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88 条记录 (耗时 0.02 秒)

    HARVESTING AND PERFUSION APPARATUS
    4.
    发明申请
    HARVESTING AND PERFUSION APPARATUS 审中-公开

    公开(公告)号：US20170101435A1

    公开(公告)日：2017-04-13

    申请号：US14881795

    申请日：2015-10-13

    申请人： Sarfaraz K. Niazi

    发明人： Sarfaraz K. Niazi

    IPC分类号： C07K1/22 ,  B01J19/24

    CPC分类号： C12M47/10

    摘要： The present invention relates to an apparatus capable of harvesting a recombinant protein from a bioreactor having a porous container comprised of a chromatography medium capable of binding the recombinant protein and a method of use thereof.

    Interconnected bioreactors
    5.
    发明授权
    Interconnected bioreactors 有权
    互连生物反应器

    公开(公告)号：US09587283B2

    公开(公告)日：2017-03-07

    申请号：US14738399

    申请日：2015-06-12

    申请人： Sarfaraz K. Niazi

    发明人： Sarfaraz K. Niazi

    IPC分类号： C12Q3/00 ,  C12M1/00 ,  C12M3/06

    CPC分类号： C12Q3/00 ,  C12M23/14 ,  C12M23/58 ,  C12M27/16

    摘要： A method of homogenously mixing the contents of a plurality of bioreactors by providing a receiving container capable of holding an appropriate quantity of the liquid and repeatedly raising and lowering the receiving container to a position above or below the position of the bioreactors resulting in mixing the contents of the bioreactors.

    摘要翻译： 一种通过提供能够保持适量的液体并且将接收容器反复升高和降低到生物反应器的位置上方或下方的位置的容纳容器来均匀地混合多个生物反应器的内容物的方法，从而使内容物 的生物反应器。

    Concentrator filter
    7.
    发明授权
    Concentrator filter 有权
    集中器过滤器

    公开(公告)号：US09364776B2

    公开(公告)日：2016-06-14

    申请号：US14191989

    申请日：2014-02-27

    申请人： Sarfaraz K. Niazi

    发明人： Sarfaraz K. Niazi

    IPC分类号： B01D29/64 ,  B01D29/11 ,  C12M1/00 ,  A01N1/02

    CPC分类号： C12N1/20 ,  A01N1/0247 ,  B01D29/114 ,  B01D29/15 ,  B01D29/64 ,  B01D29/66 ,  C07K1/34 ,  C07K14/505 ,  C12M21/00 ,  C12M23/26 ,  C12M29/04 ,  C12M29/10 ,  C12M47/02 ,  C12M47/10

    摘要： A method and an apparatus for separating suspended matter from liquid includes a concentrator filter that draws the liquid out of the suspension while the filter kept unblocked by a sparging filter that allows scrubbing of the concentrator filter by gas bubbles. This invention can be used to replace cross-flow filtration and centrifugation in the bioprocess industry and to reduce the volume of suspensions to concentrate the yield of the end product in the chemical industry.

    摘要翻译： 用于从液体中分离悬浮物的方法和装置包括：浓缩器过滤器，其将液体从悬浮液中抽出，同时过滤器通过鼓泡过滤器保持开启状态，该喷射过滤器允许通过气泡洗涤聚光过滤器。 本发明可用于替代生物过程工业中的交叉流过滤和离心，并减少悬浮液的体积以将最终产物的产率集中在化学工业中。

    BIOREACTORS FOR FERMENTATION AND RELATED METHODS
    9.
    发明申请
    BIOREACTORS FOR FERMENTATION AND RELATED METHODS 审中-公开
    生物反应器用于发酵和相关方法

    公开(公告)号：US20110117538A1

    公开(公告)日：2011-05-19

    申请号：US12618330

    申请日：2009-11-13

    申请人： Sarfaraz K. Niazi

    发明人： Sarfaraz K. Niazi

    IPC分类号： C12Q1/70 ,  C12M1/12 ,  C12Q1/06

    CPC分类号： C12M29/06

    摘要： Bioreactors suitable for housing a predetermined volume of liquid comprising nutrient medium and biological culture comprising: (a) a container having at least one interior wall; (b) at least one nutrient medium inlet; (c) at least one liquid outlet; (d) at least one gas inlet; (e) at least one gas outlet; and (f) at least one cylindrical sparging filter attached to the at least one gas inlet, wherein the sparging filter comprises a plurality of pores along its axis which permit gas to be emitted radially from the sparging filter into the liquid, wherein the diameter of the plurality of pores does not exceed about 50 μm, and wherein the orientation of the at least one sparging filter within the container provides for immersion of the plurality of pores within the liquid and substantially uniform distribution of emitted gas throughout the liquid, and related methods of using said bioreactors to prepare various biological products.

    摘要翻译： 适于容纳包含营养培养基和生物培养物的预定体积的液体的生物反应器，包括：（a）具有至少一个内壁的容器; （b）至少一个营养介质入口; （c）至少一个液体出口; （d）至少一个气体入口; （e）至少一个气体出口; 和（f）至少一个连接到所述至少一个气体入口的圆柱形喷射过滤器，其中所述喷射过滤器包括沿其轴线的多个孔，其允许气体从所述喷射过滤器径向射入液体，其中， 多个孔不超过约50μm，并且其中容器内的至少一个喷射过滤器的取向提供了多个孔浸入液体内并且基本上均匀地分布排出的气体遍及液体，并且相关方法 使用所述生物反应器来制备各种生物制品。

    TNF-alpha Protein Inhibiting mRNA Vaccine
    10.
    发明公开
    TNF-alpha Protein Inhibiting mRNA Vaccine 审中-公开

    公开(公告)号：US20240299439A1

    公开(公告)日：2024-09-12

    申请号：US18406166

    申请日：2024-01-07

    申请人： Sarfaraz K. Niazi ,  Matthias Magoola ,  Zafeer Ahmad

    发明人： Sarfaraz K. Niazi ,  Matthias Magoola ,  Zafeer Ahmad

    IPC分类号： A61K31/7105 ,  A61K9/51 ,  A61K39/00

    CPC分类号： A61K31/7105 ,  A61K9/5123 ,  A61K2039/53 ,  A61K2039/55555 ,  C12N2830/50

    摘要： TNF-alpha (Tumor Necrosis Factor-alpha) is a cytokine, a protein involved in the inflammation process in the body. It plays a crucial role in the immune system, primarily produced by activated macrophages the white blood cells. TNF-alpha is critical in the inflammatory response to infections and diseases, but it can also contribute to inflammatory and autoimmune diseases when produced in excess. Many antibodies are created to inhibit over-expressed TNF-alpha but with serious side effects. The present invention provides a mRNA vaccine to reduce the titer of TNF-alpha, leading to treating multiple life-threatening diseases including but not limited to rheumatoid arthritis, psoriatic arthritis, Crohn's disease, ankylosing spondylitis, plaque psoriasis, inflammatory bowel disease, type 2 diabetes, tumor progression, angiogenesis, and metastasis, heart failure from myocardial cell death, and atherosclerosis from fibrosis.