公开(公告)号：US12072313B2

公开(公告)日：2024-08-27

申请号：US17403915

申请日：2021-08-17

Applicant: Murata Manufacturing Co., Ltd. ,  OSAKA UNIVERSITY

Inventor： Naruto Miyakawa ,  Ayumi Shinagawa ,  Shota Ushiba ,  Masahiko Kimura ,  Kazuhiko Matsumoto ,  Takao Ono

IPC: H01L23/00 ,  G01N27/414 ,  H01L29/16

CPC classification number: G01N27/4145 ,  G01N27/4146 ,  H01L29/1606

Abstract: A graphene transistor includes a graphene layer including at least one sheet of graphene, a drain electrode and a source electrode each electrically connected to the graphene layer, a charge donor on at least one main surface of the graphene layer, the charge donor including an impurity charge, and a counter ion having a charge with a sign different from a sign of the impurity charge.

公开(公告)号：US12070498B2

公开(公告)日：2024-08-27

申请号：US17200552

申请日：2021-03-12

Applicant: OSAKA UNIVERSITY ,  FUNPEP CO., LTD.

Inventor： Hironori Nakagami ,  Ryuichi Morishita ,  Akiko Tenma

IPC: A61K39/395 ,  A61K39/00 ,  A61K39/39 ,  A61P37/04

CPC classification number: A61K39/39 ,  A61K39/00 ,  A61K39/00114 ,  A61K39/39533 ,  A61P37/04 ,  A61K2039/55527

Abstract: The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.

公开(公告)号：US20240278321A1

公开(公告)日：2024-08-22

申请号：US18643068

申请日：2024-04-23

Applicant: TOPPAN Holdings Inc. ,  OSAKA UNIVERSITY

Inventor： Takuya SEKIGUCHI ,  Chuantong CHEN ,  Katsuaki SUGANUMA

IPC: B22F7/06 ,  B22F1/00 ,  B22F1/052 ,  B22F1/054 ,  B22F3/10 ,  B22F3/24 ,  B22F9/24

CPC classification number: B22F7/062 ,  B22F1/052 ,  B22F1/056 ,  B22F1/09 ,  B22F3/10 ,  B22F9/24 ,  B22F2003/248 ,  B22F2301/10 ,  B22F2301/255 ,  B22F2304/10 ,  B22F2998/10 ,  B22F2999/00

Abstract: A sintered material containing silver particles, copper particles, a nitrogen-containing compound, and a reducing agent, in which a primary particle diameter of the silver particles is 200 nm or less, and a volume-based 50% cumulative particle diameter of the copper particles, as measured by laser diffraction/scattering particle diameter distribution measurement, is 1 μm or more.

公开(公告)号：US12066433B2

公开(公告)日：2024-08-20

申请号：US17686802

申请日：2022-03-04

Applicant: SYSMEX CORPORATION ,  OSAKA UNIVERSITY ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Masaya Okada ,  Yuki Shimaoka ,  Shigeki Iwanaga ,  Kazuki Bando ,  Katsumasa Fujita ,  Yasunori Nawa ,  Satoshi Fujita

IPC: G01N21/65 ,  G01N21/25 ,  G01N21/31 ,  G01N33/543 ,  G01N33/58 ,  G01N33/68 ,  G06N3/08 ,  G16C20/20 ,  G16C20/70

CPC classification number: G01N33/54353 ,  G01N21/255 ,  G01N21/314 ,  G01N21/658 ,  G01N33/54346 ,  G01N33/588 ,  G01N33/6812 ,  G06N3/08 ,  G16C20/20 ,  G01N2201/121 ,  G01N2201/1296 ,  G16C20/70

Abstract: Disclosed is an analytical method for analyzing a test substance contained in a measurement sample, the method comprising: generating a data set based on a plurality of optical spectra acquired from a plurality of locations in the measurement sample; inputting the data set into a deep learning algorithm having a neural network structure; and outputting information on the test substance, on the basis of an analytical result from the deep learning algorithm.

公开(公告)号：US20240269165A1

公开(公告)日：2024-08-15

申请号：US18567479

申请日：2022-05-31

Applicant: Osaka University

Inventor： Shoichi Shimada ,  Yoshihisa Koyama ,  Makoto Kondo ,  Noriyoshi Usui ,  Hikaru Kobayashi ,  Yuki Kobayashi

IPC: A61K33/00 ,  A61K9/14 ,  A61P1/16 ,  A61P1/18 ,  A61P21/00

CPC classification number: A61K33/00 ,  A61K9/14 ,  A61P1/16 ,  A61P1/18 ,  A61P21/00

Abstract: An object is to provide a pharmaceutical or the like that can prevent or treat non-alcoholic fatty liver disease, pain associated with inactivity, or acute pancreatitis. [Solving Means] When silicon small particles are orally administered or placed on a skin or a mucous membrane, non-alcoholic fatty liver disease, pain associated with inactivity, and acute pancreatitis can be prevented or treated. The silicon small particles are particles each of which generates hydrogen when brought into contact with an aqueous solution having a pH of 7 or more. Provided is a preventive or therapeutic agent, pharmaceutical composition, medical device, food, or beverage comprising the silicon small particles for non-alcoholic fatty liver disease, pain associated with inactivity, or acute pancreatitis. The silicon small particles are suitably silicon fine particles and/or aggregates of the silicon fine particles.

公开(公告)号：US20240240183A1

公开(公告)日：2024-07-18

申请号：US18563128

申请日：2022-05-24

Applicant: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  OSAKA UNIVERSITY

Inventor： Takanori YOKOTA ,  Tetsuya NAGATA ,  Kotaro YOSHIOKA ,  Satoshi OBIKA

IPC: C12N15/113 ,  A61K9/00 ,  A61P29/00 ,  A61P37/06

CPC classification number: C12N15/113 ,  A61K9/0019 ,  A61P29/00 ,  A61P37/06 ,  C12N2310/11 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/343 ,  C12N2320/30

Abstract: A problem to be solved by the present invention is to provide a double-stranded nucleic acid complex having a reduced toxicity whose effectiveness is not impaired. Provided is a double-stranded nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein: said first nucleic acid strand is capable of hybridizing to at least part of a target gene or a transcription product thereof, and has an antisense effect on said target gene or transcription product thereof, said second nucleic acid strand comprises a base sequence complementary to said first nucleic acid strand, and said first nucleic acid strand and/or said second nucleic acid strand comprises at least one bridged non-natural nucleoside represented by formula (I) or formula (II) (wherein R represents a hydrogen atom or a methyl group).

公开(公告)号：US12039722B2

公开(公告)日：2024-07-16

申请号：US17442499

申请日：2020-02-12

Applicant: OSAKA UNIVERSITY

Inventor： Kazuaki Nakane ,  Hirofumi Yamamoto ,  Sachiko Nankumo ,  Yasuyoshi Tsutsumi

IPC: G06T7/00 ,  G16H30/40 ,  G16H50/80

CPC classification number: G06T7/0012 ,  G16H30/40 ,  G16H50/80 ,  G06T2207/30024 ,  G06T2207/30096

Abstract: By analyzing an image of a cell sample, whether a cell shown in the image is cancerous or not, the type of cancer, etc. are objectively and appropriately determined. An image analyzing device (1) includes: a binarizing section (41) which carries out a binarizing process a plurality of times with respect to a single captured image so as to generate a plurality of binarized images, the binarizing section carrying out the binarizing process each time the binarizing section varies a binarization reference value; a Betti number calculating section (42) which calculates a region number, which indicates the number of hole-shaped regions, with respect to each of the plurality of binarized images which have been generated; and a cancer determining section (43) which determines a type of cancer occurring in a cell included in tissue, on the basis of the binarization reference value which has been applied at a time of generation of one of the plurality of binarized images with respect to which one the region number has a given value.

公开(公告)号：US20240229101A1

公开(公告)日：2024-07-11

申请号：US18573857

申请日：2022-06-22

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  OSAKA UNIVERSITY

Inventor： Yasunori NAWA ,  Menglu LI ,  Seiichi ISHIDA ,  Yasunari KANDA ,  Satoshi FUJITA ,  Katsumasa FUJITA

IPC: C12Q1/26 ,  G01N21/65

CPC classification number: C12Q1/26 ,  G01N21/65 ,  G01N2333/90245

Abstract: The present invention provides a method for evaluating intracellular or extracellular enzyme activity of CYP enzyme group, including a step of measuring the number of molecules of oxidized CYP enzyme group.

公开(公告)号：US20240206818A1

公开(公告)日：2024-06-27

申请号：US18288867

申请日：2022-04-22

Applicant: OSAKA UNIVERSITY

Inventor： Teruo KANKI ,  Yasushi HOTTA

IPC: A61B5/00 ,  A61B5/308 ,  A61B5/31 ,  A61B5/313

CPC classification number: A61B5/7203 ,  A61B5/308 ,  A61B5/31 ,  A61B5/313

Abstract: A measurement device includes: a first electrode; a second electrode; a ground electrode disposed between the first electrode and the second electrode; a differential circuit configured to generate a differential voltage between a first voltage input from the first electrode and a second voltage input from the second electrode; a ground terminal connected to each of the ground electrode, the differential circuit, and an output circuit; the output circuit including an input terminal to which the differential voltage is input, a reference terminal to which a reference voltage is input, and a common terminal, the output circuit being configured to generate a measurement signal based on the differential voltage and the reference voltage, and to output the generated measurement signal; and an impedance element including a first end connected to each of the ground terminal and the common terminal, and a second end connected to the reference terminal.

公开(公告)号：US20240189345A1

公开(公告)日：2024-06-13

申请号：US18550844

申请日：2022-01-17

Applicant: Osaka University

Inventor： Hisako KAYAMA ,  Kiyoshi TAKEDA ,  Hikaru KOBAYASHI ,  Yuki KOBAYASHI

IPC: A61K33/00 ,  A61K9/14 ,  A61P31/04

CPC classification number: A61K33/00 ,  A61K9/14 ,  A61P31/04

Abstract: An intestinal bacteria reducing agent of the present invention is a reducing agent which contains silicon particles or silicon fine particles and reduces the number of bacteria in the intestine. The intestinal bacteria reducing agent can reduce the number of bacteria in the intestine by a new action that cannot be explained by the heretofore known hydrogen generating capability of silicon particles or silicon fine particles, that is, the capability of eliminating hydroxyl radicals.