利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

176 条记录 (耗时 0.024 秒)

    Etoposide analogs and methods of use thereof
    41.
    发明授权
    Etoposide analogs and methods of use thereof 失效
    依托泊苷类似物及其使用方法

    公开(公告)号：US06872841B2

    公开(公告)日：2005-03-29

    申请号：US10349351

    申请日：2003-01-22

    申请人： Kuo-Hsiung Lee ,  Zhiyan Xiao ,  Kenneth F. Bastow

    发明人： Kuo-Hsiung Lee ,  Zhiyan Xiao ,  Kenneth F. Bastow

    IPC分类号： C07D493/04 ,  C07D497/04 ,  C07D317/70

    CPC分类号： C07D493/04 ,  C07D497/04

    摘要： Etoposide analogs such as 4′-O-demethyl-4β-[4″-(methyl-L-tyrosine-N-carbonyl)-anilino]-4-desoxy-podophyllotoxin (12) and 4′-O-demethyl-4β-[4″-(methyl-L-tryptophan-N-carbonyl)-anilino]-4-desoxypodophyllotoxin (13) are described, along with pharmaceutical formulations containing the same, methods of use thereof, and intermediates and methods of making the same.

    摘要翻译： 依托泊苷类似物如4'-O-脱甲基-4,4a- [4“ - （甲基-L-酪氨酸-N-羰基） - 苯胺基] -4-脱氧鬼臼毒素（12）和4'-O-脱甲基-4beta - [4“ - （甲基-L-色氨酸-N-羰基） - 苯胺基] -4-脱氧鬼臼毒素（13），以及含有其的药物制剂，其使用方法和中间体以及制备 相同。

    Dibenzonaphthyrones
    42.
    发明申请
    Dibenzonaphthyrones 失效
    二苯并噻吩

    公开(公告)号：US20020095046A1

    公开(公告)日：2002-07-18

    申请号：US09880211

    申请日：2001-06-13

    发明人： Peter Nesvadba ,  Joachim Jandke

    IPC分类号： C07D497/04

    CPC分类号： C07D493/04 ,  C08K5/1545 ,  C09B57/02

    摘要： Dibenzonaphthyrone of formula (I) 1 wherein A1 and A2 independently of each other are unsubstituted or mono- to tetra-substituted o-C6-C18arylene, with the proviso that formula (I) does not represent a dibenzonaphthyrone of the formula 2 The invention further relates to processes for the preparation thereof, to the use thereof for colouring/pigmenting high-molecular-weight organic material and to substance compositions comprising dibenzonaphthyrones.

    摘要翻译： 式（I）的二苯并萘酮其中A1和A2彼此独立地是未取代的或一至四取代的o-C 6 -C 18亚芳基，条件是式（I）不表示下式的二苯并萘酮本发明还涉及 其制备方法，其用于着色/着色高分子量有机材料的用途以及包含二苯并噻吩的物质组合物。

    Free radicals
    46.
    发明授权
    Free radicals 失效
    自由基

    公开(公告)号：US5530140A

    公开(公告)日：1996-06-25

    申请号：US220522

    申请日：1994-03-31

    申请人： Sven Andersson ,  Finn Radner ,  Anna Rydbeek ,  Rolf Servin ,  Lars-Goran Wistrand

    发明人： Sven Andersson ,  Finn Radner ,  Anna Rydbeek ,  Rolf Servin ,  Lars-Goran Wistrand

    IPC分类号： A61K49/20 ,  C07B60/00 ,  C07D493/04 ,  C07D495/04 ,  C07D497/04 ,  C07D519/00 ,  A61K49/00

    CPC分类号： C07D493/04 ,  A61K49/20 ,  C07B61/02 ,  C07D495/04 ,  C07D497/04

    摘要： The invention provides novel persistent free radicals useful in Overhauser MRI being triarylmethyl radicals having as at least one aryl group a group of formula ##STR1## (wherein each X which may be the same or different is an oxygen or sulphur atom or a group CO or S(O).sub.n, (where n is 1 to 3) with the proviso that at least one group X is a sulphur atom or a S(O).sub.n group; R.sup.1 is a hydrogen atom or group of formula --M, --XM, --X--Ar.sup.2, or --Ar.sup.2 where M is a water solubilizing group, and Ar.sup.2 represents a 5-10 membered aromatic ring optionally substituted by a water solubilizing group M; and each of the groups R.sup.7, which may be the same or different, is a hydrogen atom, or a hydrocarbon group or a water solubilizing group M, or two groups R.sup.7 together with the atom to which they are bound represent a carbonyl group or a 5 to 8 membered cycloalkylidene, mono- or di-oxacycloalkylidene, mono- or di-azacycloalkylidene or mono- or di-thiacycloalkylidene group optionally with the ring attachment carbon replaced by a silicon atom, and R.sup.7 where it is other than hydrogen, is optionally substituted by a hydroxyl group, an optionally alkoxylated, optionally hydroxylated acyloxy or alkyl group or a water solubilizing group M)). The novel radicals have good stability, long relaxation times and good relaxivity.

    摘要翻译： 本发明提供了在Overhauser MRI中有用的新型持久性自由基，其具有作为至少一个芳基的基团为具有下式的基团的三芳基甲基（其中可以相同或不同的X是氧或硫原子或 基团CO或S（O）n，（其中n为1至3），条件是至少一个基团X为硫原子或S（O）n基团; R 1为氢原子或式-M ，-XM，-X-Ar2或-Ar2，其中M是水溶性基团，Ar2表示任选被水增溶基团M取代的5-10元芳香环;并且各基团R7可以是 相同或不同的是氢原子，或烃基或水溶性基团M，或两个R 7与它们所连接的原子一起代表羰基或5-8元环亚烷基，单 - 或二 - 单环或二氮杂环亚烷基或任选具有环连接c的单 - 或二 - 芳烃被硅原子取代，并且其中不是氢的R 7任选被羟基取代，任选烷氧基化，任选羟基化的酰氧基或烷基或水溶性基团M））。 新型自由基具有良好的稳定性，较长的松弛时间和良好的松弛性。

    Substituted 1H-indazole-3-carboxamides
    49.
    发明授权
    Substituted 1H-indazole-3-carboxamides 失效
    取代的1H-吲唑-3-甲酰胺

    公开(公告)号：US5037844A

    公开(公告)日：1991-08-06

    申请号：US554918

    申请日：1990-07-20

    申请人： Derk Hamminga ,  Ineke van Wijngaarden

    发明人： Derk Hamminga ,  Ineke van Wijngaarden

    IPC分类号： C07D231/56 ,  A61K31/415 ,  A61P1/08 ,  A61P9/08 ,  A61P9/10 ,  A61P25/00 ,  A61P25/30 ,  C07D403/12 ,  C07D491/04 ,  C07D495/04 ,  C07D497/04

    CPC分类号： C07D403/12 ,  C07D491/04 ,  C07D495/04 ,  C07D497/04

    摘要： The present invention is concerned with compounds of formula 1: ##STR1## wherein R.sub.1 is straight or branched alkyl having 1-4 C-atoms, halogen or cyano;n has the value 0-1;R.sub.2 is hydrogen, (1-6 C)alkyl, (3-6 C)alkenyl, (3-6 C)alkenyl, (3-6 C)cycloalkyl, (3-6 C)cycloalkyl-(1-4 C) alkyl, phenyl, phenyl-(1-3 C)alkyl, COOR.sub.6, COR.sub.6, CONR.sub.6 R.sub.7 or SO.sub.2 --R.sub.6, wherein R.sub.6 and R.sub.7 independently of each other are hydrogen, (1-6 C)alkyl, (3-6 C)cycloalkyl, phenyl or phenyl-(1-4 C)alkyl, wherein the benzene ring is optionally substituted with a methyl group or a halogen atom, with the proviso that R.sub.6 is not hydrogen when R.sub.2 is a group COOR.sub.6 or SO.sub.2 R.sub.6 ;R.sub.3 is hydrogen, straight or branched (1-6 C)alkyl or a phenyl-(1-3 C)alkyl group optionally substituted in the benzene ring; andA is a group of formula 2 or 3 ##STR2## wherein one of the groups R.sub.8, R.sub.9 and R.sub.10 is hydrogen, (1-C)alkyl, (3-6 C)cycloalkyl, (3-4 C)alkenyl or (3-4 C)alkynyl and the two other groups, independently of each other, are hydrogen or (1-4 C)alkyl, and the pharmacologically acceptable acid addition salts thereof, which are pharmaceutically useful as strong and selective antagonists of "neuronal" 5-hydroxy tryptamine (5-HT) receptors.