公开(公告)号：US10947560B2

公开(公告)日：2021-03-16

申请号：US15700279

申请日：2017-09-11

Applicant: GenVec, Inc.

Inventor： Lisa Wei ,  Douglas E. Brough ,  C. Richter King

IPC: C12N15/861 ,  C12N15/00 ,  A61K48/00 ,  C12N15/86

Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.

公开(公告)号：US10792376B2

公开(公告)日：2020-10-06

申请号：US16352459

申请日：2019-03-13

Applicant: GenVec, Inc.

Inventor： Duncan McVey ,  Douglas E. Brough ,  Jason G. D. Gall

IPC: A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  A61K39/155 ,  A61K39/00

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

公开(公告)号：US20190233845A1

公开(公告)日：2019-08-01

申请号：US16338075

申请日：2017-09-29

Applicant: GenVec, Inc.

Inventor： Sebastien M. Maloveste ,  Damodar Ettyreddy ,  Douglas E. Brough

IPC: C12N15/86

CPC classification number: C12N15/86 ,  C07K14/005 ,  C12N2710/10322 ,  C12N2710/10343

Abstract: The invention provides adenoviral vectors and compositions for the highly efficient transduction of T cells.

公开(公告)号：US09951351B2

公开(公告)日：2018-04-24

申请号：US14879318

申请日：2015-10-09

Applicant: GenVec, Inc.

Inventor： Douglas E. Brough ,  Damodar R. Ettyreddy

IPC: C12N15/861 ,  C12N15/86 ,  A61K38/16 ,  A61K48/00

CPC classification number: C12N15/86 ,  A61K38/16 ,  A61K48/00 ,  A61K48/0058 ,  A61K48/0075 ,  C12N2710/10043 ,  C12N2710/10343 ,  C12N2830/008

Abstract: The invention is directed to a replication-deficient adenoviral vector comprising a nucleic acid sequence encoding a human atonal homolog-1 (Hath1) protein operably linked to a human glial fibrillary acidic protein (GFAP) promoter. The invention also is directed to a composition and method utilizing the adenoviral vector to generate sensory cells in the inner ear of a human.

公开(公告)号：US09629906B2

公开(公告)日：2017-04-25

申请号：US14349426

申请日：2012-10-05

Applicant: GenVec, Inc.

Inventor： Duncan McVey ,  Douglas E. Brough ,  Jason G. D. Gall

IPC: A61K39/155 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86

CPC classification number: A61K48/005 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2760/18534 ,  C12N2760/18571

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

公开(公告)号：US20160122781A1

公开(公告)日：2016-05-05

申请号：US14992152

申请日：2016-01-11

Applicant: GenVec, Inc.

Inventor： Jason G.D. Gall ,  Duncan McVey ,  Douglas E. Brough

IPC: C12N15/86 ,  C12N7/00

CPC classification number: C12N15/86 ,  A61K39/155 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10043 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10343

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

Abstract translation: 本发明提供了一种腺病毒或腺病毒载体，其特征在于包含一个或多个特定的核酸序列或一个或多个特定的氨基酸序列或其部分，涉及例如腺病毒pIX蛋白，DNA聚合酶蛋白，penton蛋白，六邻体 蛋白质和/或纤维蛋白质。

公开(公告)号：US20140314717A1

公开(公告)日：2014-10-23

申请号：US14349470

申请日：2012-10-05

Applicant: GenVec, Inc.

Inventor： Douglas E. Brough ,  Jason G.D. Gall ,  Duncan McVey

IPC: C12N15/86

CPC classification number: C12N15/86 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10343 ,  C12N2760/18034 ,  C12N2760/18522 ,  C12N2840/60

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

Abstract translation: 本发明提供了一种腺病毒或腺病毒载体，其特征在于包含一个或多个特定的核酸序列或一个或多个特定的氨基酸序列或其部分，涉及例如腺病毒pIX蛋白，DNA聚合酶蛋白，penton蛋白，六邻体 蛋白质和/或纤维蛋白质。

公开(公告)号：US20140248308A1

公开(公告)日：2014-09-04

申请号：US14349426

申请日：2012-10-05

Applicant: GenVec, Inc.

Inventor： Duncan McVey ,  Douglas E. Brough ,  Jason G.D. Gall

IPC: A61K39/155

CPC classification number: A61K48/005 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2760/18534 ,  C12N2760/18571

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

Abstract translation: 本发明提供了一种腺病毒或腺病毒载体，其特征在于包含一个或多个特定的核酸序列或一个或多个特定的氨基酸序列或其部分，涉及例如腺病毒pIX蛋白，DNA聚合酶蛋白，penton蛋白，六邻体 蛋白质和/或纤维蛋白质。

公开(公告)号：US20140248307A1

公开(公告)日：2014-09-04

申请号：US14349421

申请日：2012-10-05

Applicant: GenVec, Inc.

Inventor： Jason G.D. Gall ,  Duncan McVey ,  Douglas E. Brough

IPC: A61K39/155

CPC classification number: C12N15/86 ,  A61K39/155 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10043 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10343

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

公开(公告)号：US20040167088A1

公开(公告)日：2004-08-26

申请号：US10374271

申请日：2003-02-25

Applicant: GenVec, Inc.

Inventor： Thomas J. Wickham ,  Masaki Akiyama

IPC: A61K048/00 ,  C12N015/861

CPC classification number: C12N15/86 ,  A61K48/00 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2810/405 ,  C12N2810/50

Abstract: The invention provides a method of expressing an exogenous nucleic acid in a mammal. The method comprises slowly releasing into the bloodstream a dose of replication-deficient or conditionally-replicating adenoviral vector having reduced ability to transduce mesothelial cells and hepatocytes. The normalized average bloodstream concentration of the adenovirus over 24 hours post-administration is at least about 1%. Alternatively, the normalized average bloodstream concentration over 24 hours post-administration is at least about 5-fold greater than the normalized average bloodstream concentration for an equivalent dose of a wild-type adenoviral vector. A method of destroying tumor cells in a mammal also is provided.

Abstract translation: 本发明提供了在哺乳动物中表达外源核酸的方法。 该方法包括缓慢释放一定剂量的复制缺陷型或条件复制型腺病毒载体，其具有降低转导间皮细胞和肝细胞的能力。 给药后24小时内腺病毒的归一化平均血流浓度为至少约1％。 或者，给药后24小时内的标准化平均血流浓度比相当剂量的野生型腺病毒载体的归一化平均血流浓度高至少约5倍。 还提供了一种破坏哺乳动物肿瘤细胞的方法。