公开(公告)号：US3816251A

公开(公告)日：1974-06-11

申请号：US24386972

申请日：1972-04-13

Applicant: KYOWA HAKKO KOGYO KK

Inventor： UKITA M ,  NAKAYAMA K ,  FURUYA A

IPC: C12P19/32 ,  C12D13/06

CPC classification number: C12P19/32 ,  Y10S435/822 ,  Y10S435/83 ,  Y10S435/843

Abstract: Adenosine-3'',5''-cyclic monophosphoric acid is produced by fermentation of a nutrient medium, containing a fluoride, by a microorganism which is capable of producing the nucleotide. The adenosine-3'',5''-cyclic monophosphoric acid is accumulated in the culture medium and is thereafter recovered therefrom.

Abstract translation: 通过能够产生该核苷酸的微生物发酵包含氟化物的营养培养基来产生腺苷-3'，5'-环状单磷酸。 腺苷-3'，5'-环状单磷酸积累在培养基中，然后从中回收。

公开(公告)号：US3791925A

公开(公告)日：1974-02-12

申请号：US3791925D

申请日：1971-05-06

Applicant: KYOWA HAKKO KOGYO KK

Inventor： NAKAYAMA K ,  ARAKI K

IPC: C12P13/24 ,  C12B1/00

CPC classification number: C12P13/24 ,  Y10S435/822 ,  Y10S435/83 ,  Y10S435/837 ,  Y10S435/84 ,  Y10S435/843 ,  Y10S435/872

Abstract: L-histidine is produced by fermentation of an aqueous nutrient media, wherein the ratio of the nitrogen source to the carbon source is at least 5:100, with organisms of the genera Brevibacterium, Corynebacterium, Arthrobacter, Micrococcus, Bacillus, Nocardia and Microbacterium.

Abstract translation: L-组氨酸是通过水性营养培养基的发酵产生的，其中氮源与碳源的比例为至少5:100，具有短杆菌属，棒状杆菌属，节杆菌属，微球菌属，芽孢杆菌属，诺卡氏菌属和微杆菌属的生物体。

公开(公告)号：US3784445A

公开(公告)日：1974-01-08

申请号：US3784445D

申请日：1971-12-30

Applicant: DU PONT

Inventor： DAHLSTROM R ,  JAEHNIG J

IPC: C12P7/44 ,  C12B1/00

CPC classification number: C12P7/44 ,  Y10S435/843

Abstract: An aqueous culture medium comprising (1) 3 to 35 grams per liter of alkali metal, calcium nitrate, magnesium nitrate, strontium nitrate and/or beryllium nitrate; (2) 0.3 to 10 grams per liter of alkali metal phosphate; (3) 1 to 15 grams per liter of an alkali metal acetate, calcium acetate, magnesium acetate, strontium acetate and/or beryllium acetate; and (4) a nutrient source; and a process for the production of an alpha,omegaalkanedioic acid of 10 to 16 carbon atoms comprising (1) introducing a mutated strain of Corynebacterium into a composition which has a pH of from 6 to 9 and which comprises 1 to 50 percent by volume of an n-alkane of 10 to 16 carbon atoms and a complemental amount of the culture medium above; (2) maintaining the composition at a temperature between 20* and 45*C. for 48 t0 96 hours; and (3) separating the alpha,omegaalkanedioic acid from the resulting mixture.

Abstract translation: 一种水性培养基，其包含（1）3至35克/升碱金属，硝酸钙，硝酸镁，硝酸锶和/或硝酸铍; （2）0.3〜10克/升碱金属磷酸盐; （3）1至15克/升碱金属乙酸盐，乙酸钙，乙酸镁，乙酸锶和/或乙酸铍; 和（4）营养源; 以及制备10至16个碳原子的α，ω-链烷二酸的方法，包括（1）将突变的棒状杆菌菌株引入pH为6至9的组合物中，并且其包含1至50％的 体积为10至16个碳原子的正烷烃和互补量的上述培养基; （2）将组合物保持在20℃至45℃的温度下48小时96小时; 和（3）从所得混合物中分离出α，ω-链烷二酸。

公开(公告)号：US3784444A

公开(公告)日：1974-01-08

申请号：US3784444D

申请日：1971-10-21

Applicant: KYOWA HAKKO KOGYO KK

Inventor： NAKAYAMA K ,  TANAKA H

IPC: C12P19/32 ,  C12D13/06

CPC classification number: C12P19/32 ,  Y10S435/83 ,  Y10S435/84 ,  Y10S435/843 ,  Y10S435/859

Abstract: Ribosyl phosphates of 2-substituted 6-amino purine derivatives are produced by fermentation of an aqueous nutrient medium containing a 2-substituted 6-amino purine derivative or the riboside thereof by organisms of the genera Brevibacterium, Corynebacterium, Arthrobacter and Micrococcus.

Abstract translation: 2-取代的6-氨基嘌呤衍生物的核糖基磷酸酯通过由短杆菌属，棒状杆菌属，节杆菌属和微球菌属的生物体发酵含有2-取代的6-氨基嘌呤衍生物或其核苷的含水营养培养基来制备。

公开(公告)号：US3773620A

公开(公告)日：1973-11-20

申请号：US3773620D

申请日：1970-09-24

Applicant: KYOWA HAKKO KOGYO KK

Inventor： KIMURA K ,  NAKANISHI T

IPC: C12P7/48 ,  C12B1/00

CPC classification number: C12P7/48 ,  Y10S435/83 ,  Y10S435/84 ,  Y10S435/843 ,  Y10S435/913 ,  Y10S435/921 ,  Y10S435/93 ,  Y10S435/933 ,  Y10S435/938 ,  Y10S435/944

Abstract: Processes for producing citric acid together with microbial cells as well as producing increased yields of citric acid and/or isocitric acid by fermentation are described. Hydrocarbonassimilating microorganisms are employed in media containing hydrocarbons as the main carbon source. The addition of alcohols, such as C1-C20 saturated alcohols, to the medium permits the accumulation of citric acid together with the obtained microbial cells. The addition of ferrocyanides, such as potassium or sodium ferrocyanide, to the medium enhances the yield of isocitric acid, while the addition of monofluoroacetic acid or a salt thereof to the medium enhances the yield of citric acid.

公开(公告)号：US3769165A

公开(公告)日：1973-10-30

申请号：US3769165D

申请日：1968-06-14

Applicant: KYOWA HAKKO KOGYO KK

Inventor： NAKAYAMA K

IPC: C12P19/32 ,  C12D13/06

CPC classification number: C12P19/32 ,  Y10S435/83 ,  Y10S435/843 ,  Y10S435/859

Abstract: A process for producing adenosine triphosphate (ATP) and adenosine diphosphate (ADP) which comprises culturing a microorganism belonging to the genus Corynebacterium, Micrococcus or Arthrobacter in an aqueous nutrient medium containing adenine, a derivative of adenine, such as adenosine or adenylic acid, or a substance containing the same, accumulating ATP and ADP therein and recovering the products. The yield may be increased by including at least about 0.4 percent by weight of PO4 as inorganic phosphate in the medium.

Abstract translation: 一种生产三磷酸腺苷（ATP）和二磷酸腺苷（ADP）的方法，其包括在含有腺嘌呤，腺嘌呤或腺苷酸衍生物的含水营养培养基中培养属于棒状杆菌属，微球菌属或节杆菌属的微生物，或 含有该物质的物质，在其中积聚ATP和ADP并回收产物。 通过在介质中包含至少约0.4重量％的PO 4作为无机磷酸盐，可以提高产率。

公开(公告)号：US3767529A

公开(公告)日：1973-10-23

申请号：US3767529D

申请日：1971-11-10

Applicant: AJINOMOTO KK

Inventor： YOSHINAGA F ,  KUBOTA K ,  JUJITA I ,  OKUMURA S

IPC: C12P13/06 ,  C12R1/065 ,  C12R1/13 ,  C12R1/15 ,  C12D13/06

CPC classification number: C12P13/06 ,  Y10S435/84 ,  Y10S435/843

Abstract: Certain microorganisms of genus Brevibacterium, Coryne-bacterium and Arthrobacter produce L-isoleucine directly from glucose or acetic acid in the culture medium.

Abstract translation: 短杆菌属，棒状杆菌属和节杆菌属的某些微生物在培养基中直接从葡萄糖或乙酸生产L-异亮氨酸。

公开(公告)号：US3759790A

公开(公告)日：1973-09-18

申请号：US3759790D

申请日：1971-07-16

Applicant: KYOWA HAKKO KOGYO KK

Inventor： NAKAYAMA K ,  HAGINO H

IPC: C12P13/22 ,  C12R1/15 ,  C12D13/06

CPC classification number: C12P13/222 ,  Y10S435/822 ,  Y10S435/83 ,  Y10S435/843 ,  Y10S435/861

Abstract: L-PHENYLALANINE IS PRODUCED IN SUBSTANTIAL YIELD BY FERMENTATION FROM AN L-PHENYLALANINE-PRODUCING STRAIN OF CORYNEFORM GLUTAMIC ACID-PRODUCING BACTERIA REPRESENTED BY CORYNEBACTERIUM GLUTAMICUM. SPECIFICALLY MUTATED STRAINS OF THE ABOVE NOTED BACTERIA THAT EXHIBIT RESISTANCE TO AT LEAST ONE COMPOUND SELECTED FROM THE GROUP CONSISTING OF TYROSINE, PHENYLALANINE AND ANALOGUES THEREOF AND EXHIBIT A TYROSINE REQUIREMENT, PRODUCE LARGE AMOUNTS OF L-PHENYLALANINE WHEN CULTURED IN A SUITABLE NUTRIENT MEDIUM.

公开(公告)号：US3751339A

公开(公告)日：1973-08-07

申请号：US3751339D

申请日：1971-04-26

Applicant: KYOWA HAKKO KOGYO KK

Inventor： SUZUKI T ,  HONDA H

IPC: C07C233/00 ,  C07C233/16 ,  C12D13/00

CPC classification number: C07C233/00 ,  C07C233/16 ,  Y10S435/83 ,  Y10S435/843 ,  Y10S435/872

Abstract: THE PRESENT INVENTION RELATES TO A PROCESS FOR PREPARING ANALOGUS OF CHLORAMPHENICOL, CHARACTERIZED BY CULTURING A MICROORGANISM CAPABLE OF PRODUCING D-THREO-2-PROPINOAMIDO-1-P-NITROPHENYL-1,3-PROPANEDIOL (HEREINAFTER DESIGNATED AS SUBSTANCE A) AND/OR D-THREO-2-ISOBUTYRAMIDO-1-P-NITROPHENYL-1,3-PROPANEDIOL (HEREINAFTER DESIGNATED AS SUBSTANCE B), UNDER AEROBIC CONDITIONS IN A CULTURE MEDIUM CONTAINING ASSIMILABLE CARBON SOURCES TO FORM AND ACCUMULATE SAID ANALOGUES OF CHLORAMPHENICOL THEREIN AND ISOLATING AND RECOVERING THE SAME THEREFROM.

公开(公告)号：US3741870A

公开(公告)日：1973-06-26

申请号：US3741870D

申请日：1971-10-12

Applicant: LILLY CO ELI

Inventor： MALLETT G

IPC: C12P33/00 ,  C07C167/14 ,  C07C167/18

CPC classification number: C12P33/00 ,  Y10S435/843

Abstract: $9(11)-ESTROME ISPREPARED FROM 19-HYDROXY CHOLESTEROL BY FERMENTATION USING A CORYNEBACTERIUM SPECIES.