公开(公告)号：US20230024752A1

公开(公告)日：2023-01-26

申请号：US17504243

申请日：2021-10-18

申请人： Bayer Pharma Aktiengesellschaft

发明人： Eloisa JIMENEZ NUNEZ ,  Jens ACKERSTAFF ,  Susanne ROEHRIG ,  Alexander HILLISCH ,  Katharina MEIER ,  Stefan HEITMEIER ,  Adrian TERSTEEGEN ,  Jan STAMPFUSS ,  Pascal ELLERBROCK ,  Daniel MEIBOM ,  Dieter LANG

IPC分类号： C07D401/10 ,  C07D401/14 ,  C07D413/14 ,  C07D413/10 ,  A61P7/02

摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

公开(公告)号：US20220402903A1

公开(公告)日：2022-12-22

申请号：US17754970

申请日：2020-10-13

申请人： SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. ,  JIANGSU YANGNONG CHEMICAL CO., LTD.

发明人： Jichun YANG ,  Aiying GUAN ,  Dongliang CUI ,  Qiao WU ,  Hongjuan MA ,  Enming WU ,  Changling LIU

IPC分类号： C07D413/10 ,  A01N43/80

摘要： An isoxazoline compound with optical activity is shown in the formula (I). The compound of the formula (I) has excellent herbicidal activity, can be used for weeding pre- and post-emergence, and can also be used for soil treatment. The compound of the formula (I) can effectively control various broad-leaved weeds, grass weeds and Cyperaceae weeds, and can control various resistant weeds, such as glyphosate-resistant weeds. The excellent weeding effect can be obtained at a low dose. The compound has good safety to crops such as corn, wheat, rice, soybean and sugar beet. The compound can be used as a selective herbicide in crop fields in agriculture, and can also be used as a non-selective herbicide in non-cultivated land, fallow land, woodland, orchards and ridges.

公开(公告)号：US11518751B2

公开(公告)日：2022-12-06

申请号：US17058888

申请日：2018-05-28

申请人： Transitions Optical, Ltd.

发明人： Robert W. Walters ,  Chien-Yang Chiu ,  Anu Chopra ,  Darrin R. Dabideen ,  Sujit Mondal ,  Nick J. Parise ,  Wenjing Xiao

IPC分类号： C07D311/94 ,  C07D413/10 ,  G02B1/04 ,  G02B5/23 ,  G03C1/73

摘要： A photochromic compound including a core skeletal structure represented by the following Formula (I), wherein D is oxygen or sulfur; E is oxygen, sulfur, or NR2′; a is 0 or 1; R1 is hydrogen, or substituted or unsubstituted alkyl; R2 and R2′ are each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heterocycloalkyl; and the photochromic compound is a thermally reversible photochromic compound.

公开(公告)号：US20220352474A1

公开(公告)日：2022-11-03

申请号：US17231835

申请日：2021-04-15

申请人： ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.

发明人： Dong-Hyung Lee ,  Chi-Sik KIM ,  Yoo-Jin DOH ,  Seung-Hoon YOO ,  Soo-Yong LEE ,  Hyun-Woo KANG

IPC分类号： H01L51/00 ,  C07D307/91 ,  C09K11/06 ,  C07D491/048 ,  C07D251/24 ,  C07D413/10 ,  C07D491/06

摘要： The present disclosure relates to an organic electroluminescent device. The organic electroluminescent device of the present disclosure may exhibit low voltage, high efficiency, and/or long lifespan by including a light-emitting layer comprising a specific combination of the compounds, and an electron transport zone.

公开(公告)号：US11472784B2

公开(公告)日：2022-10-18

申请号：US17212373

申请日：2021-03-25

申请人： Daiichi Sankyo Company, Limited

发明人： Keiji Saito ,  Katsuyoshi Nakajima ,  Toru Taniguchi ,  Osamu Iwamoto ,  Satoshi Shibuya ,  Yasuyuki Ogawa ,  Kazumasa Aoki ,  Nobuya Kurikawa ,  Shinji Tanaka ,  Momoko Ogitani ,  Eriko Kioi ,  Kaori Ito ,  Natsumi Nishihama ,  Tsuyoshi Mikkaichi ,  Wataru Saitoh

IPC分类号： C07D307/94 ,  C07D405/04 ,  C07D405/10 ,  C07D407/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  A61K31/343 ,  A61K31/4155 ,  A61K31/4245

摘要： An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.
The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

公开(公告)号：US20220324835A1

公开(公告)日：2022-10-13

申请号：US16964979

申请日：2019-01-25

申请人： Nurix Therapeutics, Inc.

发明人： Paul A. BARSANTI ,  Neil F. BENCE ,  Jennifa GOSLING ,  Anjanabha SAHA ,  Asad M TAHERBHOY ,  Christoph W. ZAPF ,  Kathleen BOYLE ,  Mario CARDOZO ,  Jeffrey MIHALIC ,  Morgan LAWRENZ ,  Mark GALLOP ,  Jilliane BRUFFEY ,  Thomas CUMMINS ,  Daniel ROBBINS ,  Hiroko TANAKA ,  Chenbo WANG ,  Frederick COHEN ,  Wylie PALMER ,  Arthur T. SANDS ,  Hunter SHUNATONA

IPC分类号： C07D401/14 ,  A61K35/17 ,  A61K39/00 ,  C07D249/12 ,  A61K31/4196 ,  C07D401/12 ,  A61K31/455 ,  C07D403/12 ,  A61K31/506 ,  A61K31/4725 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/4375 ,  C07D471/04 ,  A61K31/427 ,  C07D417/12 ,  C07D405/14 ,  A61K31/428 ,  C07D413/14 ,  A61K31/423 ,  A61K31/4545 ,  A61K31/496 ,  C07D413/12 ,  C07D491/107 ,  C07D413/10 ,  A61K31/4245 ,  A61K31/4155 ,  A61K31/4178 ,  C07D403/10 ,  C07D487/04 ,  A61K31/433 ,  C07D491/052 ,  C07D451/02 ,  A61K31/55 ,  C07D471/08 ,  A61K31/5377 ,  A61K31/541 ,  C07D403/14 ,  C07D417/14 ,  A61K31/438 ,  A61K31/499 ,  A61K31/4985 ,  C07D491/08 ,  A61K31/436 ,  A61K31/4748 ,  A61K31/437 ,  C07D498/04 ,  A61K31/5386 ,  C07D498/10 ,  A61P35/00 ,  A61K39/39 ,  C07D453/02 ,  C12N5/0783 ,  C12N5/0781

摘要： Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo.

公开(公告)号：US11453661B2

公开(公告)日：2022-09-27

申请号：US17030504

申请日：2020-09-24

申请人： Takeda Pharmaceutical Company Limited

发明人： Masahiro Ito ,  Hideyuki Sugiyama ,  Takeshi Yamamoto ,  Keiko Kakegawa ,  Jinxing Li ,  Junsi Wang ,  Takahito Kasahara ,  Masato Yoshikawa

IPC分类号： C07D413/14 ,  A61P25/28 ,  C07D413/10

摘要： The present invention provides a heterocyclic compound having a HDAC6 inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

公开(公告)号：US20220281827A1

公开(公告)日：2022-09-08

申请号：US17627831

申请日：2020-07-17

申请人： SYNGENTA CROP PROTECTION AG

发明人： Kenneth Bruce LING ,  Peter Timothy SEDEN ,  Christopher John MATHEWS ,  Stephen Edward SHANAHAN ,  Christiana KITSIOU ,  John FINNEY

IPC分类号： C07D237/04 ,  A01N43/58 ,  A01N43/653 ,  C07D403/10 ,  C07D401/10 ,  C07D413/10 ,  A01N43/76 ,  A01N43/713 ,  A01N43/84 ,  C07D405/10 ,  C07D417/10 ,  A01N43/78 ,  C07D409/10 ,  A01P13/00 ,  A01N25/32

摘要： The present invention relates to herbicidal substituted phenyl-pyridazine-diones and substituted phenyl-pyridazinone derivatives of formula (I), as well as to processes and intermediates used for the preparation of such derivatives. The invention further extends to herbicidal compositions comprising such derivatives, as well as to the use of such compounds and compositions in controlling undesirable plant growth: in particular the use in controlling weeds, such as broad-leaved dicotyledonous weeds, in crops of useful plants.

公开(公告)号：US20220251051A1

公开(公告)日：2022-08-11

申请号：US17610983

申请日：2019-05-22

申请人： ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD. ,  ROHM AND HAAS ELECTRONIC MATERIALS SHANGHAI LTD.

发明人： Chi-Sik KIM ,  Soo-Yong LEE ,  Dong Hyung LEE ,  Yuchen LIU

IPC分类号： C07D263/57 ,  H01L51/00 ,  C07D413/10 ,  C07D493/04 ,  C07D277/66 ,  C07D417/10 ,  C07D487/14 ,  C07D209/88 ,  C07D209/86 ,  C07D307/91 ,  C07F1/02 ,  C07D519/00

摘要： The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By comprising the organic electroluminescent compound of the present disclosure, it is possible to provide an organic electroluminescent device having an operating voltage lower than that of a conventional organic electroluminescent device and thus achieving higher power efficiency.

公开(公告)号：US11352332B2

公开(公告)日：2022-06-07

申请号：US16975437

申请日：2019-02-26

申请人： AlzeCure Pharma AB

发明人： Gunnar Nordvall

IPC分类号： C07D251/30 ,  A61K31/53 ,  C07D401/04 ,  C07D403/10 ,  C07D405/12 ,  C07D409/04 ,  C07D413/10 ,  C07D417/04

摘要： There is provided herein a compound of formula (I) wherein R1, R2, n, X, Q, L, m, R3 and p are as defined herein, which compounds are useful in the treatment of treatment of diseases characterised by impaired signalling of neurotrophins and/or other trophic factors, such as Alzheimer's disease and the like.