利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

138 条记录 (耗时 0.029 秒)

    Method for preparing intermediate of 4-methoxypyrrole derivative
    52.
    发明授权
    Method for preparing intermediate of 4-methoxypyrrole derivative 有权

    公开(公告)号：US11345660B2

    公开(公告)日：2022-05-31

    申请号：US16608924

    申请日：2018-06-21

    申请人： Daewoong Pharmaceutical Co., Ltd.

    发明人： Jeong-Taek Shin ,  Jeong-Hyun Son ,  Seung Chul Lee

    IPC分类号： C07D207/36

    摘要： The present invention relates to a method for preparing intermediates of 4-methoxypyrrole derivatives. The preparation method according to the present invention has advantages that the production cost can be lowered by using inexpensive starting materials, a high-temperature reaction is not required as a whole, inexpensive and non-explosive reagents are used instead of (trimethylsilyl)diazomethane, and further an intermediate of 4-methoxypyrrole derivatives can be prepared as a whole at a high yield.

    TWO-CHAMBER TYPE COMBINED CONTAINER-SYRINGE
    56.
    发明申请
    TWO-CHAMBER TYPE COMBINED CONTAINER-SYRINGE 有权

    公开(公告)号：US20210322272A1

    公开(公告)日：2021-10-21

    申请号：US17253667

    申请日：2018-11-27

    申请人： DAEWOONG PHARMACEUTICAL CO., LTD.

    发明人： Duck Soo Lim ,  Jun Sik Kim ,  Tae Ho Lee ,  Sung Hoon Park

    IPC分类号： A61J1/20

    摘要： The present invention provides a two-chamber type combined container-syringe including: a cylinder having a first end portion, a second end portion in an opposite direction of the first end portion, and a bypass portion disposed between the first end portion and the second end portion; a finger grip mounted on the second end portion of the cylinder; a first stopper, a second stopper, and a third stopper that are sequentially disposed from the first end portion toward the second end portion in a space of the cylinder; and a plunger rod that is connected to the third stopper and has a plurality of support ribs provided to come in contact with an inner surface of the finger grip, wherein a space between the first stopper and the second stopper forms a front chamber, a space between the second stopper and the third stopper forms a rear chamber, a first ingredient and a second ingredient are accommodated in the front chamber and the rear chamber, respectively, a length ratio of the front chamber and the rear chamber is in a range of 1.6:1 to 3:1 when the plunger rod is at an initial position which is a state before the front chamber and the rear chamber communicate with each other through the bypass portion, and at the initial position, one or more support ribs are disposed in at least one of the finger grip and a region in the cylinder that is adjacent to the finger grip.

    METHOD FOR PRODUCING INTERMEDIATE USEFUL FOR SYNTHESIS OF SGLT INHIBITOR
    57.
    发明申请
    METHOD FOR PRODUCING INTERMEDIATE USEFUL FOR SYNTHESIS OF SGLT INHIBITOR 有权

    公开(公告)号：US20210292291A1

    公开(公告)日：2021-09-23

    申请号：US17266844

    申请日：2019-08-09

    申请人： Daewoong Pharmaceutical Co., Ltd.

    发明人： Qing Ri LI ,  Hee Kyoon YOON

    IPC分类号： C07D307/79

    摘要： A method of preparing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as an SGLT inhibitor is described. A method of synthesizing a compound of Formula 7 can address problems of existing synthesis processes requiring the synthesis of the Grignard reagent and management of related substances. In addition, the method can minimize the generation of related substances, and thus does not require reprocessing of reaction products, thereby simplifying the process. Accordingly, the production yield of a diphenylmethane derivative can be maximized.

    Composition for dermal injection
    58.
    发明授权
    Composition for dermal injection 有权

    公开(公告)号：US11116715B2

    公开(公告)日：2021-09-14

    申请号：US16489363

    申请日：2018-02-27

    申请人： CG Bio Co., Ltd. ,  DNCompany ,  Daewoong Pharmaceutical Co., Ltd.

    发明人： Ji Sun Lee ,  Su Hyun Jung ,  Hak Su Jang ,  Jung Eun Choo ,  Hye Young Jung

    IPC分类号： A61K8/73 ,  A61K8/64 ,  A61Q19/08

    摘要： The present invention relates to a composition for dermal injection which includes two or more types of cross-linked hyaluronic acid particles having different particle diameters and non-cross-linked hyaluronic acid. The composition for dermal injection according to the present invention satisfies viscosity, extrusion force, and viscoelasticity conditions for dermal injection, and an extrusion force deviation is low so that the user does not feel fatigue when the composition is injected into the dermal thereof. Also, the composition is excellent in viscoelasticity and tissue restoring ability, is maintained for a long period of time, allows rapid recovery because an initial swelling degree is low, and also is excellent in safety and stability in the body.