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公开(公告)号：US20210369316A1
公开(公告)日：2021-12-02
申请号：US17346942
申请日：2021-06-14
Applicant: University of Kansas
Inventor： Terence Edward McIff , Edward Bruce Toby
IPC: A61B17/86 , A61B17/064 , A61B17/68
Abstract: Embodiments of the present invention relate to systems, methods, and apparatus for immobilizing and/or securing bone portions. Particularly, at least one embodiment involves a compact anti-rotation device that can secure adjacent bones and/or bone portions in a manner that prevents or limits relative rotational movement thereof.
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公开(公告)号：US11162143B2
公开(公告)日：2021-11-02
申请号：US17236561
申请日：2021-04-21
Inventor： Mei He
IPC: G01N27/00 , B03C5/00 , G01N27/12 , C12Q1/6886 , A61K47/69 , G01N33/574 , G01N33/543 , B03C1/015 , B03C1/30 , B01L3/00 , A61K49/00
Abstract: Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.
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公开(公告)号：US11160832B2
公开(公告)日：2021-11-02
申请号：US16924950
申请日：2020-07-09
Applicant: The Children's Mercy Hospital , The University of Kansas
Inventor： Amara Seng , Ryan Fischer , Thomas Yankee , Mary Markiewicz , John Szarejko
IPC: C12N5/00 , A61K35/17 , C12N15/86 , C12N5/0783
Abstract: Cell therapy compositions comprising engineered human regulatory T cells (eTregs) characterized by ectopic overexpression of FOXP3 and Helios protein, produced via introduction of separate nucleic acid constructs respectively encoding FOXP3 and Helios (FOXP3+Helios+eTregs). Cell therapy compositions comprising mixed populations of CD4+ and CD8+ Treg cells each with ectopic overexpression of FOXP3 and Helios. Methods of making and use the same for therapies involving inflammation and/or a disorder of the immune system.
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公开(公告)号：US20210322569A1
公开(公告)日：2021-10-21
申请号：US17354514
申请日：2021-06-22
Inventor： Steven R. BUCHMAN , Mark COHEN , Alexis DONNEYS , Noah NELSON , Laird FORREST , Ti ZHANG , Qiuhong YANG
IPC: A61K47/69 , A61K9/51 , A61L27/50 , A61K47/61 , A61P19/00 , A61P19/08 , A61K31/16 , A61L27/20 , A61L27/54 , A61L27/58
Abstract: The present invention relates to novel therapeutic nanoparticles. In particular, the present invention is directed to nanoparticles associated (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) with angiogenesis-activating-agents, methods of synthesizing the same, devices or compositions comprising such nanoparticles, as well as systems and methods utilizing the nanoparticles (e.g., in therapeutic settings for enhancing and/or activating angiogenesis at targeted tissue region).
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公开(公告)号：US20210317067A1
公开(公告)日：2021-10-14
申请号：US17280235
申请日：2019-09-30
Applicant: University of Kansas
Inventor： Russell Swerdlow , Laird Forrest , Jordan Hunt , Heather Wilkins , Eli Michaelis
IPC: C07C69/716 , A61P25/28
Abstract: Compounds, compositions, and methods related to bioenergetic metabolism are provided. The compounds and com positions are suited to promote bioenergetic processes including cellular respiration and glycolytic flux and may be used to treat mitochondrial disorders, neurodegenerative diseases (such as Alzheimer's disease (AD), Parkinson's disease, and/or amyotrophic lateral sclerosis), multiple sclerosis, and/or epilepsy.
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Patent Agency Ranking
公开(公告)号：US11033311B2
公开(公告)日：2021-06-15
申请号：US13741263
申请日：2013-01-14
Applicant: University of Kansas
Inventor： Terence Edward McIff , Edward Bruce Toby
IPC: A61B17/86 , A61B17/064 , A61B17/68 , A61B17/00
Abstract: Embodiments of the present invention relate to systems, methods, and apparatus for immobilizing and/or securing bone portions. Particularly, at least one embodiment involves a compact anti-rotation device that can secure adjacent bones and/or bone portions in a manner that prevents or limits relative rotational movement thereof.
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公开(公告)号：US10961631B2
公开(公告)日：2021-03-30
申请号：US16224972
申请日：2018-12-19
Applicant: University of Kansas
Inventor： Kevin C. Leonard , Joseph M. Barforoush , Tess E. Seuferling , Kelly R. Song
Abstract: A method for making a metal oxyhydroxide electrocatalytic material comprises titrating a precursor solution with a (bi)carbonate salt, the precursor solution comprising a first metal salt and a solvent, wherein the titration induces reactions between the (bi)carbonate salt and the first metal salt to provide first metal carbonate species in the titrated precursor solution; and exposing the titrated precursor solution to microwave radiation to decompose the first metal carbonate species to form the metal oxyhydroxide electrocatalytic material and carbon dioxide. Mixed metal oxyhydroxide electrocatalytic materials such as nickel-iron oxyhydroxide may be formed. Also provided are the materials themselves, electrocatalytic systems comprising the materials, and methods of using the materials and systems.
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公开(公告)号：US20210040074A1
公开(公告)日：2021-02-11
申请号：US16977897
申请日：2019-03-06
Applicant: David R. Sibley , Kathryn D. Luderman , Jennie L. Conroy , R. Benjamin Free , Prashi Jain , Noel T. Southall , Marc Ferrer , Jeffrey Aubé , Kevin Frankowski , The United States of America,as represented by the Secretary,Department of Health and Human Service , University of Kansas , The University of North Carolina at Chapel Hill
Inventor： David R. Sibley , Kathryn D. Luderman , Jennie L. Conroy , R. Benjamin Free , Prashi Jain , Noel T. Southall , Marc Ferrer , Jeffrey Aubé , Kevin Frankowski
IPC: C07D409/12 , C07D471/04
Abstract: Disclosed are compounds of formulas (I) and (III) for treating or preventing a disease or disorder responsive to activation of a D1 dopamine receptor agonist in a mammal in need thereof, wherein m, n, R1-R6, and R11-R13 are as defined herein. Examples of such disease or disorder include Alzheimer's Disease, schizophrenia, Parkinson's disease, a dyskinesia, and Huntington's disease.
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公开(公告)号：US20210015813A1
公开(公告)日：2021-01-21
申请号：US16978542
申请日：2019-03-07
Applicant: Victoria Link Ltd. , University of Kansas
IPC: A61K31/485 , A61P25/28
Abstract: The present invention relates generally to methods of using nalfurafine for treating and/or preventing demyelinating disease in a subject, and in particular for treating and/or preventing multiple sclerosis (MS). Also disclosed is nalfurafine for use in treating and/or preventing MS as well as pharmaceutical compositions and unit dosage forms comprising nalfurafine for use for treating and/or preventing demyelinating disease in a subject, and in particular for treating and/or preventing MS.
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公开(公告)号：US10787439B2
公开(公告)日：2020-09-29
申请号：US15672574
申请日：2017-08-09
Applicant: University of Kansas , The Regents of the University of Michigan , Wayne State University , Sanford-Burnham Medical Research Institute
Inventor： Jennifer E. Golden , Jeffrey Aube , Daniel P. Flaherty , Andrew M. Fribley , Randal J. Kaufman , Thomas D. Y. Chung , Anthony B. Pinkerton , Michael Pablo Hedrick
IPC: A61K31/4525 , C07D405/12 , C07D307/71 , A61K31/496 , A61K31/5377 , A61K45/06 , C07C303/36
Abstract: N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
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