公开(公告)号：US20230132385A9

公开(公告)日：2023-04-27

申请号：US17278261

申请日：2019-09-20

Applicant: Tikcro Technologies Ltd. ,  Yeda Research and Development Co. Ltd.

Inventor： Ami Navon ,  Aviv Boim ,  Ariel Stanhill ,  Leehee Weinberger ,  Yuval Avnir

IPC: C07K16/28

Abstract: Disclosed herein are anti-CTLA-4 antibodies possessing superior binding and biological activities relative to ipibmumab and tremelimumab, pharmaceutical compositions comprising such. Also provided herein are therapeutic and diagnostic applications of such anti-CTLA-4 antibodies.

公开(公告)号：US20230076246A1

公开(公告)日：2023-03-09

申请号：US17800245

申请日：2020-02-17

Applicant: Yeda Research and Development Co. Ltd. ,  Mor Research Applications Ltd.

Inventor： Eran SEGAL ,  Smadar SHILO ,  Yotam AMAR

IPC: A61B5/00 ,  G06N3/08 ,  A61B5/145

Abstract: A method of predicting an analyte level comprises receiving a time-ordered series of levels of the analyte, monitored over a time-period; feeding a trained neural network procedure with the monitored levels; and displaying, based on an output received from the procedure, a predicted level of the analyte in a future time. The procedure can comprise a plurality of layers, wherein for at least one pair of layers, a number of inter-layer connections within the pair is higher for later monitored levels than for earlier monitored levels.

公开(公告)号：US20230072222A1

公开(公告)日：2023-03-09

申请号：US17583378

申请日：2022-01-25

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD

Inventor： Helena SHOMAR MONGES ,  Rotem SOREK ,  Lianet NODA GARCIA ,  Arthur MACHLENKIN ,  David SPERANDIO

IPC: C07H19/20 ,  C07H19/10 ,  A61P31/14

Abstract: Disclosed herein are 3, 4-didehydro- and 3′-deoxy-3, 4-didehydro-compounds and pharmaceutical compositions thereof. Methods of use of these pharmaceutical compositions include those for treating diseases including virus-induced diseases, cancer, autoimmune diseases, immune disorders, and bacterial-associated diseases or infections, or combinations thereof. Examples of viral-induced diseases include viral infections by RNA or DNA viruses, for example SAR-CoV-2, EBV, BKV, JCV and HCMV.

公开(公告)号：US11600264B2

公开(公告)日：2023-03-07

申请号：US16767110

申请日：2018-11-26

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Elisha Moses ,  Tirza Biron ,  Dominik Freche ,  Daniel Baum ,  Nadav Matalon ,  Netanel Ehrmann ,  Eyal Weinreb

IPC: G10L15/22 ,  G10L15/18 ,  G10L15/02 ,  G10L15/05

Abstract: A prosodic speech recognition engine configured to identify prosodic features and patterns in a speech continuum for the extraction of linguistic content including para-syntactic content, discourse function, information structure, meaning, and speaker sentiment.

公开(公告)号：US11593638B2

公开(公告)日：2023-02-28

申请号：US16412675

申请日：2019-05-15

Applicant: New York University ,  Yeda Research And Development Co. Ltd.

Inventor： Itay Kezurer ,  Yoram Eshel ,  Achiau Ludomirsky ,  Yaron Lipman

IPC: G06N3/08 ,  G06T7/00 ,  A61B8/00 ,  G06T3/20 ,  G06T11/00 ,  G16H30/40 ,  A61B5/00 ,  A61B8/13 ,  G09B23/28 ,  G06T3/60

Abstract: A downloadable navigator for a mobile ultrasound unit having an ultrasound probe, implemented on a portable computing device. The navigator includes a trained orientation neural network to receive a non-canonical image of a body part from the mobile ultrasound unit and to generate a transformation associated with the non-canonical image, the transformation transforming from a position and rotation associated with a canonical image to a position and rotation associated with the non-canonical image; and a result converter to convert the transformation into orientation instructions for a user of the probe and to provide and display the orientation instructions to the user to change the position and rotation of the probe.

公开(公告)号：US20220392571A1

公开(公告)日：2022-12-08

申请号：US17884594

申请日：2022-08-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Amos TANAY ,  Amir GILADI ,  Merav COHEN

IPC: G16B25/10

Abstract: A method of determining cell members of a cell cluster in a tissue of interest is disclosed. The cell members physically interact with one another in the cell cluster. Computer software products capable of carrying out the method are also disclosed.

公开(公告)号：US11491301B2

公开(公告)日：2022-11-08

申请号：US16545007

申请日：2019-08-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Anat Arzi ,  Lee Sela ,  Anton Plotkin ,  Aharon Weissbrod ,  Noam Sobel

IPC: A61M16/00 ,  A61M21/02 ,  A61M16/10 ,  A61M15/08 ,  A61M21/00

Abstract: A device for controlling respiration during sleep based on the user physiological characteristic. The device includes an odor disperser for dispersing an odor; at least one detector for detecting a physiological characteristic of a user; and a controller for controlling respiration of the user by instructing the odor dispenser to disperse an odor responsive to detections by the at least one detector.

公开(公告)号：US20220328185A1

公开(公告)日：2022-10-13

申请号：US17614024

申请日：2020-05-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran SEGAL ,  Smadar SHILO ,  Nitzan ARTZI

IPC: G16H50/20 ,  G16H50/30 ,  G16H10/60 ,  G16H50/70 ,  G16H10/20

Abstract: A method of predicting likelihood for gestational diabetes, comprises: obtaining a plurality of parameters characterizing a female subject, accessing a computer readable medium storing a machine learning procedure trained for predicting likelihoods for gestational diabetes, feeding the procedure with the plurality of parameters, and receiving from the procedure an output indicative of a likelihood that the subject has, or expected to develop, gestational diabetes, wherein the output indicative is related non-linearly to the parameters.

公开(公告)号：US20220314221A1

公开(公告)日：2022-10-06

申请号：US17839667

申请日：2022-06-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Roy BAR-ZIV ,  Eyal KARZBRUN ,  Alexandra TAYAR

IPC: B01L3/00 ,  C12P21/02 ,  B01J19/00

Abstract: A microfluidic device is disclosed which comprises: (i) at least one reaction unit having a test chamber connected to at least one microchannel, wherein a surface of at least a portion of said reaction unit is attached to an isolated nucleic acid; and (ii) a flow-through channel having at least one inlet port and at least one outlet port, said flow-through channel and said microchannel being of dimensions to allow reactant diffusion to and from said reaction unit, wherein the diffusion time of said reactant along the microchannel is shorter than the flow time along the microchannel.

公开(公告)号：US20220265726A1

公开(公告)日：2022-08-25

申请号：US17737052

申请日：2022-05-05

Applicant: Yeda Research and Development Co. Ltd. ,  Board of Regents, The University of Texas System

Inventor： Yair REISNER ,  Aloukick Kumar SINGH

IPC: A61K35/28 ,  A61K35/17 ,  A61P7/00 ,  A61P37/06 ,  A61K45/06

Abstract: A method of treating or preventing a sickle cell disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting immature hematopoietic cells into the subject; and (b) administering to the subject a therapeutically effective amount of an isolated population of non-GVHD inducing anti-third party cells comprising cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and capable of homing to the lymph nodes following transplantation.