-
51.发明授权公开(公告)号：US11746318B2
公开(公告)日：2023-09-05
申请号：US16347147
申请日：2017-11-03
发明人： Klearchos K. Papas
CPC分类号： C12M41/34 , C12M25/02 , C12M29/00 , C12M41/18 , C12M41/26 , C12M41/32 , C12N5/0676 , C12N2500/02
摘要： Methods and systems for measuring viability and function of islet cells or stem cell-derived beta cells in an implantable device featuring setting the temperature of the cells in the implantable device to a low temperature to reduce metabolic levels of the cells and reduce oxygen requirements of the cells, and measuring oxygen consumption rates. An oxygen sensor at the inlet of the implantable device and an oxygen sensor at the outlet of the implantable device are used to calculate oxygen consumption rates of the cells, which in turn are indicative of viability. The reduction in temperature can also be used for loading cells into the implantable devices to help reduce ischemic and/or physical injury. The present invention may be used with other cell types, e.g. hepatocytes, heart cells, muscle cells, etc.
-
公开(公告)号：US20230250094A1
公开(公告)日：2023-08-10
申请号：US18015775
申请日：2021-07-15
发明人： May Khanna , Vijay Gokhale , Liberty Francois-Moutal , David Scott , Haley Williams , Judith Tello , Niloufar Mollasalehi
IPC分类号： C07D413/12
CPC分类号： C07D413/12
摘要： This invention is in the field of medicinal pharmacology. In particular, the present invention relates to pharmaceutical agents which function as inhibitors of TDP-43 activity. The invention further relates to methods of treating and/or ameliorating symptoms related to conditions associated with TDP-43 activity (e.g., neurodevelopmental disorders), comprising administering to a subject (e.g., a human patient) a composition comprising one or more pharmaceutical agents which function as inhibitors of TDP-43 activity.
-
公开(公告)号：US20230235280A1
公开(公告)日：2023-07-27
申请号：US17768146
申请日：2020-10-09
IPC分类号： C12N5/0735 , C12N15/10 , C12N15/86
CPC分类号： C12N5/0606 , C12N15/102 , C12N15/86 , C12N2501/599 , C12N2506/02 , C12N2510/00 , C12N2750/14143
摘要： The present invention provides modified stem cells (SCs) and use of the SCs to treat disease.
-
公开(公告)号：US11703617B2
公开(公告)日：2023-07-18
申请号：US17100133
申请日：2020-11-20
发明人： Erol Ozgur , Daniel Reetz , Farhad Akhoundi , Gholam Peyman
CPC分类号： G02B3/14 , A61B3/0285 , A61B3/04 , G02B3/06 , G02B2003/0093 , G02C7/022
摘要： The invention relates to cylindrical tunable fluidic lenses. The cylindrical optical power of the lenses may be continuously tuned within at least ±10 diopters, without inducing any significant spherical aberration, or any other significant aberrations. The lenses feature a geometry that produces minimal or no spherical defocus. These cylindrical tunable fluidic lenses could be used to induce and/or correct cylindrical optical aberrations in adaptive optical systems, particularly in ophthalmologic applications related to objective and automatic assessment of the refractive error of the eye, without the need of receiving feedback from the subjects.
-
55.发明公开公开(公告)号：US20230221557A1
公开(公告)日：2023-07-13
申请号：US17927332
申请日：2021-05-24
发明人： Hong Hua , Miaomiao XU
CPC分类号： G02B27/0172 , G02B30/10 , G02B6/005 , G02B2027/0134 , G02B2027/0123
摘要： A head-mounted lightfield display including a lightfield rendering unit, a numerical aperture (NA) expander for receiving an optical output from the lightfield rendering unit and for creating an expanded lightfield, and a substrate-guided optical combiner optically coupled to the NA expander for receiving the expanded lightfield and transmitting the expanded light field to an eyebox for viewing by a user.
-
56.发明授权公开(公告)号：US11698494B2
公开(公告)日：2023-07-11
申请号：US17430218
申请日：2020-02-11
发明人： Judith Su , Shuang Hao , Gwangho Choi
CPC分类号： G02B6/29341 , G01N21/7746
摘要： A miniaturized integrated frequency locked optical whispering evanescent resonator comprises: an optical source; an optical path having a first end and a second end, the optical path coupled to the optical source at the first end; an optical resonator disposed along a side of the optical path between the first and second ends, the optical resonator coupled to the optical path through an evanescent field to excite an optical whispering-gallery mode; an optical receiver coupled to the second end of the optical path; and a digital data processor configured to communicate with the optical receiver and the optical source, wherein the digital data processor comprises a frequency locking system and a data acquisition system, wherein the frequency locking system tunes the frequency of the optical source to the optical whispering-gallery mode of the optical resonator, and wherein the resonator weighs less than 15 kg and is containable within a volume less than 30 liters.
-
公开(公告)号：US11692226B2
公开(公告)日：2023-07-04
申请号：US16635233
申请日：2018-07-31
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , ARIZONA BOARD OF REGENTS ON BEHALF OF THE NORTHERN ARIZONA UNIVERSITY
IPC分类号： C12Q1/6883
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/178
摘要： The invention disclosed herein generally relates to genotyping one or more single nucleotide polymorphisms (SNPs) to stratify cancer risk and/or prognosis.
-
公开(公告)号：US11674005B2
公开(公告)日：2023-06-13
申请号：US16622875
申请日：2018-06-14
发明人： Dong-Chul Pyun , Richard S. Glass , Kyle Carothers , Yueyan Zhang
IPC分类号： C08J3/26 , C08G75/0209 , C08G75/0222
CPC分类号： C08J3/26 , C08G75/0209 , C08G75/0222 , C08J2309/10
摘要： Methods of vulcanization using a high content sulfur polymer, instead of elemental sulfur, have been developed. These high sulfur content polymers are referred to as Chalcogenide Hybrid Inorganic/Organic Polymers (CHIP) materials and have good polymer compatibility in that they are soluble in a number of polymers. Furthermore, CHIP materials may have weaker bonds than the S—S bonds of elemental sulfur and thus provide for a higher crosslinking efficiency vulcanization.
-
公开(公告)号：US11668699B2
公开(公告)日：2023-06-06
申请号：US16918352
申请日：2020-07-01
发明人： Marvin J. Slepian , Sui Ling Leung
IPC分类号： C12M3/00 , B01L3/00 , G01N33/00 , G01N33/483 , G01N15/10 , G01N15/14 , B03C5/00 , B03C5/02 , G01N15/00
CPC分类号： G01N33/4836 , B01L3/502761 , G01N15/1031 , G01N15/1463 , B01L2200/0663 , B01L2300/0645 , B01L2400/0424 , B03C5/005 , B03C5/026 , B03C2201/26 , G01N2015/0084 , G01N2015/1006 , G01N2015/1495
摘要： Provided herein are systems and method for measuring cell stiffness. In particular, provided herein are microelectrode configuration and systems for measuring platelet deformation and stiffness.
-
公开(公告)号：US20230146937A1
公开(公告)日：2023-05-11
申请号：US17906541
申请日：2021-04-09
发明人： Frank Porreca , Hisakatsu Ito , Edita Navratilova
IPC分类号： A61K31/485 , A61K31/4709 , A61K31/40 , A61P25/20 , A61P25/04
CPC分类号： A61K31/485 , A61K31/4709 , A61K31/40 , A61P25/20 , A61P25/04
摘要： Chronic pain patients complain about sleep disturbance with a high probability, while sleep loss increases pain in chronic pain patients. Sleep problems and pain promote a vicious spiral, suggesting a need for simultaneous treatment of both. The present invention provides a method to treat pain-related sleep disorders through distribution of a therapeutic amount of a KOR antagonist. The use of KOR antagonist could be a novel therapeutic agent for sleep disturbance in chronic pain patients. Additionally, KOR antagonists could be used to improve sleep in other conditions, such as depression or general anxiety disorder, where KOR signaling is induced.
-
-
-
-
-
-
-
-
-
搜索结果
1526 条记录 (耗时 0.04 秒)
