Process for the preparation of isobenzofurandiones
    52.
    发明授权
    Process for the preparation of isobenzofurandiones 失效
    异苯并呋喃二酸的制备方法

    公开(公告)号:US5672719A

    公开(公告)日:1997-09-30

    申请号:US528388

    申请日:1995-09-13

    CPC classification number: C07C51/377

    Abstract: Isobenzofurandiones are obtained in particularly advantageous manner by the dehydrogenation of tetrahydroisobenzofurandiones in the presence of catalysts at elevated temperature by a process in which distilled tetrahydro-isobenzofurandiones are heated to temperatures of between 120.degree. and 300.degree. C. in the presence of supported palladium and/or platinum catalysts and in the presence of maleic acid derivatives in a trickle-phase or liquid-phase procedure, the temperature in the liquid-phase procedure being increased at a rate of 0.6.degree. to 3.degree. C. per minute above 80.degree. to 110.degree. C.

    Abstract translation: 通过在催化剂存在下,在升高的温度下,通过四氢异苯并呋喃二酸脱氢的方法,通过在负载的钯和/或碱存在下将蒸馏的四氢异苯并呋喃二酸加热至120-300℃的温度, 或铂催化剂,并且在涓流或液相方法中存在马来酸衍生物时,液相方法中的温度以每分钟高于80℃至110℃的速度增加至110℃ DEG C.

    Process for the preparation of methylene compounds and the novel
compound 2-(2,4-Dichloro-5-fluorobenzyl)thiophene
    54.
    发明授权
    Process for the preparation of methylene compounds and the novel compound 2-(2,4-Dichloro-5-fluorobenzyl)thiophene 失效
    制备亚甲基化合物和新化合物2-(2,4-二氯-5-氟苄基)噻吩的方法

    公开(公告)号:US5591869A

    公开(公告)日:1997-01-07

    申请号:US568050

    申请日:1995-12-06

    CPC classification number: C07D307/38 C07B31/00 C07D333/08 C07D333/12

    Abstract: Methylene compounds are preferably prepared by reducing an aluminum halide complex of the formula ##STR1## in which R.sup.1 represents a C.sub.6 -C.sub.10 -aryl radical which is optionally substituted by 1 to 4 C.sub.1 -C.sub.4 -alkyl radicals, 1 to 4 fluorine, chlorine and/or bromine atoms, one C.sub.1 -C.sub.8 -alkoxy group and/or one acetoxy group, or represents a heteroaryl radical which is optionally substituted by one C.sub.1 -C.sub.4 -alkyl radical and/or one fluorine, chlorine or bromine atom and contains 5 to 10 C atoms and one O or S atom andR.sup.2 represents a C.sub.1 -C.sub.12 -alkyl radical which is optionally substituted by 1 to 5 fluorine, chlorine and/or bromine atoms, independently of R.sup.1 represents a radical as defined for R.sup.1 and, in the case where R.sup.1 =a C.sub.6 -C.sub.10 -aryl radical which is substituted by 1 to 4 fluorine, chlorine and/or bromine atoms, also represents a furyl or thienyl radical,Y represents fluorine, chlorine or bromine,with an amineborane of the formula ##STR2## in which R.sup.3 represents C.sub.1 -C.sub.4 -alkyl andR.sup.4 represents hydrogen or C.sub.1 -C.sub.4 -alkyl and/orwith sodium borohydride and/or with potassium borohydride.2-(2,4-Dichloro-5-fluorobenzyl)thiophene is obtainable in this way for the first time.

    Abstract translation: 亚甲基化合物优选通过还原任选被1至4个C 1 -C 4烷基,1至4个氟,氯和/或溴原子,一个C 1 -C 8 - 烷氧基取代的式偕基的卤化铝配合物 和/或一个乙酰氧基,或表示任选被一个C 1 -C 4 - 烷基和/或一个氟,氯或溴原子取代且含有5至10个C原子和一个O或S原子且R 2表示 任选被1至5个氟,氯和/或溴原子取代的C1-C12-烷基,独立于R1表示对R1定义的基团,并且在R1 = C6-C10芳基的情况下,其中 被1至4个氟,氯和/或溴原子取代,也代表呋喃基或噻吩基,Y代表氟,氯或溴,与式(III)的胺硼烷反应,其中R 3表示C 1 -C 4 - 烷基和R 4表示氢或C 1 -C 4烷基和/或与硼氢化钠 ydride和/或用硼氢化钾。 2-(2,4-二氯-5-氟苄基)噻吩可以首次以这种方式获得。

    Process for isolating M-dichlorobenzene from mixtures of dichlorobenzene
isomers
    57.
    发明授权
    Process for isolating M-dichlorobenzene from mixtures of dichlorobenzene isomers 失效
    从二氯苯异构体的混合物中分离M-二氯苯的方法

    公开(公告)号:US5436377A

    公开(公告)日:1995-07-25

    申请号:US300614

    申请日:1994-09-02

    CPC classification number: C07C17/392

    Abstract: In a particularly advantageous process for isolating m-dichlorobenzene from mixtures of dichlorobenzene isomers by crystallization as eutectic crystals using a processing aid, the processing aid used is a compound of the formula (I) ##STR1## in which R.sup.1 to R.sup.6 are, independently of one another, hydrogen, halogen, C.sub.1 -C.sub.4 -alkyl, hydroxyl, NH.sub.2 or R--CO-- having R=C.sub.1 -C.sub.4 -alkyl,with 1-bromo-4-chlorobenzene and 1,4-dibromobenzene being excepted.

    Abstract translation: 在使用加工助剂通过结晶作为共晶晶体从二氯苯异构体的混合物中分离间二氯苯的特别有利的方法中,所用的加工助剂是式(I)化合物,其中R 1至R 6为 独立地是具有R = C 1 -C 4 - 烷基的氢,卤素,C 1 -C 4 - 烷基,羟基,NH 2或R-CO-,除了1-溴-4-氯苯和1,4-二溴苯外。

    Preparation of phosphoric acid derivatives and intermediates
    59.
    发明授权
    Preparation of phosphoric acid derivatives and intermediates 失效
    磷酸衍生物和中间体的制备

    公开(公告)号:US5010193A

    公开(公告)日:1991-04-23

    申请号:US282712

    申请日:1988-12-09

    Abstract: A process for the preparation of a compound of the formula ##STR1## in which R is hydrogen, alkoxy, alkylamino, dialkylamino or an optionally substituted radical from the group consisting of alkyl, cycloalkyl, aralkyl and aryl,R.sup.1 is an optionally substituted radical from the group consisting of alkyl, alkoxy, alkylthio, mono- or dialkylamino and phenyl,R.sup.2 is optionally substituted alkyl, andY is oxygen or sulphur,comprising(a1) reacting a compound of the formula ##STR2## with ##STR3## or withR.sup.5 COOHin whichR.sup.5 is R except for hydrogen, or equivalent, to produce ##STR4## oxidizing that compound or its salt to ##STR5## and phosphorylating. Several of the intermediates are new.

    Abstract translation: 制备式(I)化合物的方法,其中R是氢,烷氧基,烷基氨基,二烷基氨基或任选取代的基团,其由烷基,环烷基,芳烷基和芳基组成的组中,R 1是任选的 取代基由烷基,烷氧基,烷硫基,一烷基或二烷基氨基和苯基组成的组中,R 2为任选取代的烷基,Y为氧或硫,包括(a1)使式(IIa)化合物与 (III)或其中R5为R的R5 COOH,或氢等价物,以产生氧化该化合物或其盐至(V)并进行磷酸化的(VIa)(Ⅳa)。 几个中间体是新的。

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