公开(公告)号：US20160251609A1

公开(公告)日：2016-09-01

申请号：US15154827

申请日：2016-05-13

Applicant: SCARAB GENOMICS, LLC

Inventor： Frederick R. BLATTNER ,  Balint CSORGO ,  Gyorgy POSFAL

IPC: C12N1/20 ,  C12P21/00

CPC classification number: C12N1/08 ,  C12N9/1007 ,  C12N9/1252 ,  C12N15/70 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19 ,  C12Y201/01037

Abstract: Reduced genome bacteria with improved genetic stability are provided. Also provided are methods of producing polypeptides using the reduced genome bacteria with improved genetic stability.

Abstract translation: 提供了具有改善的遗传稳定性的减少的基因组细菌。 还提供了使用具有改善的遗传稳定性的还原的基因组细菌产生多肽的方法。

公开(公告)号：US20150218514A1

公开(公告)日：2015-08-06

申请号：US14420549

申请日：2013-08-09

Applicant: NATIONAL CANCER CENTER ,  DS PHARMA BIOMEDICAL CO., LTD.

Inventor： Takahiro Ochiya ,  Luc Gailhouste

IPC: C12N5/071 ,  C12Q1/68 ,  G01N33/50 ,  C12N15/113

CPC classification number: C12N5/067 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2501/65 ,  C12Q1/6883 ,  C12Q2600/142 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Y201/01037 ,  G01N33/5067

Abstract: The present invention provides a promoter of differentiation from a hepatic progenitor cell into a hepatocyte, which contains a substance that suppresses expression of Dnmt-1 or a substance that inhibits the function of Dnmt-1 as an active ingredient, and a method of producing a hepatocyte (preferably hepatocyte with high maturity) from a hepatic progenitor cell.

Abstract translation: 本发明提供了从肝祖细胞分化为肝细胞的启动子，其含有抑制Dnmt-1的表达的物质或抑制Dnmt-1的功能的物质作为有效成分的方法， 来自肝祖细胞的肝细胞（优选成熟肝细胞）。