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    VISTA regulatory T cell mediator protein, VISTA binding agents and use thereof
    52.
    发明授权
    VISTA regulatory T cell mediator protein, VISTA binding agents and use thereof 有权

    公开(公告)号：US10781254B2

    公开(公告)日：2020-09-22

    申请号：US15467118

    申请日：2017-03-23

    申请人： The Trustees of Dartmouth College

    发明人： Randolph J. Noelle ,  Lili Wang

    IPC分类号： C07K14/705 ,  C12N15/86 ,  A61K48/00 ,  C07K16/28 ,  A61K39/00

    摘要： The present invention relates to a novel regulatory T cell protein. This protein, designated PD-L3 OR VISTA resembles members of the PD-L1 family, identified a novel and structurally-distinct, Ig-superfamily inhibitory ligand, whose extracellular domain bears homology to the B7 family ligand PD-L1. This molecule is designated as PD-L3 OR VISTA or V-domain Immunoglobulin Suppressor of T cell Activation (VISTA). Expression of VISTA is primarily within the hematopoietic compartment and is highly regulated on myeloid APCs and T cells. Therapeutic intervention of the VISTA inhibitory pathway represents a novel approach to modulate T cell-mediated immunity for the treatment of a wide variety of cancers, e.g., ovarian, bladder cancer and melanomas. Also, VISTA proteins, especially multimeric VISTA proteins and antibodies may be used to suppress T cell immunity in autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis and artritic conditions such as RA.

    Systems and methods for providing a sound masking environment
    55.
    发明授权
    Systems and methods for providing a sound masking environment 有权

    公开(公告)号：US10645908B2

    公开(公告)日：2020-05-12

    申请号：US16266781

    申请日：2019-02-04

    申请人： Radio Systems Corporation

    发明人： Richard Alan Seltzer ,  Jon Huber ,  Geoffrey Kyle Gift

    IPC分类号： G08B23/00 ,  A01K29/00 ,  A01K27/00 ,  A61B5/16 ,  A61B5/00 ,  G10L21/0232 ,  G10K11/175 ,  G10L25/51 ,  G10K11/178

    摘要： A system is described herein that comprises a collar device including a sound masking component, the collar device including one or more collar device sensors for detecting physiological data of an animal. The system includes one or more environmental sensors configured to detect environmental data of the animal's environment and to transmit the environmental data to the collar device. The collar device comprises one or more applications running on at least one processor for detecting an occurrence of one or more events using at least one of the physiological data, the environmental data, and outcome data. The one or more applications are configured to use information of the one or more events to select a sound masking signal for delivery after the occurrence of the one or more events The system includes a sound masking component for delivering the sound masking signal.

    Integrated dog tracking and stimulus delivery system
    60.
    发明授权
    Integrated dog tracking and stimulus delivery system 有权

    公开(公告)号：US10154651B2

    公开(公告)日：2018-12-18

    申请号：US14340493

    申请日：2014-07-24

    申请人： Radio Systems Corporation

    发明人： Brent Goetzl ,  Harri Piltonen ,  Jason Edwards ,  Kevin Zinn ,  Kenneth Wacasey

    IPC分类号： A01K15/02 ,  A01K27/00

    摘要： A system and apparatus to track and control an animal is described, including a tracking unit to track the animal, and a stimulus unit to provide a stimulus to the animal, wherein the tracking unit and stimulus unit are configured to be coupled together. The stimulus unit is entirely a slave device to the tracking unit and has no independent smart circuitry, no independent power supply and no antennae. Accordingly, the stimulation unit is dependent upon the tracking unit for operation, power and for communication to and from a remote hand held control device.