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公开(公告)号：US07060181B2
公开(公告)日：2006-06-13
申请号：US10776042
申请日：2004-02-10
CPC分类号： A01K63/045
摘要： The invention relates to aquarium filters providing improved water filtration without accelerated clogging. The present invention also relates to methods of using such filters.
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公开(公告)号：US06425578B1
公开(公告)日：2002-07-30
申请号：US09395866
申请日：1999-09-14
IPC分类号： B65H306
CPC分类号： B65H3/0684 , B65H3/5223 , B65H3/565 , B65H2301/31122 , B65H2301/42324 , B65H2301/448 , B65H2403/20 , B65H2403/512 , B65H2403/72 , B65H2511/40 , B65H2513/42 , B65H2553/24 , B65H2701/18264 , B65H2701/1928 , B65H2220/01 , B65H2220/02
摘要： Image recording apparatus for recording an image on a recording plate, the apparatus comprising a plate store (1) for storing a stack (12) of recording plates separated by interleaved sheets; a drum image scanner (6) on which recording plates are located for recordal of an image; and a frictional feed apparatus (2) for withdrawing recording plates from the store (1) and feeding them singly to the drum image scanner (6).
摘要翻译： 一种用于在记录板上记录图像的图像记录装置，该装置包括：用于存储由交错片分隔开的记录板的堆叠（12）的板存储器（1）;记录板位于其上以记录的滚筒图像扫描器 的图像 以及用于从存储器（1）取出记录板并将它们单独供给到滚筒图像扫描器（6）的摩擦进给装置（2）。
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公开(公告)号：US06214611B1
公开(公告)日：2001-04-10
申请号：US09548076
申请日：2000-04-12
IPC分类号： C12P722
CPC分类号： C07C43/23 , C07F7/1804 , C12P7/22 , C12P41/004
摘要： A propargylic alcohol, enriched in the (R)-enantiomer, has the formula wherein R is C1-4 alkoxy, halogen, or C1-4 alkyl optionally substituted by OH or halogen. This is prepared by the steps of: (a) enantioselective (R)-esterification of the racemic alcohol using any acyl donor and a first enzyme; (b) removal of the untreated (S)-alcohol; and (c) enantioselective hydrolysis of the (R)-ester, using a second enzyme.
摘要翻译： 富含（R） - 对映异构体的炔丙醇具有式R的化合物，其中R是任选被OH或卤素取代的C 1-4烷氧基，卤素或C 1-4烷基。 这通过以下步骤制备：（a）使用任何酰基供体和第一种酶对外消旋醇进行对映选择性（R）酯化反应;（b）除去未处理的（S） - 醇; 和（c）使用第二种酶对（R） - 酯的对映选择性水解。
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公开(公告)号：US6114367A
公开(公告)日：2000-09-05
申请号：US187833
申请日：1998-11-06
IPC分类号： A61K31/42 , A61K31/423 , A61K31/4709 , A61P3/02 , A61P7/00 , A61P11/00 , A61P17/00 , A61P27/16 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , C07D261/04 , C07D413/12 , A61K31/47
CPC分类号： C07D413/12 , A61K31/42 , A61K31/423 , A61K31/4709 , C07D261/04
摘要： This invention relates to isoxazoline compounds which are inhibitors of tumor necrosis factor (TNF). The isoxazoline compounds are useful for inhibiting TNF in a mammal in need thereof and in the treatment or alleviation of inflammatory conditions or disease, including but not limited to rheumatoid arthritis, osteoarthritis, asthma, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and inflammatory bowel disease, sepsis, septic shock, tuberculosis, graft versus host disease and cachexia associated with AIDS or cancer. This invention also relates to pharmaceutical compositions useful therefor comprising such compounds.
摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）抑制剂的异恶唑啉化合物。 异恶唑啉化合物可用于抑制有需要的哺乳动物和治疗或缓解炎性病症或疾病的TNF，包括但不限于类风湿性关节炎，骨关节炎，哮喘，支气管炎，慢性阻塞性气道疾病，牛皮癣，过敏性鼻炎， 皮炎和炎性肠病，败血症，败血症休克，结核病，移植物抗宿主病和与艾滋病或癌症相关的恶病质。 本发明还涉及包含这些化合物的药物组合物。
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55.发明授权
公开(公告)号：US6066737A
公开(公告)日：2000-05-23
申请号：US101058
申请日：1998-06-29
IPC分类号： B01J23/72 , A61K31/451 , A61P25/24 , C07B61/00 , C07D211/22 , C07D405/12 , C07D211/20 , C07D211/40 , C07D211/60
CPC分类号： C07D405/12 , C07D211/22
摘要： The subject invention pertains to optically-enriched compounds of formula (1), wherein Ar is a C.sub.6-20 aryl group; and R.sup.1 and R.sup.2 are independently H, alkyl or aryl. The subject invention also pertains to method of preparing these compounds. The subject compounds can be prepared by reduction of the corresponding 1,4-dihydropyridine-3-aldehyde, e.g., using hydrogen an a catalyst. The aldehyde can be prepared by hydrolytic cleavage of an aminal obtainable by the reaction of 3-pyridinecarboxaldehyde and a chiral C-2 symmetric diamine, an then stereoselective introduction of the Ar and COOCHR.sup.1 R.sup.2 groups. ##STR1##
摘要翻译： PCT No.PCT / GB96 / 03242 Sec。 371日期1998年6月29日第 102（e）1998年6月29日PCT 1996年12月30日PCT PCT。 公开号WO97 / 24323 日期1997年7月10日本发明涉及式（1）的光学富集化合物，其中Ar为C6-20芳基; 且R 1和R 2独立地为H，烷基或芳基。 本发明还涉及制备这些化合物的方法。 可以通过还原相应的1,4-二氢吡啶-3-醛来制备主题化合物，例如使用氢气和催化剂。 醛可以通过水解裂解通过3-吡啶甲醛和手性C-2对称二胺反应得到的胺，然后立即选择性引入Ar和COOCHR1R2基团来制备。
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公开(公告)号：US5869511A
公开(公告)日：1999-02-09
申请号：US700431
申请日：1996-09-05
IPC分类号： A61K31/42 , A61K31/423 , A61K31/4709 , A61P3/02 , A61P7/00 , A61P11/00 , A61P17/00 , A61P27/16 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , C07D261/04 , C07D413/12 , A61K31/47
CPC分类号： C07D413/12 , A61K31/42 , A61K31/423 , A61K31/4709 , C07D261/04
摘要： This invention relates to isoxazoline compounds of formula (I) which are inhibitors of tumor necrosis factor (TNF). The isoxazoline compounds are useful for inhibiting TNF in a mammal in need thereof and in the treatment or alleviation of inflammatory conditions or disease, including but not limited to rheumatoid arthritis, osteoarthritis, asthma, bronchitis, chronic obstructive airways disease, psoriais, allergic rhinitis, dermatitis and inflammatory bowel disease, sepsis, septic shock, tuberculosis, graft versus host disease and cachexia associated with AIDS or cancer. This invention also relates to pharmaceutical compositions useful therefor comprising such compounds of formula (I) wherein X.sup.1 is --(CH.sub.2).sub.q OH, --CHOHR.sup.5 or --(CH.sub.2).sub.m CON(R.sup.6)(OH); wherein q and m are each independently 0 or an integer from 1 to 5; R.sup.5 is (C.sub.1 -C.sub.4)alkyl; and R.sup.6 is hydrogen or (C.sub.1 -C.sub.3)alkyl; n is 0, 1, 2 or 3; Y.sup.1 and Y.sup.2 are as defined in the application.
摘要翻译： PCT No.PCT / IB95 / 00078 Sec。 371日期：1996年9月5日 102（e）日期1996年9月5日PCT提交1995年2月3日PCT公布。 公开号WO95 / 24398 日期1995年9月14日本发明涉及作为肿瘤坏死因子（TNF）抑制剂的式（I）的异恶唑啉化合物。 异恶唑啉化合物可用于抑制有需要的哺乳动物和治疗或缓解炎性病症或疾病的TNF，包括但不限于类风湿性关节炎，骨关节炎，哮喘，支气管炎，慢性阻塞性气道疾病，牛皮癣，过敏性鼻炎， 皮炎和炎性肠病，败血症，败血症休克，结核病，移植物抗宿主病和与艾滋病或癌症相关的恶病质。 本发明还涉及包含其中X 1为 - （CH 2）q OH，-CHOHR 5或 - （CH 2）m CON（R 6）（OH）的式（I）化合物的药物组合物。 其中q和m各自独立地为0或1至5的整数; R5是（C1-C4）烷基; 和R6是氢或（C1-C3）烷基; n为0,1,2或3; Y1和Y2如申请中所定义。
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公开(公告)号：US5789408A
公开(公告)日：1998-08-04
申请号：US586832
申请日：1996-01-11
IPC分类号： C07D277/62 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/47 , A61K31/495 , A61K31/50 , A61K31/505 , A61P31/12 , C07D417/12 , C07D213/60 , C07D215/16 , C07D277/30
CPC分类号： C07D417/12
摘要： Compounds of formula (I) are active antiviral compounds useful in the treatment of viral infections in mammals. The compounds of the invention are readily prepared by reaction of a suitable 2-thiothiazole derivative with an appropriate Het-(CH.sub.2).sub.n -halide.
摘要翻译： PCT No.PCT / IB94 / 00113 Sec。 371日期1996年1月11日 102（e）日期1996年1月11日PCT 1994年5月19日PCT PCT。 公开号WO95 / 05378 日期2月23日，式（I）化合物是用于治疗哺乳动物病毒感染的活性抗病毒化合物。 通过合适的2-噻唑衍生物与合适的Het-（CH 2）n - 卤化物的反应容易地制备本发明的化合物。
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58.发明授权Method and system for matching unknown software component to known software component 有权将未知软件组件与已知软件组件相匹配的方法和系统公开(公告)号：US08825689B2
公开(公告)日：2014-09-02
申请号：US13476160
申请日：2012-05-21
IPC分类号： G06F17/30
CPC分类号： G06F17/30017 , G06F8/71 , G06F17/30864 , G06F21/16
摘要： A computer system or method identifies components. A component fingerprint storage is configured to memorize known fingerprints of known components. The term “component” used herein is defined to be a specific version of pre-existing executable software, or a reusable pre-existing self-contained software code building block which is not a complete stand-alone finished product ready for use and which is binary or source code. A fingerprint is generated for a normalized unknown component and fingerprints are generated for all normalized components included in the unknown component. It is determined whether any of the fingerprints generated for the normalized unknown component and for the normalized components included in the unknown component match any of the known fingerprints of known components.
摘要翻译： 计算机系统或方法识别组件。 组件指纹存储器被配置为存储已知组件的已知指纹。 本文使用的术语“组件”被定义为预先存在的可执行软件的特定版本，或者是可重用的预先存在的独立软件代码构建块，其不是完整的独立成品准备使用，并且是 二进制或源代码。 为归一化未知分量生成指纹，并为包含在未知分量中的所有归一化分量生成指纹。 确定为归一化未知分量生成的任何指纹和包括在未知分量中的归一化分量的任何指纹是否与已知分量的任何已知指纹相匹配。
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公开(公告)号：US08753496B2
公开(公告)日：2014-06-17
申请号：US12928650
申请日：2010-12-16
IPC分类号： G01N27/447 , B01D15/10 , B01D15/24 , B01D57/02 , C12N15/10
CPC分类号： C12N15/1003 , B01D57/02 , G01N27/44721
摘要： A device for separating and purifying useful quantities of particles comprises: (a) an anolyte reservoir connected to an anode, the anolyte reservoir containing an electrophoresis buffer; (b) a catholyte reservoir connected to a cathode, the catholyte reservoir also containing the electrophoresis buffer; (c) a power supply connected to the anode and to the cathode; (d) a column having a first end inserted into the anolyte reservoir, a second end inserted into the catholyte reservoir, and containing a separation medium; (e) a light source; (f) a first optical fiber having a first fiber end inserted into the separation medium, and having a second fiber end connected to the light source; (g) a photo detector; (h) a second optical fiber having a third fiber end inserted into the separation medium, and having a fourth fiber end connected to the photo detector; and (i) an ion-exchange membrane in the anolyte reservoir.
摘要翻译： 用于分离和净化有用量的颗粒的装置包括：（a）连接到阳极的阳极电解液储存器，含有电泳缓冲液的阳极电解液储存器; （b）连接阴极的阴极电解液储存器，阴极电解液储存器还含有电泳缓冲液; （c）连接到阳极和阴极的电源; （d）具有插入阳极电解液容器的第一端的柱，插入阴极电解液储存器中的第二端，并包含分离介质; （e）光源; （f）第一光纤，其具有插入分离介质中的第一光纤端，并且具有连接到光源的第二光纤端; （g）光电检测器; （h）第二光纤，其具有插入分离介质中的第三光纤端，并且具有连接到光电检测器的第四光纤端; 和（i）阳极电解液容器中的离子交换膜。
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公开(公告)号：US08627270B2
公开(公告)日：2014-01-07
申请号：US13231162
申请日：2011-09-13
申请人： Brian Edward Fox , Joel Orlina
发明人： Brian Edward Fox , Joel Orlina
IPC分类号： G06F9/44
CPC分类号： G06F8/70 , G06F8/71 , G06F11/302 , G06F11/3051 , G06F11/3089 , G06F21/577
摘要： A computer system is provided, comprising: a transceiver; and a processor configured to facilitate: collecting and storing information related to a software project having one or more software artifacts, the information including: a project identifier, artifact identifiers for the artifacts used by the project, information about the temporal version for the artifacts, and contact information for a project user; collecting, from a repository, artifact metadata associated with the software artifacts, the artifact metadata including: information identifying the artifact, information about security risks associated with the artifact, information about a license associated with the artifact, or information indicative of a level of use or user rating of the artifact; periodically monitoring the metadata to determine whether there has been any actionable change in the artifact metadata; and notifying the project user using the contact information if it is determined that there has been an actionable change in the artifact metadata.
摘要翻译： 提供一种计算机系统，包括：收发机; 以及处理器，被配置为便于：收集和存储与具有一个或多个软件工件的软件项目相关的信息，所述信息包括：项目标识符，项目使用的工件的工件标识符，关于工件的时间版本的信息， 和项目用户的联系信息; 从存储库收集与所述软件工件相关联的工件元数据，所述工件元数据包括：识别所述工件的信息，与所述工件相关联的安全风险的信息，与所述工件相关联的许可证的信息，或指示使用级别的信息 或用户评价的神器; 定期监控元数据，以确定是否在工件元数据中有任何可操作的变化; 并且如果确定工件元数据中存在可操作的更改，则通知项目用户使用联系人信息。
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