公开(公告)号：US12066433B2

公开(公告)日：2024-08-20

申请号：US17686802

申请日：2022-03-04

申请人： SYSMEX CORPORATION ,  OSAKA UNIVERSITY ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

发明人： Masaya Okada ,  Yuki Shimaoka ,  Shigeki Iwanaga ,  Kazuki Bando ,  Katsumasa Fujita ,  Yasunori Nawa ,  Satoshi Fujita

IPC分类号： G01N21/65 ,  G01N21/25 ,  G01N21/31 ,  G01N33/543 ,  G01N33/58 ,  G01N33/68 ,  G06N3/08 ,  G16C20/20 ,  G16C20/70

CPC分类号： G01N33/54353 ,  G01N21/255 ,  G01N21/314 ,  G01N21/658 ,  G01N33/54346 ,  G01N33/588 ,  G01N33/6812 ,  G06N3/08 ,  G16C20/20 ,  G01N2201/121 ,  G01N2201/1296 ,  G16C20/70

摘要： Disclosed is an analytical method for analyzing a test substance contained in a measurement sample, the method comprising: generating a data set based on a plurality of optical spectra acquired from a plurality of locations in the measurement sample; inputting the data set into a deep learning algorithm having a neural network structure; and outputting information on the test substance, on the basis of an analytical result from the deep learning algorithm.

公开(公告)号：US20220283154A1

公开(公告)日：2022-09-08

申请号：US17686784

申请日：2022-03-04

申请人： SYSMEX CORPORATION ,  OSAKA UNIVERSITY ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

发明人： Yuki SHIMAOKA ,  Masaya Okada ,  Shigeki Iwanaga ,  Kazuki Bando ,  Katsumasa Fujita ,  Yasunori Nawa ,  Satoshi Fujita

IPC分类号： G01N33/543 ,  G01N33/68 ,  G01N21/65 ,  G01N33/58

摘要： Disclosed is a preparation method for preparing a measurement sample comprising an aggregate of metal nanoparticles having an analyte bound thereto, the preparation method comprising: contacting the analyte with a linker to bind the analyte to the linker; and contacting the linker that has been bound to the analyte with the metal nanoparticles to bind the linker to the metal nanoparticles.

公开(公告)号：US11598952B2

公开(公告)日：2023-03-07

申请号：US16246916

申请日：2019-01-14

申请人： Sysmex Corporation

发明人： Masaya Okada ,  Shigeki Iwanaga

IPC分类号： G02B27/00 ,  G02B21/00 ,  G01N21/64

摘要： An optical device comprises a shared phase modulation mask configured to impart a first phase modulation to light of a first wavelength, and imparts a second phase modulation to light of a second wavelength, an irradiation optical system configured to cause the light of the first wavelength and the light of the second wavelength to enter the same incident region in the phase modulation mask, and a light collecting optical system configured to collect the light of the first phase-modulated first wavelength and the light of the second phase-modulated second wavelength to form an image corresponding to a point spread function.

公开(公告)号：US10904491B2

公开(公告)日：2021-01-26

申请号：US16578433

申请日：2019-09-23

申请人： SYSMEX CORPORATION

发明人： Masaya Okada ,  Shigeki Iwanaga

IPC分类号： H04N7/18 ,  G06K9/62 ,  G06T3/40

摘要： A method according to one or more aspects may control a microscope system including an imaging unit configured to image a sample, and a display unit including a first display region and a second display region. The method may include: sequentially displaying, in the first display region, first images sequentially captured by the imaging unit; and displaying, in the second display region, a second image generated based on information extracted from the sequentially captured first images.

公开(公告)号：USD827008S1

公开(公告)日：2018-08-28

申请号：US29596818

申请日：2017-03-10

申请人： Sysmex Corporation

设计人： Masaya Okada ,  Fumie Shibata ,  Shigeki Iwanaga ,  Masayuki Seki

公开(公告)号：US20210255191A1

公开(公告)日：2021-08-19

申请号：US17163993

申请日：2021-02-01

申请人： Eisai R&D Management Co., Ltd. ,  SYSMEX CORPORATION

发明人： Daiki HARA ,  Takafumi Motoki ,  Yuji Kazuta ,  Yoshihiko Norimine ,  Hiroyuki Amino ,  Masatoshi Suganuma ,  Shingo Fujiyama ,  Kazuto Yamashita ,  Masaya Okada ,  Yoichi Nishikawa ,  Shigeki Iwanaga

IPC分类号： G01N33/58 ,  C09B57/00 ,  G01N21/64

摘要： Disclosed is: a fluorescent dye comprising a compound, a tautomer of the compound, or a salt of the compound or the tautomer; a labeled composite substance comprising the fluorescent dye and a composite substance which are bonded to each other; a composition containing the fluorescent dye or the labeled composite substance; and a method for acquiring information about a substance of interest by a super-resolution microscopy.

公开(公告)号：US10676784B2

公开(公告)日：2020-06-09

申请号：US15075358

申请日：2016-03-21

申请人： SYSMEX CORPORATION

发明人： Takuya Kubo ,  Shigeki Iwanaga

IPC分类号： G01N21/64 ,  C12Q1/6841 ,  G02B21/00

摘要： A sample analyzing method includes: denaturing DNA by heating a measurement specimen; bleaching the measurement specimen to inhibit autofluorescence from the measurement specimen; binding a fluorescent dye to a test substance in the measurement specimen; and capturing an image of fluorescence originated from the fluorescent dye by irradiating the measurement specimen with light. The DNA denaturation treatment is performed before the bleaching.

公开(公告)号：US11366097B2

公开(公告)日：2022-06-21

申请号：US15883329

申请日：2018-01-30

申请人： SYSMEX CORPORATION

发明人： Masaya Okada ,  Shigeki Iwanaga

IPC分类号： G01N33/49 ,  G01N15/14 ,  G01N1/10 ,  C12Q1/68 ,  G01N33/487 ,  G01N33/50 ,  G01N21/17 ,  G01N15/10

摘要： Disclosed is a cell imaging method including: forming a light sheet with respect to a flow cell; causing a measurement sample containing a plurality of cells to flow in the flow cell; and receiving lights generated from the plurality of cells passing through the light sheet, by an imaging device via an element configured to extend a depth of focus, and taking images of the plurality of cells by the imaging device.

公开(公告)号：US11112404B2

公开(公告)日：2021-09-07

申请号：US15951375

申请日：2018-04-12

申请人： SYSMEX CORPORATION

发明人： Kenji Akama ,  Toshihiro Watanabe ,  Masaya Okada ,  Kazuto Yamashita ,  Akshay Ganguly ,  Shigeki Iwanaga

IPC分类号： G01N33/543 ,  C07K16/18 ,  G01N33/533 ,  G01N33/68 ,  G01N33/58

摘要： Disclosed is a method for obtaining information of a test substance, the method including: forming a complex by causing a capture substance to bind to a test substance in a specimen; selectively collecting at least the complex from the specimen; immobilizing the complex collected from the specimen, onto a base plate; and obtaining information regarding a structure of the test substance from the complex immobilized on the base plate.

公开(公告)号：US11385448B2

公开(公告)日：2022-07-12

申请号：US16583328

申请日：2019-09-26

申请人： SYSMEX CORPORATION

发明人： Masaya Okada ,  Shigeki Iwanaga

IPC分类号： G02B21/00 ,  G02B21/26 ,  G02B21/36 ,  G02B21/16 ,  G02B21/12 ,  G01N21/64

摘要： A microscope apparatus includes: a sample setting unit in which a sample is set; an imaging unit configured to image the sample set in the sample setting unit; a housing unit on which the sample setting unit is arranged, and which is configured to internally accommodate the imaging unit; a first light source configured to irradiate light for fluorescence excitation on the sample in the sample setting unit; a first cover configured to be movable to a first position that covers the sample setting unit and a second position that opens the sample setting unit; and a second cover configured to be movable within the first cover; and a second light source arranged in a space covered with the second cover and configured to irradiate light on the sample in the sample setting unit.