摘要:
The present invention concerns substituted triazolone, tetrazolone and imidazolone derivatives according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1, having selective α2C-adrenoceptor antagonist activity. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of central nervous system disorders, mood disorders, anxiety disorders, stress-related disorders associated with depression and/or anxiety, cognitive disorders, personality disorders, schizoaffective disorders, Parkinson's disease, dementia of the Alzheimer's type, chronic pain conditions, neurodegenerative diseases, addiction disorders, mood disorders and sexual dysfunction.
摘要:
The present invention concerns substituted pyrazinone derivatives according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1, having selective α2C-adrenoceptor antagonist activity. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of central nervous system disorders, mood disorders, anxiety disorders, stress-related disorders associated with depression and/or anxiety, cognitive disorders, personality disorders, schizoaffective disorders, Parkinson's disease, dementia of the Alzheimer's type, chronic pain conditions, neurodegenerative diseases, addiction disorders, mood disorders and sexual dysfunction.
摘要:
Various operations are provided that improve the scalability of virtual TLBs in multi-processor virtual machines, and they include: implicitly locking SPTs using per-processor generation counters; waiting for pending fills on other virtual processors to complete before servicing a GVA invalidation using the counters; write-protecting or unmaping guest pages in a deferred two-stage process or reclaiming SPTs in a deferred two-stage process; periodically coalescing two SPTs that shadow the same GPT with the same attributes; sharing SPTs between two SASes only at a specified level in a SPTT; flushing the entire virtual TLB using a generation counter; allocating a SPT to GPT from a NUMA node on which the GPT resides; having an instance for each NUMA node on which a virtual machine runs; and, correctly handling the serializing instructions executed by a guest in a virtual machine with more than one virtual processor sharing the virtual TLB.
摘要:
Various operations are disclosed for improving the operational efficiency of interrupt handling in a virtualized environment. A virtualized interrupt controller may obviate the need for an explicit end-of-interrupt command by providing an automatic EOI capability even when a physical interrupt controller offers no such mechanism. The use of a message pending bit for inter-partition communications facilitates avoiding an EOI command of inter-processor interrupts used in inter-partition communications whenever no further messages are cued for a particular message slot. A virtualized interrupt controller facilitates the selective EOI of an interrupt even when it is not the highest priority in-service interrupt irrespective of whether a physical interrupt controller provides such functionality.
摘要:
To determine whether to deploy a candidate VM to a candidate host, taking into consideration resources available from the candidate host and resources required by the candidate VM, a sub-rating is calculated for each of several resources available from the candidate host, where the sub-rating for the resource corresponds to an amount of the resource that is free after the candidate VM is deployed to the candidate host. Thereafter, a rating is calculated from the calculated sub-ratings to characterize how well the candidate host can accommodate the candidate VM. The rating for the candidate host are presented to a selector that determines whether to deploy the candidate VM to the candidate host based on the rating thereof.
摘要:
A machine for treating soil which includes a holding structure supported on two wheels mounted centrally of the rear of said structure and two other wheels mounted on arms connected to independent hydraulic means on the sides of the front end of said structure, gang plows mounted between said wheels on said front end of said structure having weirs leading to a vibratable screen, windlasses with transversal vanes mounted above said screen to smash, crush and send backwards the soil received from the plows, breaker discs mounted in front of said plows and a side duct mounted between the rear end of said screen and the rear wheels for discarding material to the side of the machine.
摘要:
A method for manufacturing an edible, multi-ring, can holder comprises the steps of dehydrating beer by-product to produce a dried pulp, grinding the dried pulp into a powder, forming a pulp slurry by adding the powder into a mixture comprising plant fibers, an environment-friendly, oil-repellent chemical, an environment-friendly, water-repellent chemical, and water, a water-to-other ingredient ratio being approximately 1000 liters of water to approximately 60 kg of the powder, the plant fibers, the oil-repellent chemical, and the water-repellent chemical, injecting the pulp slurry into a mold having an interior cavity in the shape of at least one six-pack ring, and applying pressure and heat to the mold containing the pulp slurry to produce at least one edible six-pack ring.
摘要:
The present invention relates to novel triazolo[4,3-a]pyridine derivatives of Formula (I) wherein all radicals are as defined in the claims. The compounds according to the invention are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”), which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.
摘要:
Various aspects are disclosed herein for attenuating spin waiting in a virtual machine environment comprising a plurality of virtual machines and virtual processors. Selected virtual processors can be given time slice extensions in order to prevent such virtual processors from becoming de-scheduled (and hence causing other virtual processors to have to spin wait). Selected virtual processors can also be expressly scheduled so that they can be given higher priority to resources, resulting in reduced spin waits for other virtual processors waiting on such selected virtual processors. Finally, various spin wait detection techniques can be incorporated into the time slice extension and express scheduling mechanisms, in order to identify potential and existing spin waiting scenarios.
摘要:
The present invention relates to novel triazolo[4,3-a]pyridine derivatives of Formula (I) wherein all radicals are as defined in the claims. The compounds according to the invention are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”), which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.