公开(公告)号：US20240405160A1

公开(公告)日：2024-12-05

申请号：US17839268

申请日：2022-06-13

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Office of Technology Transfer

Inventor： Ayush PANDEY ,  Zetian MI

IPC: H01L33/14 ,  H01L33/00 ,  H01L33/02 ,  H01L33/06 ,  H01L33/32

Abstract: The presented devices and methods are directed to efficient and effective photon emission. In one embodiment, high-performance tunnel junction deep ultraviolet (UV) light-emitting diodes (LEDs) are created using plasma-assisted molecular beam epitaxy. The device heterostructure was grown under slightly Ga-rich conditions to promote the formation of nanoscale clusters in the active region. The nanoscale clusters can act as charge containment configurations. In one exemplary implementation, a device operates at approximately 255 nm light emission with a maximum external quantum efficiency (EPE) of 7.2% and wall-plug efficiency (WPE) of 4%, which are nearly one to two orders of magnitude higher than previously reported tunnel junction devices operating at this wavelength. The devices exhibit highly stable emission originating from highly localized carriers in Ga-rich regions formed in the active region, with nearly constant emission peak with increasing current density up to 200 A/cm2, due to the strong charge carrier confinement related to the presence of nanoclusters (e.g., Ga-rich) and radiative emission originating from highly localized carriers in Ga-rich regions formed in the active region

公开(公告)号：US20230404465A1

公开(公告)日：2023-12-21

申请号：US18135738

申请日：2023-04-18

Applicant: Galiana Technology Inc. ,  National Institutes of Health, Office of Technology Transfer

Inventor： Bruce T Hope ,  Mark A Wells ,  Gregory D Sutton

IPC: A61B5/00 ,  A61B5/07 ,  A61B5/1473 ,  A61B5/145

CPC classification number: A61B5/4064 ,  A61B5/076 ,  A61B5/1473 ,  A61B5/14546 ,  A61B5/6868 ,  A61B5/0031 ,  A61B2562/028 ,  A61B2560/0204 ,  A61B2562/0285 ,  Y10S977/774

Abstract: An intracellular monitoring device (IMD) that fits completely inside a living cell, and causes no significant impairment, to a cell's normal biological processes. The IMD monitors a cell for its level of a biological substance (e.g., calcium ion concentration) of interest. If the biological substance reaches or exceeds a threshold, the IMD transmits an electromagnetic signal, received by an antenna outside the cell. Each IMD has its electromagnetic signal encoded with a unique frequency. Detection of the frequency components, in the signals received by an antenna, permits identification of the source IMD's. A high calcium ion concentration is indicative of a strongly-activated cerebral cortex neuron. Brain tissue is relatively transparent to near infrared, making it a good frequency band, for the electromagnetic signals from neuron-monitoring IMD's. The near infrared of each IMD can be produced by quantum dots, powered by bioelectric catalysis triggered by high calcium ion concentration.

公开(公告)号：US20210079055A1

公开(公告)日：2021-03-18

申请号：US15930057

申请日：2020-05-12

Applicant: The Board of Trustees of the Leland Stanford Junior University ,  United States Department of Health and Human Services, Office of Technology Transfer, National Insti

Inventor： Christopher K. Garcia ,  Suman Mitra ,  Warren J. Leonard ,  Aaron M. Ring

IPC: C07K14/55 ,  A61K38/00

Abstract: Novel human interleukin-2 (IL-2) muteins or variants thereof are provided. In particular, provided are IL-2 muteins that have an increased binding capacity for IL-2Rβ receptor and a decreased binding capacity for IL-2Rγc receptor, as compared to wild-type IL-2. Such IL-2 muteins are useful, for example, as IL-2 partial agonist and antagonists in applications where reduction or inhibition of one or more IL-2 and/or IL-15 functions is useful (e.g., in the treatment of graft versus host disease (GVHD) and adult T cell leukemia). Also provided are nucleic acids encoding such IL-2 muteins, methods of making such IL-2 muteins, pharmaceutical compositions that include such IL-2 muteins and methods of treatment using such pharmaceutical compositions.

公开(公告)号：US10654905B2

公开(公告)日：2020-05-19

申请号：US16175709

申请日：2018-10-30

Applicant: The Board of Trustees of the Leland Stanford Junior University ,  United States Department of Health and Human Services, Office of Technology Transfer, National Institutes of Health

Inventor： Christopher K. Garcia ,  Suman Mitra ,  Warren J. Leonard ,  Aaron M. Ring

IPC: A61K38/20 ,  C07K14/55 ,  A61K38/00

Abstract: Novel human interleukin-2 (IL-2) muteins or variants thereof are provided. In particular, provided are IL-2 muteins that have an increased binding capacity for IL-2Rβ receptor and a decreased binding capacity for IL-2Rγc receptor, as compared to wild-type IL-2. Such IL-2 muteins are useful, for example, as IL-2 partial agonist and antagonists in applications where reduction or inhibition of one or more IL-2 and/or IL-15 functions is useful (e.g., in the treatment of graft versus host disease (GVHD) and adult T cell leukemia). Also provided are nucleic acids encoding such IL-2 muteins, methods of making such IL-2 muteins, pharmaceutical compositions that include such IL-2 muteins and methods of treatment using such pharmaceutical compositions.

公开(公告)号：US10590074B2

公开(公告)日：2020-03-17

申请号：US15830244

申请日：2017-12-04

Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services, Office of Technology Transfer, National Institutes of Health

Inventor： Amy Hauck Newman ,  Oluyomi M. Okunola-Bakare ,  Jianjing Cao

IPC: C07C323/60 ,  A61K45/06 ,  A61K31/135 ,  C07C317/44 ,  C07C317/28 ,  C07C323/25 ,  C07D295/08 ,  C07D295/088 ,  C07D295/108 ,  C07D295/185

Abstract: Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephrine (NE) reuptake via their respective transporters, DAT, SERT and NET. Also disclosed are methods for eliciting a wake-promoting or cognitive or attention enhancing effect and for treating substance use disorders, attention deficit (hyperactivity) disorder, depressive disorders, bipolar disorder or other neuropsychiatric disorders sleep disorders or cognitive impairment using the compounds.

公开(公告)号：US09896484B2

公开(公告)日：2018-02-20

申请号：US14887115

申请日：2015-10-19

Applicant: The United States of America as Represented by the Secretary of the Department of Health and Human Services, National Institutes of Health, Office of Technology Transfer

Inventor： Surender Khurana ,  Hana Golding

IPC: C07K14/005 ,  A61K39/145 ,  G01N33/559 ,  G01N33/569 ,  A61K39/12 ,  C12N7/00 ,  A61K39/00

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/55566 ,  A61K2039/575 ,  C07K2319/21 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16152 ,  G01N33/559 ,  G01N33/56983 ,  G01N2333/11

Abstract: The present invention includes influenza Hemagglutinin protein fragments that fold properly when expressed in bacteria.

公开(公告)号：US20170067974A1

公开(公告)日：2017-03-09

申请号：US15309336

申请日：2015-05-07

Applicant: Joseph A. Murphy-Boesch ,  Stephen Dodd ,  Chunqi Qian ,  Alan Koretsky ,  OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH

Inventor： Joseph A. Murphy-Boesch ,  Stephen Dodd ,  Chunqi Qian ,  Alan Koretsky

IPC: G01R33/36 ,  G01R33/561

CPC classification number: G01R33/3621 ,  G01R33/3642 ,  G01R33/3692 ,  G01R33/5616

Abstract: A novel MRI-compatible amplifier design uses positive feedback from a low-noise Field-Effect Transistor to amplify the signal current within a resonant NMR coil. The amplified signal current in this low-power circuit produces RF flux can be coupled out to receiving loops positioned externally without significant loss in sensitivity. In other aspects, the amplifier may be remotely powered by external resonant loops, a small non-magnetic battery, or optical power, such that the NMR coil can be positioned during highly invasive procedures such as for surgical resection of tumors in deep-lying tissues to develop high-resolution images.

Abstract translation: 一种新颖的MRI兼容放大器设计使用来自低噪声场效应晶体管的正反馈来放大谐振NMR线圈内的信号电流。 该低功率电路中放大的信号电流产生的RF通量可以耦合到外部定位的接收回路，而灵敏度没有显着的损失。 在其他方面，放大器可以由外部谐振回路，小型非磁性电池或光学功率远程供电，使得NMR线圈可以在高侵入性程序中定位，例如用于在深层组织中手术切除肿瘤 开发高分辨率图像。

公开(公告)号：US20170012680A1

公开(公告)日：2017-01-12

申请号：US15071025

申请日：2016-03-15

Applicant: University of Hawai'i, Office of Technology Transfer and Economic Development

Inventor： John M. J. Madey ,  Julius M. J. Madey

IPC: H04B7/04

CPC classification number: G01S13/12 ,  G01S13/66 ,  G01S13/88

Abstract: Systems are configured to detect advanced fields, and are therefore able to provide instantaneous communications, radar detection, and remote telemetry. Receiving stations in communications systems and some telemetry systems communicate by modulating a variable termination resistor across the receiver's input terminals. Radar systems and some telemetry systems are sensitive to differential absorption at the targets.

Abstract translation: 系统被配置为检测高级字段，因此能够提供即时通信，雷达检测和远程遥测。 通信系统和一些遥测系统中的接收站通过在接收机的输入端子上调制可变终端电阻来进行通信。 雷达系统和一些遥测系统对目标的差分吸收敏感。

公开(公告)号：US20040214995A1

公开(公告)日：2004-10-28

申请号：US10685977

申请日：2003-10-15

Applicant: Government of the United States of America, represented by the Secretary, Department of Health ,  and Human Services Office of Technology Transfer

Inventor： Yutaka Kawakami ,  Steven A. Rosenberg

IPC: C07K016/30

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/4748 ,  G01N33/5743

Abstract: The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognoses a mammal afflicted with melanoma or metastata melanoma. This invention also provides immunogenic peptides derived from the MART-1 melanoma antigen and a second melanoma antigen designated gp100. This invention further provides immunogenic peptides derived from the MART-1 melanoma antigen or gp100 antigen which have been modified to enhance their immunogenicity. The proteins and peptides provided can serve as an immunogen or vaccine to prevent or treat melanoma.

Abstract translation: 本发明提供编码被称为MART-1的T淋巴细胞识别的黑素瘤抗原的核酸序列。 本发明还涉及使用本发明的核酸序列，蛋白质或抗体诊断，评估或预测患有黑素瘤或转移性黑素瘤的哺乳动物的生物测定。 本发明还提供衍生自MART-1黑素瘤抗原的免疫原性肽和称为gp100的第二黑素瘤抗原。 本发明还提供衍生自MART-1黑素瘤抗原或gp100抗原的免疫原性肽，其已被修饰以增强其免疫原性。 所提供的蛋白质和肽可以作为预防或治疗黑素瘤的免疫原或疫苗。

公开(公告)号：US20030169618A1

公开(公告)日：2003-09-11

申请号：US10079938

申请日：2002-02-19

Applicant: The Regents of the University of California Office of Technology Transfer

Inventor： Jonathan S. Lindsey ,  David F. Bocian ,  Karl-Heinz Schweikart ,  Werner G. Kuhr

IPC: G11C011/00

CPC classification number: G11C13/0014 ,  B82Y10/00 ,  G11B9/14 ,  G11B9/149 ,  G11C11/34 ,  G11C11/5664 ,  G11C13/0009 ,  G11C13/025 ,  G11C2213/77

Abstract: This invention provides novel high density memory devices that are electrically addressable permitting effective reading and writing, that provide a high memory density (e.g., 1015 bits/cm3), that provide a high degree of fault tolerance, and that are amenable to efficient chemical synthesis and chip fabrication. The devices are intrinsically latchable, defect tolerant, and support destructive or non-destructive read cycles. In a preferred embodiment, the device comprises a fixed electrode electrically coupled to a storage medium having a multiplicity of different and distinguishable oxidation states wherein data is stored in said oxidation states by the addition or withdrawal of one or more electrons from said storage medium via the electrically coupled electrode. The storage medium typically comprises a storage molecule that is a triple-decker sandwich heterodimer. Such dimers can provide 8 or more oxidation states and permit the storage of at least 3 bits per molecule.

Abstract translation: 本发明提供了新颖的高密度存储器件，其可电寻址以允许有效读取和写入，其提供高存储密度（例如，1015比特/ cm 3），其提供高度的容错性，并且适于有效的化学合成 和芯片制造。 器件本质上可锁定，缺陷容忍，并支持破坏性或非破坏性的读取周期。 在优选实施例中，该装置包括电耦合到存储介质的固定电极，该存储介质具有多种不同且可区分的氧化态，其中通过经由该存储介质从所述存储介质中添加或撤出一个或多个电子而将数据存储在所述氧化态中 电耦合电极。 存储介质通常包含作为三层三明治夹心异二聚体的储存分子。 这种二聚体可以提供8个或更多个氧化态，并允许每分子存储至少3位。