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51 条记录 (耗时 0.011 秒)

    Diazepinoindoles
    42.
    发明授权
    Diazepinoindoles 失效
    地西泮吲哚

    公开(公告)号：US3867374A

    公开(公告)日：1975-02-18

    申请号：US82872769

    申请日：1969-05-28

    申请人： MCNEILAB INC

    发明人： REYNOLDS BRIAN E ,  CARSON JOHN R

    IPC分类号： C07D487/04 ,  C07D53/02

    CPC分类号： C07D487/04

    摘要： Compounds of the class of 2,3,4,5-tetrahydro-1H-1,4diazepino(1,2a)indoles useful for their pharmacological properties and novel intermediates used in the syntheses thereof. The 2,3,4,5-tetrahydro-1H-1,4-diazepino (1,2a) indoles are useful agents for lowering blood pressure.

    摘要翻译： 可用于其药理学性质的2,3,4,5-四氢-1H-1,4-二氮杂[1,2a]吲哚类化合物和用于其合成的新中间体。 2,3,4,5-四氢-1H-1,4-二氮杂[1,2a]吲哚是降低血压的有用试剂。

    Tetrahydro diazepinones and their preparation from hydrazines and delta-carbonylacids
    44.
    发明授权
    Tetrahydro diazepinones and their preparation from hydrazines and delta-carbonylacids 失效
    四氢番茄红素及其制备从水解和三羧酸的方法

    公开(公告)号：US3790563A

    公开(公告)日：1974-02-05

    申请号：US3790563D

    申请日：1971-12-16

    申请人： SYNTHELABO

    发明人： WERMUTH C ,  CAHN J

    IPC分类号： C07C59/84 ,  C07C59/88 ,  C07C59/90 ,  C07D53/02

    CPC分类号： C07C59/84 ,  C07C59/88 ,  C07C59/90

    摘要： A HYDRAZINE IS REACTED WITH A O-CARBONYL ACID TO PROVIDE 2,3,5,6-TETRAHYDRO-4H-1,2-DIAZEPINE-3-ONES OF THE FORMULA

    2-R,3-(O=),4-R1,5-R2,6-R3,7-AR-2,3,5,6-TETRAHYDRO

    4H-1,2-DIAZEPINE

    WHEREIN AR IS PHENYL, TOLYL, HALOPHENYL, METHOXYPHENYL, NAPHTHYL, OR THIENYL, R IS HYDROGEN, LOWER ALKYL, CARBOXYL (LOWER ALKYL), DI(LOWER ALKYL) AMINO (LOWER ALKYL), MORPHOLINO(LOWER ALKYL) OR PYRROLIDINO(LOWER ALKYL), AND EACH OF R1, R2 AND R3 IS INDEPENDENTLY HYDROGEN, LOWER ALKYL, OR A PHENYL GROUP, AND THE PHARMACEUTICALLY ACCEPTABLE SALTS AND QUANTERNARY AMMONIUM DERIVATIVES THEREOF. THE COMPOUNDS ARE USEFUL IN PHAROACEUTICAL CHEMISTRY, HAVING BEEN FOUND PARTICULARYL USEFUL AS PSYCHOTROPIC AGENTS.

    Derivatives of dibenzo(b,e)(1,4)diazepin-11(10)-one
    46.
    发明授权
    Derivatives of dibenzo(b,e)(1,4)diazepin-11(10)-one 失效
    二苯并（B，E）（1,4）DIAZEPIN-11（10） - 酮的衍生物

    公开(公告)号：US3565889A

    公开(公告)日：1971-02-23

    申请号：US3565889D

    申请日：1968-03-14

    申请人： TANABE SEIYAKU CO

    发明人： KUGITA HIROSHI ,  TAKEDA MIKIO ,  MATSUBARA MITSURU

    IPC分类号： C07D243/38 ,  C07D53/02

    CPC分类号： C07D243/38

    摘要： NOVEL 8-ALKYLSULFONYL DERIVATIVES OF 5-METHYL-10-(W-DIALKYLAMINOALKYL)-5H-DIBENZO(B,E)(1,4)DIAZEPIN - 11(10ONE REPRESENTED BY THE FORMULA:

    5-CH3,8-(R-SO2-),10-(R''-N(-R")-CNH2N-)-5H-DIBENZO(B,E)-

    (1,4)DIAZEPIN-11(10H)-ONE

    WHEREIN R, R'' AND R" ARE LOWER ALKYL AND N IS 2 OR 3, WHICH ARE USEFUL AS ANTIDEPRESSANT HAVING LOW TOXICITY, PREPARED BY THE REACTION OF THE CORRESPONDING 10-UNSUBSTITUTED-DIBENZODIAZEPIN-11(10)-ONE COMPOUNDS WITH AN W-DIALKYLAMINOALKYL HALIDE.

    Tetrahydrobenzothienodiazepinone compounds
    47.
    发明授权
    Tetrahydrobenzothienodiazepinone compounds 失效
    四氢苯并噻唑酮酮化合物

    公开(公告)号：US3558606A

    公开(公告)日：1971-01-26

    申请号：US3558606D

    申请日：1969-09-02

    申请人： PARKE DAVIS & CO

    发明人： TINNEY FRANCIS J

    IPC分类号： C07D307/36 ,  C07D307/38 ,  C07D307/42 ,  C07D307/79 ,  C07D307/92 ,  C07D333/08 ,  C07D333/24 ,  C07D333/54 ,  C07D333/56 ,  C07D333/58 ,  C07D333/66 ,  C07D333/74 ,  C07D339/08 ,  C07D495/04 ,  C08K5/00 ,  C07D53/02 ,  C07D63/18

    CPC分类号： C07D307/38 ,  C07D307/36 ,  C07D307/42 ,  C07D307/79 ,  C07D307/92 ,  C07D333/08 ,  C07D333/24 ,  C07D333/54 ,  C07D333/56 ,  C07D333/58 ,  C07D333/66 ,  C07D333/74 ,  C07D339/08 ,  C07D495/04 ,  C08K5/005

    摘要： AND SALTS THEREOF; WHERE R1 IS HYDROGEN OR METHYL, AND AR IS PHENYL, O-FLUOROPHENYL, O-CHLOROPHENYL, OR 2-TRIENYL; AND THEIR PRODUCTION BY (A) REACTING A 3-AROYL-2-(2-HALOACETAMIDO)TETRAHYDROBENZOTHIOPHENE OR A SALT THEREOF WITH AMMONIA, (B) REACTING A 3-AROYL-2-(2-PHTHALIMIDOACETAMIDO)TETRAHYDROBENZOTHIOPHENE WITH ANHYDROUS HYDRAZINE, (C) REACTING A 2-(2-AMINOACETAMIDO)-3-AROYLTETRAHYDROBENZOTHIOPHENE SALT WITH A BASE, AND (D) REACTING ONE OF THE TETRAHYDROBENZOTHIENODIAZEPINONE COMPOUNDS WHEREIN R1 IS HYDROGEN WITH A METHHLATING AGENT IN THE PRESENCE OF A BASE. THE COMPOUNDS OF THE INVENTION ARE USEFUL AS ANTICONVULSANT AND ANTI-ANXIETY AGENTS.

    1,4-DIAZEPIN-2-ONE

    1-R1,5-AR-2,3,6,7,8,9-HEXAHYDRO-1H-1-BENZOTHIENO(2,3-E)-

    TETRAHYDROBENZOTHIENODIAZEPINONE COMPOUNDS HAVING THE FORMULA

    摘要翻译： 本发明涉及一类新化合物以及制备这些化合物的新方法。 （A）含有至少一个具有至少一个环氧原子和/或一个环硫原子的五元至六元杂环，（b）至少一个环状氧原子和/或一个环硫原子的五元至六元杂环， 没有可以被碱金属取代的环氮原子和氢原子，（c）通过环碳原子与B1的环碳原子键合，或者具有与两个相邻的环碳共同的两个相邻的环碳原子 B1的原子，其中（a）B1表示苯环或含有5〜6个环成员的芳香族杂环，允许这些环含有进一步缩合的芳香族，杂环或芳族五元至六元环 但优选只有一个这样的环，和（b）v表示1至2的整数，和（c）其中m表示在A1和B1之间的单键情况下从1至4的整数，以及 表示情况o中的数字1或2 f环A1和B1彼此稠合，并且其中E1表示含有五至六个环成员的芳族碳环或杂环体系，其可以含有碳环或杂环性质的进一步缩合的芳族或芳香族环系统，并且可以含有 芳族，芳脂族，脂环族，脂族或其他非发色取代基，甲基除外，其能够在碱金属离子存在下形成碳负离子。

    Process for preparing substituted hexahydro-1,4-diazepines
    48.
    发明授权
    Process for preparing substituted hexahydro-1,4-diazepines 失效
    制备取代的十六氢-1,4-二氮杂的方法

    公开(公告)号：US3557086A

    公开(公告)日：1971-01-19

    申请号：US3557086D

    申请日：1966-11-03

    申请人： MONTEDISON SPA

    发明人： CANTATORE GIUSEPPE ,  BONVICINI ALBERTO

    IPC分类号： C07D243/08 ,  C07D53/02

    CPC分类号： C07D243/08

    摘要： ALKYL SUBSTITUTED HEXAHYDRO-1,4-DIAZEPINES HAVING THE FORMULA

    2,2,3,3,5,5,6,6,7,7-DECA(R-)HEXAHYDRO-1,4-DIAZEPINE

    WHEREIN THE R SUBSTITUENTS ARE THE SAME OR DIFFERENT AND ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN ATOMS AND ALKYL GROUPS CONTAINING 1 TO 18 CARBON ATOMS ARE PREPARED BY REACTING AN ETHYLENE-DIAMINE WITH AN ALIPHATIC ALPHA-BETA UNSATURATED ALDEHYDE OR KETON AND THEN CATALYTICALLY HYDROGENATING THE REACTION MIXTURE. NOVEL ALKYL SUBSTITUTED HEXAHYDRO-1,4-DIAZEPINES ARE DISCLOSED.