-
公开(公告)号：US11677071B2
公开(公告)日：2023-06-13
申请号：US16847909
申请日：2020-04-14
Applicant: National Technology & Engineering Solutions of Sandia, LLC , The Board of Regents of the University of Texas System
Inventor： Nelson S. Bell , Nancy A. Missert , Karen Lozano , Yatinkumar N. Rane
IPC: H01M4/04 , H01M4/131 , H01M4/13 , H01M4/505 , H01M4/525 , H01M4/36 , H01M4/1391 , H01M10/052 , H01M4/139 , H01M4/02
CPC classification number: H01M4/366 , H01M4/04 , H01M4/0471 , H01M4/13 , H01M4/131 , H01M4/139 , H01M4/1391 , H01M4/505 , H01M4/525 , H01M10/052 , H01M2004/021 , H01M2004/028
Abstract: A novel lithium battery cathode, a lithium ion battery using the same and processes and preparation thereof are disclosed. The battery cathode is formed by force spinning. Fiber spinning allows for the formation of core-shell materials using material chemistries that would be incompatible with prior spinning techniques. A fiber spinning apparatus for forming a coated fiber and a method of forming a coated fiber are also disclosed.
-
公开(公告)号：US11666634B2
公开(公告)日：2023-06-06
申请号：US16858557
申请日：2020-04-24
Inventor： William T. Phillips
CPC classification number: A61K38/22 , A61K49/10 , A61K49/1815 , A61P1/00
Abstract: Described herein are methods of management of functional dyspepsia in a patient by administering an amylin analogue or a CCK composition to the patient. Methods of diagnosing such patient include a standard gastric-emptying assessment using a standardized solid meal along with measurements of blood glucose levels. Another method of diagnosing such patient includes a gastric-emptying scintigraphy assessment with labeled carbohydrates or other assessments to diagnose rapid carbohydrate gastric emptying.
-
公开(公告)号：US20230165887A1
公开(公告)日：2023-06-01
申请号：US17934169
申请日：2022-09-21
Inventor： William S. KORINEK , James D. LECHLEITER , Theodore E. LISTON
IPC: A61K31/7076 , A61K31/52 , A61P25/00
CPC classification number: A61K31/7076 , A61K31/52 , A61P25/00
Abstract: The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.
-
54.发明公开公开(公告)号：US20230149295A1
公开(公告)日：2023-05-18
申请号：US17906027
申请日：2021-03-09
Applicant: University of Houston System , The Board of Regents of The University of Texas System , Tract Pharmaceuticals, Inc.
Inventor： Frank McKEON , Rahul NEUPANE , Jingzhong XIE , Wa XIAN , Matthew VINCENT , Shan WANG
CPC classification number: A61K9/0024 , A61K47/34 , A61K45/06
Abstract: The present disclosure addresses IBD from the standpoint of inhibiting or ablating pathogenic mucosal stem cells cloned from defined regions of disease in the gastrointestinal tract. In the case of Crohn's disease, for example, isolation of those stem cells according to the methods of the present disclosure reveals a pattern of inflammatory gene expression in stem cells from the terminal ileum and colon that is epigenetically maintained despite months of continuous cultivation in the absence of immune or stromal cells, or of intestinal microbes. Superimposed on this distributed inflammatory phenotype is a differentiation defect that profoundly and specifically alters the mucosal barrier properties of the terminal ileum. The co-existence of diseased and normal stem cells within the same endoscopic biopsies of Crohn's disease patients implicates an epigenetically enforced heterogeneity among mucosal stem cells in the dynamics of this condition.
-
公开(公告)号：US11651847B2
公开(公告)日：2023-05-16
申请号：US16558698
申请日：2019-09-03
Inventor： Troy Long , Mingli Chen , Steve Jiang , Weiguo Lu
CPC classification number: G16H20/40 , A61N5/1031
Abstract: A method and system for generating a voxel-based quadratic penalty model for automatic intensity modulated radiation therapy (IMRT) treatment planning are disclosed herein. A computing system generates an initial assignment of threshold values to a penalty function for IMRT treatment planning. The computing system receives an update to a dose value associated with the IMRT treatment planning. The computing system dynamically updates the threshold values based on the updated dose value. The computing system continues to iterate the threshold values based on further updated dose values.
-
Patent Agency Ranking
公开(公告)号：US11648209B2
公开(公告)日：2023-05-16
申请号：US17839699
申请日：2022-06-14
Inventor： Qiang Cheng , Tuo Wei , Daniel J. Siegwart
CPC classification number: A61K9/5123 , A61K48/0033 , C12N9/22 , C12N15/11 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/20 , C12N2320/32
Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
-
公开(公告)号：US20230139593A1
公开(公告)日：2023-05-04
申请号：US17911346
申请日：2021-03-12
Inventor： Thomas Avery , Andrew Abell , Dion Turner , Peter M. Grace , Jiahe Li
IPC: A61K31/216 , A61K31/22 , A61K31/40 , A61K31/4409 , A61K31/341 , A61P25/02
Abstract: The present invention relates to the treatment of disorders associated with oxidative stress including neuropathic pain and small synthetically derived compounds for treating such disorders.
-
公开(公告)号：US11634699B2
公开(公告)日：2023-04-25
申请号：US17052116
申请日：2019-05-01
Applicant: The Regents of the University of California , The Board of Regents of The University of Texas System
Inventor： Robert T. Clubb , Brendan Rayhan Amer , Janine Y. Fu , Scott McConnell , Hung Ton-That , Chungyu Chang
Abstract: Covalently cross-linked pilus polymers displayed on the cell surface of Gram-positive bacteria are assembled by class C sortase enzymes. These pilus-specific transpeptidases located on the bacterial membrane catalyze a two-step protein ligation reaction—first, cleaving the LPXTG motif of one pilin protomer to form an acyl-enzyme intermediate, and second, joining the terminal threonine to the nucleophilic lysine residue residing within the pilin motif of another pilin protomer. Informed by the high-resolution crystal structures of corynebacterial pilus-specific sortase (SrtA) and by developing structural variants of the sortase enzyme whose catalytic pocket has been unmasked by activating mutations, we have developed new reagents capable of forming isopeptide bonds in vitro. The reagents disclosed herein can catalyze ligation of isolated SpaA domains in vitro provide a facile and versatile new platform for protein engineering and bio-conjugation that has major implications for biotechnology.
-
公开(公告)号：US11624050B2
公开(公告)日：2023-04-11
申请号：US17000235
申请日：2020-08-21
Inventor： Lingqian Chang , R. Lyle Hood , Forhad Akhter
Abstract: Disclosed is the design, fabrication, and characterization of a novel system comprising a parallel set of nanopore microneedles (NPMs) for cell transfection through controlled nanoelectroporation (NEP) and electrophoretic insertion of genetic materials.
-
公开(公告)号：US20230101768A1
公开(公告)日：2023-03-30
申请号：US17819620
申请日：2022-08-13
Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Somshuvra Mukhopadhyay , Chunyi Liu , Donald Smith
IPC: A61K31/472 , A61K31/513 , A61K31/4704 , A61K31/437 , A61K31/5377 , A61K31/4418 , A61P3/12
Abstract: Disclosed is a method for treating manganese (manganese) toxicity in a subject. The method includes administering to the subject an effective amount of a hypoxia inducible factor (HIF) prolyl hydroxylase inhibitor or a pharmaceutically acceptable salt or solvate thereof.
-
-
-
-
-
-
-
-
-
Search Results
1244
records
(took 0.045 seconds)
