公开(公告)号：US07294624B2

公开(公告)日：2007-11-13

申请号：US10321144

申请日：2002-12-17

Applicant: Jingwu Duan ,  Bin Jiang ,  Lihua Chen ,  Zhonghui Lu ,  Joseph Barbosa ,  William J. Pitts

Inventor： Jingwu Duan ,  Bin Jiang ,  Lihua Chen ,  Zhonghui Lu ,  Joseph Barbosa ,  William J. Pitts

IPC: A01N43/58 ,  A61K31/50 ,  C07D237/00 ,  C07D239/02

CPC classification number: C07D239/54 ,  C07D239/62 ,  C07D239/70 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D471/10 ,  C07D487/10 ,  C07D491/10

Abstract: The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Za are defined in the present specification, which are useful as TNF-α converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.

Abstract translation: 本申请描述了式I的新型巴比妥酸衍生物或其药学上可接受的盐或前药形式，其中A，B，L，R 1，R 2， R 4，R 4，R 5，n，W，U，X，Y，Z，U a， 在本说明书中定义，其可用作TNF-α转化酶（TACE）和/或 基质金属蛋白酶（MMP）抑制剂。

公开(公告)号：US20170071323A1

公开(公告)日：2017-03-16

申请号：US15177467

申请日：2016-06-09

Applicant: Bin Jiang YANG

Inventor： Bin Jiang YANG

IPC: A46B9/02 ,  A46B3/00

CPC classification number: A46B9/02 ,  A46B3/00 ,  A46B9/023 ,  A46B15/0055

Abstract: An improved hair brush having a prism shaped brush head, such as a cylindrical brush head, with spaced apart brush tips or tufts of bristles distributed around a portion of the 360° of the outer surface. The spaced apart brush tips or bristles may be present in only ⅓ (i.e. 120°) to ½ (i.e. 180°) of the entire outer surface, or it may cover more or less than this range to improve the smoothing or curling of a user's hair. Each tuft of bristles may have different lengths and randomly be directed at different directions.

Abstract translation: 一种具有棱柱形刷头（例如圆柱形刷头）的改进的发刷，具有分布在外表面的360°的一部分上的刷毛尖或刷毛簇。 间隔开的刷头或刷毛可以仅存在于整个外表面的1/3（即120°）至1/2（即180°）中，或者可以覆盖更多或更小于该范围以改善用户的平滑或卷曲 头发。 每束刷毛可能具有不同的长度，随机地指向不同的方向。

公开(公告)号：US09221826B2

公开(公告)日：2015-12-29

申请号：US14005572

申请日：2012-03-16

Applicant: Stephen T. Wrobleski ,  Jagabandhu Das ,  Lidia M. Doweyko ,  Junqing Guo ,  John Hynes ,  Bin Jiang ,  James Kempson ,  Shuqun Lin ,  Steven H. Spergel ,  John S. Tokarski ,  Hong Wu ,  Bingwei Vera Yang

Inventor： Stephen T. Wrobleski ,  Jagabandhu Das ,  Lidia M. Doweyko ,  Junqing Guo ,  John Hynes ,  Bin Jiang ,  James Kempson ,  Shuqun Lin ,  Steven H. Spergel ,  John S. Tokarski ,  Hong Wu ,  Bingwei Vera Yang

IPC: A61K31/5025 ,  A61K31/675 ,  C07D487/04 ,  C07F9/6561

CPC classification number: C07D487/04 ,  C07F9/6561

Abstract: Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.

Abstract translation: 公开了式（I）的化合物及其药学上可接受的盐。 式（I）化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎性和自身免疫性疾病。

公开(公告)号：US08987268B2

公开(公告)日：2015-03-24

申请号：US14005568

申请日：2012-03-16

Applicant: Stephen T. Wrobleski ,  Jagabandhu Das ,  Jingwu Duan ,  Junqing Guo ,  John Hynes ,  Bin Jiang ,  James Kempson ,  Shuqun Lin ,  Zhonghui Lu ,  William J. Pitts ,  Steven H. Spergel ,  Hong Wu ,  Bingwei Vera Yang

Inventor： Stephen T. Wrobleski ,  Jagabandhu Das ,  Jingwu Duan ,  Junqing Guo ,  John Hynes ,  Bin Jiang ,  James Kempson ,  Shuqun Lin ,  Zhonghui Lu ,  William J. Pitts ,  Steven H. Spergel ,  Hong Wu ,  Bingwei Vera Yang

IPC: C07D487/04 ,  C07D471/04 ,  A01N43/58 ,  A61K31/50

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.

Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎症和自身免疫性疾病。

公开(公告)号：US08846673B2

公开(公告)日：2014-09-30

申请号：US13388700

申请日：2010-08-11

Applicant: Jingwu Duan ,  Bin Jiang ,  Zhonghui Lu

Inventor： Jingwu Duan ,  Bin Jiang ,  Zhonghui Lu

IPC: A61K31/535 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, (I) are useful as kinase modulators, including Btk modulation, wherein A1, A2, A3, R4 are as defined herein.

Abstract translation: 具有式（I）的化合物及其对映异构体和非对映异构体，药学上可接受的盐，（I）可用作激酶调节剂，包括Btk调节，其中A1，A2，A3，R4如本文所定义。

公开(公告)号：US20140011795A1

公开(公告)日：2014-01-09

申请号：US14005570

申请日：2012-03-16

Applicant: Stephen T. Wrobleski ,  Gregory D. Brown ,  Lidia M. Doweyko ,  Jingwu Duan ,  Junqing Guo ,  John Hynes ,  Bin Jiang ,  James Kempson ,  Shuqun Lin ,  Zhonghui Lu ,  Steven H. Spergel ,  John S. Tokarski ,  Hong Wu ,  Bingwei Vera Yang

Inventor： Stephen T. Wrobleski ,  Gregory D. Brown ,  Lidia M. Doweyko ,  Jingwu Duan ,  Junqing Guo ,  John Hynes ,  Bin Jiang ,  James Kempson ,  Shuqun Lin ,  Zhonghui Lu ,  Steven H. Spergel ,  John S. Tokarski ,  Hong Wu ,  Bingwei Vera Yang

IPC: C07D487/04 ,  C07D471/04

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (I), and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.

Abstract translation: 公开了式（I）的化合物及其药学上可接受的盐。 式（I）化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎性和自身免疫性疾病。

公开(公告)号：US20130137235A1

公开(公告)日：2013-05-30

申请号：US13512415

申请日：2011-04-22

Applicant: Qi Yu ,  Xiangzhan Wang ,  Ning Ning ,  Jingchun Li ,  Hongdong Yang ,  Xianwei Ying ,  Weijie Zhou ,  Bin Jiang ,  Yong Wang

Inventor： Qi Yu ,  Xiangzhan Wang ,  Ning Ning ,  Jingchun Li ,  Hongdong Yang ,  Xianwei Ying ,  Weijie Zhou ,  Bin Jiang ,  Yong Wang

IPC: H01L29/66

CPC classification number: H01L29/4983 ,  H01L21/823807 ,  H01L21/823828 ,  H01L21/823864 ,  H01L29/0649 ,  H01L29/0653 ,  H01L29/7842 ,  H01L29/7843 ,  H01L29/7845 ,  H01L29/7848 ,  H01L29/7849

Abstract: A MOS transistor (60, 62) is provided. The structure of the transistor (60, 62) includes: a semiconductor substrate (10), a channel area (20, 24), source/drain regions (22, 26), a gate (30, 32), a gate insulating layer (11), a shallow trench isolation region (12), a passive layer (50, 52), and holes (40, 42) formed with a certain distance to the gate insulating layer (11). Wherein both the shapes of the holes (40, 42) and the Young's modulus' difference between the material in the holes (40, 42) and that around the holes (40, 42) contribute to the stress concentration effect, thus the stress in the channel area (20, 24) is enhanced. The structure of the transistor (60, 62) can greatly reduce the stress attenuation during the transmission from stress resource to the sensitive region, and concentrate the stress in the sensitive region. The structure can be involved in large size device, especially.

Abstract translation: 提供了MOS晶体管（60,62）。 晶体管（60,62）的结构包括：半导体衬底（10），沟道区（20,24），源极/漏极区（22,26），栅极（30,32），栅极绝缘层 （11），浅沟槽隔离区（12），钝化层（50,52）和与栅绝缘层（11）形成一定距离的孔（40,42）。 其中孔（40,42）的形状和孔（40,42）中的材料与孔（40,42）周围的材料之间的杨氏模量差都有助于应力集中效应，因此应力 增加了通道区域（20,24）。 晶体管（60,62）的结构可以大大降低从应力资源向敏感区域传输过程中的应力衰减，并将应力集中在敏感区域。 该结构可以涉及大尺寸装置，特别是。

公开(公告)号：US20120291493A1

公开(公告)日：2012-11-22

申请号：US13417045

申请日：2012-03-09

Applicant: Kuo-Chuan Hsu ,  Yan-Bin Jiang ,  Chao Qu

Inventor： Kuo-Chuan Hsu ,  Yan-Bin Jiang ,  Chao Qu

IPC: C03B20/00 ,  C03B13/00

CPC classification number: C03B25/08 ,  C03B5/245 ,  C03B5/265 ,  C03B13/04 ,  C03B32/02 ,  C03C3/097 ,  C03C10/0027 ,  Y02P40/57

Abstract: A consecutive molding method for crystallized glass comprises: a process to obtain molten glass by melting glass raw materials; a process to obtain a band-shaped plate glass by roll forming the molten glass; a crystallization process to obtain a band-shaped crystallized glass plate by conducting thermal treatment on the band-shaped plate glass to crystallize it; and a process to cut the band-shaped crystallized glass plate, wherein the crystallization process includes: a process to form crystal nuclei in the band-shaped plate glass by disposing it in the atmosphere of a crystal nucleus-formation temperature and retaining it at the temperature; a process to raise the temperature of the band-shaped plate glass with crystal nuclei to a crystal-growth temperature; a process to retain the band-shaped plate glass with crystal nuclei at the crystal-growth temperature to produce a band-shaped crystallized glass plate; and a process to slowly cool down the band-shaped crystallized glass plate.

Abstract translation: 结晶玻璃的连续成型方法包括：通过熔化玻璃原料获得熔融玻璃的方法; 通过辊压成形熔融玻璃获得带状平板玻璃的方法; 通过对带状平板玻璃进行热处理以使其结晶化而获得带状结晶化玻璃板的结晶化方法; 以及切割带状结晶玻璃板的方法，其中结晶方法包括：在带状平板玻璃中通过将其设置在晶核形成温度的气氛中形成晶核的工艺，并将其保持在 温度; 将具有晶核的带状平板玻璃的温度升高至晶体生长温度的工序; 在结晶生长温度下保持具有晶核的带状平板玻璃以产生带状结晶玻璃板的工艺; 以及缓慢冷却带状结晶化玻璃板的工序。

公开(公告)号：US20120291492A1

公开(公告)日：2012-11-22

申请号：US13417036

申请日：2012-03-09

Applicant: Kuo-Chuan Hsu ,  Yan-Bin Jiang ,  Chao Qu

Inventor： Kuo-Chuan Hsu ,  Yan-Bin Jiang ,  Chao Qu

IPC: C03B27/012 ,  C03B13/00

CPC classification number: C03B13/04 ,  C03B5/245 ,  C03B5/265 ,  C03B25/08 ,  C03B32/02 ,  C03C3/097 ,  C03C10/0027 ,  Y02P40/57

Abstract: A consecutive molding method for crystallized glass comprises: a melting process to obtain molten glass by melting glass raw materials; a molding process to obtain a band-shaped plate glass by roll forming the molten glass to become band-shaped; a crystallization process to obtain a band-shaped crystallized glass plate by conducting thermal treatment on the band-shaped plate glass to crystallize it; and a cutting process to cut the band-shaped crystallized glass plate, wherein the crystallization process includes: a temperature-raising process to produce the band-shaped crystallized glass plate by disposing the band-shaped plate glass obtained in the molding process, in the atmosphere of a crystal nucleus-formation temperature and raising the temperature to a crystal-growth temperature or above to grow crystals as well as form crystal nuclei; and a slow-cooling process to slowly cool down the band-shaped crystallized glass plate.

Abstract translation: 结晶玻璃的连续成型方法包括：通过熔化玻璃原料获得熔融玻璃的熔融过程; 通过将熔融玻璃辊成型为带状而获得带状平板玻璃的成型方法; 通过对带状平板玻璃进行热处理以使其结晶化而获得带状结晶化玻璃板的结晶化方法; 以及切割带状结晶玻璃板的切割工序，其中结晶工艺包括：通过将在模塑工艺中获得的带状平板玻璃设置在该方法中来生产带状结晶玻璃板的升温过程 晶体生成温度的气氛，将温度升高至晶体生长温度以上，生长晶体，形成晶核; 以及缓慢冷却带状结晶玻璃板的缓慢冷却过程。

公开(公告)号：US08304539B2

公开(公告)日：2012-11-06

申请号：US12866270

申请日：2009-02-05

Applicant: Jingwu Duan ,  David S. Weinstein ,  Bin Jiang

Inventor： Jingwu Duan ,  David S. Weinstein ,  Bin Jiang

IPC: C07D491/147 ,  C07D413/00

CPC classification number: C07D491/147

Abstract: Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including metabolic and inflammatory and immune diseases or disorders, having the structure of formula (I): an enantiomer, diastereomer, or taυtomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; •A is a S- to 8-membered carbocyclic ring or a S- to 8-membered heterocyclic ring; B1 and B2 rings are pyridyl rings, wherein the B1 and B2 rings are each fused to the A ring and the B1 ring is optionally substituted by one to three groups which are the same or different and are independently selected from R1, R2, and R4, and the B2 ring is optionally substituted by one to three groups which are the same or different and are independently selected from R5, R7, and R3 J1, J2, and J3 are at each occurrence the same or different and are independently -A1QA2-; Q is a bond, O, S, S(O), or S(O)2; A1 and A2 are the same or different and are at each occurrence independently selected from a bond, C1-3 alkylene, substituted C1-3 alkylene, C2-4 alkenylene, and substituted C2-4 alkenylene, provided that A1 and A2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R1 to R11 are as defined herein.

Abstract translation: 提供新的非甾体化合物，其可用于治疗与调节糖皮质激素受体，AP-1和/或NF-κB活性相关的疾病或病症，包括具有结构的代谢和炎症和免疫疾病或病症 式（I）的化合物：其对映异构体，非对映异构体或其互变异构体或其前药酯或其药学上可接受的盐，其中：Z是杂环基或杂芳基; A是5至8元碳环或5至8元杂环; B1和B2环是吡啶环，其中B1和B2环各自与A环稠合，B1环任选被一至三个相同或不同并且独立地选自R 1，R 2和R 4的基团取代 并且B2环任选被一至三个相同或不同并且独立地选自R5，R7和R8的基团取代，J1，J2和J3在每次出现时相同或不同，并且独立地为-A 1 QA 2 - ; Q是键，O，S，S（O）或S（O）2; A1和A2相同或不同，并且在每次出现时独立地选自键，C1-3亚烷基，取代的C1-3亚烷基，C2-4亚烯基和取代的C2-4亚烯基，条件是A1和A2被选择为 该环A为5-至8-元碳环或杂环; R1至R11如本文所定义。