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    Superagonists, Partial Agonists and Antagonists of Interleukin-2
    53.
    发明申请
    Superagonists, Partial Agonists and Antagonists of Interleukin-2 审中-公开
    超级激素，部分激动剂和白介素-2拮抗剂

    公开(公告)号：US20170044229A1

    公开(公告)日：2017-02-16

    申请号：US15305831

    申请日：2015-04-24

    Applicant: The Board of Trustees of the Leland Stanford Junior University ,  United States Department of Health and Human Service, Office of Technology Transfer, National

    Inventor： Christopher K. GARCIA ,  Suman MITRA ,  Warren J. LEONARD ,  Aaron M. RING

    IPC: C07K14/55

    CPC classification number: C07K14/55 ,  A61K38/00 ,  C07K2319/30

    Abstract: Novel human interleukin-2 (IL-2) muteins or variants thereof are provided. In particular, provided are IL-2 muteins that have an increased binding capacity for IL-2RP receptor and a decreased binding capacity for IL-2Rγc receptor, as compared to wild-type IL-2. Such IL-2 muteins are useful, for example, as IL-2 partial agonist and antagonists in applications where reduction or inhibition of one or more IL-2 and/or IL-15 functions is useful (e.g., in the treatment of graft versus host disease (GVHD) and adult T cell leukemia). Also provided are nucleic acids encoding such IL-2 muteins, methods of making such IL-2 muteins, pharmaceutical compositions that include such IL-2 muteins and methods of treatment using such pharmaceutical compositions.

    Abstract translation: 提供新的人白细胞介素-2（IL-2）突变蛋白或其变体。 特别地，与野生型IL-2相比，IL-2突变蛋白具有增加的IL-2RP受体的结合能力和降低的IL-2Rγc受体的结合能力。 在IL-2和/或IL-15功能减少或抑制有用的应用中，例如IL-2部分激动剂和拮抗剂可用于这样的IL-2突变蛋白（例如，在治疗移植物抗体 宿主病（GVHD）和成人T细胞白血病）。 还提供了编码这种IL-2突变蛋白的核酸，制备这种IL-2突变蛋白的方法，包括这种IL-2突变蛋白的药物组合物和使用这种药物组合物的治疗方法。

    PATHOGEN DETECTION BY STRAIN-SPECIFIC BACTERIAL RECOGNITION AND PLASMONIC AMPLIFICATION AND READOUT
    54.
    发明申请
    PATHOGEN DETECTION BY STRAIN-SPECIFIC BACTERIAL RECOGNITION AND PLASMONIC AMPLIFICATION AND READOUT 审中-公开
    通过应变特异性细菌识别和等离子体放大和读出的病原体检测

    公开(公告)号：US20150276730A1

    公开(公告)日：2015-10-01

    申请号：US14440345

    申请日：2013-11-01

    Applicant: UNIVERSITY OF NOTRE DAME DU LAC OFFICE OF TECHNOLOGY TRANSFER

    Inventor： Marvin J. Miller ,  Cheng Ji ,  Paul Bohn ,  Sean Branagan ,  Yang Yang

    IPC: G01N33/543 ,  B03C5/00 ,  G01N27/447 ,  G01N33/569 ,  G01N27/327

    CPC classification number: G01N33/54393 ,  B03C5/005 ,  B82Y15/00 ,  G01N21/553 ,  G01N21/554 ,  G01N27/3275 ,  G01N27/44756 ,  G01N33/569 ,  G01N33/56911

    Abstract: The present invention relates to a method and kit for detecting bacteria in a sample. Substrate having a surface comprising an interdigitated Au electrode array and a plurality of siderophores specific to the bacteria and covalently attached to the surface. In one embodiment, the siderophore may contain a free OH (alcohol), amine, or carboxylic acid to which linker may be attached via ester (on the OH), amide (on the amine) or reverse the ester or amide using the siderophore carboxyl. The linker chain can then be short or long with and without heteroatom substitution to improve solubility as needed. The linker can terminate with a thiol which will react with a gold surface. Alternatively, the linker can terminate with another alcohol, amine or acid which can then be attached to corresponding functionality on the surface of choice.

    Abstract translation: 本发明涉及一种用于检测样品中细菌的方法和试剂盒。 底物具有包括交错的Au电极阵列和多个特定于细菌并且共价连接到表面的铁载体的表面。 在一个实施方案中，载体基团可以含有游离的OH（醇），胺或羧酸，连接体可以通过酯（在OH上），酰胺（在胺上）或相反的酯或酰胺上使用铁载体羧基 。 然后可以使用和不具有杂原子取代的接头链短或长，以根据需要提高溶解度。 接头可以与将与金表面反应的硫醇终止。 或者，接头可以用另一种醇，胺或酸终止，然后可以将其连接到所选表面上的相应官能团。

    Molecular computing elements: gates and flip-flops
    56.
    发明申请
    Molecular computing elements: gates and flip-flops 审中-公开
    分子计算元素：门和触发器

    公开(公告)号：US20040235043A1

    公开(公告)日：2004-11-25

    申请号：US10873774

    申请日：2004-06-21

    Applicant: Department of Health and Human Service National Institutes of Health Office of Technology Transfer

    Inventor： Thomas Schneider ,  Paul N. Hengen

    IPC: C12Q001/68 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50 ,  C07H021/04 ,  C12P021/04

    CPC classification number: B82Y10/00 ,  C12N15/10 ,  C12N15/63 ,  C12N15/635 ,  G06N3/123

    Abstract: This invention relates to novel molecular constructs that act as various logic elements, i.e. gates and flip-flops. The constructs are useful in a wide variety of contexts including, but not limited to, computation and control systems. The basic functional unit of the construct comprises a nucleic acid having at least two protein binding sites that cannot be simultaneously occupied by their cognate binding protein. This basic unit can be assembled in number of formats providing molecular constructs that act like traditional digital logic elements (flip-flops, gates, inverters, etc.).

    Abstract translation: 本发明涉及用作各种逻辑元件即门和触发器的新型分子结构。 这些结构在各种各样的上下文中是有用的，包括但不限于计算和控制系统。 构建体的基本功能单元包含具有至少两个蛋白质结合位点的核酸，其不能被同源结合蛋白同时占据。 该基本单元可以以提供与传统数字逻辑元件（触发器，门，逆变器等）相似的分子结构的多种格式组装。

    Nanostructured proton exchange membrane fuel cells
    57.
    发明申请
    Nanostructured proton exchange membrane fuel cells 审中-公开
    纳米结构质子交换膜燃料电池

    公开(公告)号：US20040167014A1

    公开(公告)日：2004-08-26

    申请号：US10713774

    申请日：2003-11-13

    Applicant: The Regents of the Univ. of California, Office of Technology Transfer, University of California

    Inventor： Yushan Yan ,  Cheng Wang

    IPC: B05D005/12 ,  H01M004/88

    CPC classification number: B82Y30/00 ,  H01M4/8605 ,  H01M4/8875 ,  H01M4/92 ,  H01M4/926 ,  H01M8/0234 ,  H01M8/1004

    Abstract: A novel proton exchange membrane fuel cell with nanostructured components with higher precious metal utilization rate at the electrodes, higher power density, and lower cost. Aligned arrays of carbon nanotubes, either single wall or multiwall, are prepared by catalyzed chemical vapor deposition (CVD), or plasma assisted CVD and used as support for catalyst. Solubilized perfluorosulfonate ionomer membrane is incorporated into the spare space between nanotubes to form a 4-phase boundary of gas, metal, proton conductor, and electron conductor. By assembling the as-prepared electrodes with perfluorosulfonate ionomer membrane, backing layers and electron collectors, proton exchange membrane fuel cells are developed.

    Abstract translation: 一种具有纳米结构组分的新型质子交换膜燃料电池，其电极的贵金属利用率更高，功率密度更高，成本更低。 通过催化化学气相沉积（CVD）或等离子体辅助CVD制备碳纳米管（单壁或多壁）的对齐阵列，并用作催化剂的载体。 将溶解的全氟磺酸盐离聚物膜并入纳米管之间的备用空间，形成气体，金属，质子导体和电子导体的4相边界。 通过将所制备的电极与全氟磺酸盐离聚物膜，背衬层和电子收集器组装，开发了质子交换膜燃料电池。

    Carotid artery filter system for single view dental panoramic radiographs
    58.
    发明申请
    Carotid artery filter system for single view dental panoramic radiographs 失效
    颈动脉过滤系统用于单视野全景X光片

    公开(公告)号：US20040052329A1

    公开(公告)日：2004-03-18

    申请号：US10244103

    申请日：2002-09-13

    Applicant: University of Rochester Medical Center Office of Technology Transfer

    Inventor： Dov M. Almog

    IPC: A61B006/14

    CPC classification number: A61B6/4035 ,  A61B6/14

    Abstract: A method and a suite of filters for detecting carotid artery calcification in a panoramic dental radiograph, including imposing a filter between an x-ray radiation beam source and an imaging medium, wherein the imposing attenuates the effect of the incident x-ray in the region of the carotid artery; obtaining a panoramic dental radiograph while imposing the filter, wherein the imposing enhances the contrast of the radiograph in the region of carotid artery; and detecting a calcification region in the area of the radiograph wherein the x-ray image's contrast has been enhanced by using the filter, and which area corresponds with the location of the carotid artery. The suite of filters include a patient format, a cassette format, an x-ray unit format and a software-based format.

    Abstract translation: 一种用于在全景牙科X射线照片中检测颈动脉钙化的方法和一套过滤器，包括在X射线辐射束源和成像介质之间施加过滤器，其中强制性衰减入射X射线在该区域中的影响 的颈动脉; 在施加过滤器的同时获得全景牙科X射线照片，其中强化提高了颈动脉区域中的放射照片的对比度; 并且通过使用所述滤波器，检测X射线图像的对比度增强的X射线照片区域中的钙化区域，以及哪个区域对应于颈动脉的位置。 一套过滤器包括病人格式，磁带格式，X光单元格式和基于软件的格式。

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