公开(公告)号：US5741936A

公开(公告)日：1998-04-21

申请号：US710474

申请日：1996-09-18

Applicant: Klaus-Christian Paetz ,  Helmut Fiege ,  Wolfram Kissener

Inventor： Klaus-Christian Paetz ,  Helmut Fiege ,  Wolfram Kissener

IPC: C07C201/08 ,  C07C205/45 ,  C07C45/61

CPC classification number: C07C201/08

Abstract: 3-Chloro-3'-nitro-4'-methoxybenzophenone with substantially lower contents of dinitro derivatives than hitherto is obtained if 3-chloro-4'-methoxybenzophenone is nitrated in from 65 to 85% strength by weight sulfuric acid with nitric acid at temperatures in the range from -20.degree. to +60.degree. C.

Abstract translation: 迄今为止，如果将3-氯-4'-甲氧基二苯甲酮硝酸化为65-85％的硫酸与硝酸的强度，则得到3-二氯硝基-4'-甲氧基二苯甲酮，其中二硝基衍生物的含量基本较低 温度范围为-20°C至+60°C

公开(公告)号：US5672719A

公开(公告)日：1997-09-30

申请号：US528388

申请日：1995-09-13

Applicant: Josef Kasbauer ,  Helmut Fiege

Inventor： Josef Kasbauer ,  Helmut Fiege

IPC: C07D307/89 ,  B01J23/42 ,  B01J23/44 ,  C07B61/00 ,  C07C51/377 ,  C07D307/77

CPC classification number: C07C51/377

Abstract: Isobenzofurandiones are obtained in particularly advantageous manner by the dehydrogenation of tetrahydroisobenzofurandiones in the presence of catalysts at elevated temperature by a process in which distilled tetrahydro-isobenzofurandiones are heated to temperatures of between 120.degree. and 300.degree. C. in the presence of supported palladium and/or platinum catalysts and in the presence of maleic acid derivatives in a trickle-phase or liquid-phase procedure, the temperature in the liquid-phase procedure being increased at a rate of 0.6.degree. to 3.degree. C. per minute above 80.degree. to 110.degree. C.

Abstract translation: 通过在催化剂存在下，在升高的温度下，通过四氢异苯并呋喃二酸脱氢的方法，通过在负载的钯和/或碱存在下将蒸馏的四氢异苯并呋喃二酸加热至120-300℃的温度， 或铂催化剂，并且在涓流或液相方法中存在马来酸衍生物时，液相方法中的温度以每分钟高于80℃至110℃的速度增加至110℃ DEG C.

公开(公告)号：US5672708A

公开(公告)日：1997-09-30

申请号：US521941

申请日：1995-08-31

Applicant: Gunter Rauchschwalbe ,  Bernhard Beitzke ,  Wolfgang Eymann ,  Helmut Fiege

Inventor： Gunter Rauchschwalbe ,  Bernhard Beitzke ,  Wolfgang Eymann ,  Helmut Fiege

IPC: C07D317/48 ,  C07C227/06 ,  C07C227/10 ,  C07C229/34 ,  C07D213/61 ,  C07D213/74 ,  C07D215/56 ,  C07D319/18 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D471/04 ,  C07D491/044 ,  C07D491/056 ,  C07D491/14 ,  C07D491/22 ,  C07D491/02 ,  C07C205/00 ,  C07C229/00 ,  C07D307/00

CPC classification number: C07D215/56 ,  C07C227/10 ,  C07C229/34

Abstract: N-arylaminoacrylic acid derivatives are obtained in good yields and in high purities when benzoylacetic acid derivatives are reacted with N-arylimino ethers. The products thus prepared are used, in particular, for the preparation of 4-quinolone-3-carboxylic acid derivatives, which have an outstanding bactericidal action.

Abstract translation: 当苯甲酰乙酸衍生物与N-芳基亚氨基醚反应时，得到N-芳基氨基丙烯酸衍生物，产率高，纯度高。 这样制备的产品特别用于制备具有优异杀菌作用的4-喹诺酮-3-羧酸衍生物。

公开(公告)号：US5591869A

公开(公告)日：1997-01-07

申请号：US568050

申请日：1995-12-06

Applicant: Helmut Fiege ,  Ferdinand Hagedorn

Inventor： Helmut Fiege ,  Ferdinand Hagedorn

IPC: C07B31/00 ,  C07C1/32 ,  C07C17/35 ,  C07D307/38 ,  C07D333/08 ,  C07D333/12

CPC classification number: C07D307/38 ,  C07B31/00 ,  C07D333/08 ,  C07D333/12

Abstract: Methylene compounds are preferably prepared by reducing an aluminum halide complex of the formula ##STR1## in which R.sup.1 represents a C.sub.6 -C.sub.10 -aryl radical which is optionally substituted by 1 to 4 C.sub.1 -C.sub.4 -alkyl radicals, 1 to 4 fluorine, chlorine and/or bromine atoms, one C.sub.1 -C.sub.8 -alkoxy group and/or one acetoxy group, or represents a heteroaryl radical which is optionally substituted by one C.sub.1 -C.sub.4 -alkyl radical and/or one fluorine, chlorine or bromine atom and contains 5 to 10 C atoms and one O or S atom andR.sup.2 represents a C.sub.1 -C.sub.12 -alkyl radical which is optionally substituted by 1 to 5 fluorine, chlorine and/or bromine atoms, independently of R.sup.1 represents a radical as defined for R.sup.1 and, in the case where R.sup.1 =a C.sub.6 -C.sub.10 -aryl radical which is substituted by 1 to 4 fluorine, chlorine and/or bromine atoms, also represents a furyl or thienyl radical,Y represents fluorine, chlorine or bromine,with an amineborane of the formula ##STR2## in which R.sup.3 represents C.sub.1 -C.sub.4 -alkyl andR.sup.4 represents hydrogen or C.sub.1 -C.sub.4 -alkyl and/orwith sodium borohydride and/or with potassium borohydride.2-(2,4-Dichloro-5-fluorobenzyl)thiophene is obtainable in this way for the first time.

Abstract translation: 亚甲基化合物优选通过还原任选被1至4个C 1 -C 4烷基，1至4个氟，氯和/或溴原子，一个C 1 -C 8 - 烷氧基取代的式偕基的卤化铝配合物 和/或一个乙酰氧基，或表示任选被一个C 1 -C 4 - 烷基和/或一个氟，氯或溴原子取代且含有5至10个C原子和一个O或S原子且R 2表示 任选被1至5个氟，氯和/或溴原子取代的C1-C12-烷基，独立于R1表示对R1定义的基团，并且在R1 = C6-C10芳基的情况下，其中 被1至4个氟，氯和/或溴原子取代，也代表呋喃基或噻吩基，Y代表氟，氯或溴，与式（III）的胺硼烷反应，其中R 3表示C 1 -C 4 - 烷基和R 4表示氢或C 1 -C 4烷基和/或与硼氢化钠 ydride和/或用硼氢化钾。 2-（2,4-二氯-5-氟苄基）噻吩可以首次以这种方式获得。

公开(公告)号：US5502256A

公开(公告)日：1996-03-26

申请号：US350552

申请日：1994-12-07

Applicant: Ferdinand Hagedorn ,  Helmut Fiege ,  Robert So/ llner ,  Rudolf Helm

Inventor： Ferdinand Hagedorn ,  Helmut Fiege ,  Robert So/ llner ,  Rudolf Helm

IPC: C07C319/22 ,  C07C323/09

CPC classification number: C07C319/22

Abstract: 2,2'-Dinitrodiphenyl disulphide is obtained in particularly good yields and purities in a simple manner by reacting 2-chloronitrobenzene with an aqueous alkali metal disulphide solution in the presence of phase transfer catalysts and an organic solvent.

Abstract translation: 在相转移催化剂和有机溶剂的存在下，2-氯硝基苯与碱金属二硫化物水溶液反应，以简单的方式获得了特别好的收率和纯度的2,2'-二硝基二苯基二硫化物。

公开(公告)号：US5475142A

公开(公告)日：1995-12-12

申请号：US288632

申请日：1994-08-10

Applicant: Stefan Antons ,  Helmut Fiege ,  Werner Bussmann ,  Hartmut Richter

Inventor： Stefan Antons ,  Helmut Fiege ,  Werner Bussmann ,  Hartmut Richter

IPC: B01J27/128 ,  C07B61/00 ,  C07C315/04 ,  C07C317/14

CPC classification number: C07C315/04

Abstract: Alkyl-(3-chlorophenyl)-sulphones are particularly advantageously obtained by chlorination of alkylphenylsulphones if alkylphenylsulphones are chlorinated in molten form with elemental chlorine in the presence of iron(III) chloride and optionally iodine and/or sulphur.

Abstract translation: 如果烷基苯基砜在氯化铁（III）和任选的碘和/或硫的存在下，用元素氯以熔融形式氯化，则烷基 - （3-氯苯基） - 砜特别有利地通过氯化烷基苯基砜获得。

公开(公告)号：US5436377A

公开(公告)日：1995-07-25

申请号：US300614

申请日：1994-09-02

Applicant: Michael Pies ,  Kai Rohlk ,  Helmut Lahr ,  Helmut Fiege

Inventor： Michael Pies ,  Kai Rohlk ,  Helmut Lahr ,  Helmut Fiege

IPC: C07C17/392 ,  C07C25/08

CPC classification number: C07C17/392

Abstract: In a particularly advantageous process for isolating m-dichlorobenzene from mixtures of dichlorobenzene isomers by crystallization as eutectic crystals using a processing aid, the processing aid used is a compound of the formula (I) ##STR1## in which R.sup.1 to R.sup.6 are, independently of one another, hydrogen, halogen, C.sub.1 -C.sub.4 -alkyl, hydroxyl, NH.sub.2 or R--CO-- having R=C.sub.1 -C.sub.4 -alkyl,with 1-bromo-4-chlorobenzene and 1,4-dibromobenzene being excepted.

Abstract translation: 在使用加工助剂通过结晶作为共晶晶体从二氯苯异构体的混合物中分离间二氯苯的特别有利的方法中，所用的加工助剂是式（I）化合物，其中R 1至R 6为 独立地是具有R = C 1 -C 4 - 烷基的氢，卤素，C 1 -C 4 - 烷基，羟基，NH 2或R-CO-，除了1-溴-4-氯苯和1,4-二溴苯外。

公开(公告)号：US5315049A

公开(公告)日：1994-05-24

申请号：US108367

申请日：1993-08-18

Applicant: Heinrich Schrage ,  Helmut Fiege

Inventor： Heinrich Schrage ,  Helmut Fiege

IPC: B01J31/28 ,  B01J31/02 ,  B01J31/30 ,  C07B61/00 ,  C07C17/12 ,  C07C25/02 ,  C07C25/18 ,  C07C25/00

CPC classification number: B01J31/0204 ,  B01J31/068 ,  B01J31/30 ,  C07C17/12 ,  B01J2231/40

Abstract: Alkylaromatics are subjected to nuclear chlorination in the liquid phase in the presence of Friedel-Crafts catalyst mixtures comprising compounds of iron and antimony and cocatalysts of the formula (II) ##STR1## wherein the substituents have the meaning given in the description.

Abstract translation: 在包含铁和锑化合物的Friedel-Crafts催化剂混合物和式（II）的助催化剂（II）的存在下，将烷基芳族化合物在液相中进行核氯化，其中取代基具有在说明书中给出的含义。

公开(公告)号：US5010193A

公开(公告)日：1991-04-23

申请号：US282712

申请日：1988-12-09

Applicant: Fritz Maurer ,  Reinhard Lantzsch ,  Helmut Fiege ,  Albert Schnatterer

Inventor： Fritz Maurer ,  Reinhard Lantzsch ,  Helmut Fiege ,  Albert Schnatterer

IPC: C07D239/06 ,  C07D239/10 ,  C07D239/14 ,  C07D239/36 ,  C07D239/46 ,  C07D239/47 ,  C07D239/52 ,  C07F9/6512

CPC classification number: C07D239/06 ,  C07D239/14 ,  C07D239/36 ,  C07D239/46 ,  C07F9/65125

Abstract: A process for the preparation of a compound of the formula ##STR1## in which R is hydrogen, alkoxy, alkylamino, dialkylamino or an optionally substituted radical from the group consisting of alkyl, cycloalkyl, aralkyl and aryl,R.sup.1 is an optionally substituted radical from the group consisting of alkyl, alkoxy, alkylthio, mono- or dialkylamino and phenyl,R.sup.2 is optionally substituted alkyl, andY is oxygen or sulphur,comprising(a1) reacting a compound of the formula ##STR2## with ##STR3## or withR.sup.5 COOHin whichR.sup.5 is R except for hydrogen, or equivalent, to produce ##STR4## oxidizing that compound or its salt to ##STR5## and phosphorylating. Several of the intermediates are new.

Abstract translation: 制备式（I）化合物的方法，其中R是氢，烷氧基，烷基氨基，二烷基氨基或任选取代的基团，其由烷基，环烷基，芳烷基和芳基组成的组中，R 1是任选的 取代基由烷基，烷氧基，烷硫基，一烷基或二烷基氨基和苯基组成的组中，R 2为任选取代的烷基，Y为氧或硫，包括（a1）使式（IIa）化合物与 （III）或其中R5为R的R5 COOH，或氢等价物，以产生氧化该化合物或其盐至（V）并进行磷酸化的（VIa）（Ⅳa）。 几个中间体是新的。

公开(公告)号：US4990687A

公开(公告)日：1991-02-05

申请号：US436156

申请日：1989-11-13

Applicant: Alfons Klein ,  Helmut Fiege ,  Lothar Puppe ,  Werner Jeblick

Inventor： Alfons Klein ,  Helmut Fiege ,  Lothar Puppe ,  Werner Jeblick

IPC: C07C37/11 ,  C07B61/00 ,  C07C37/14 ,  C07C37/16 ,  C07C39/15

CPC classification number: C07C37/16 ,  C07C37/14 ,  B01J2229/183 ,  B01J29/084 ,  B01J29/088 ,  C07C2101/14

Abstract: 4-Methyl-2-cyclohexylphenol can be prepared by alkylation of p-cresol with cyclohexanol or cyclohexene by performing the reaction in the liquid phase in the presence of 1-10% by weight, based on the amount of p-cresol, of a large pore, acidic zeolite.

Abstract translation: 4-甲基-2-环己基苯酚可以通过使对甲酚与环己醇或环己烯烷基化来制备，通过在1-10％（重量）的对甲苯酚的存在下，在液相中进行反应， 大孔，酸性沸石。