公开(公告)号：US20060264506A1

公开(公告)日：2006-11-23

申请号：US10567130

申请日：2004-07-15

申请人： Ivars Kalvinsh ,  Anatolijs Birmans

发明人： Ivars Kalvinsh ,  Anatolijs Birmans

IPC分类号： A61K31/205

CPC分类号： A61K9/0095 ,  A61K9/0031 ,  A61K9/0056 ,  C07C53/16 ,  C07C55/07 ,  C07C55/10 ,  C07C55/14 ,  C07C57/145 ,  C07C57/15 ,  C07C59/08 ,  C07C59/265 ,  C07C243/14

摘要： New salts of Meldonium, the method of their preparation, and pharmaceutical formulation on their basis have been described. The general formula of these salts is X−(CH3)3N+NHCH2CH2COOH where X− is an acid anion selected from the group of pharmaceutically acceptable acids. Practically non-hygroscopic and/or increased thermal stability and/or lasting action Meldonium hydrogen salts of fumaric acid, phosphoric acid, oxalic acid, maleic acid, and pamoic acid as well as Meldonium orotate and galactarate are especially suitable. Novel pharmaceutical formulations containing non-hygroscopic and/or increased thermal stability and/or and/or lasting action 3-(2,2,2-trimethylhydrazinium) propionate salts for oral parenteral, rectal, and transdermal introduction are concurrently described.

摘要翻译： 已经描述了Meldonium的新盐，其制备方法和药物制剂。 这些盐的通式为X - - （CH 3）3 N + NHCH 2 CH 2 COOH，其中X为 - 选自药学上可接受的酸的酸性阴离子。 实际上非吸湿性和/或增加的热稳定性和/或持续作用富马酸，磷酸，草酸，马来酸和双羟萘酸以及乳酸和乳酸半乳糖酸酯的麦曲坦氢盐是特别合适的。 同时描述了含有非吸湿性和/或增加的热稳定性和/或持久作用的新型药物制剂，用于口服肠胃外，直肠和经皮引入的3-（2,2,2-三甲基肼鎓）丙酸盐。

公开(公告)号：US20060247468A1

公开(公告)日：2006-11-02

申请号：US10548171

申请日：2004-03-03

申请人： Avraham Baniel ,  Asher Vitner ,  David Gonen ,  David Heidel

发明人： Avraham Baniel ,  Asher Vitner ,  David Gonen ,  David Heidel

IPC分类号： C07C59/265

CPC分类号： C07C51/43 ,  C07C51/48 ,  C07C59/265

摘要： The invention provides a process for the recovery of citric acid from an aqueous solution feed stream originating in fermentation of carbohydrates and utilizing an amine solvent extraction step for separation of impurities comprising: subjecting said aqueous solution feed stream A to a treatment for partial recovery of citric acid, wherein said treatment is other than amine solvent extraction, to form a first portion of purified citric acid B and a secondary feed stream F; subjecting at least a portion G of said secondary feed stream F to a treatment consisting of amine solvent extraction to form a second portion of purified citric acid solution and to reject substantial of impurities initially present in said portion of said secondary feed stream; subjecting said second portion of purified citric acid solution to crystallization; and recycling mother liquor from said crystallization.

摘要翻译： 本发明提供了一种从源于碳水化合物发酵的水溶液进料流中回收柠檬酸的方法，并利用胺溶剂萃取步骤分离杂质，其包括：使所述水溶液进料流A处理部分回收柠檬酸 酸，其中所述处理不是胺溶剂萃取，以形成纯化柠檬酸B的第一部分和第二进料流F; 使至少一部分G的所述二次进料流F经受由胺溶剂萃取组成的处理以形成第二部分纯化的柠檬酸溶液并且排除最初存在于所述第二进料流的所述部分中的大量杂质; 对所述第二部分纯化柠檬酸溶液进行结晶; 并从所述结晶中回收母液。

公开(公告)号：US07001625B2

公开(公告)日：2006-02-21

申请号：US10342598

申请日：2003-01-15

申请人： Stefaan Van Dyck ,  Clifford Adams ,  Andre Meeuwsen ,  Leen van Campenhout

发明人： Stefaan Van Dyck ,  Clifford Adams ,  Andre Meeuwsen ,  Leen van Campenhout

IPC分类号： C07C55/00 ,  C07C51/42 ,  C07C59/08 ,  A23K1/00 ,  A23L1/216

CPC分类号： C07C51/47 ,  A23K20/10 ,  A23K20/105 ,  A23K30/00 ,  A23K40/10 ,  A23K50/75 ,  C07C51/412 ,  C07D307/62 ,  C07C53/124 ,  C07C59/265 ,  C07C53/02 ,  C07C53/08 ,  C07C53/122 ,  C07C57/15 ,  C07C59/08

摘要： A process for the solid-phase synthesis of salts of organic acids in a granular, free-flowing, and dust-free form particularly suited for use as animal feed additives. A mixture of liquid organic acids, including butyric acid, is applied to an inert, absorbent carrier. A solid base is then added during stirring. The acid is slowly released from the carrier preventing the fast reactions that lead to the formation of clumps. The exothermic reaction releases heat which assists in reducing the moisture content of the product. The addition of butyric acid results in a product which has an improved effect on animal growth over the animal feed additive without the addition of butyric acid.

摘要翻译： 固相合成颗粒状，自由流动和无尘形式的有机酸盐的方法，特别适合用作动物饲料添加剂。 将液体有机酸（包括丁酸）的混合物施加到惰性吸收剂载体上。 然后在搅拌过程中加入固体碱。 酸从载体缓慢释放，防止导致团块形成的快速反应。 放热反应释放有助于降低产品含水量的热量。 丁酸的添加产生的产物对动物生长比对动物饲料添加剂的影响更大，而不添加丁酸。

公开(公告)号：US06903235B2

公开(公告)日：2005-06-07

申请号：US10682045

申请日：2003-10-08

申请人： Yih-Ming Hsiao ,  Hsueh-Hung Chiu ,  Hsiu-Ching Wang ,  Yu-Chen Chang

发明人： Yih-Ming Hsiao ,  Hsueh-Hung Chiu ,  Hsiu-Ching Wang ,  Yu-Chen Chang

IPC分类号： A61K31/295 ,  C07C51/41 ,  C07C51/42 ,  C07C55/22 ,  C07F15/02

CPC分类号： C07C51/412 ,  C07C59/265

摘要： The present invention relates to pharmaceutical-grade ferric citrate. Pharmaceutical-grade ferric citrate contains a definite composition and a definite hydrate. The present invention also relates to a method using a solid—solid reaction to produce pharmaceutical-grade ferric citrate. The present invention also relates to a pharmaceutical composition comprising a therapeutically effective amount of pharmaceutical-grade ferric citrate and a food comprising pharmaceutical-grade ferric citrate.

摘要翻译： 本发明涉及药用级柠檬酸铁。 药用柠檬酸铁含有一定的组成和一定的水合物。 本发明还涉及使用固体 - 固体反应生产药用级柠檬酸铁的方法。 本发明还涉及包含治疗有效量的药学级柠檬酸铁和包含药物级柠檬酸铁的食品的药物组合物。

公开(公告)号：US20030000894A1

公开(公告)日：2003-01-02

申请号：US10225016

申请日：2002-08-21

发明人： Francis H. Verhoff ,  Sanet Grond ,  Fadl Hendricks ,  Lakshminarayanan Pattabiraman Raman

IPC分类号： B01D061/00

CPC分类号： C07C51/42 ,  C07C59/265

摘要： A process for treating a liquid comprising subjecting a liquid containing, in solution, citric acid as well as a less desirable component having a similar molecular weight to citric acid, to nanofiltration in a filtration step. From the filtration step, a permeate in which the ratio of the concentration of the citric acid to that of the less desirable component is greater than the ratio of the concentration of the citric acid to that of the less desirable component in the solution, is obtained.

摘要翻译： 一种用于处理液体的方法，包括在过滤步骤中将含有溶液中的柠檬酸的液体以及具有相似分子量的较不理想的组分与柠檬酸一起进行纳滤。 从过滤步骤获得柠檬酸浓度与不理想组分的浓度之比大于柠檬酸浓度与溶液中较不理想组分的比例的渗透物 。

公开(公告)号：US5219889A

公开(公告)日：1993-06-15

申请号：US803689

申请日：1991-12-03

申请人： Neill B. Walsdorf ,  George Alexandrides ,  Charles Y. C. Pak

发明人： Neill B. Walsdorf ,  George Alexandrides ,  Charles Y. C. Pak

IPC分类号： A23L1/304 ,  A61K31/19 ,  C07C59/265

CPC分类号： A61K31/19 ,  A23L33/16 ,  C07C59/265

摘要： A method for supplementing dietary potassium, magnesium and citrate is disclosed that comprises orally administering an effective amount of potassium magnesium citrate in a single salt. Methods for decreasing urinary calcium and oxalate by the administration of potassium magnesium citrate in a single salt are also disclosed.

摘要翻译： 公开了一种补充膳食钾，镁和柠檬酸盐的方法，其包括在单一盐中口服施用有效量的柠檬酸钾钾。 还公开了通过在单一盐中施用柠檬酸钾钾来降低尿钙和草酸盐的方法。

公开(公告)号：US4978673A

公开(公告)日：1990-12-18

申请号：US172799

申请日：1988-03-28

申请人： Carlo Meroni ,  Stefano Maiorana ,  Mario Brufani ,  Massimo Pomponi ,  Riccardo Bernardi ,  Pier L. Rugarli ,  Pier G. Pagella

发明人： Carlo Meroni ,  Stefano Maiorana ,  Mario Brufani ,  Massimo Pomponi ,  Riccardo Bernardi ,  Pier L. Rugarli ,  Pier G. Pagella

IPC分类号： A61K31/40 ,  A61P21/00 ,  A61P25/02 ,  C07C57/145 ,  C07C59/255 ,  C07C59/265 ,  C07D487/04

CPC分类号： C07D487/04 ,  C07C57/145 ,  C07C59/255 ,  C07C59/265

摘要： Organic salts of physostigmine derivatives, having the following general mula: ##STR1## in which R is a linear or branched C.sub.2 -C.sub.12 alkyl or a cycloalkyl or an aryl, and X.sub.- is the anion of an organic acid, the process for their preparation and their pharmaceutical use for acetylcholinesterase inhibition purposes.

公开(公告)号：US4652444A

公开(公告)日：1987-03-24

申请号：US681565

申请日：1984-12-14

申请人： Gerald L. Maurer

发明人： Gerald L. Maurer

IPC分类号： A61K8/365 ,  A61Q11/00 ,  C07C51/41 ,  C07C59/265 ,  A61K7/16 ,  A61K31/28 ,  A61K31/30

CPC分类号： C07C59/265 ,  A61K8/365 ,  A61Q11/00 ,  C07C51/418 ,  A61K2800/58

摘要： Novel methods and dental compositions for treating dental structures, such as teeth and subgingival structures, are disclosed. Uniquely, the dental compositions contain metal complexes which are characterized as having an unique aqueous proton induced dissociation property represented by a sigmoidally-shaped curve on a cartesian coordinate plot of the negative log of the metal ion concentration versus the negative log of the hydrogen ion concentration. This unique dissociation property enables the metal complexes to release therapeutic metal ions in the oral cavity for forming metal coordination complexes or salts within the dental structures. The formation of such complexes or salts within the dental structures is particularly effective and highly resistant to enzymatic degradation associated with microbial activity. Also, the metal ions of this invention are highly effective in inactivating the enzymes secreted by microbes in the oral cavity to further attenuate the disintegration process. The metal complexes of the new and vastly improved dental compositions advantageously are highly soluble yet readily dissociable at pH ranges normally encountered in the human mouth. As the active ingredient, the dental compositions contain a monometal complex of a multivalent heavy metal ion and a polyfunctional organic ligand in a ratio of about 1:1. An example of a dental composition employed is disodium monocopper(II) citrate in an amount of about 4 mg./ml., as copper, in a liquid vehicle having a pH of about 7.

摘要翻译： 公开了用于治疗诸如牙齿和龈下结构之类牙科结构的新方法和牙科组合物。 独特地，牙科用组合物含有金属络合物，其特征在于具有独特的质子诱导的解离性质，由金属离子浓度的负对数相对于氢离子浓度的负对数的笛卡儿坐标图表示的乙状结构曲线 。 这种独特的解离性使得金属络合物能够在口腔中释放治疗性金属离子，以在牙科结构内形成金属配位络合物或盐。 牙科结构内这种复合物或盐的形成对于与微生物活性相关的酶降解是特别有效的。 此外，本发明的金属离子在灭活口腔中微生物分泌的酶方面是非常有效的，以进一步减弱崩解过程。 新的和大大改进的牙科组合物的金属络合物有利地是高度可溶的，但在人口通常遇到的pH范围容易解离。 作为活性成分，牙科用组合物含有约1:1的多价重金属离子和多官能有机配体的单金属络合物。 使用的牙科用组合物的一个实例是柠檬酸二钠（柠檬酸钠），其pH值约为7，液体载体中约4mg./ml，作为铜。

公开(公告)号：US4483866A

公开(公告)日：1984-11-20

申请号：US397786

申请日：1982-07-13

申请人： Masaru Ogata ,  Katsuya Tawara ,  Yoshihachi Watanabe ,  Hiroshi Matsumoto ,  Toshio Takahashi

发明人： Masaru Ogata ,  Katsuya Tawara ,  Yoshihachi Watanabe ,  Hiroshi Matsumoto ,  Toshio Takahashi

IPC分类号： A01N43/50 ,  C07C53/08 ,  C07C55/06 ,  C07C55/10 ,  C07C59/245 ,  C07C59/255 ,  C07C59/265 ,  C07C65/10 ,  C07D233/54 ,  C07D233/56 ,  C07D233/60 ,  C07D521/00

CPC分类号： C07D233/64 ,  A01N43/50 ,  C07C53/08 ,  C07C55/06 ,  C07C55/10 ,  C07C59/245 ,  C07C59/255 ,  C07C59/265 ,  C07C65/10 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： Novel benzylimidazole derivatives of the formula: ##STR1## wherein X is halogen, nitro, alkyl, alkoxy, or halobenzyloxy;m is an integer of 0 to 3;Y is oxa, thia or substituted- or unsubstituted-imino;R.sup.1 is alkyl, dialkylaminoalkyl, dibenzylaminoalkyl, 1-pyrrolidinyl, 2-imidazolin-2-yl, or a group of --(CH.sub.2)n--Z--Q(wherein n is an integer of 0 to 4; Z is oxa, thia, or a single bond; and Q is substituted- or unsubstituted-phenyl or thienyl) ##STR2## is methylene, 1-(1-imidazolyl)-1-methylmethylene, 1-(1-imidazolyl)-1-phenylmethylene, 1-phenylmethylene, or substituted or unsubstituted alkylidene;the benzene ring of the above formula being optionally condensed with another benzene ringwith the proviso that when ##STR3## is methylene said benzene ring is condensed with another benzene ring, and acid addition salts thereof which are useful as an antimycotic drug or agricultural fungicide.

摘要翻译： 下式的新型苄基咪唑衍生物：其中X是卤素，硝基，烷基，烷氧基或卤代苄氧基; m为0〜3的整数。 Y是氧杂，噻吩或取代或未取代的亚氨基; R1是烷基，二烷基氨基烷基，二苄基氨基烷基，1-吡咯烷基，2-咪唑啉-2-基或 - （CH2）nZQ（其中n是0-4的整数; Z是氧杂，硫杂或单键） ;和Q是取代或未取代的苯基或噻吩基）是甲亚甲基，1-（1-咪唑基）-1-甲基亚甲基，1-（1-咪唑基）-1-苯基亚甲基，1-苯基亚甲基，或取代或未取代的 未取代的亚烷基; 上式的苯环任选地与另一个苯环稠合，条件是当亚甲基时，苯环与另一个苯环缩合，其酸加成盐可用作抗真菌药物或农药杀真菌剂。

公开(公告)号：US4473447A

公开(公告)日：1984-09-25

申请号：US405217

申请日：1982-08-04

申请人： Herbert Gutwein ,  Edwin Erben ,  August Muhlratzer ,  Boy Cornils ,  Bela Tihanyi ,  Werner DeWin

发明人： Herbert Gutwein ,  Edwin Erben ,  August Muhlratzer ,  Boy Cornils ,  Bela Tihanyi ,  Werner DeWin

IPC分类号： C07C59/265 ,  C25D3/12 ,  F24J2/48 ,  C25D3/56

CPC分类号： C07C59/265 ,  C25D3/12 ,  F24J2/487 ,  Y02E10/40 ,  Y10S205/923

摘要： Method for manufacturing solar absorption layers by electrodeposition of heavy metals, such as Ni and Co, from aqueous citrate solutions. The heavy metal citrates are produced by direct reaction of metal oxides or carbonates with citric acid. The electrolyte concentration is a maximum 5% and has a pH of between 8 and 11. The deposition process takes place at room temperature, bath voltages of 8 to 30 V, and current densities of 3 to 10 A/dm.sup.2. The layers produced by this method are well bonded black layers resistant to temperatures up to 700.degree. C.

摘要翻译： 通过从柠檬酸水溶液中电沉积重金属如Ni和Co制造太阳能吸收层的方法。 柠檬酸重金属由金属氧化物或碳酸盐与柠檬酸的直接反应产生。 电解质浓度最大为5％，pH值介于8和11之间。沉积过程发生在室温，浴电压为8至30 V，电流密度为3至10A / dm2。 通过该方法制备的层是耐高达700℃的良好粘合的黑色层。