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公开(公告)号：US20050187217A1
公开(公告)日：2005-08-25
申请号：US10912912
申请日：2004-08-05
申请人： Dean Wilson , Andreas Termin , Timothy Neubert , Jian Wang , Yulian Zhang , Jesus Gonzalez , Esther Martinborough , Nicole Zimmerman
发明人： Dean Wilson , Andreas Termin , Timothy Neubert , Jian Wang , Yulian Zhang , Jesus Gonzalez , Esther Martinborough , Nicole Zimmerman
IPC分类号： A61K31/517 , A61K31/5377 , A61P25/00 , A61P29/00 , C07D239/70 , C07D239/91 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D413/02 , C07D471/04 , C07D495/04 , C07D43/02
CPC分类号： C07D401/04 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20060217377A1
公开(公告)日：2006-09-28
申请号：US10935008
申请日：2004-09-02
申请人： Jesus Gonzalez , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Zimmerman
发明人： Jesus Gonzalez , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Zimmerman
IPC分类号： A61K31/5377 , A61K31/517 , C07D413/02 , C07D43/02
CPC分类号： C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20050049247A1
公开(公告)日：2005-03-03
申请号：US10884865
申请日：2004-07-02
申请人： Dean Wilson , Esther Martinborough , Timothy Neubert , Andreas Termin , Jesus Gonzalez , Nicole Zimmerman
发明人： Dean Wilson , Esther Martinborough , Timothy Neubert , Andreas Termin , Jesus Gonzalez , Nicole Zimmerman
IPC分类号： C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/04 , A61K31/541 , A61K31/506 , A61K31/5377 , C07D413/14 , C07D417/14 , C07D43/14
CPC分类号： C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20060025415A1
公开(公告)日：2006-02-02
申请号：US11060719
申请日：2005-02-17
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/502
CPC分类号： C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US20050137190A1
公开(公告)日：2005-06-23
申请号：US10914988
申请日：2004-08-09
IPC分类号： A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/46 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
CPC分类号： C07D417/14 , C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US08283354B2
公开(公告)日：2012-10-09
申请号：US11216376
申请日：2005-08-31
申请人： Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
发明人： Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
IPC分类号： A01N43/54 , A61K31/517 , C07D401/00
CPC分类号： C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20060173018A1
公开(公告)日：2006-08-03
申请号：US11216376
申请日：2005-08-31
申请人： Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
发明人： Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
IPC分类号： A61K31/517 , C07D403/04
CPC分类号： C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US20090312342A1
公开(公告)日：2009-12-17
申请号：US11367954
申请日：2006-03-03
申请人： Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
发明人： Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
IPC分类号： A61K31/496 , C07D403/12 , A61K31/517 , A61P29/00 , A61P19/02 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/24 , A61P25/28 , A61P25/22
CPC分类号： C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D493/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07928107B2
公开(公告)日：2011-04-19
申请号：US11367954
申请日：2006-03-03
申请人： Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
发明人： Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
IPC分类号： A61K31/496 , A61K31/517 , C07D239/94
CPC分类号： C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D493/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20070238733A1
公开(公告)日：2007-10-11
申请号：US11786166
申请日：2007-04-11
申请人： Pramod Joshi , Paul Krenitsky , Jesus Gonzalez , Jian Wang , Dean Wilson , Andreas Termin
发明人： Pramod Joshi , Paul Krenitsky , Jesus Gonzalez , Jian Wang , Dean Wilson , Andreas Termin
IPC分类号： A61K31/53 , A61K31/4965 , A61K31/505 , A61K31/501 , A61K31/44 , A61K31/433 , A61K31/4245 , A61K31/426 , A61K31/421
CPC分类号： C07C311/46 , C07C323/62 , C07D207/327 , C07D213/56 , C07D213/65 , C07D213/68 , C07D213/74 , C07D213/82 , C07D231/12 , C07D233/36 , C07D233/64 , C07D233/70 , C07D239/34 , C07D257/04 , C07D285/08 , C07D295/096 , C07D295/155 , C07D295/205 , C07D317/68
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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