articulating coupling (10, 16) provided between the distal and proximal ends allowing controlled articulation of the first and second bones. The bone-abutting platform is shaped to conform to and translate upon the end of the first bone. A kit for assembly to form the implant of the invention, and the use of the implant to treat osteoarthritis in a bone joint, are also described.

公开(公告)号：US10710922B2

公开(公告)日：2020-07-14

申请号：US15560829

申请日：2016-03-15

申请人： National University of Ireland, Galway

发明人： Gerard O'Connor ,  Adam Collins

IPC分类号： C03B33/02 ,  B23K26/0622 ,  B23K26/073 ,  B23K26/364 ,  B23K26/402 ,  B23K26/08 ,  B23K26/082 ,  B23K101/18 ,  B23K103/00

摘要： Methods and apparatus for cutting a substrate are disclosed. In one arrangement, a plurality of recesses are formed in the surface of the substrate. The recesses as such that a stress can be applied to the substrate that is concentrated by the recesses. The concentrated stress causes the substrate to be cut along a cutting line that passes through the recesses. The cutting occurs via propagation of a crack through the recesses.

公开(公告)号：US10602973B2

公开(公告)日：2020-03-31

申请号：US15571225

申请日：2016-05-06

申请人： National University of Ireland, Galway

发明人： Sarah Loughney ,  Mark Bruzzi ,  Martin O'Halloran ,  Prem Puri ,  Ricardo Eleuterio

IPC分类号： A61B5/05 ,  A61B5/20 ,  A61B5/00 ,  A61B5/053 ,  A61B5/11 ,  A61B5/01

摘要： The present relates to a method, system and a device for non-invasive detection of urine flow from the bladder into the kidney(s). The method, system and device rely on measurements made at distinct time points and can be used to detect Vesicoureteral reflux. The method, system and device are designed to detect changes in urine volume in the ureter(s), bladder and/or kidney(s). The method and device measure conductivity changes by bioelectrical impedance or electrical impedance tomography technology.

公开(公告)号：US20200069725A1

公开(公告)日：2020-03-05

申请号：US16339512

申请日：2017-10-03

申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY

发明人： Abhay PANDIT ,  Vijaya KRISHNA ,  Sit ISMAIL ,  Peadar ROONEY

IPC分类号： A61K31/728 ,  A61K47/26 ,  A61K9/00 ,  A61K9/06 ,  A61P13/10

摘要： A hydrogel composition for treatment of interstitial cystitis is described and comprises crosslinked hyaluronan particles dispersed throughout a crosslinked hyaluronan hydrogel matrix, wherein the hyaluronan is high molecular weight hyaluronan. The composition is formulated for direct bladder instillation in a human. The hyaluronan particles are nano-sized hyaluronan particles, or agglomerates of nano-sized hyaluronan particles, or a mixture thereof.

公开(公告)号：US20190167437A1

公开(公告)日：2019-06-06

申请号：US16271452

申请日：2019-02-08

申请人： National University of Ireland, Galway

发明人： Gerry CLARKE ,  Brendan BOLAND ,  Mark BRUZZI ,  Amy L. LADD ,  Arnold-Peter C. WEISS ,  Filip STOCKMANS

IPC分类号： A61F2/42

摘要： An implant (30) for a mammalian bone joint (3) for spacing a first bone (2) of the joint from a second bone (1) of the joint while allowing translational movement of the second bone in relation to the first bone is described. The implant comprises (a) a distal part (31) configured for intramedullary engagement with an end of the second bone, (b) a proximal part (34) having a platform (15) configured for non-engaging abutment of an end of the first bone and translational movement thereon, and (c) an articulating coupling (10, 16) provided between the distal and proximal ends allowing controlled articulation of the first and second bones. The bone-abutting platform is shaped to conform to and translate upon the end of the first bone. A kit for assembly to form the implant of the invention, and the use of the implant to treat osteoarthritis in a bone joint, are also described.

公开(公告)号：US20180271556A1

公开(公告)日：2018-09-27

申请号：US15936635

申请日：2018-03-27

申请人： National University of Ireland Galway

发明人： Mark BRUZZI ,  Saeid KASIRI GHAHI ,  Paul HENEGHAN

IPC分类号： A61B17/3207 ,  A61B17/3205 ,  A61B17/221 ,  A61B17/32 ,  A61B17/00

CPC分类号： A61B17/320725 ,  A61B17/221 ,  A61B17/32056 ,  A61B17/320758 ,  A61B17/320783 ,  A61B2017/00685 ,  A61B2017/2212 ,  A61B2017/320008 ,  A61B2017/320064 ,  A61B2217/005

摘要： A device suitable for use in a body lumen and comprises an elongated control member having a distal and a proximal end, and a radially expansible member disposed at or near the distal end and adapted for collection and/or shearing of matter (i.e. thrombus) from a wall of the body lumen (i.e. a vein or an artery). The radially expansible member has a proximal end and a distal end and is adjustable between a contracted orientation and an expanded orientation. The elongated control member comprising a proximal arm connected at or adjacent to the proximal end of the radially expansible member and a distal arm connected at or adjacent to the distal end of the radially expansible member such that movement of one arm relative to the other arm effects adjustment of the diameter or radial strength of the radially expansible member. The device comprises a control mechanism operatively connected to both arms and adapted to provide resistance to the movement of one arm relative to the other. The control mechanism may be a biasing means, a brake means, or both.

公开(公告)号：US10028733B2

公开(公告)日：2018-07-24

申请号：US15595619

申请日：2017-05-15

申请人： National University of Ireland, Galway

发明人： Eoin Bambury ,  Moshe Zilversmit

IPC分类号： A61B17/08 ,  A61B17/00 ,  A61B17/04

摘要： A fistula treatment system comprises a guide such as a guide coil 1101 which is adapted to extend partially around a tissue tract and an implant element 1102. The implant element 1102 is activated to draw tissue surrounding the tract inwardly.

公开(公告)号：US10012492B2

公开(公告)日：2018-07-03

申请号：US15027056

申请日：2014-10-08

申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY

发明人： Sergey Alexandrov ,  Hrebesh Subhash ,  Martin J. Leahy ,  Azhar Zam

IPC分类号： G01B9/02 ,  G01N21/47 ,  A61B5/00 ,  G01N21/17

CPC分类号： G01B9/02044 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02004 ,  G01B9/02083 ,  G01B9/02087 ,  G01B9/02091 ,  G01N21/4795 ,  G01N2021/1787

摘要： An OCT imaging system (100) comprising a radiation emitter (SLD), a radiation receiver CCD), an interferometer (FC, PC, X-Scan, Y-Scan), a controller (COMP) which controls the emitter and processes received radiation data according to OCT to provide an output image. The controller (COMP) forms a spectrum of spatial frequencies along the depth direction. It calculates from the spectrum local spectra of spatial frequencies or periods along the depth direction for individual volume elements along the depth direction. It translates the local spectra of spatial frequencies or periods along the depth direction into the OCT image domain. It maps the local spectra into the volume elements to provide sensitivity on the nano-scale whereas the volume elements are in the micro-scale. The controller calculates information parameters from the translated and mapped local spectra. Thus the system (100) achieves nano-scale sensitivity although the volume elements are at the micro-scale.

公开(公告)号：US09944996B2

公开(公告)日：2018-04-17

申请号：US12997479

申请日：2009-06-15

申请人： Thomas Gerard Barry ,  Majella Maher ,  Terry James Smith ,  Marcin Jankiewicz ,  Louise O'Connor ,  Nina Tuite ,  Sinead Lahiff

发明人： Thomas Gerard Barry ,  Majella Maher ,  Terry James Smith ,  Marcin Jankiewicz ,  Louise O'Connor ,  Nina Tuite ,  Sinead Lahiff

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6895

摘要： The current invention relates to a diagnostic kit for a yeast or fungal species comprising at least one oligonucleotide probe capable of binding to at least a portion of the eIF2y gene or its corresponding mRNA.