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    METHODS AND KITS FOR DIAGNOSING, PROGNOSING AND MONITORING PARKINSON'S DISEASE
    53.
    发明申请
    METHODS AND KITS FOR DIAGNOSING, PROGNOSING AND MONITORING PARKINSON'S DISEASE 审中-公开
    诊断，预防和监测帕金森病的方法和工具

    公开(公告)号：US20160244832A1

    公开(公告)日：2016-08-25

    申请号：US14870931

    申请日：2015-09-30

    Applicant: Rosalind Franklin University of Medicine and Science

    Inventor： Judith Ann POTASHKIN ,  Jose Alfredo SANTIAGO

    IPC: C12Q1/68

    CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

    Abstract: Increasing evidence indicates that Parkinson's disease (PD) and type 2 diabetes (T2DM) share dysregulated molecular networks. 84 genes shared between PD and T2DM were identified from curated disease-gene databases. Nitric oxide biosynthesis, lipid and carbohydrate metabolism, insulin secretion and inflammation were identified as common dysregulated pathways. A network prioritization approach was implemented to rank genes according to their distance to seed genes and their involvement in common biological pathways. This disclosure reinforces the idea that shared molecular networks between PD and T2DM provide an additional source of biologically meaningful biomarkers.

    Abstract translation: 越来越多的证据表明帕金森病（PD）和2型糖尿病（T2DM）共享失调的分子网络。 从策划的疾病 - 基因数据库中鉴定了PD和T2DM之间共有84个基因。 一氧化氮生物合成，脂质和碳水化合物代谢，胰岛素分泌和炎症被鉴定为常见的失调途径。 实施了网络优先化方法，以根据其与种子基因的距离及其参与常规生物学途径的方式对基因进行排序。 本公开强调了PD和T2DM之间的共享分子网络提供了生物学有意义的生物标志物的额外来源的想法。

    Mobile Sensor System and Methods for Use
    54.
    发明申请
    Mobile Sensor System and Methods for Use 审中-公开
    移动传感器系统和使用方法

    公开(公告)号：US20160166193A1

    公开(公告)日：2016-06-16

    申请号：US14964690

    申请日：2015-12-10

    Applicant: Rosalind Franklin University of Medicine and Science

    Inventor： Fang Lin ,  Sai V. Yalla

    IPC: A61B5/00 ,  A61B3/113

    Abstract: The present disclosure provides a system including one or more sensors, a mounting system configured to removeably mount a computing device such that a camera of the computing device is positioned facing an eye of a subject, and a control system. The control system is configured to (a) receive sensor data from the one or more sensors, (b) determine whether the sensor data is indicative of balance instability of the subject, (c) track a position of the eye of the subject to assess vestibular dysfunction, (d) determine whether the camera data is indicative of vestibular dysfunction of the subject, and (e) in response to (i) the sensor data being indicative of balance instability of the subject and/or (ii) the camera data being indicative of vestibular dysfunction of the subject, display an indication of symptoms that are characteristic of a traumatic brain injury or concussion.

    Abstract translation: 本公开提供了一种包括一个或多个传感器的系统，配置成可移除地安装计算设备的安装系统，使得计算设备的照相机定位成面向被摄体的眼睛，以及控制系统。 所述控制系统被配置为（a）从所述一个或多个传感器接收传感器数据，（b）确定所述传感器数据是否指示所述对象的平衡不稳定性，（c）跟踪所述对象的眼睛的位置以评估 前庭功能障碍，（d）确定相机数据是否指示受试者的前庭功能障碍，以及（e）响应于（i）传感器数据指示受试者的平衡不稳定性和/或（ii）相机数据 指示受试者的前庭功能障碍，显示出具有创伤性脑损伤或脑震荡特征的症状的指征。

    Durability Test System for Repetitive Loading of a Prosthetic Socket
    58.
    发明申请
    Durability Test System for Repetitive Loading of a Prosthetic Socket 有权

    公开(公告)号：US20230095380A1

    公开(公告)日：2023-03-30

    申请号：US17936539

    申请日：2022-09-29

    Applicant: Rosalind Franklin University of Medicine & Science

    Inventor： Sai V. Yalla ,  Sunjung Kim ,  Noah J. Rosenblatt

    IPC: A61F2/76 ,  G01N3/06 ,  G01N3/08 ,  G01N3/32

    Abstract: The present disclosure relates to a system for repetitive loading of a prosthetic socket to test the durability of the prosthetic socket. The system includes a base and a load cell coupled to the base. The system further includes a first coupling mechanism positioned vertically above the load cell, and a second coupling mechanism positioned vertically above the first coupling mechanism. The first coupling mechanism is configured to be removably coupled to a first end of the prosthetic socket, and the second coupling mechanism is configured to be removably coupled to a second end of the prosthetic socket. The system further includes a rod having a first end and a second end opposite the first end. The first end of the rod is coupled to the second coupling mechanism. The system further includes a motor coupled to the second end of the rod, a support structure extending vertically from the base, and an actuator coupled to the support structure such that the actuator is positioned vertically above the second coupling mechanism. The system further includes a curved rail coupled to the actuator and positioned between the actuator and the second coupling mechanism. The curved rail is configured to contact the second coupling mechanism along an arc defined by the curved rail such that the second coupling mechanism moves along the arc when the motor moves the rod.

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