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公开(公告)号：US20050227342A1
公开(公告)日：2005-10-13
申请号：US10165036
申请日：2001-10-19
Applicant: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
Inventor： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
CPC classification number: C07K14/705
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US06936254B2
公开(公告)日：2005-08-30
申请号：US09945587
申请日：2001-08-31
Applicant: Kevin P. Baker , David Botstein , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Mary A. Napier , Margaret Ann Roy , Daniel Tumas , William I. Wood
Inventor： Kevin P. Baker , David Botstein , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Mary A. Napier , Margaret Ann Roy , Daniel Tumas , William I. Wood
IPC: A61K39/00 , C07K20060101 , C07K14/475 , C07K16/22 , C12N20060101 , C12N15/12 , C12N15/62
CPC classification number: C07K14/47
Abstract: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及分泌和跨膜多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US06908993B2
公开(公告)日：2005-06-21
申请号：US09945584
申请日：2001-08-31
Applicant: David Botstein , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Margaret Ann Roy , William I. Wood
Inventor： David Botstein , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Margaret Ann Roy , William I. Wood
CPC classification number: C07K14/47 , C07K14/705
Abstract: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050037458A1
公开(公告)日：2005-02-17
申请号：US10805667
申请日：2004-07-23
Applicant: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
Inventor： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
CPC classification number: C07K14/47 , G01N33/6872
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US06764679B2
公开(公告)日：2004-07-20
申请号：US09896096
申请日：2001-06-28
Applicant: Avi J. Ashkenazi , David Botstein , Kelly H. Dodge , Audrey Goddard , Austin L. Gurney , Kyung Jin Kim , David A. Lawrence , Robert Pitti , Margaret A. Roy , Daniel B. Tumas , William I. Wood
Inventor： Avi J. Ashkenazi , David Botstein , Kelly H. Dodge , Audrey Goddard , Austin L. Gurney , Kyung Jin Kim , David A. Lawrence , Robert Pitti , Margaret A. Roy , Daniel B. Tumas , William I. Wood
IPC: C07K1628
CPC classification number: A01K67/0275 , A01K2217/05 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/2875 , C07K16/2878 , C07K2317/73 , C07K2319/00 , C12N2799/026
Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.
Abstract translation: 提供了标识为DcR3的TNFR同源物。 还提供了编码DcR3的核酸分子，嵌合分子和DcR3的抗体。
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Patent Agency Ranking
公开(公告)号：US06413770B1
公开(公告)日：2002-07-02
申请号：US09136801
申请日：1998-08-19
Applicant: Paul Godowski , Austin Gurney , Kenneth J. Hillan , David Botstein , Audrey Goddard , Margaret Roy , Napoleone Ferrara , Daniel Tumas , Ralph Schwall
Inventor： Paul Godowski , Austin Gurney , Kenneth J. Hillan , David Botstein , Audrey Goddard , Margaret Roy , Napoleone Ferrara , Daniel Tumas , Ralph Schwall
IPC: C07K14475
CPC classification number: C07K14/515 , A61K38/00 , C07K2319/00 , G01N2800/32 , Y10S977/773 , Y10S977/788 , Y10S977/915
Abstract: The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL1, NL5, NL8, and NL4, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
Abstract translation: 本发明涉及编码新型TIE配体NL1，NL5，NL8和NL4的分离的核酸分子，由这些核酸分子编码的蛋白质以及用于制备和使用该核酸和蛋白质分子的方法和手段。
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57.发明授权Tissue plasminogen activator having zymogenic or fibrin specific properties 失效组织纤溶酶原激活剂具有酶原或纤维蛋白特异性
公开(公告)号：US5614190A
公开(公告)日：1997-03-25
申请号：US429364
申请日：1995-04-26
Applicant: Stephen Anderson , William F. Bennett , David Botstein , Deborah L. Higgins , Nicholas F. Paoni , Mark J. Zoller
Inventor： Stephen Anderson , William F. Bennett , David Botstein , Deborah L. Higgins , Nicholas F. Paoni , Mark J. Zoller
IPC: A61K38/00 , A61K38/48 , C07H21/04 , C12N1/21 , C12N5/10 , C12N9/64 , C12N9/72 , C12N15/55 , C12N15/58 , C12N15/63 , C12N15/70 , C12N15/86 , A61K38/49 , C12N9/50
CPC classification number: C12N9/6456 , A61K38/00
Abstract: Tissue plasminogen activator (t-PA) zymogens and variants are prepared, including a fibrinolytically active variant of t-PA that has an amino acid alteration at a site within the protease domain of t-PA as compared with the corresponding wild-type t-PA, which alteration renders the variant zymogenic in the presence of plasmin-degraded fibrinogen, and/or fibrin (or plasma clot) specific, as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the zymogens and variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The zymogens and variants may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation or reformation in mammals.
Abstract translation: 制备组织纤溶酶原激活剂（t-PA）酶原和变体，包括t-PA的纤维蛋白溶解活性变体，其在t-PA的蛋白酶结构域内的位置具有氨基酸改变，与相应的野生型t- PA，与相应的野生型t-PA相比，其改变使纤维蛋白溶酶原纤维蛋白原和/或纤维蛋白（或血浆凝块）存在下的变形酶原。 可以制备编码酶原和变体的DNA序列，以及掺入DNA序列的表达载体和用表达载体转化的宿主细胞。 酶原和变体可用于药物制剂中以治疗血管疾病或病症或预防纤维蛋白沉积或哺乳动物中的粘附形成或重新形成。
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58.发明授权Method for identifying tissue plasminogen activator having zymogenic or fibrin specific properties 失效用于鉴定具有酶原或纤维蛋白特异性的组织纤溶酶原激活物的方法
公开(公告)号：US5411871A
公开(公告)日：1995-05-02
申请号：US179059
申请日：1994-01-07
Applicant: Stephen Anderson , William F. Bennett , David Botstein , Deborah L. Higgins , Nicholas F. Paoni , Mark J. Zoller
Inventor： Stephen Anderson , William F. Bennett , David Botstein , Deborah L. Higgins , Nicholas F. Paoni , Mark J. Zoller
IPC: A61K38/00 , A61K38/48 , C07H21/04 , C12N1/21 , C12N5/10 , C12N9/64 , C12N9/72 , C12N15/55 , C12N15/58 , C12N15/63 , C12N15/70 , C12N15/86 , C12Q1/37
CPC classification number: C12N9/6456 , A61K38/00
Abstract: Tissue plasminogen activator (t-PA) zymogens and variants are prepared, including a fibrinolytically active variant of t-PA that has an amino acid alteration at a site within the protease domain of t-PA as compared with the corresponding wild-type t-PA, which alteration renders the variant zymogenic in the presence of plasmin-degraded fibrinogen, and/or fibrin (or plasma clot) specific, as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the zymogens and variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The zymogens and variants may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation or reformation in mammals.
Abstract translation: 制备组织纤溶酶原激活剂（t-PA）酶原和变体，包括t-PA的纤维蛋白溶解活性变体，其在t-PA的蛋白酶结构域内的位置具有氨基酸改变，与相应的野生型t- PA，与相应的野生型t-PA相比，其改变使纤维蛋白溶酶原纤维蛋白原和/或纤维蛋白（或血浆凝块）存在下的变形酶原。 可以制备编码酶原和变体的DNA序列，以及掺入DNA序列的表达载体和用表达载体转化的宿主细胞。 酶原和变体可用于药物制剂中以治疗血管疾病或病症或预防纤维蛋白沉积或哺乳动物中的粘附形成或重新形成。
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公开(公告)号：US5139936A
公开(公告)日：1992-08-18
申请号：US283812
申请日：1988-12-13
Applicant: David Botstein , Ronald W. Davis , Gerald R. Fink , Alison Taunton-Rigby , Robert G. Knowlton , Jen-i Mao , Donald T. Moir , Christopher G. Goff
Inventor： David Botstein , Ronald W. Davis , Gerald R. Fink , Alison Taunton-Rigby , Robert G. Knowlton , Jen-i Mao , Donald T. Moir , Christopher G. Goff
CPC classification number: C12N9/6481 , C07K14/56 , C07K14/61 , C12N15/66 , C12N15/81 , Y10S435/942
Abstract: A DNA segment contains a GAL1 promoter of Saccharomyces cerevisae linked to a gene other than the galoctokinase gene, for directing the expression of the gene within a yeast cell.A GAL1 promoter portion of Saccharomyces cerevisae is linked to a foreign DNA segment for use in expressing a desired protein. Yeast cells containing the GAL1 promoter linked to a foreign DNA segment are grown in a medium containing glucose, wherein the yeast cells metabolize the glucose and are permitted to express a polypeptide when galactose is present in the medium.
Abstract translation: DNA片段含有连接到除了胆囊酯酶基因之外的基因的酿酒酵母的GAL1启动子，用于将基因的表达指导在酵母细胞内。 酿酒酵母的GAL1启动子部分与外源DNA片段连接，用于表达所需蛋白质。 包含与外来DNA片段连接的GAL1启动子的酵母细胞在含有葡萄糖的培养基中生长，其中酵母细胞代谢葡萄糖，并且当半乳糖存在于培养基中时允许表达多肽。
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公开(公告)号：US4661454A
公开(公告)日：1987-04-28
申请号：US470911
申请日：1983-02-28
Applicant: David Botstein , Ronald W. Davis , Gerald R. Fink , Alison Taunton-Rigby , Robert G. Knowlton , Jen-i Mao , Donald T. Moir , Christopher G. Goff
Inventor： David Botstein , Ronald W. Davis , Gerald R. Fink , Alison Taunton-Rigby , Robert G. Knowlton , Jen-i Mao , Donald T. Moir , Christopher G. Goff
IPC: C12N15/09 , C07H21/04 , C07K14/00 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/575 , C07K14/61 , C12N1/16 , C12N9/64 , C12N15/66 , C12N15/81 , C12P21/02 , C12R1/865 , C12N1/18 , C07H15/12 , C12N1/00 , C12N15/00
CPC classification number: C12N9/6481 , C07K14/56 , C07K14/61 , C12N15/66 , C12N15/81 , Y10S435/942 , Y10S930/12 , Y10S930/142
Abstract: A DNA segment containing a GAL1 promoter linked to a gene other than the galactokinase gene for directing the expression of the gene within a yeast cell.
Abstract translation: 包含连接到除了半乳糖激酶基因之外的基因的GAL1启动子的DNA片段，用于指导酵母细胞内基因的表达。
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