BIOREACTOR EXHAUST
    51.
    发明申请
    BIOREACTOR EXHAUST 审中-公开
    生物反应器排气

    公开(公告)号:US20150210974A1

    公开(公告)日:2015-07-30

    申请号:US14685250

    申请日:2015-04-13

    申请人: Sarfaraz K. NIAZI

    发明人: Sarfaraz K. NIAZI

    IPC分类号: C12M1/00 C12M1/34

    摘要: An exhaust system suitable for high volume exhaust from flexible disposable bags is described that prevents nutrient media volume loss and prevents cross-contamination without using any filters. The invention described here allows the use of disposable two-dimensional bioreactors for the cultivation of bacterial and other organisms and cells require high aeration.

    摘要翻译: 描述了适用于来自柔性一次性袋的高体积排气的排气系统,其防止营养物质体积损失并防止不使用任何过滤器的交叉污染。 这里描述的发明允许使用一次性二维生物反应器来培养细菌和其他生物体,细胞需要高通风。

    CONCENTRATOR FILTER
    52.
    发明申请
    CONCENTRATOR FILTER 审中-公开
    浓缩过滤器

    公开(公告)号:US20140175029A1

    公开(公告)日:2014-06-26

    申请号:US14191989

    申请日:2014-02-27

    申请人: Sarfaraz K. Niazi

    发明人: Sarfaraz K. Niazi

    IPC分类号: B01D29/64 B01D29/11

    摘要: A method and an apparatus for separating suspended matter from liquid includes a concentrator filter that draws the liquid out of the suspension while the filter kept unblocked by a sparging filter that allows scrubbing of the concentrator filter by gas bubbles. This invention can be used to replace cross-flow filtration and centrifugation in the bioprocess industry and to reduce the volume of suspensions to concentrate the yield of the end product in the chemical industry.

    摘要翻译: 用于从液体中分离悬浮物的方法和装置包括:浓缩器过滤器,其将液体从悬浮液中抽出,同时过滤器通过鼓泡过滤器保持开启状态,该喷射过滤器允许通过气泡洗涤聚光过滤器。 本发明可用于替代生物过程工业中的交叉流过滤和离心,并减少悬浮液的体积以将最终产物的产率集中在化学工业中。

    Baffled Single Use Bioreactor
    54.
    发明申请
    Baffled Single Use Bioreactor 有权
    挡板单用生物反应器

    公开(公告)号:US20140024105A1

    公开(公告)日:2014-01-23

    申请号:US13555149

    申请日:2012-07-21

    申请人: Sarfaraz K. Niazi

    发明人: Sarfaraz K. Niazi

    IPC分类号: C12M1/00

    摘要: A flexible disposable bioreactor having three, stagger-baffled compartments wherein the middle compartment houses a sparging rod is described to provide the highest degree of sparging and mixing to produce biological products.

    摘要翻译: 具有三个交错挡板的柔性一次性生物反应器被描述为提供最高程度的喷射和混合以产生生物制品。

    UNIVERSAL BIOREACTORS AND METHODS OF USE
    56.
    发明申请
    UNIVERSAL BIOREACTORS AND METHODS OF USE 有权
    通用生物反应器及其使用方法

    公开(公告)号:US20100261226A1

    公开(公告)日:2010-10-14

    申请号:US12423587

    申请日:2009-04-14

    申请人: Sarfaraz K. Niazi

    发明人: Sarfaraz K. Niazi

    CPC分类号: C12M29/04 C12M23/26 C12M23/58

    摘要: Bioreactors suitable for housing a predetermined volume of culture medium comprising a plurality of containers of approximately equal internal volume in which the culture medium resides, wherein the predetermined volume of culture medium is retained in approximately equal amounts within each of the plurality of containers during operation of the bioreactor, and wherein the internal volume of each container is selected so that the amount of culture medium in each container exceeds 50 vol. % of the container internal volume during operation of the bioreactor, and related methods of use.

    摘要翻译: 适于容纳预定体积的培养基的生物反应器,所述培养基包含培养基所在的大致相同的内部容积的多个容器,其中在所述多个容器的运行期间,所述预定体积的培养基在所述多个容器的每一个内保持大致相等的量 生物反应器,并且其中选择每个容器的内部体积,使得每个容器中的培养基的量超过50体积。 在生物反应器运行期间容器内部容积的百分比以及相关的使用方法。

    Composition and method for the treatment of diaper rash using natural products
    57.
    发明授权
    Composition and method for the treatment of diaper rash using natural products 有权
    使用天然产物治疗尿布疹的组合物和方法

    公开(公告)号:US06419963B1

    公开(公告)日:2002-07-16

    申请号:US09681520

    申请日:2001-04-22

    申请人: Sarfaraz K Niazi

    发明人: Sarfaraz K Niazi

    IPC分类号: A61K3578

    摘要: Provided here is a pharmaceutical composition containing beeswax, olive oil, &bgr;-sitosterol and the herb Coptis chinesis Franch for safe and quick treatment for infant and adult diaper rash. Also provided here is a methodology for the treatment of diaper rash wherein the treatment consists of compositions that contain naturally derived anti-inflammatory agents, an antimicrobial agents and such components that they provide an occlusive coating when applied to the afflicted surface.

    摘要翻译: 这里提供了一种含有蜂蜡,橄榄油,β-谷甾醇和草本黄连黄连的药物组合物,用于婴儿和成人尿布疹的安全和快速治疗。 这里还提供了一种治疗尿布疹的方法,其中治疗由含有天然衍生抗炎剂的组合物,抗微生物剂和这些组分组成,当它们施用于受影响的表面时,它们提供闭塞性涂层。

    Composition and method of use in treating sexual dysfunction using cGMP-specific phosphodiesterase type 5 inhibitors
    58.
    发明授权
    Composition and method of use in treating sexual dysfunction using cGMP-specific phosphodiesterase type 5 inhibitors 有权
    使用cGMP特异性磷酸二酯酶5型抑制剂治疗性功能障碍的组合物和方法

    公开(公告)号:US06338862B1

    公开(公告)日:2002-01-15

    申请号:US09681362

    申请日:2001-03-26

    申请人: Sarfaraz K Niazi

    发明人: Sarfaraz K Niazi

    IPC分类号: A61K3578

    摘要: The inhibitors of cyclic guanosine monophosphate (cGMP) phosphodiesterases type 5 (cGMP-PDE5) such as sildenafil citrate (Viagra®) act by increasing the level of cGMP in sexual organs to produce enhanced blood flow and an erectile response of sexual organs. Though sildenafil citrate is a specific inhibitor of cGMP-PDE5, its effects on other body organs produce many side effects including fatalities. Described here is a method of combining cGMP-PDE5 inhibitors with natural sources of nutrients that instantly enhance the levels of endogenous cGMP and thus reduce the therapeutic dose and therefore the side effects of cGMP-PDE5 inhibitors. We have discovered that if sildenafil citrate, as a prototype of cGMP-PDE5, is combined with L-arginine, ginseng, vitamin B6, vitamin B12, and folic acid, all natural and safe ingredients, the dose requirements for sildenafil citrate can be reduced substantially. The specific composition described here assists in the action of sildenafil primarily by increasing the production of cGMP through modulation of nitric oxide pathway (L-arginine→nitric oxide→cGMP) and secondarily by having its own effect on improving blood circulation to sexual organs.

    摘要翻译: 5型(cGMP)磷酸二酯酶(cGMP-PDE5)如柠檬酸西地那非(Viagra)的抑制剂通过增加性器官中cGMP的水平来产生增强的血流量和性器官的勃起反应。 虽然西地那非柠檬酸盐是cGMP-PDE5的特异性抑制剂,但其对其他身体器官的作用也会产生许多副作用,包括死亡。 这里描述了一种将cGMP-PDE5抑制剂与天然营养来源组合的方法,其立即增强内源性cGMP的水平,从而降低治疗剂量,从而降低cGMP-PDE5抑制剂的副作用。 我们已经发现,如果西地那非柠檬酸盐作为cGMP-PDE5的原型与L-精氨酸,人参,维生素B6,维生素B12和叶酸,所有天然和安全的成分组合,可以减少柠檬酸西地那非的剂量要求 实质上 这里描述的具体组合主要通过调节一氧化氮途径(L-精氨酸 - >一氧化氮 - > cGMP)来增加cGMP的产生,其次通过对改善对性器官的血液循环的效果来辅助西地那非的作用 。