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    LASER MICROMACHINING OF MEMS RESONATORS FROM BULK OPTICALLY TRANSPARENT MATERIAL
    52.
    发明申请
    LASER MICROMACHINING OF MEMS RESONATORS FROM BULK OPTICALLY TRANSPARENT MATERIAL 有权

    公开(公告)号：US20250091861A1

    公开(公告)日：2025-03-20

    申请号：US18727238

    申请日：2023-01-06

    Applicant: The Regents of the University of California

    Inventor： Daryosh VATANPARVAR ,  Andrei M. SHKEL ,  Danmeng WANG

    IPC: B81C1/00

    Abstract: Systems, processes and devices are provided for laser-based manufacturing of resonators and MEMS devices from bulk material including optically transparent material. Processes include digital marking of resonator structures in bulk material through non-linear interaction of ultrafast laser beam inscribing and material. The resonator structure may be defined and released through selective wet etching of the laser-modified areas, utilizing a combination of basic and acidic aqueous solutions. Processes can also include hydrofluoric thinning prior to wet etching to prevent laser surface damages. Systems and processes can pattern and fabricate resonator structures and concentricring structures. Embodiments provide miniaturized vibratory sensors from low loss material, such as fused silica and quartz, with an improved resolution and accuracy of measurements for inertial sensing, time referencing, bio-sensing and acoustic sensing.

    Single-atom tailoring of platinum nanocatalysts for high-performance multifunctional electrocatalysis
    55.
    发明授权
    Single-atom tailoring of platinum nanocatalysts for high-performance multifunctional electrocatalysis 有权

    公开(公告)号：US12255339B2

    公开(公告)日：2025-03-18

    申请号：US17605192

    申请日：2020-04-21

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Xiangfeng Duan ,  Yu Huang ,  Chengzhang Wan ,  Mufan Li

    IPC: H01M12/06 ,  C25B11/081 ,  C25B11/089 ,  H01M4/92 ,  H01M12/08

    Abstract: Provided herein are catalyst materials comprising a catalyst support; and PtM′ nanowires affixed to the catalyst support, wherein the PtM′ nanowires include single atomic species of M′ at exterior surfaces of the PtM′ nanowires, and M′ represents at least one metal, e.g., a metal different from Pt. Also disclosed are manufacturing methods comprising: providing initial MM′ nanowires having an initial molar ratio of M:M′, wherein M is a noble metal, and M′ is a metal different from M; subjecting the initial MM′ nanowires to electrochemical dealloying to partially remove M′ and form partially dealloyed MM′ nanowires having a subsequent molar ratio of M:M′, wherein the subsequent molar ratio of M:M′ is greater than the initial molar ratio of M:M′; and affixing the partially dealloyed MM′ nanowires to a catalyst support.

    STRETCHABLE MEDICAL PRODUCT FOR SURGICAL USE
    57.
    发明申请
    STRETCHABLE MEDICAL PRODUCT FOR SURGICAL USE 有权

    公开(公告)号：US20250084290A1

    公开(公告)日：2025-03-13

    申请号：US18946031

    申请日：2024-11-13

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： PHILLIP B. MESSERSMITH ,  Subhajit PAL ,  Kelsey G. DEFRATES ,  Jisoo SHIN

    IPC: C09J181/04 ,  A61L24/04 ,  C08G75/14 ,  C08G75/26

    Abstract: Adhesive compositions for medical and non-medical uses are provided. The adhesive compositions can include cyclic disulfide monomers, oligomers of reactions between the cyclic disulfides, polymers of the cyclic disulfides, solid articles formed formed from the polymers, and any combination thereof. Methods of making, using, and recycling the adhesive compositions are provided, including use of the adhesive compositions on a variety of substrates that include biological tissue; biomaterials, including synthetics and natural such as bone, wood, and cellulosics; metals and alloys; polymers, plastics, and rubbers; ceramics; composites; and, any combination of these materials. The adhesives can adhere to substrates in a variety of environmental conditions that include ambient atmospheric conditions, wet conditions that include adhering materials underwater, and in a wide variety of temperatures and pressures, such as those temperatures and pressures found in medical environments, including in living tissue, as well as many residential, commercial, industrial, and manufacturing environments.

    PTPRS IN AUTOIMMUNITY
    59.
    发明申请
    PTPRS IN AUTOIMMUNITY 有权

    公开(公告)号：US20250082734A1

    公开(公告)日：2025-03-13

    申请号：US18290679

    申请日：2022-07-29

    Applicant: The Regents of the University of California

    Inventor： Nunzio Bottini

    IPC: A61K38/46 ,  A61K38/17 ,  C07K14/705 ,  C12N9/16

    Abstract: The methods and compositions of the disclosure are used to prevent or treat autoimmune diseases and disorders, such as lupus, by administering a PTPRS activating agent. The agent does not deplete pDCs or cause a general blockade of IFNα signaling and therefore is less immunosuppressive and easier to combine with other immunosuppressants.

    NEURAL SIGNAL DETECTION OF IMMUNE RESPONSES
    60.
    发明申请
    NEURAL SIGNAL DETECTION OF IMMUNE RESPONSES 有权

    公开(公告)号：US20250082258A1

    公开(公告)日：2025-03-13

    申请号：US18292659

    申请日：2022-07-25

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： Imanuel Lerman ,  Ramesh Rao ,  Ming-Xiong Huang ,  Todd P. Coleman ,  Yifeng Bu

    IPC: A61B5/00 ,  A61B5/248 ,  A61B5/388 ,  G16H10/60

    Abstract: Disclosed are devices, systems and methods for neural signal detection of immune responses. In some aspects, a system includes a processing unit: a receiving unit configured to receive at least one sensor signal from a wearable sensor, where the wearable sensor is configured to detect at least one neural signal of a patient; and a tangible non-transitory computer readable medium having instructions configured to cause the processing unit to automatically receive a data signal from the receiving unit, automatically detect an immune response based at least in part on the data signal, automatically create a notification based at least in part on the immune response, and automatically present the notification to a user of the system.

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