公开(公告)号：US4107428A

公开(公告)日：1978-08-15

申请号：US790628

申请日：1977-04-25

申请人： Sheldon Farber

发明人： Sheldon Farber

IPC分类号： B41M5/136 ,  B41M5/145 ,  B41M5/327 ,  C07D209/36 ,  C07D307/88 ,  C07D307/92 ,  C07D313/00 ,  C07D313/20 ,  C07D491/04 ,  C07D491/048 ,  C09B23/00 ,  C09B57/00 ,  C07D401/06 ,  C07D401/14 ,  C07D403/14

CPC分类号： C07D307/88 ,  B41M5/145 ,  B41M5/327 ,  C07D209/36 ,  C07D307/92 ,  C07D313/00 ,  C07D313/20 ,  C07D491/04

摘要： A chromogenic compound of normally colorless form is disclosed having the following structural formula: ##STR1## wherein A and B can be ##STR2## X and Y can be aryl and heterocyclic, each substituted Z is hydrogen and E can be tetrachloro-and tetrabromo-substituted ##STR3## STRUCTURES. The compound is eligible for use in pressure-sensitive record materials and manifold marking systems. Because of light absorption characteristics, selected compounds of this invention are especially useful where machine readability and machine copiability are important.

摘要翻译： 公开了通常为无色形式的显色化合物，具有以下结构式：其中A和B可以是X，Y可以是芳基和杂环，每个取代的Z是氢，E可以是四氯 - 和四溴 - 取代的结构。 该化合物可用于压敏记录材料和歧管标记系统。 由于光吸收特性，本发明的选择的化合物在机器可读性和机器可复性性很重要的情况下特别有用。

公开(公告)号：US3703524A

公开(公告)日：1972-11-21

申请号：US3703524D

申请日：1970-03-26

申请人： GEIGY CHEM CORP

发明人： BRAENDSTROEM ARNE ELOF ,  CARLSSON STIG AKE INGEMAR ,  GAGNEUX ANDRE

IPC分类号： A61K31/00 ,  C07D209/36 ,  C07D401/12 ,  C07D29/26

CPC分类号： A61K31/00 ,  C07D209/36 ,  Y10S514/849

摘要： THE COMPOUNDS ARE OF THE CLASS OF INDOLE DERIVATIVES, MORE PARTICULARLY INDOLE DERIVATIVES SUBSTITUTED IN 2- AND 3-POSITIONS AND ACID ADDITION SALTS THEREOF. THE COMPOUNDS ARE USEFUL AS ANALGESIC, ANTI-INFLAMMATORY, ANTITUSSIVE, TRANQUILIZING, ANTI-ALLERGIC AND ANAESTHESIA-POTENTIATING AGENTS. AN ILLUSTRATIVE EMBODIMENT IS 2-BENZOYL-3(2-PYRROLIDINOETHOXY)INDOLE.

公开(公告)号：US3631063A

公开(公告)日：1971-12-28

申请号：US3631063D

申请日：1969-05-28

申请人： UPJOHN CO

发明人： LEDNICER DANIEL

IPC分类号： C07D209/36 ,  C07D27/40

CPC分类号： C07D209/36

摘要： COMPOUNDS OF THE FORMULA:

1-((R2-)2-N-(CH2)N-),2-R1,2-R2,3-(O=),X-INDOLINE

WHEREIN X IS HYDROGEN, LOWER-ALKYL, HALOGEN OR -CF3; WHEREIN R1 AND R2 ARE LOWER-ALKYL OR -C6H4X'' IN WHICH X'' IS HYDROGEN, LOWER-ALKYL, HALOGEN, LOWER-ALKOXY OR -CF3; WHEREIN R3 IS LOWER-ALKYL OR TOGETHER -N(R3)2 IS 1-PYRROLIDINYL, 1-PIPERIDINYL OR 4-MORPHOLINYL; AND WHEREIN N IS AN INTEGER FROM 2 TO 4, INCLUSIVE, ARE MADE FROM 3H-INDOL-3-OLS. THE PRODUCTS AS WELL AS THEIR PHARMACOLGICALLY ACCEPTABLE ACID ADDITION SALTS HAVE SEDATIVE ACTIVITY AND CAN BE ADMINISTERED TO TRANQUILIZE MAMMALS.

公开(公告)号：US3557142A

公开(公告)日：1971-01-19

申请号：US3557142D

申请日：1968-02-20

申请人： STERLING DRUG INC

发明人： BELL MALCOLM R

IPC分类号： C09J7/02 ,  C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/36 ,  C07D27/54

CPC分类号： C07D209/12 ,  C07D209/08 ,  C07D209/10 ,  C07D209/36

摘要： NEW 3-SUBSTITUTED-1 - INDOLE- AND 4,5,6,7 - TETRAHYDROINDOLE-LOWER-ALKANOIC ACIDS AND ESTERS HAVING USEFUL ANTIINFLAMMATORY ACTIVITY AND PREPARED BY ALKYLATION OF A 3 - SUBSTITUTED - INDOLE WITH AN APPROPRIATE HALO-LOWER-ALKANOIC ACID OR ESTER OR BY CYCLIZATION OF A 2-(2-R2-2-OXOETHYL) CYCLOHEXANONE OR 2-(1 -PHENYL-2-OXO-LOWER-ALKYL) CYCLOHEXANONE WITH AN AMINO ACID OR ESTER.

公开(公告)号：US3158475A

公开(公告)日：1964-11-24

申请号：US662560

申请日：1960-02-04

申请人： GEVAERT PHOTO PROD NV

发明人： MARIA CASSIERS PAUL ,  MARIE NYS JEAN ,  FRANS WILLEMS JOZEF

IPC分类号： C07D209/08 ,  C07D209/36 ,  C07D233/54 ,  C07D235/02 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18 ,  C07D235/20 ,  C07D263/32 ,  C07D263/52 ,  C07D263/56 ,  C07D263/57 ,  C07D277/66 ,  C07D403/04 ,  C07D417/04 ,  C09B23/02 ,  C09B23/10 ,  C09B23/16 ,  G03G5/06

CPC分类号： C07D233/64 ,  C07D209/08 ,  C07D209/36 ,  C07D235/02 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18 ,  C07D235/20 ,  C07D263/32 ,  C07D263/52 ,  C07D263/56 ,  C07D263/57 ,  C07D277/66 ,  C07D403/04 ,  C07D417/04 ,  C09B23/02 ,  C09B23/10 ,  C09B23/164 ,  G03G5/0629 ,  G03G5/0631 ,  G03G5/0661 ,  G03G5/0668 ,  Y10S260/15 ,  Y10S260/16 ,  Y10S260/17 ,  Y10S260/19 ,  Y10S260/20

公开(公告)号：US2506294A

公开(公告)日：1950-05-02

申请号：US74959247

申请日：1947-05-21

申请人： BELGE PRODUITS CHIMIQUES SA

发明人： GEORGES DECHAMPS ,  LE BIHAN HENRI ,  CAMILLE BEAUDET

IPC分类号： C07D209/36

CPC分类号： C07D209/36

公开(公告)号：US1827828A

公开(公告)日：1931-10-20

申请号：US19170227

申请日：1927-05-16

申请人： NAT ANILINE & CHEM CO INC

发明人： SPALDING WILLIAM L

IPC分类号： C07D209/36

CPC分类号： C07D209/36 ,  Y10S261/09

公开(公告)号：US11834412B2

公开(公告)日：2023-12-05

申请号：US18179841

申请日：2023-03-07

申请人： AZORA THERAPEUTICS, INC.

发明人： Matthew Davidson ,  Julie Saiki ,  Robert Lum ,  Steven R. Schow

IPC分类号： C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D209/36 ,  A61P1/04

CPC分类号： C07D209/36 ,  A61P1/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14

摘要： A compound having one of the following structures of Formula (IV) or (V):




or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, R4, R5 R6, R7, R8, R10, R11a R11b, R12a R12b, X, Y, and Z are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

公开(公告)号：US20220340526A1

公开(公告)日：2022-10-27

申请号：US17556820

申请日：2021-12-20

申请人： Clark Atlanta University

发明人： Shafiq A. Khan ,  Silvia Caggia ,  Adegboyega K. Oyelere ,  Subhasish Tapadar

IPC分类号： C07D209/36 ,  C07D209/08 ,  C07D333/54

摘要： The disclosure relates to novel compounds and methods of use of the compounds to maintain the Gαi2 protein in its inactive GDP-bound state. The disclosure describes the knockdown or inhibition of Gαi2 negatively regulated migration of breast and ovarian cancer cell lines. The novel compounds inhibit the migratory behavior of PC3, DU145 and E006AA prostate cancer cell lines. Specifically, the novel compounds block the activation of Gαi2 in oxytocin-stimulated prostate cancer PC3 cells and inhibits the migratory capability of DU145 cells overexpressing constitutively active form of Gαi2, under basal and EGF-stimulated conditions.

公开(公告)号：US11098045B2

公开(公告)日：2021-08-24

申请号：US16899116

申请日：2020-06-11

申请人： PHARMAXIS LTD.

发明人： Alison Dorothy Findlay ,  Craig Ivan Turner ,  Mandar Deodhar ,  Jonathan Stuart Foot ,  Wolfgang Jarolimek ,  Wenbin Zhou ,  Alan Duncan Robertson

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K45/06 ,  C07D209/42 ,  A61P1/16 ,  A61P13/12 ,  A61P11/00 ,  A61K31/4025 ,  A61K31/4045 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/506 ,  C07D209/14 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D413/10 ,  A61K31/5025 ,  A61K31/519 ,  C07D209/20 ,  C07D209/36

摘要： The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.