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公开(公告)号：US20090176769A1
公开(公告)日：2009-07-09
申请号：US11955874
申请日：2007-12-13
申请人： Corey Anderson , Andreas Termin , Sara Hadida-Ruah , Pramod Joshi , Sanghee Yoo , Daniele Bergeron , Hayley Binch , Jon Come , Jingrong Cao , Suganthi Nanthakumar , Elaine Krueger , John Maxwell , Arnaud Le Tiran , Yusheng Liao
发明人： Corey Anderson , Andreas Termin , Sara Hadida-Ruah , Pramod Joshi , Sanghee Yoo , Daniele Bergeron , Hayley Binch , Jon Come , Jingrong Cao , Suganthi Nanthakumar , Elaine Krueger , John Maxwell , Arnaud Le Tiran , Yusheng Liao
IPC分类号： A61K31/551 , C07D417/14 , C07D471/04 , A61K31/496 , A61K31/437 , A61P25/06 , A61P19/02
CPC分类号： C07D277/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D471/10 , C07D498/10 , C07D513/10
摘要： The present invention relates to CGRP receptor antagonists, pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions.
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公开(公告)号：US20080255147A1
公开(公告)日：2008-10-16
申请号：US11441487
申请日：2006-05-26
申请人： Dean Wilson , Andreas Termin , Lev T.D. Fanning , Paul Krenitsky , Pramod Joshi
发明人： Dean Wilson , Andreas Termin , Lev T.D. Fanning , Paul Krenitsky , Pramod Joshi
IPC分类号： A61K31/496 , A61K31/454 , C07D417/04 , A61P25/00 , C07D417/14
CPC分类号： C07D277/38 , C07D285/08 , C07D417/04
摘要： The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20080167305A1
公开(公告)日：2008-07-10
申请号：US12050289
申请日：2008-03-18
申请人： Dean Wilson , Lev T.D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
发明人： Dean Wilson , Lev T.D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
IPC分类号： A61K31/5377 , A61K31/517 , C07D413/14 , C07D403/14
CPC分类号： C07D403/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20080119453A1
公开(公告)日：2008-05-22
申请号：US11432997
申请日：2006-05-12
申请人： Andreas Termin , Nicole Zimmermann , Tara Leanne Knoll , Gabriel Martinez Botella , Esther Martinborough
发明人： Andreas Termin , Nicole Zimmermann , Tara Leanne Knoll , Gabriel Martinez Botella , Esther Martinborough
IPC分类号： A61K31/55 , A61P23/00 , C07D215/227 , A61K31/473 , C12N5/06 , C07D401/12 , A61K31/506 , C07D223/16
CPC分类号： C07D417/12 , C07D401/12
摘要： The present invention relates to bicyclic compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的双环化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20070287717A1
公开(公告)日：2007-12-13
申请号：US11811909
申请日：2007-06-12
申请人： Lev Fanning , Pramod Joshi , Paul Krenitsky , Andreas Termin , Dean Wilson , Yulian Zhang
发明人： Lev Fanning , Pramod Joshi , Paul Krenitsky , Andreas Termin , Dean Wilson , Yulian Zhang
IPC分类号： A61K31/519 , C07D498/14 , C07D498/02
CPC分类号： C07D495/14 , C07D333/20 , C07D495/04
摘要： The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20070203130A1
公开(公告)日：2007-08-30
申请号：US11517754
申请日：2006-09-08
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/53 , A61K31/501 , A61K31/497 , A61K31/496 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D417/12 , C07D277/52
摘要： Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译： 本文公开了用作离子通道拮抗剂的双环衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
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公开(公告)号：US20070099873A1
公开(公告)日：2007-05-03
申请号：US11434677
申请日：2006-05-15
申请人： Andreas Termin , Dean Wilson , Pramod Joshi
发明人： Andreas Termin , Dean Wilson , Pramod Joshi
IPC分类号： A61K31/675 , C07D215/38 , A61K31/496 , A61K31/4709 , C07D403/02 , C07D401/02
CPC分类号： C07D215/38 , C07D217/22 , C07D401/02 , C07D401/04 , C07D403/02
摘要： The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20050049247A1
公开(公告)日：2005-03-03
申请号：US10884865
申请日：2004-07-02
申请人： Dean Wilson , Esther Martinborough , Timothy Neubert , Andreas Termin , Jesus Gonzalez , Nicole Zimmerman
发明人： Dean Wilson , Esther Martinborough , Timothy Neubert , Andreas Termin , Jesus Gonzalez , Nicole Zimmerman
IPC分类号： C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/04 , A61K31/541 , A61K31/506 , A61K31/5377 , C07D413/14 , C07D417/14 , C07D43/14
CPC分类号： C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US06593351B2
公开(公告)日：2003-07-15
申请号：US09887479
申请日：2001-06-22
申请人： Kevin Koch , Andreas Termin , John A. Josey
发明人： Kevin Koch , Andreas Termin , John A. Josey
IPC分类号： C07D21156
CPC分类号： C07D223/12
摘要： Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of inflamation, tissue degradation and related diseases. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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60.发明授权Carboxylic acid substituted heterocycles, derivatives thereof and methods of use 失效羧酸取代的杂环，其衍生物和使用方法公开(公告)号：US06291450B1
公开(公告)日：2001-09-18
申请号：US09588978
申请日：2000-06-07
申请人： Kevin Koch , Andreas Termin , John A. Josey
发明人： Kevin Koch , Andreas Termin , John A. Josey
IPC分类号： C07D40100
CPC分类号： C07D223/12
摘要： Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of inflamation, tissue degradation and related diseases. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 选择的新型羧酸取代的杂环化合物对预防和治疗炎症，组织降解，癌症，纤维化和相关疾病是有效的。 本发明包括新型化合物，类似物，前药和其药学上可接受的盐，用于预防和治疗炎症，组织降解和相关疾病的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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